EMBO Journal最新文献

The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-07 DOI: 10.1038/s44318-025-00430-3

Qing Guo, Zhao-Feng Li, Dong-Yan Hu, Pei-Jun Li, Kai-Nian Wu, Hui-Hui Fan, Jie Deng, Hong-Mei Wu, Xiong Zhang, Jian-Hong Zhu

{"title":"The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.","authors":"Qing Guo, Zhao-Feng Li, Dong-Yan Hu, Pei-Jun Li, Kai-Nian Wu, Hui-Hui Fan, Jie Deng, Hong-Mei Wu, Xiong Zhang, Jian-Hong Zhu","doi":"10.1038/s44318-025-00430-3","DOIUrl":"10.1038/s44318-025-00430-3","url":null,"abstract":"Dopaminergic neuron dysfunction has been implicated in multiple neurological and psychiatric disorders. SELENOT is a selenocysteine-containing protein of the ER membrane with antioxidant and neuroprotective activities, but its pathophysiological role in dopaminergic neurons remains unclear. In this study we show that male mice with SELENOT-deficient dopaminergic neurons exhibit attention deficit/hyperactivity disorder (ADHD)-like symptoms, including hyperlocomotion, recognition memory deficits, repetitive movements, and impulsivity. Dopamine metabolism, extrasynaptic dopamine levels, spontaneous excitatory postsynaptic currents in the striatum, and electroencephalography theta power are all enhanced in these animals, while dopaminergic neurons in the substantia nigra are slightly reduced but with normal firing and cellular stress levels. Our results also indicate that the expression of dopamine transporter (DAT) is significantly reduced in the absence of SELENOT. Both the development of ADHD-like phenotypes and DAT downregulation are also observed when SELENOT is absent from the whole brain, but not when its conditional knockout is restricted to astrocytes. Mechanistically, we show that SELENOT downregulates DAT expression via interaction with SERCA2 of the ER -but not with IP3R or RYR- to regulate the ER-cytosol Ca2+ flux and, subsequently, the activity of transcription factor NURR1 and the expression levels of DAT. Treatment with amphetamine or methylphenidate, which are commonly used to treat ADHD, reverses the hyperactivity observed in mice with SELENOT-deficient dopaminergic neurons. Our study demonstrates that SELENOT in mouse dopaminergic neurons maintains proper dopamine signaling in the midbrain against the development of ADHD-like behaviors.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updated values for Table 1 of fastest rubisco carboxylation rates in Davidi et al 2020.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-07 DOI: 10.1038/s44318-025-00419-y

Yi-Chin Candace Tsai, Zhijun Guo, Ron Milo, Oliver Mueller-Cajar

引用次数: 0

Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-07 DOI: 10.1038/s44318-025-00423-2

Ábel Szkalisity, Lauri Vanharanta, Hodaka Saito, Csaba Vörös, Shiqian Li, Antti Isomäki, Teemu Tomberg, Clare Strachan, Ilya Belevich, Eija Jokitalo, Elina Ikonen

{"title":"Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling.","authors":"Ábel Szkalisity, Lauri Vanharanta, Hodaka Saito, Csaba Vörös, Shiqian Li, Antti Isomäki, Teemu Tomberg, Clare Strachan, Ilya Belevich, Eija Jokitalo, Elina Ikonen","doi":"10.1038/s44318-025-00423-2","DOIUrl":"10.1038/s44318-025-00423-2","url":null,"abstract":"Cholesteryl esters (CEs) and triacylglycerols (TAGs) are stored in lipid droplets (LDs), but their compartmentalisation is not well understood. Here, we established a hyperspectral stimulated Raman scattering microscopy system to identify and quantitatively assess CEs and TAGs in individual LDs of human cells. We found that nuclear envelope-associated lipid droplets (NE-LDs) were enriched in cholesteryl esters compared to lipid droplets in the cytoplasm. Correlative light-volume-electron microscopy revealed that NE-LDs projected towards the cytoplasm and associated with type II nuclear envelope (NE) invaginations. The nuclear envelope localization of sterol O-acyltransferase 1 (SOAT1) contributed to NE-LD generation, as trapping of SOAT1 to the NE further increased their number. Upon stimulation by the pro-inflammatory cytokine TNFα, the number of NE-LDs moderately increased. Moreover, TNFα-induced NF-κB nuclear translocation was fine-tuned by SOAT1: increased SOAT1 activity and NE-LDs associated with faster NF-κB translocation, whereas reduced SOAT1 activity and NE-LDs associated with slower NF-κB translocation. Our findings suggest that the NE is enriched in CEs and that cholesterol esterification can modulate nuclear translocation.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-07 DOI: 10.1038/s44318-025-00421-4

Rameez Raja, Banhi Biswas, Rachy Abraham, Yiran Wang, Che-Yuan Chang, Ivo A Hendriks, Sara C Buch-Larsen, Hongrui Liu, Xingyi Yang, Chenyao Wang, Hien Vu, Anne Hamacher-Brady, Danfeng Cai, Anthony K L Leung

{"title":"Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system.","authors":"Rameez Raja, Banhi Biswas, Rachy Abraham, Yiran Wang, Che-Yuan Chang, Ivo A Hendriks, Sara C Buch-Larsen, Hongrui Liu, Xingyi Yang, Chenyao Wang, Hien Vu, Anne Hamacher-Brady, Danfeng Cai, Anthony K L Leung","doi":"10.1038/s44318-025-00421-4","DOIUrl":"10.1038/s44318-025-00421-4","url":null,"abstract":"Biomolecular condensates are cellular compartments without enveloping membranes, enabling them to dynamically adjust their composition in response to environmental changes through post-translational modifications. Recent work has revealed that interferon-induced ADP-ribosylation (ADPr), which can be reversed by a SARS-CoV-2-encoded hydrolase, is enriched within a condensate. However, the identity of the condensate and the responsible host ADP-ribosyltransferase remain elusive. Here, we demonstrate that interferon induces ADPr through transcriptional activation of PARP14, requiring both the physical presence and catalytic activity of PARP14 for condensate formation. Interferon-induced ADPr colocalizes with PARP14 and its associated E3 ligase, DTX3L. These PARP14/ADPr condensates contain key components of p62 bodies-including the selective autophagy receptor p62, its binding partner NBR1 and the associated protein TAX1BP1, along with K48-linked and K63-linked polyubiquitin chains-but lack the autophagosome marker LC3B. Knockdown of p62 disrupts the formation of these ADPr condensates. Importantly, these structures are unaffected by autophagy inhibition, but depend on ubiquitination and proteasome activity. Taken together, these findings demonstrate that interferon triggers PARP14-mediated ADP-ribosylation in p62 bodies, which requires an active ubiquitin-proteasome system.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GAF-dependent chromatin plasticity determines promoter usage to mediate locust gregarious behavior.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-07 DOI: 10.1038/s44318-025-00428-x

Xiao Li, Feng Jiang, Qing Liu, Zizheng Zhang, Wenjing Fang, Yutong Wang, Hongran Liu, Le Kang

{"title":"GAF-dependent chromatin plasticity determines promoter usage to mediate locust gregarious behavior.","authors":"Xiao Li, Feng Jiang, Qing Liu, Zizheng Zhang, Wenjing Fang, Yutong Wang, Hongran Liu, Le Kang","doi":"10.1038/s44318-025-00428-x","DOIUrl":"https://doi.org/10.1038/s44318-025-00428-x","url":null,"abstract":"Locusts, as devastating pests, can reversibly transform between solitary individuals and gregarious swarms with markedly different behaviors. Epigenetic regulation orchestrated by changes in chromatin openness modulates behavioral plasticity by controlling gene expression. However, the gene regulation mechanisms by which chromatin openness controls behavioral changes remain largely unknown. Here, we explored the regulatory function of chromatin openness in modulating behavioral plasticity, in which the remodeler GAF regulated brain-specific promoter usage in locusts. The increased chromatin openness in gregarious locusts initiated transcription of the brain-specific promoter of henna, a critical gene in dopamine synthesis and gregarious behavior mediation. Furthermore, GAF-dependent chromatin openness responded coordinately to population density changes. Fragment mutagenesis abolished henna promoter activity due to the dysfunction of the GAF-binding site. Mechanistically, the three GAF-binding sites played a synergetic role in remodeling chromatin openness and activating transcription initiation. Our study reveals a novel epigenetic mechanism linking chromatin regulation with behavioral polyphenism in insects during environmental changes.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural insights into small-molecule agonist recognition and activation of complement receptor C3aR.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-07 DOI: 10.1038/s44318-025-00429-w

Jinuk Kim, Saebom Ko, Chulwon Choi, Jungnam Bae, Hyeonsung Byeon, Chaok Seok, Hee-Jung Choi

{"title":"Structural insights into small-molecule agonist recognition and activation of complement receptor C3aR.","authors":"Jinuk Kim, Saebom Ko, Chulwon Choi, Jungnam Bae, Hyeonsung Byeon, Chaok Seok, Hee-Jung Choi","doi":"10.1038/s44318-025-00429-w","DOIUrl":"10.1038/s44318-025-00429-w","url":null,"abstract":"The complement system plays crucial roles in innate immunity and inflammatory responses. The anaphylatoxin C3a mediates pro-inflammatory and chemotactic functions through the G protein-coupled receptor C3aR. While the active structure of the C3a-C3aR-Gi complex has been determined, the inactive conformation and activation mechanism of C3aR remain elusive. Here we report the cryo-EM structure of ligand-free, G protein-free C3aR, providing insights into its inactive conformation. In addition, we determine the structures of C3aR in complex with the synthetic small-molecule agonist JR14a in two distinct conformational states: a G protein-free intermediate, and a fully active Gi-bound state. The structure of the active JR14a-bound C3aR reveals that JR14a engages in highly conserved interactions with C3aR, similar to the binding of the C-terminal pentapeptide of C3a, along with JR14a-specific interactions. Structural comparison of C3aR in the apo, intermediate, and fully active states provides novel insights into the conformational landscape and activation mechanism of C3aR and defines a molecular basis explaining its high basal activity. Our results may aid in the rational design of therapeutics targeting complement-related inflammatory disorders.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-04 DOI: 10.1038/s44318-025-00424-1

Candice Merle, Calvin Rodrigues, Atefeh Pourkhalili Langeroudi, Robin Journot, Fabian Rost, Yiteng Dang, Steffen Rulands, Silvia Fre

{"title":"Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells.","authors":"Candice Merle, Calvin Rodrigues, Atefeh Pourkhalili Langeroudi, Robin Journot, Fabian Rost, Yiteng Dang, Steffen Rulands, Silvia Fre","doi":"10.1038/s44318-025-00424-1","DOIUrl":"10.1038/s44318-025-00424-1","url":null,"abstract":"The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that engage into differentiation during embryonic development. However, adult MaSCs maintain the ability to reactivate multipotency in non-physiological contexts. We previously reported that Notch1 activation in committed basal cells triggers a basal-to-luminal cell fate switch in the mouse mammary gland. Here, we report conservation of this mechanism and found that in addition to the mammary gland, constitutive Notch1 signaling induces a basal-to-luminal cell fate switch in adult cells of the lacrimal gland, the salivary gland, and the prostate. Since the lineage transition is progressive in time, we performed single-cell transcriptomic analysis on index-sorted mammary cells at different stages of lineage conversion, generating a temporal map of changes in cell identity. Combining single-cell analyses with organoid assays, we demonstrate that cell proliferation is indispensable for this lineage conversion. We also reveal the individual transcriptional landscapes underlying the cellular plasticity switching of committed mammary cells in vivo with spatial and temporal resolution. Given the roles of Notch signaling in cancer, these results may help to better understand the mechanisms that drive cellular transformation.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-01 Epub Date: 2025-02-17 DOI: 10.1038/s44318-025-00364-w

Ludivine Roumbo, Batool Ossareh-Nazari, Suzanne Vigneron, Ioanna Stefani, Lucie Van Hove, Véronique Legros, Guillaume Chevreux, Benjamin Lacroix, Anna Castro, Nicolas Joly, Thierry Lorca, Lionel Pintard

{"title":"The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans.","authors":"Ludivine Roumbo, Batool Ossareh-Nazari, Suzanne Vigneron, Ioanna Stefani, Lucie Van Hove, Véronique Legros, Guillaume Chevreux, Benjamin Lacroix, Anna Castro, Nicolas Joly, Thierry Lorca, Lionel Pintard","doi":"10.1038/s44318-025-00364-w","DOIUrl":"10.1038/s44318-025-00364-w","url":null,"abstract":"MAST-like, or Greatwall (Gwl), an atypical protein kinase related to the evolutionarily conserved MAST kinase family, is crucial for cell cycle control during mitotic entry. Mechanistically, Greatwall is activated by Cyclin B-Cdk1 phosphorylation of a 550 amino acids-long insertion in its atypical activation segment. Subsequently, Gwl phosphorylates Endosulfine and Arpp19 to convert them into inhibitors of PP2A-B55 phosphatase, thereby preventing early dephosphorylation of M-phase targets of Cyclin B-Cdk1. Here, searching for an elusive Gwl-like activity in C. elegans, we show that the single worm MAST kinase, KIN-4, fulfills this function in worms and can functionally replace Greatwall in the heterologous Xenopus system. Compared to Greatwall, the short activation segment of KIN-4 lacks a phosphorylation site, and KIN-4 is active even when produced in E. coli. We also show that a balance between Cyclin B-Cdk1 and PP2A-B55 activity, regulated by KIN-4, is essential to ensure asynchronous cell divisions in the early worm embryo. These findings resolve a long-standing puzzle related to the supposed absence of a Greatwall pathway in C. elegans, and highlight a novel aspect of PP2A-B55 regulation by MAST kinases.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":"1943-1974"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meru co-ordinates spindle orientation with cell polarity and cell cycle progression.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-01 DOI: 10.1038/s44318-025-00420-5

Melissa M McLellan, Birgit L Aerne, Jennifer J Banerjee Dhoul, Maxine V Holder, Tania Auchynnikava, Nicolas Tapon

{"title":"Meru co-ordinates spindle orientation with cell polarity and cell cycle progression.","authors":"Melissa M McLellan, Birgit L Aerne, Jennifer J Banerjee Dhoul, Maxine V Holder, Tania Auchynnikava, Nicolas Tapon","doi":"10.1038/s44318-025-00420-5","DOIUrl":"10.1038/s44318-025-00420-5","url":null,"abstract":"Correct mitotic spindle alignment is essential for tissue architecture and plays an important role in cell fate specification through asymmetric cell division. Spindle tethering factors such as Drosophila Mud (NuMA in mammals) are recruited to the cell cortex and capture astral microtubules, pulling the spindle in the correct orientation. However, how spindle tethering complexes read the cell polarity axis and how spindle attachment is coupled to mitotic progression remains poorly understood. We explore these questions in Drosophila sensory organ precursors (SOPs), which divide asymmetrically to give rise to epidermal mechanosensory bristles. We show that the scaffold protein Meru, which is enriched at the posterior cortex by the Frizzled/Dishevelled planar cell polarity complex, in turn recruits Mud, linking the spindle tethering and polarity machineries. Furthermore, Cyclin A/Cdk1 associates with Meru at the posterior cortex, promoting the formation of the Mud/Meru/Dsh complex via Meru and Dsh phosphorylation. Thus, Meru couples spindle orientation with cell polarity and provides a cell cycle-dependent cue for spindle tethering.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different Ras isoforms regulate synaptic plasticity in opposite directions.

IF 9.4 1区生物学

EMBO Journal Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1038/s44318-025-00390-8

Esperanza López-Merino, Alba Fernández-Rodrigo, Jessie G Jiang, Silvia Gutiérrez-Eisman, David Fernández de Sevilla, Alberto Fernández-Medarde, Eugenio Santos, Carmen Guerra, Mariano Barbacid, José A Esteban, Víctor Briz

{"title":"Different Ras isoforms regulate synaptic plasticity in opposite directions.","authors":"Esperanza López-Merino, Alba Fernández-Rodrigo, Jessie G Jiang, Silvia Gutiérrez-Eisman, David Fernández de Sevilla, Alberto Fernández-Medarde, Eugenio Santos, Carmen Guerra, Mariano Barbacid, José A Esteban, Víctor Briz","doi":"10.1038/s44318-025-00390-8","DOIUrl":"10.1038/s44318-025-00390-8","url":null,"abstract":"The small GTPase Ras is an intracellular signaling hub required for long-term potentiation (LTP) in the hippocampus and for memory formation. Genetic alterations in Ras signaling (i.e., RASopathies) are linked to cognitive disorders in humans. However, it remains unclear how Ras controls synaptic plasticity, and whether different Ras isoforms play overlapping or distinct roles in neurons. Using genetically modified mice, we show here that H-Ras (the most abundant isoform in the brain) does not promote LTP, but instead long-term depression mediated by metabotropic glutamate receptors (mGluR-LTD). Mechanistically, H-Ras is activated locally in spines during mGluR-LTD via c-Src, and is required to trigger Erk activation and de novo protein synthesis. Furthermore, H-Ras deletion impairs object recognition as well as social and spatial memory. Conversely, K-Ras is the isoform specifically required for LTP. This functional specialization correlates with a differential synaptic distribution of the two isoforms H-Ras and K-Ras, which may have important implications for RASopathies and cognitive function.","PeriodicalId":50533,"journal":{"name":"EMBO Journal","volume":" ","pages":"2106-2133"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0