Developing World Bioethics最新文献

{"title":"Dual-use research assessment in emerging medical biotechnology: An ethical perspective from China.","authors":"Xiaonan Wang, Xiaomei Zhai","doi":"10.1111/dewb.12472","DOIUrl":"https://doi.org/10.1111/dewb.12472","url":null,"abstract":"<p><p>Emerging medical biotechnology, with its dual-use nature, presents both unprecedented opportunities and challenges for human society. As we benefit from technological innovation, it is crucial for Chinese academics and policymakers to effectively identify and address potential risks. However, the current framework for evaluating dual-use research faces multiple challenges, including difficulties in identifying dual-use issues, a lack of consideration for broader impacts in assessments, and a lack of consensus on balancing benefits and risks. Furthermore, inadequacies in the review mechanism, such as uneven progress among institutions, insufficient review capabilities, and lacking specialized knowledge among assessment personnel, hamper the effectiveness of evaluation efforts. This article aims to explore these challenges and propose practical recommendations for strengthening the evaluation and governance mechanisms of dual-use research. By effectively mitigating the risks associated with dual-use research, it facilitates the promotion of responsible scientific progress in emerging medical biotechnologies in China and internationally.</p>","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THANK YOU TO DEVELOPING WORLD BIOETHICS REVIEWERS","authors":"","doi":"10.1111/dewb.12473","DOIUrl":"https://doi.org/10.1111/dewb.12473","url":null,"abstract":"","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":"24 4","pages":"342"},"PeriodicalIF":0.9,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of implementing the elective oocyte cryopreservation in China: A case study.","authors":"Yijing Xie, Xiaomei Zhai","doi":"10.1111/dewb.12471","DOIUrl":"https://doi.org/10.1111/dewb.12471","url":null,"abstract":"<p><p>In China, a prominent case exists wherein a medically fit woman filed a lawsuit against a hospital for denying her request to undergo oocyte cryopreservation. She contended the hospital had infringed upon her rights. This paper focuses on medicalization and gender equality to discuss whether or not a hospital can infringe upon a woman's rights. We believe elective oocyte cryopreservation is not a medical treatment and it may lead to an overwhelming utilization of extensive medical resources. Reproductive medicine may face the risk of resource commercialization due to the practice of selective egg freezing. There are physiological disparities between males and females. The ability of men to cryopreserve sperm does not necessarily extend to a woman's capacity for oocyte cryopreservation. We contend that the application of this technology should continue to adhere to the principle of prudence.</p>","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adults aged 65 years and older in South Africa have a responsibility to vaccinate against influenza.","authors":"Ruach Sarangarajan, Cornelius Ewuoso","doi":"10.1111/dewb.12470","DOIUrl":"https://doi.org/10.1111/dewb.12470","url":null,"abstract":"<p><p>In this article, we draw on the thinking about incompleteness and conviviality grounded in Afro-communitarianism ethics from the Global South to argue that adults aged 65 years and above have a prima facie responsibility to vaccinate against influenza. Notably, adults aged 65 years and above have a duty of conviviality to act in ways that limit harm to them and others. This article is intrinsically valuable to promote epistemic justice, thereby contributing towards the decolonisation of the global healthcare system. Moreover, this project has social significance in contributing to mitigation efforts against future public health challenges associated with population ageing in resource-limited developing African nations, wherein the impact of population transition will be felt most.</p>","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revision of a self-assessment tool for research ethics committees in low- and middle-income countries: Incorporation of elements that safeguard participants' rights and welfare.","authors":"Hany Sleem, Henry J Silverman","doi":"10.1111/dewb.12469","DOIUrl":"10.1111/dewb.12469","url":null,"abstract":"<p><p>Evaluating the quality of research ethics committees (RECs) is crucial but challenging due to the difficulty of developing meaningful quality measures. Recently, commentators assessed ten quality instruments for RECs, including the Research Ethics Committee Quality Assurance Self-Assessment Tool developed for RECs in the Arab Middle East. They identified several missing items in this tool regarding safeguarding participants' rights and welfare. To address these gaps, we aimed to redesign the tool. Using the Delphi method, we involved 15 REC chairs to provide feedback and recommendations for a revised tool. This process led to a modified instrument that incorporated the missing items and additional elements regarding the monitoring of research conduct (an essential oversight function of RECs), and the independence of the RECs from institutional and external influences. We conclude that the revised tool effectively addresses the quality of RECs by including elements relevant to participant outcomes, board deliberations, and participant protection. The added focus on ethics oversight enhances its robustness, significantly impacting participants' rights and welfare.</p>","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From COVID-19 to mpox vaccine hoarding - Has the Global North learned its global health lessons?","authors":"Udo Schuklenk","doi":"10.1111/dewb.12468","DOIUrl":"10.1111/dewb.12468","url":null,"abstract":"&lt;p&gt;During the COVID-19 pandemic many writers decried the global north's hoarding of COVID-19 vaccines. The response ranged from authors calling said hoarding tamely ‘unethical’1 or, more aggressively, labeling this conduct as ‘Vaccine Apartheid.’2 Now that we have established that at a certain point in time in a WHO declared ‘public health emergency of international concern’3 vaccine hoarding becomes ethically problematic, how are things playing out in the currently ongoing mpox outbreak on the African continent? After all, in August this year the WHO declared just that. The Africa Centres for Disease Control and Prevention declared the mpox outbreak ‘a public health emergency of continental security’.4 This clearly constitutes a call to arms, both directed at partners in the global north, as well as to African governments, to take this outbreak seriously, and to commit the resources required to address it efficiently.&lt;/p&gt;&lt;p&gt;Mpox was first described in the Democratic Republic of Congo (DRC) in 1970. At the time of writing this editorial, it is spreading rapidly in a number of African countries, including Burundi, Kenya, and Uganda, countries where mpox had never been reported before. Since then, it has also spread to South Africa and caused disease and death there, as well as to Sweden and Thailand. Such is the nature of global travel that an illness that is often sexually transmitted moves around quickly. At greatest risk of death are seemingly young children and people living with compromised immune systems, which undoubtedly will include many in sub-Saharan Africa who don't have reliable access to HIV medication.&lt;/p&gt;&lt;p&gt;At this point in time the DRC ‘remains the epicentre of disease, accounting for 96% of new cases and deaths.’ It is estimated that the currently affected African countries require about 10 million vaccine doses to get the mpox outbreak under control. Only around 2.6-3.6 million doses are available, and countries of the global north haven't donated what is needed, despite having uncontroversial ethical obligations to do so.5&lt;sup&gt;,&lt;/sup&gt;6&lt;/p&gt;&lt;p&gt;Of course, there will be much talk about the need for transparency, but African countries’ governments will recall what happened after they reported truthfully the discovery of the COVID-19 Omicron variant. Racist, punitive travel bans were issued, and the harms they did to African people was much worse than anything caused by Omicron. None of that travel ban grandstanding implemented in many nation states, partly in order to avoid inflaming already existing xenophobic sentiments, prevented the rapid spread of the variant across the globe. One would hope Western governments have learned relevant lessons from this.&lt;/p&gt;&lt;p&gt;As a result of the failure of the global north to provide COVID-19 vaccines to people in the global south in a timely fashion, the WHO's legally binding International Health Regulations (IHR) were updated to include equitable access to lifesaving countermeasures. The IHR als","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":"24 4","pages":"265-266"},"PeriodicalIF":0.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/dewb.12468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moral challenges and understanding of clinical ethics in Tanzanian hospitals: Perspectives of healthcare professionals.","authors":"Shija Kevin Kuhumba, Bert A C Molewijk, Jan Helge Solbakk, Nandera Ernest Mhando, Trygve Johannes Lereim Sævareid","doi":"10.1111/dewb.12467","DOIUrl":"https://doi.org/10.1111/dewb.12467","url":null,"abstract":"<p><p>Healthcare professionals encounter many moral challenges in their daily clinical practice. However, there have been few studies on the subject matter in Tanzania. This study aims to provide an account of moral challenges faced by healthcare professionals in Tanzanian hospitals, their understanding of clinical ethics, and the ethics education they have received. Many participants reported receiving some kind of ethics training through formal education and on-the-job training. Some participants understood ethics in healthcare settings as adherence to established laws, regulations, guidelines, procedures, norms, and rules essential in clinical practice. Analysis of the data identified four themes of moral challenges. These challenges are related to 1) decision-making and communication in clinical practice, 2) scarcity of medical resources and prioritization in clinical practice, 3) withdrawal of curative treatment, and 4) conflicts between professional judgment, religious convictions and adherence to alternative treatments. Based on the findings, we suggest a context-sensitive form of clinical ethics training to prepare healthcare professionals to recognize and address these moral challenges.</p>","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indigenous Peoples' human genomic sovereignty: Lessons for Africa.","authors":"Faith Kabata","doi":"10.1111/dewb.12466","DOIUrl":"https://doi.org/10.1111/dewb.12466","url":null,"abstract":"<p><p>Human genomics research with indigenous peoples has often been characterised by tension between the 'western' science ideologies and indigenous peoples' cultural beliefs in relation to their human genetic resources and data. This article explores this tension from the lens of the concept of indigenous peoples' human genomic sovereignty and tests the applicability of the concept in Africa. The article achieves this by first highlighting the tension between 'western' science and indigenous peoples through three case studies from Canada, the USA, and South Africa. It then analyses indigenous peoples' human genomic sovereignty in the USA and Canada and compares it with the notion of indigenous peoples' sovereignty in Africa. The article concludes by highlighting lessons that indigenous groups in Africa can draw from the USA and Canada in their quest for human genomic sovereignty.</p>","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping review of the ethical regulations for Alzheimer's Disease and Alzheimer's Disease Related Dementia research in Africa.","authors":"Aminu Yakubu, Isaac Adedeji, Ayodele Jegede, Diana Mendoza-Carvantes, Clement Adebamowo","doi":"10.1111/dewb.12465","DOIUrl":"https://doi.org/10.1111/dewb.12465","url":null,"abstract":"<p><p>We conducted a scoping review to ascertain the landscape of ethics regulations for AD/ADRD research in Africa using Arksey and O'Malley's framework. We sourced regulations from the International Compilation of Human Research Standards. We included regulations from 14 countries published between 1997 and 2020. Provisions in the regulations applicable to research in AD/ADRD were part of broader sub-provisions for research such as with persons under legal disability. Regulations mostly required the appointment of Legally Authorised Representatives, as a major protection for persons with AD/ADRD. Provisions supporting capacity assessment and advance directives were only provided in regulations from five and two countries respectively. No regulation cited the Convention on the Rights of Persons with Disabilities as a foundational instrument for its provisions. In conclusion, regulations specifically applicable to research among AD/ADRD or other cognitively impaired persons in Africa are scarce and provisions in existing regulations mostly lack specificity for practical implementation.</p>","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":" ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142394939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical analysis of informed consent methods in longitudinal cohort studies: A Chinese perspective","authors":"Kun Li, Mingtao Huang, Xiaomei Zhai, Chen Wang","doi":"10.1111/dewb.12460","DOIUrl":"https://doi.org/10.1111/dewb.12460","url":null,"abstract":"In longitudinal cohort studies involving large populations over extended periods, informed consent entails numerous urgent challenges. This paper explores challenges regarding informed consent in long‐term, large‐scale longitudinal cohort studies based on the longitudinal and dynamic nature of such research. It analyzes and evaluates widely recognized broad consent and dynamic consent methods, highlighting limitations concerning their ability to adapt to evolving research objectives and participant perspectives. This paper discusses trust‐based informed consent and emphasizes the needs to establish and maintain trust with research participants and to balance information disclosure with respect for participants' autonomy. Informed consent in long‐term studies is an evolving process that must adapt to changing research environments. Based on participant trust, researchers should observe and assess potential research risks. Finally, the paper recommends enhancing institutional credibility, implementing reconsent procedures, and ensuring robust ethical oversight to safeguard participants' rights despite the complexity of modern biomedical research.","PeriodicalId":50590,"journal":{"name":"Developing World Bioethics","volume":"19 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}