ILAE neonatal seizure framework to aide in determining etiology.

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Epileptic Disorders Pub Date : 2024-11-27 DOI:10.1002/epd2.20312

Elissa G Yozawitz, Maria Roberta Cilio, Eli M Mizrahi, Jee-Young Moon, Solomon L Moshé, Magda L Nunes, Perrine Plouin, Sameer Zuberi, Ronit M Pressler

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Abstract

Objective: To employ the neonatal seizure framework developed by the International League Against Epilepsy (ILAE) Neonatal Task force to assess its usefulness in determining the etiology of neonatal seizures.

Methods: The members of the ILAE Neonatal Task Force evaluated 157 seizures from 146 neonates to determine internal validity and associations between semiology and a specific etiology.

Results: Provoked neonatal electrographic and electroclinical seizures were due to multiple etiologies. For electroclinical seizures, unilateral clonic seizures were typically seen with vascular etiologies, focal tonic seizures and sequential seizures with genetic etiologies, and myoclonic seizures with inborn errors of metabolism. Electrographic seizures were often seen in hypoxic-ischemic encephalopathy or vascular etiologies.

Significance: These data suggest that the ILAE neonatal seizure classification may be used as a bedside tool to aid and guide workup to determine the etiology of seizures.

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ILAE 新生儿癫痫发作框架，以帮助确定病因。

目的：采用国际抗癫痫联盟（ILAE）新生儿工作组制定的新生儿癫痫发作框架，评估其在确定新生儿癫痫发作病因方面的实用性：方法：ILAE新生儿工作组的成员评估了146名新生儿的157次癫痫发作，以确定其内部有效性以及半身像与特定病因之间的关联：结果：诱发新生儿电图和电临床癫痫发作的病因多种多样。就电临床发作而言，单侧阵挛性发作通常与血管病因有关，局灶强直性发作和连续性发作与遗传病因有关，肌阵挛性发作与先天性代谢错误有关。电图癫痫发作通常见于缺氧缺血性脑病或血管性病因：这些数据表明，ILAE 新生儿癫痫发作分类可作为床旁工具，帮助和指导确定癫痫发作病因的工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epileptic Disorders 医学-临床神经学

CiteScore

4.10

自引率

8.70%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Epileptic Disorders is the leading forum where all experts and medical studentswho wish to improve their understanding of epilepsy and related disorders can share practical experiences surrounding diagnosis and care, natural history, and management of seizures. Epileptic Disorders is the official E-journal of the International League Against Epilepsy for educational communication. As the journal celebrates its 20th anniversary, it will now be available only as an online version. Its mission is to create educational links between epileptologists and other health professionals in clinical practice and scientists or physicians in research-based institutions. This change is accompanied by an increase in the number of issues per year, from 4 to 6, to ensure regular diffusion of recently published material (high quality Review and Seminar in Epileptology papers; Original Research articles or Case reports of educational value; MultiMedia Teaching Material), to serve the global medical community that cares for those affected by epilepsy.