ECS Sensors PlusPub Date : 2024-05-10DOI: 10.1149/2754-2726/ad49b0
Megan E. Kizer, Jason R. Dwyer
{"title":"Deciphering the Glycan Kryptos by Solid-State Nanopore Single-Molecule Sensing: A Call for Integrated Advancements Across Glyco- and Nanopore Science.","authors":"Megan E. Kizer, Jason R. Dwyer","doi":"10.1149/2754-2726/ad49b0","DOIUrl":"https://doi.org/10.1149/2754-2726/ad49b0","url":null,"abstract":"\u0000 Glycans, or complex carbohydrates, are information-rich biopolymers critical to many biological processes and with considerable importance in pharmaceutical therapeutics. Our understanding, though, is limited compared to other biomolecules such as DNA and proteins. The greater complexity of glycan structure and the limitations of conventional chemical analysis methods hinder glycan studies. Auspiciously, nanopore single-molecule sensors—commercially available for DNA sequencing—hold great promise as a tool for enabling and advancing glycan analysis. We focus on two key areas to advance nanopore glycan characterization: molecular surface coatings to enhance nanopore performance including by molecular recognition, and high-quality glycan chemical standards for training.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-05-10DOI: 10.1149/2754-2726/ad49af
Courtney J Weber, Megan D Whisonant, Olivia M Clay, Olja Simoska
{"title":"Surface-display Techniques in Electrochemical Biosensor Designs for Health Monitoring","authors":"Courtney J Weber, Megan D Whisonant, Olivia M Clay, Olja Simoska","doi":"10.1149/2754-2726/ad49af","DOIUrl":"https://doi.org/10.1149/2754-2726/ad49af","url":null,"abstract":"\u0000 Enzymatic and microbial electrochemical biosensors integrate enzymes and microorganisms as biological recognition elements into the sensor design and functionality. Enzyme-based sensors offer high sensitivity and selectivity for target analyte detection. However, these have limited stability necessary for continuous analyte monitoring. Contrarily, microbe-based electrochemical sensors provide a means for continuous analyte sensing but are associated with challenges related to analyte selectivity in complex samples. To address these limitations, surface-display methods, which bind enzymes to microbial surfaces, enhance biosensor selectivity and sensitivity. This perspective outlines the application of surface-display techniques, offering a promising avenue for health monitoring.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140992358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantum Biosensors: Principles and Applications in Medical Diagnostics","authors":"Suparna Das, Hirak Mazumdar, Kamil Reza Khondakar, A. Kaushik, Yogendra Kumar Mishra","doi":"10.1149/2754-2726/ad47e2","DOIUrl":"https://doi.org/10.1149/2754-2726/ad47e2","url":null,"abstract":"\u0000 Originating at the intersection of physics and biosensing, quantum biosensors (QB) are transforming medical diagnostics and personalized medicine by exploiting quantum phenomena to amplify sensitivity, specificity, and detection speed compared to traditional biosensors. Their foundation lies in the fusion of biological entities like DNA, proteins, or enzymes with quantum sensors, which elicits discernible alterations in light emissions when interacting with sample molecules. Their prowess in identifying disease-linked biomarkers presents an avenue for early diagnoses of conditions like Alzheimer's and cancer. Beyond this, they enable real-time monitoring of treatment responses by capturing the dynamism of biomarkers, but QB still face challenges, such as issues of stability, reproducibility, and intricate quantum interactions. Moreover, seamless integration into prevailing diagnostic frameworks necessitates careful consideration. Looking ahead, the evolution of QB navigates uncharted territories. Innovations in fabrication techniques, interdisciplinary collaborations, and standardization protocols emerge as pivotal areas of exploration. This comprehensive discourse encapsulates QB's principles, diverse iterations, and burgeoning medical utilities. It delves into inherent challenges and limitations, shedding light on the potential trajectories of future research. As QB continues to evolve, its potential to redefine medical diagnostics becomes increasingly tangible. The saga of QB resonates with possibilities, poised to reshape the diagnostic landscape profoundly.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":"14 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141005014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-04-19DOI: 10.1149/2754-2726/ad408e
Richa Pandey
{"title":"Electrochemical Bio-wearables for Cortisol Monitoring","authors":"Richa Pandey","doi":"10.1149/2754-2726/ad408e","DOIUrl":"https://doi.org/10.1149/2754-2726/ad408e","url":null,"abstract":"\u0000 Cortisol is a key biomarker for stress, and its measurement has historically relied on intrusive and sporadic techniques like blood or saliva samples. By offering continuous, non-invasive monitoring, electrochemical cortisol monitors: a relatively recent innovation—offer a revolutionary strategy. This viewpoint examines the development, underlying ideas, scientific developments, and possible uses of electrochemical cortisol bio-wearables. The significance of these tools for stress research, clinical application, and individualized healthcare is also highlighted.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140683765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-04-18DOI: 10.1149/2754-2726/ad4045
D. Rajkumar, Umamahesvari Hemakumar
{"title":"Enhancing Structural Integrity, Optical Properties, and Room Temperature Formaldehyde Sensing Through Optimized Spray Deposition Rates","authors":"D. Rajkumar, Umamahesvari Hemakumar","doi":"10.1149/2754-2726/ad4045","DOIUrl":"https://doi.org/10.1149/2754-2726/ad4045","url":null,"abstract":"\u0000 This study explores the impact of deposition rate on the properties of TiO2 thin films produced via spray pyrolysis, focusing on their application in gas sensors. The analysis covers structural, morphological, optical, and gas sensing characteristics of TiO2 films deposited at rates between 1 and 2.5 ml/min. Studies show optimizing TiO2 film deposition rates at 2 ml/min significantly enhances formaldehyde detection, improving selectivity and achieving a rapid response of 7.52 at 20 ppm concentration. This study underscores the pivotal role of deposition rate optimization in augmenting the gas-sensing efficacy of TiO2 films, particularly for formaldehyde detection at ambient conditions. Optimal deposition rates are instrumental in enhancing sensor performance. The synergistic application of XRD and Raman spectroscopy unequivocally confirmed the presence of the TiO2 anatase phase, which is of paramount significance in gas sensing applications. FESEM furnished high-resolution insights into the surface morphology, revealing a spherical architecture. Furthermore, UV-Vis spectroscopy was employed to assess the optical band gap of the films, which exhibited a decrement correlating with the rate of deposition. Notably, a deposition rate of 2 ml/min markedly improved the TiO2 films' sensing performance. These insights are critical for developing cost-effective, high-performance gas sensors for cutting-edge applications.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140688192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-04-09DOI: 10.1149/2754-2726/ad3c4f
Nadiah M. Alyamni, J. Abot, A. Zestos
{"title":"Perspective—Advances in Voltammetric Methods for the Measurement of Biomolecules","authors":"Nadiah M. Alyamni, J. Abot, A. Zestos","doi":"10.1149/2754-2726/ad3c4f","DOIUrl":"https://doi.org/10.1149/2754-2726/ad3c4f","url":null,"abstract":"Voltammetry is a powerful electroanalytical tool that makes fast, real-time measurements of neurotransmitters and other molecules. Electroanalytical methods like cyclic, pulse, and stripping voltammetry are useful for qualitative and quantitative examination. Neurochemical sensing has been enhanced using carbon-based electrodes and waveform modification methods that improve sensitivity and stability of electrode performance. Voltammetry has revolutionized neurochemical monitoring by providing real-time information on neurotransmitter dynamics for neurochemical studies. Selectivity and electrode fouling remain issues for biomolecule detection, but recent advances promise new methods of analysis for other applications to enhance spatiotemporal resolution, sensitivity, selectivity, and other important considerations.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140724558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-04-04DOI: 10.1149/2754-2726/ad3a58
Dalton L. Glasco, Manar M. Elhassan, William T. McLeod, Jeffrey G. Bell
{"title":"Nonenzymatic Detection of Glucose Using 3D Printed Carbon Electrodes in Human Saliva","authors":"Dalton L. Glasco, Manar M. Elhassan, William T. McLeod, Jeffrey G. Bell","doi":"10.1149/2754-2726/ad3a58","DOIUrl":"https://doi.org/10.1149/2754-2726/ad3a58","url":null,"abstract":"\u0000 One of the most prevalent diseases where point-of-care (POC) diagnostics has focused is diabetes, which impacts hundreds of millions of people globally. Due to the severe negative outcomes including renal failure, nerve damage, and stroke, many POC sensors have been designed to streamline low-cost testing. Recently, the utility of 3D printing for rapidly fabricating housings, electrodes, and sensors for use at the POC has been exploited toward diverse applications. Particularly interesting are 3D printed carbon electrodes (3DpCEs) in POC diagnostics owing to their simplicity, affordability, and mass production capabilities for developing sensors either for direct use or through post-printing surface modifications. Herein, we report a copper modified 3DpCE as a sensitive and selective nonenzymatic biosensor for glucose. Copper deposition, paired with an optimized activation protocol, produced a sensitive and selective sensor for glucose with a larger detection range, enhanced sensitivity, and better reproducibility compared to nonactivated and alkaline immersed 3DpCEs. The sensor displayed excellent linearity between 10-1800 µM and proved to be highly selective over common biologically relevant interferants. The 3D printed sensor successfully determined biologically relevant concentrations of glucose in human saliva which resulted in percent recoveries of 101+8%, 106+6%, and 98+6% for 74, 402, and 652 µM glucose, respectively","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":"18 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-04-01DOI: 10.1149/2754-2726/ad3950
Emily DeVoe, Silvana Andreescu
{"title":"Review—Catalytic Electrochemical Biosensors for Dopamine: Design, Performance, and Healthcare Applications","authors":"Emily DeVoe, Silvana Andreescu","doi":"10.1149/2754-2726/ad3950","DOIUrl":"https://doi.org/10.1149/2754-2726/ad3950","url":null,"abstract":"\u0000 The effect of an Al2TiO5 (ALT) interlayer between Ni and YSZ on enhancing the thermal stability of Ni-YSZ solid oxide fuel cell was examined. Atomic layer deposition (ALD) was used to provide precise control of the structure and thickness of the ALT interlayer. The study’s findings demonstrate that a 2 nm thick ALT interlayer deposited by ALD does not adversely affect the cell’s ohmic resistance and effectively prevents Ni sintering and the loss of active area during high-temperature heat treatments. ALT layers thicker than 2 nm, although they enhanced Ni stability, were found to impede oxygen ion transport in the electrode and significantly increase the ohmic resistance of the cell, leading to a decline in performance.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-03-19DOI: 10.1149/2754-2726/ad3561
Niamh Marie Cusack, Prabhuraj Venkatraman, Umar Raza, Azmy Faisal
{"title":"Review—Smart Wearable Sensors for Health and Lifestyle Monitoring: Commercial and Emerging Solutions","authors":"Niamh Marie Cusack, Prabhuraj Venkatraman, Umar Raza, Azmy Faisal","doi":"10.1149/2754-2726/ad3561","DOIUrl":"https://doi.org/10.1149/2754-2726/ad3561","url":null,"abstract":"\u0000 The rapid growth of urbanisation has brought about various health concerns for citizens living in urban environments. Sedentary lifestyles, increased pollution levels, and high levels of stress have become prevalent issues affecting the overall well-being of urban populations. In recent years, the emergence of smart wearable devices has offered a promising avenue to address these health concerns and promote healthier lifestyles. This review evaluatse the effectiveness of smart wearables in mitigating health concerns and improving the lifestyles of urban citizens. The review involves 50 relevant peer-reviewed smart wearable studies and supporting literature from electronic databases PubMed, Ovid, Web of Science, and Scopus. Results indicate that smart wearables have the potential to positively impact the health of urban citizens by promoting physical activity, tracking vital signs, monitoring sleep patterns, and providing personalised feedback and recommendations to promote physical activity levels. Furthermore, these devices can help individuals manage stress levels, enhance self-awareness, and foster healthier behaviours. However, the review also identifies several challenges, including the accuracy and reliability of wearable data, user engagement and adherence, and ethical considerations regarding data privacy and security.","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":"28 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140229248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ECS Sensors PlusPub Date : 2024-03-13DOI: 10.1149/2754-2726/ad33a3
Shivangi Srivastava, Narendra Kumar Pandey, V. Verma, Peramjeet Singh, Amit Verma, Neetu Yadav
{"title":"Fabrication of Highly Sensitive YCeO Chemo-resistive Gas Sensor for Selective Detection of CO2","authors":"Shivangi Srivastava, Narendra Kumar Pandey, V. Verma, Peramjeet Singh, Amit Verma, Neetu Yadav","doi":"10.1149/2754-2726/ad33a3","DOIUrl":"https://doi.org/10.1149/2754-2726/ad33a3","url":null,"abstract":"\u0000 A room-temperature-operated CO2 gas sensor based on YCeO nanocomposite was effectively prepared by the simple hydrothermal technique to detect low traces of CO2 (50-250 ppm). The YCeO granular morphological features were observed using field-emission scanning electron microscopy, which confirmed successful fabrication of nanocomposite of Y2O3 and CeO2. X-ray diffraction of YCeO showed the Cubic structure of space group Fm3m having density 6.74 gmcm-3. Rietveld refinement was performed for the analysis of complete crystal structural property. Surface porosity and specific surface area were observed by Brunnauer-Emmet Teller analysis. Optical properties were observed using UV-Visible spectroscopy. The band gap, optical conductivity, and refractive index calculated were 3.44 eV, 2.63×106, and 0.1164, respectively. Fourier transform infrared spectroscopy was done to analyze the functional and elastic properties of as-prepared nanomaterial. The highest sensor response recorded was 2.14. The response and recovery time at 50 ppm observed were 75.6 and 107.3 s, respectively. The YCeO chemo-resistive sensor confirmed long-term stability and selectivity to CO2 as compared to other gases viz. LPG, NH3, CH4, H2S, NO2 and H2. The relative humidity exposure was also performed at 15, 55 and 95% RH, in which it was confirmed that the sensor would give best response at mid humidity level i.e. 55 %RH. Sensing characteristics curve of YCeO nanocomposite at different temperature (30-90°C) at 50 ppm confirmed that YCeO sensor performed excellent at room temperature. This report unlocks an innovative opening for the fabrication of sensing devices that are room-temperature-operatable, highly-sensitive and selective for quick detection of CO2 gas for its commercialization","PeriodicalId":505590,"journal":{"name":"ECS Sensors Plus","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140245922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}