量子生物传感器:医学诊断原理与应用

Suparna Das, Hirak Mazumdar, Kamil Reza Khondakar, A. Kaushik, Yogendra Kumar Mishra
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摘要

量子生物传感器(QB)起源于物理学和生物传感学的交叉学科,与传统生物传感器相比,它利用量子现象提高灵敏度、特异性和检测速度,正在改变医疗诊断和个性化医疗。量子传感器的基础在于将 DNA、蛋白质或酶等生物实体与量子传感器融合在一起,当与样本分子相互作用时,量子传感器的光发射会产生明显的变化。量子传感器在识别与疾病相关的生物标志物方面的优势为阿尔茨海默氏症和癌症等疾病的早期诊断提供了一条途径。除此之外,它们还能捕捉生物标志物的动态变化,从而实现对治疗反应的实时监测,但 QB 仍然面临着各种挑战,如稳定性、可重复性和复杂的量子相互作用等问题。此外,将其无缝整合到现有诊断框架中也需要慎重考虑。展望未来,QB 的发展还处于未知领域。制造技术、跨学科合作和标准化协议等方面的创新成为探索的关键领域。本报告全面论述了 QB 的原理、不同的迭代和蓬勃发展的医疗用途。它深入探讨了固有的挑战和局限性,揭示了未来研究的潜在轨迹。随着 QB 的不断发展,其重新定义医疗诊断的潜力也变得越来越明显。QB 的传奇故事蕴含着无限的可能性,有望深刻重塑诊断领域的格局。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quantum Biosensors: Principles and Applications in Medical Diagnostics
Originating at the intersection of physics and biosensing, quantum biosensors (QB) are transforming medical diagnostics and personalized medicine by exploiting quantum phenomena to amplify sensitivity, specificity, and detection speed compared to traditional biosensors. Their foundation lies in the fusion of biological entities like DNA, proteins, or enzymes with quantum sensors, which elicits discernible alterations in light emissions when interacting with sample molecules. Their prowess in identifying disease-linked biomarkers presents an avenue for early diagnoses of conditions like Alzheimer's and cancer. Beyond this, they enable real-time monitoring of treatment responses by capturing the dynamism of biomarkers, but QB still face challenges, such as issues of stability, reproducibility, and intricate quantum interactions. Moreover, seamless integration into prevailing diagnostic frameworks necessitates careful consideration. Looking ahead, the evolution of QB navigates uncharted territories. Innovations in fabrication techniques, interdisciplinary collaborations, and standardization protocols emerge as pivotal areas of exploration. This comprehensive discourse encapsulates QB's principles, diverse iterations, and burgeoning medical utilities. It delves into inherent challenges and limitations, shedding light on the potential trajectories of future research. As QB continues to evolve, its potential to redefine medical diagnostics becomes increasingly tangible. The saga of QB resonates with possibilities, poised to reshape the diagnostic landscape profoundly.
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