Epileptic Disorders最新文献_第8页

Meduna and the origins of the idea that seizures can be therapeutic. 以及癫痫可以治疗的想法的起源。

IF 2.5 4区医学

Epileptic Disorders Pub Date : 2026-09-30 DOI: 10.1002/epd2.70429

Eliza S Schnitzer, Ronan Soltesz, Ivan Soltesz

{"title":"Meduna and the origins of the idea that seizures can be therapeutic.","authors":"Eliza S Schnitzer, Ronan Soltesz, Ivan Soltesz","doi":"10.1002/epd2.70429","DOIUrl":"https://doi.org/10.1002/epd2.70429","url":null,"abstract":"Electroconvulsive therapy (ECT) has been well discussed in psychiatry as one of the oldest, yet still enduring and effective treatments for several psychiatric disorders, including depression, catatonia, mania, and psychoses. However, the intellectual history of ECT is much less known in the field of epilepsy, in spite of the fact that the therapy's origins are squarely in epilepsy neuropathology. Therefore, this historical review's primary aim is to retrace the scientific roots of ECT from a uniquely epilepsy-focused perspective. We focus on the key contributions of a neuropathologist studying epilepsy, László Meduna, who was the first to wonder if seizures may be beneficial in certain psychiatric disorders. In addition, we highlight the controversies surrounding his initial results, the transition from chemoconvulsants to electrical seizure induction, and that, despite the long-standing clinical use of ECT, it is still not well understood in mechanistic terms why inducing a seizure could relieve symptoms of certain psychiatric illnesses. The history of ECT for epileptologists is particularly insightful not only because it chronicles how an idea originating from studies focusing on seizures has come to have such an enduring impact on clinical care in an area outside of epilepsy but also because it highlights how bold testing of innovative hypotheses stemming from seemingly disconnected observations can lead to tangible breakthroughs in translation.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of electroclinical findings in an adult patient with SETD1B-related epilepsy. 1例与setd1b相关癫痫的成人患者的电临床表现的持续性

IF 2.5 4区医学

Epileptic Disorders Pub Date : 2026-09-30 DOI: 10.1002/epd2.70414

Rohan Shankar, Abdulrahman Bukhari, Irfan S Sheikh

引用次数: 0

Integrating rapid response teams and structured care pathways improves outcomes in status epilepticus: A prospective cohort study. 整合快速反应小组和结构化护理途径改善癫痫持续状态的结果：一项前瞻性队列研究。

IF 2.5 4区医学

Epileptic Disorders Pub Date : 2026-09-30 DOI: 10.1002/epd2.70397

Xiao Fan, Yueming Dong, Jian Wu, Guanghui Zhang

{"title":"Integrating rapid response teams and structured care pathways improves outcomes in status epilepticus: A prospective cohort study.","authors":"Xiao Fan, Yueming Dong, Jian Wu, Guanghui Zhang","doi":"10.1002/epd2.70397","DOIUrl":"https://doi.org/10.1002/epd2.70397","url":null,"abstract":"Objective: To evaluate the effectiveness of an integrated nursing model combining a rapid response team (RRT) with a structured care pathway (SCP) for the emergency management of status epilepticus (SE).Methods: This study included 168 SE patients treated at the First Affiliated Hospital of Kangda College of Nanjing Medical University. Patients were divided into an intervention group (n = 86), managed via the novel RRT-SCP model (June 2023-May 2025), and a historical control group (n = 82), which received routine care (June 2021-May 2023). Key performance indicators included the 2-h seizure control rate, physician response time, diagnostic test completion time, nonconvulsive SE (NCSE) recognition rate, complication incidence, and family satisfaction.Results: The intervention group demonstrated a significantly higher 2-h seizure control rate compared to the control group (87.2% vs. 72.0%, p < 0.05). Both physician response time (5.2 ± 1.5 min vs. 8.4 ± 1.7 min) and diagnostic test completion time (37.1 ± 10.5 min vs. 53.6 ± 12.8 min) were significantly shorter in the intervention group (p < 0.01). Furthermore, the intervention group showed superior early recognition of NCSE (77.8% vs. 23.1%, p < 0.01), a reduced complication rate (17.4% vs. 49.0%, p < 0.05), and higher family satisfaction (91.2% vs. 74.7%, p < 0.01). Year-by-year sensitivity analyses showed generally consistent directions of effect, particularly for response time and complication reduction.Conclusion: The RRT-SCP model can significantly improve the rescue efficiency and success rate for SE patients while reducing complications.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of an AI agent to improve epilepsy diagnosis. 使用人工智能来提高癫痫的诊断。

IF 2.5 4区医学

Epileptic Disorders Pub Date : 2026-09-28 DOI: 10.1002/epd2.70401

Juan G Ochoa, Angie Zuniga, Luis Carlos Mayor

{"title":"Use of an AI agent to improve epilepsy diagnosis.","authors":"Juan G Ochoa, Angie Zuniga, Luis Carlos Mayor","doi":"10.1002/epd2.70401","DOIUrl":"https://doi.org/10.1002/epd2.70401","url":null,"abstract":"Objective: To assess the efficacy of an AI-driven History of Present Illness (HPI) tool in improving the diagnostic accuracy of epilepsy.Background: Diagnosing epilepsy remains a significant challenge, particularly for non-neurologists and primary care providers. The median diagnostic delay for patients with new-onset focal epilepsy is estimated at 12 months. This study investigates whether an AI agent can improve diagnosis by standardizing the collection of clinical history.Methods: We conducted a retrospective analysis of de-identified histories from 40 consecutive patients admitted to an inpatient Epilepsy Monitoring Unit. The quality of histories recorded by neurology residents was evaluated by a blinded, independent, and experienced epileptologist. We developed a web-based AI agent incorporating critical diagnostic questions. The AI Epilepsy HPI tool was used to process the clinical data, and its results were compared against video EEG Monitoring, the \"gold standard\" of epilepsy diagnosis.Results: The independent epileptologist determined that the HPIs obtained by residents were adequate for diagnosis in only 58% of cases. Consequently, the expert's diagnostic accuracy based on those HPIs alone was also 58%. In contrast, the AI Epilepsy HPI tool achieved a diagnostic accuracy of 90% when compared to the video-EEG results. Also, the expert diagnosis was improved by the AI tool to 80% accuracy.Significance: This study demonstrates that an AI agent can effectively assist providers in the systematic collection of clinical symptomatology for epilepsy. By standardizing the history-taking process, this tool has the potential to improve the education of junior neurology residents.","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond "status non-epilepticus": Toward a unified, accurate, and non-stigmatizing terminology. 超越“非癫痫持续状态”：走向统一、准确、非污名化的术语。

IF 2.5 4区医学

Epileptic Disorders Pub Date : 2026-09-26 DOI: 10.1002/epd2.70424

Stephane Legriel

引用次数: 0

Status non-epilepticus: Authors' response to León-Ruiz et al. 非癫痫持续状态：作者对León-Ruiz等人的反应。

IF 2.5 4区医学

Epileptic Disorders Pub Date : 2026-09-26 DOI: 10.1002/epd2.70426

Ronen Spierer, Moshe Herskovitz

引用次数: 0

Epilepsy with eyelid myoclonia in a patient with CUX1-related disorder. cux1相关疾病患者伴眼睑肌阵挛性癫痫1例。