Annals of the National Academy of Medical Sciences (India)最新文献

{"title":"Loss of lateral femoral condyle following sepsis of knee region in infancy: The hypothesis of vascular pathogenesis and clinical course","authors":"Anil Agarwal, Ravi Jethwa","doi":"10.25259/anams-2022-8-10-(714)","DOIUrl":"https://doi.org/10.25259/anams-2022-8-10-(714)","url":null,"abstract":"Complete loss of lateral femoral condyle of the femur following sepsis of the knee region in infancy is a well-recognized entity. The etiopathogenesis of the sequelae is poorly understood with synovial plicae and post-septic growth disturbance postulated as possible causes. Two illustrative cases are presented to elucidate the clinical effects of condylar loss in the pediatric age group.There is a typical pattern of unicondylar damage, loss of adjacent metaphysis, and metaphyseal spur in involved cases. Abnormal loading of the knee, ligament laxity, and the presence of a physeal bar contribute additionally to deformity. The deformity progression can be as rapid as 2.8 degrees per month. The lesion is most often treated by balancing the knee mechanics using osteotomies and growth modulations. The lesion progresses downhill due to the absence of lateral support of the knee joint configuration. The anatomical region supplied by the superior lateral genicular vessels closely matches with the lateral unicondylar femoral loss seen post-sepsis. A vascular etiology is therefore hypothesized for the lesion.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The woes and challenges of medical publications in India","authors":"M. Sunkad, S. Javali","doi":"10.25259/anams_64_2024","DOIUrl":"https://doi.org/10.25259/anams_64_2024","url":null,"abstract":"","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141833092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished LC3 Expression with Unchanged Beclin 1 Levels in Right Atrial Appendage Tissue of Diabetic Patients Undergoing Coronary Artery Bypass Graft","authors":"Raji Sasikala Rajendran, N. Jayakumari, V. Pillai, J. Karunakaran, S. Gopala","doi":"10.1055/s-0043-1772578","DOIUrl":"https://doi.org/10.1055/s-0043-1772578","url":null,"abstract":"Abstract Type 2 diabetes potentiates the risk of heart failure. A vital physiologic process, autophagy, may be impaired in the diabetic heart. The aim of this study was to explore the autophagic status in a human diabetic heart. Techniques like immunohistochemistry and western blotting were employed to examine the expression of some of the important proteins involved in the autophagic machinery. Our brief study reports for the first time evidence of decreased cardiac autophagic levels in diabetic patients.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139172658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Perspective on Vitamins and SARS-CoV-2 Disease (COVID-19)","authors":"Himanshi Goyal, Diksha Rana, Renuka Sharma, Dikshit Lamba, J. Kaur","doi":"10.1055/s-0043-1777316","DOIUrl":"https://doi.org/10.1055/s-0043-1777316","url":null,"abstract":"Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly pathogenic and transmissible coronavirus, has resulted in a pandemic named coronavirus disease 2019 (COVID-19). It has taken over the world in no time causing nearly 5 million deaths and almost 500 million people being affected as of June 2022 causing an extensive burden on healthcare facilities globally. Though the disease onset is via respiratory tract, but it affects almost all organs of the body and due to induction of mutations in the virus, combating with the disease is extremely difficult. The major damage associated with disease is driven through inflammatory pathways in tissues with accompanying cytokine storm mediated mainly by macrophages. Building a strong immune system requires maintenance of a healthy diet along with keeping vitamin and coenzyme deficiencies away. The review focuses on the importance of the vitamins for maintaining a good immune system to reduce the susceptibility to SARS-CoV-2 infection, to fight the infection efficiently, and to reduce the impact of the disease. Vitamins play an essential role in modulating the immune responses to infection via altering the signaling pathways, which can act as potential weapons against the disease. Various water- and fat-soluble vitamins like vitamin B, C, D, and E have crucial roles in mediating primary interferon response, improving innate as well as adaptive functions of immunity and antioxidant properties. The current understanding about the supplementation of various vitamins as an adjunct therapeutic strategy to fight COVID-19 disease has also been discussed.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of Intact Serum Parathormone and Corrected Serum Calcium after Thyroid Surgery","authors":"Sweety Kumari, Rahul Khanna, Neeraj K. Agrawal, Ritika Khanna, R. Meena","doi":"10.1055/s-0043-1768138","DOIUrl":"https://doi.org/10.1055/s-0043-1768138","url":null,"abstract":"Abstract Postoperative hypocalcemia is an important complication of thyroid surgery. The present study was undertaken to measure the serum levels of intact parathormone (iPTH) and corrected serum calcium (CSC) in the immediate postoperative period and then sequentially till 1 month after thyroid surgery. A total of 36 patients undergoing total thyroidectomy and 44 undergoing hemithyroidectomy had measurement of the level of iPTH and CSC at 1 hour, 1 day, 1 week, and 1 month after surgery. A mean drop of 9.3% in CSC, 40% in iPTH, and 10% in ionic calcium levels was noted 1 hour after total thyroidectomy. All the patients recovered to near preoperative levels at the 1-month follow-up. Among hemithyroidectomy patients, significant postsurgery drop in levels was not observed. The importance of the study is early recognition of a hypoparathyroid state at 1 hour after surgery and institution of calcium replacement, thereby sparing the patient from unpleasant symptoms of hypocalcemia. Furthermore, patients with a drop in the iPTH levels below the defined hypoparathyroidism levels should have careful evaluation of their thyroidectomy specimen for identification and possible autotransplantation of the parathyroid gland intraoperatively or in the immediate postoperative time frame.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Video-Based Educational Intervention on Knowledge, Attitude, and Practice (KAP) of COVID-19 Health Care Workers: Lesson for Future Pandemic Preparedness","authors":"Surbhi Gupta, Binita Goswami, S. V. Madhu, Ann Natl, Acad Med, Anand Vihar","doi":"10.1055/s-0043-1772218","DOIUrl":"https://doi.org/10.1055/s-0043-1772218","url":null,"abstract":"Abstract Introduction  As we have seen from the previous health emergencies, most recently the COVID-19 pandemic, public health education is often the first line of defense in any disease prevention. Through a short educational video intervention, this study aims to improve the awareness regarding COVID-19 infection control practices to be followed in a clinical laboratory. Methods  An online pre- and posttest survey was conducted. After pretest, an educational video was shared among the study participants followed by post test survey. This questionnaire contains items on three domains: knowledge, safe laboratory practices, and attitude. Results  Significant improvement occurred in all three domains in study participants post educational intervention. Conclusion  Simple educational video intervention can substantially improve the readiness of frontline workers to deal with any kind of pandemic situation.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Hypokalemic Paresis—A Possibility of Liddle-Gitelman Overlap","authors":"Nauman Amin Siddiqui, Vrinda Goel, Shiva Narang, Amitesh Aggarwal","doi":"10.1055/s-0043-1777317","DOIUrl":"https://doi.org/10.1055/s-0043-1777317","url":null,"abstract":"Abstract Hypokalemia can occur due to various causes that have diverse manifestations varying from mild asthenias to acute onset paraparesis to life-threatening cardiac arrhythmias. A proper algorithmic evaluation for hypokalemia can help us identify various correctable causes and can be life-saving. Here, we discuss a case of 35-year-old hypertensive female who had presented as a case of acute onset flaccid paraparesis. We have further discussed our approach in reaching her diagnosis and stressed upon importance of algorithmic approach in the evaluation of patients presenting with recurrent hypokalemia. It may help in unmasking a rarer cause.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Docking Insights of Newly Synthesized Schiff Base Monomers and Evaluating the Anticancer Activity of Their Polymers","authors":"A. M. Ibrahim, T. K. Shabeer, Ann Natl, Acad Med, PhD PG Mohammed Ibrahim","doi":"10.1055/s-0043-1777313","DOIUrl":"https://doi.org/10.1055/s-0043-1777313","url":null,"abstract":"Abstract Introduction  The molecular docking technique has shown efficacy with small molecules but faces challenges when applied to macromolecules. To overcome this limitation, a focused approach targeting the active repeat units (monomers) of macromolecules was adopted. This study synthesized ten new dihydroxy Schiff base monomers (SBM1-SBM10) featuring azo moieties and alkoxy side groups. These were attached to human 3-alpha-hydroxysteroid dehydrogenase type 3 (4XO6), a protein linked to breast cancer, using molecular docking via the AutoDock tool. Materials and Methods  The synthesis of dihydroxy Schiff base monomers SBM1-SBM10 with azo moieties and alkoxy side groups was carried out. These synthesized monomers were then docked with human 3-alpha-hydroxysteroid dehydrogenase type 3 (4XO6) utilizing AutoDock. Among these, the most promisingly docked monomer, SBM8, was selected for further experimentation. SBM8 was polymerized with terephthaloyl chloride to produce a novel polyester termed PolySyringaldehydeDiaminodiphenylSulfone (PSDS). The anticancer activity of PSDS was assessed using the MCF7 human breast cancer cell line. Concurrently, its cytotoxicity was evaluated via the MTT assay employing a normal VERO cell line. Results  The molecular docking analysis revealed the best-docked monomer, SBM8, which was subsequently used for the synthesis of PSDS. The newly formed polyester, PSDS, demonstrated significant anticancer properties against the MCF7 human breast cancer cell line. Simultaneously, the cytotoxicity evaluation on the normal VERO cell line indicated a favorable safety profile for PSDS. Conclusion  The study's findings highlight the successful synthesis and docking of dihydroxy Schiff base monomers with 4XO6, resulting in the creation of PSDS. This newly synthesized polyester, PSDS, exhibited promising anticancer activity against the MCF7 cell line while demonstrating minimal cytotoxicity towards normal VERO cells. These results suggest the potential of PSDS as a targeted therapeutic agent against breast cancer, warranting further investigation and development.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139329218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on Applicability and Bioactivity of Rogan-I-Kunjad (Sesamum indicum L-Oil): Unani Prospective","authors":"Saima Naseem, Asif Ahmad Khan, Qamar Uddin, A. Jabeen, Kamal Ahmad, Mohd Asad","doi":"10.1055/s-0043-1775599","DOIUrl":"https://doi.org/10.1055/s-0043-1775599","url":null,"abstract":"Abstract Sesame oil has a long history of usage as a food and medicine. It is the most used oil as a medicine or as a base oil for preparations of many compound drugs in the Unani system of medicine. It has a wide range of biological activities as mentioned in Unani classical text; this review highlights its pharmacological activities and their possible mode of action. Searched many Unani classical literature online and offline and simultaneously did parallel search on databases like PubMed, and Science Direct, and extraction of data related to sesame oil, sesame seeds with its pharmacological activities, mode of action, then interpretation and summarization of all related data. Sesame oil possesses many biological activities like anti-inflammatory, antihyperlipidemic, antiatherosclerotic, hepatoprotective, antiasthmatic, analgesic, emollient, antipruritic, and wound healing effects, which were scientifically demonstrated as mentioned in Unani literature. Sesame oil has a hopeful effect on modulating diseases with no significant toxic effect; so, there is a need to identify its safety and efficacy on human subjects to develop a new potential drug.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scientometric Analysis of the most Highly Cited Publications on Fracture Research from India: 1989–2022","authors":"Raju Vaishya, Brij Mohan Gupta, Mallikarjun Kappi, A. Vaish","doi":"10.1055/s-0043-1775600","DOIUrl":"https://doi.org/10.1055/s-0043-1775600","url":null,"abstract":"Abstract Background  India bears a huge burden of accidents and fractures. This study aimed to study the bibliometric characteristics of India's fracture research output during last three decades. The most highly cited publications (HCPs; with 20 or more citations) on orthopaedic fracture research from India were analyzed on various parameters. Methodology  The Scopus database was used to identify publications on fractures that originated from India, between 1989 to 2022. The top HCPs were retrieved. A bibliometric and network analysis was used to identify the key players, such as organizations, authors and journals, and important keywords besides identifying their collaborative interactions and visual co-occurrences of significant keywords using VOSviewer and Biblioshiny software. Results  Of the total 1,048 Indian publications, 126 (10.02%) were HCPs (cited 4,695 times). External funding was received in 1.59%, and international collaboration in 15.08%. The most productive organizations were All India Institute of Medical Sciences (AIIMS), New Delhi, followed by Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, and Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS), Rohtak. The most impactful organizations were Maulana Azad Medical College (MAMC), Delhi, followed by the Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, and Sancheti Institute of Orthopaedic Research & Rehabilitation, Pune. The most productive authors were R. Malhotra, M.S. Dhillon, and N.K. Magu, and the most impactful authors were U.K. Meena, A.P. Singh, and P. Sancheti. Delhi was the epic of research, followed by Karnataka, Tamil Nadu, and Chandigarh. Conclusion  This study provides an insight into the research trends, the most influential contributions, and the performance of Indian organizations and authors. It gives some ideas about the past, present, and future hotspots in research.","PeriodicalId":505103,"journal":{"name":"Annals of the National Academy of Medical Sciences (India)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139328710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}