Raji Sasikala Rajendran, N. Jayakumari, V. Pillai, J. Karunakaran, S. Gopala
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引用次数: 0
摘要
摘要 2 型糖尿病会增加心力衰竭的风险。糖尿病心脏的一个重要生理过程--自噬可能会受到损害。本研究旨在探讨人类糖尿病心脏的自噬状态。研究采用了免疫组化和 Western 印迹等技术来检测参与自噬机制的一些重要蛋白质的表达。我们的简要研究首次报告了糖尿病患者心脏自噬水平下降的证据。
Diminished LC3 Expression with Unchanged Beclin 1 Levels in Right Atrial Appendage Tissue of Diabetic Patients Undergoing Coronary Artery Bypass Graft
Abstract Type 2 diabetes potentiates the risk of heart failure. A vital physiologic process, autophagy, may be impaired in the diabetic heart. The aim of this study was to explore the autophagic status in a human diabetic heart. Techniques like immunohistochemistry and western blotting were employed to examine the expression of some of the important proteins involved in the autophagic machinery. Our brief study reports for the first time evidence of decreased cardiac autophagic levels in diabetic patients.
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