Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology最新文献_第5页

The 1059G>C Polymorphism in C-Reactive Protein Gene and Its Association with Susceptibility to Type 2 Diabetes in the Moroccan Population 摩洛哥人 C-Reactive 蛋白基因中的 1059G>C 多态性及其与 2 型糖尿病易感性的关系

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-18 DOI: 10.21608/eajbsc.2023.330319

Fatima-Zahrae Aboubakr, Youssef Nouhi, Otmane El Brini, B. Benazzouz, Younes Filali-Zegzouti, Omar Akhouayri

{"title":"The 1059G>C Polymorphism in C-Reactive Protein Gene and Its Association with Susceptibility to Type 2 Diabetes in the Moroccan Population","authors":"Fatima-Zahrae Aboubakr, Youssef Nouhi, Otmane El Brini, B. Benazzouz, Younes Filali-Zegzouti, Omar Akhouayri","doi":"10.21608/eajbsc.2023.330319","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.330319","url":null,"abstract":". Human C-reactive protein (CRP) is an acute phase reactant involved in chronic and acute inflammation, which plays an important role in developing many diseases, such as type 2 diabetes (T2D). This study aimed to evaluate the association between CRP 1059G>C Polymorphism and predisposition to T2D in patients from a population of Morocco. We analyzed data from 212 patients with T2D and 158 controls. After the DNA is extracted from the blood samples, Polymerase Chain Reaction (PCR) and agarose gel electrophoresis are performed to determine the CRP gene's 1059G>C polymorphism. In the comparison between the control and patient groups, there was a significant difference in both genotype and allele frequencies (P < 0.0001 and P < 0.0001, respectively). The prevalence of GG and GC genotypes in diabetic patients was 96.7% and 3.3%, respectively, while in controls, it was 81.6% and 18.4%, respectively. The heterozygote GC was associated with a higher risk of T2D compared to the GG genotype (OR = 0.15, 95%CI = 0.06–0.35, P < 0.001). Regarding the allele frequencies, in the diabetic group, the G and C alleles were found at 98.3% and 1.7%, respectively, while in controls, they were present at frequencies of 90.8% and 9.2%, respectively. The CRP C allele was associated with a 0.16-fold decreased risk of T2D compared to the G allele (OR = 0.16, 95%CI = 0.07–0.38, P < 0.001). These results indicate a significant association between the CRP 1059G>C polymorphism and T2D in the Moroccan population.","PeriodicalId":505538,"journal":{"name":"Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology","volume":"18 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139173336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance 有胰岛素抵抗和无胰岛素抵抗的多囊卵巢综合征妇女的 Visfatin 水平及其基因多态性（rs61330082）测量结果

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-18 DOI: 10.21608/eajbsc.2023.330322

Dhuha Noori, H. Omear, S. Mohsin

{"title":"Measurement Visfatin Level and Its Genetic Polymorphisms (rs61330082) in Women with Polycystic Ovary Syndrome With and Without Insulin Resistance","authors":"Dhuha Noori, H. Omear, S. Mohsin","doi":"10.21608/eajbsc.2023.330322","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.330322","url":null,"abstract":"Bachground : Polycystic ovary syndrome (PCOS) is a common condition that often leads to metabolic complications such as insulin resistance (IR) and obesity. Visfatin is a peptide that plays a role in endocrine, autocrine, and paracrine functions. Methods : Samples were collected from 90 women aged 16 to 40 years, divided into two groups. The PCOS group comprised 60 samples, with 30 women who had insulin resistance and 30 women who did not. The healthy group included 30 samples. The visfatin levels for all participants and performed genotyping for specific regions of the visfatin (rs1330082) gene using Real-time PCR were measured. The statistical significance is defined as p ≤ 0.05 for all comparisons. Results: The results showed that women with PCOS and insulin resistance had significantly higher levels of serum visfatin compared to other studies (6.640±0.3886, p <0.0001). However, there was no significant difference regarding the frequency of visfatin rs1330082 allele between the study groups. Conclusion: The research indicates that measuring serum visfatin levels could be a helpful tool for predicting insulin resistance in women with PCOS. However, we did not find any significant correlation between visfatin allele frequencies (rs1330082) and susceptibility to PCOS when compared to healthy controls.","PeriodicalId":505538,"journal":{"name":"Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139176039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimation of The Levels of Hormonal Parameters in Patients with Osteoporosis and Heart Diseases in Samarra City 萨迈拉市骨质疏松症和心脏病患者荷尔蒙参数水平的估计

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-14 DOI: 10.21608/eajbsc.2023.330065

Muhannad Majeed, Wijdan Abd-al-Wahab, Mousa M. Marbut

{"title":"Estimation of The Levels of Hormonal Parameters in Patients with Osteoporosis and Heart Diseases in Samarra City","authors":"Muhannad Majeed, Wijdan Abd-al-Wahab, Mousa M. Marbut","doi":"10.21608/eajbsc.2023.330065","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.330065","url":null,"abstract":"A Cross-Sectional study that includes an assessment of the relation of the physiological and immunological factors among postmenopausal women with osteoporosis and heart diseases who attended Samarra General Hospital in Salah AL-Din Governorate .The study started from January 2022 to November 2022 on a study population whose ages ranged from 45-70 years, their total number is 100 women, 25 of whom are healthy who are considered as a control group, and 75 of them are represented by groups of patients that were distributed into three main groups: 25 women with heart disease only include myocardial infarction and 25 women with osteoporosis only and 25 women with heart disease and osteoporosis .Blood samples were collected from patients and healthy subjects and then serum separated for testing. The present study was designed to obtain more clarification of some hormonal changes in women patients with osteoporosis and heart diseases. It find out the role of some hormonal parameters Calcitonin(CT) , Parathyroid (PTH), and Estrogen ( E 2 ) in the serum of women patients with osteoporosis and heart diseases. The result of hormonal parameters include: Calcitonin, Estrogen showed significantly decreased (P≤0.05) in groups of osteoporosis, Heart disease, and osteoporosis with heart disease in comparison with control group. Parathyroid showed a significant increase (P≤0.05) in groups of osteoporosis, heart disease, and osteoporosis with heart disease in comparison with the control group. To investigate the physiological relationship between hormonal parameters,","PeriodicalId":505538,"journal":{"name":"Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology","volume":"46 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and Transformation Mi gene Using Chitosan Nanoparticle Into Cucumber to Resist Root-Knot Nematode 利用壳聚糖纳米粒子分离和转化黄瓜抗根结线虫基因

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-13 DOI: 10.21608/eajbsc.2023.329312

Amira Ayad, Ashraf Bakry Abdel Razik, Eman Hussein, Entesar Taha, Samir Ibrahim, S. Elateek

引用次数: 0

Assessment of Serum Protein Carbonyls and Glycemic Biomarkers in Patients with Type 2 Diabetic Proliferative Retinopathy 评估 2 型糖尿病增殖性视网膜病变患者的血清蛋白羰基和血糖生物标志物

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-13 DOI: 10.21608/eajbsc.2023.329310

Zaid Neamah, Omar bdul Rasheed, Alyaa Kareem

引用次数: 0

Molecular Detection of IMP Gene Isolated from Stenotrophomonas maltophilia Bacteria 从嗜麦芽血单胞菌中分离出的 IMP 基因的分子检测

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-12 DOI: 10.21608/eajbsc.2023.329307

Hala Abbas, Fadhil Nasser, Laith ounus, Motaweq, Yosif

引用次数: 0

Biochemical Study of the Influence of FSH, LH, and PRL Hormones in Infertile Female 不孕女性受 FSH、LH 和 PRL 激素影响的生化研究

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-12 DOI: 10.21608/eajbsc.2023.329305

Nada Obaid

引用次数: 0

Protective Role of Nano-Quercetin and Different Natural Extracts against Cardiotoxicity Induced by Glucocorticoids (Anti-COVID-19 Drugs): Molecular and Biochemical Studies 纳米槲皮素和不同天然提取物对糖皮质激素（抗COVID-19药物）诱导的心脏毒性的保护作用：分子和生化研究

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-08 DOI: 10.21608/eajbsc.2023.328553

Rasha Ebiya, Marwa Hassen

{"title":"Protective Role of Nano-Quercetin and Different Natural Extracts against Cardiotoxicity Induced by Glucocorticoids (Anti-COVID-19 Drugs): Molecular and Biochemical Studies","authors":"Rasha Ebiya, Marwa Hassen","doi":"10.21608/eajbsc.2023.328553","DOIUrl":"https://doi.org/10.21608/eajbsc.2023.328553","url":null,"abstract":"glucocorticoids such as azithromycin and dexamethasone. The study was designed to demonstrate the cardiotoxic consequences of anti-COVID-19 drugs and to clarify the protective role and mechanisms of different dietary natural extracts. Methods Forty-eight rats were divided into eight groups; Control, groups II-VI received 30 mg/kg azithromycin, 30 mg/kg dexamethasone and anti-COVID-19 protocol (30 mg /kg azithromycin, 30 mg/kg dexamethasone, 6.7 mg/kg vitamin C and 0.26 mg /kg zinc) orally for fourteen days, groups V-VIII received co-treatment of anti-COVID-19 protocol plus orally administration of 7.5 mg/kg Arabic gum, 4 ml/kg Nigella sativa oil, 83 µmol /kg nano-quercetin, and 500 mg/kg Thymus vulgaris extract, respectively for 14 days. Results anti COVID-19 drugs showed significant elevation in cardiac enzymes, malondialdehyde, nuclear factor-kappa B and interleukin-1 Beta besides a decrease in superoxide dismutase level. In addition, significant upregulation in expression levels of tumor necrosis factor-alpha, caspase-3 genes and alpha-smooth muscle actin in myocardial cells. However Arabic gum, Nigella sativa oil, nano-quercetin, and Thymus vulgaris extract co-treatments significantly improved these alterations and attenuated the expression of caspase-3, TNF-α genes and α-SMA protein. Conclusion: combined treatment with the examined dietary natural extracts especially nano quercetin established ameliorative effects against cardiotoxicity induced by anti-COVID-19 drugs through anti-inflammatory and anti-apoptotic effects.","PeriodicalId":505538,"journal":{"name":"Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology","volume":"28 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139185269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha 1- Anti-chymotrypsin and Other Inflammatory Factors As Biomarkers for Alzheimer's Disease 作为阿尔茨海默病生物标记物的α1-抗糜蛋白酶和其他炎症因子

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-07 DOI: 10.21608/eajbsc.2023.328457

Haneen Alkaales, Shifaa Ibrahim

引用次数: 0

Estimation of the Body Mass Index (BMI), Thyroglobulin, and Interleukin 1 Beta of Hyperthyroidism Patients in Samarra City. 萨迈拉市甲状腺功能亢进症患者的体重指数 (BMI)、甲状腺球蛋白和白细胞介素 1 Beta 的估计。

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology Pub Date : 2023-12-05 DOI: 10.21608/eajbsc.2023.328306

Jasim Awad, W. Abd-alwahab, Omar Al-Obaidi

引用次数: 0