Epileptic Disorders最新文献

{"title":"Disease spectrum of nonconvulsive status epilepticus in children: A study based on clinical subtype characteristics and prognostic stratification.","authors":"Lianqin Mo, Xiaoqi Chen, Lu Yang, Xiao Xiao, Peng Wu, Li Jiang, Yue Hu","doi":"10.1002/epd2.70244","DOIUrl":"https://doi.org/10.1002/epd2.70244","url":null,"abstract":"<p><strong>Objective: </strong>To investigate risk factors affecting the short- and long-term prognosis of pediatric status epilepticus (SE) complicated by nonconvulsive status epilepticus (NCSE) during the disease course and to analyze the clinical heterogeneity of this group to effectively identify population characteristics and subgroups influencing prognosis.</p><p><strong>Methods: </strong>This study is a single-center retrospective cohort study. Clinical data from 215 pediatric patients diagnosed with SE at Chongqing Medical University Children's Hospital between February 2005 and September 2024, who met the diagnostic criteria for NCSE during their illness, were included. Univariate analysis and multivariate logistic regression were employed to identify factors associated with short-term and long-term adverse outcomes. Hierarchical cluster analysis was conducted based on clinical characteristics.</p><p><strong>Results: </strong>The in-hospital mortality rate was 3.3% (7/215), increasing to 6.0% (12/200) in long-term follow-up. The short-term poor prognosis rate was 29.8% (64/215), while the long-term poor prognosis rate was 20.5% (41/200). Multivariate analysis revealed that independent risk factors for poor short-term prognosis included GCS scores of 3-8, global developmental delay, interictal EEG showing periodic discharges, and diffuse MRI abnormalities. Poor long-term prognosis was primarily associated with GCS scores of 3-8, global developmental delay, and electroclinical syndromes. Further clinical phenotype clustering analysis revealed four heterogeneous subgroups: super-refractory subgroup (characterized by profound impaired consciousness and diffuse brain injury), young-age metabolic subgroup (age < 24 months with multifocal abnormalities), focal structural subgroup (manifesting as focal neurological deficits and structural etiology), and benign reactive subgroup (mild altered consciousness and treatment sensitivity).</p><p><strong>Significance: </strong>Level of consciousness, electroencephalogram (EEG), neurodevelopmental status, and electroclinical syndromes can serve as core indicators for prognostic stratification in children with NCSE; subtyping based on clinical features can effectively distinguish heterogeneous subgroups, providing a clinical phenotypic basis for individualized stratified diagnosis, treatment, and prognostic assessment of pediatric NCSE, thereby addressing the current lack of a multidimensional stratification framework in clinical practice.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological and trauma-related differences in psychogenic nonepileptic seizures: An exploratory severity-based comparison.","authors":"Mehmet Murat Kırpınar, Memet Şakir Delil, Halil İbrahim Deniz, Gülsüm Hançer, Öznur Demirel, Nesibe Boyraz, Bengi Gül Türk, Şenol Turan, Seher Naz Yeni","doi":"10.1002/epd2.70242","DOIUrl":"https://doi.org/10.1002/epd2.70242","url":null,"abstract":"<p><strong>Objective: </strong>This study examined psychological and trauma-related characteristics of patients with psychogenic nonepileptic seizures (PNES) and explored whether a clinically informed severity grouping distinguished distinct psychosocial patterns. PNES patients were compared with individuals with epilepsy and healthy controls.</p><p><strong>Methods: </strong>Participants included mild PNES (n = 20), severe PNES (n = 28), epilepsy (n = 48), and healthy controls (n = 50). Assessments measured anxiety, depression, childhood trauma, dissociation, somatization, and alexithymia. PNES severity was defined using clinical indicators such as acute healthcare utilization and ictal motor intensity.</p><p><strong>Results: </strong>Both mild and severe PNES groups showed significantly higher anxiety scores than epilepsy patients and healthy controls (p < .01). Depression scores were highest in the mild PNES group and differed significantly from severe PNES, epilepsy, and healthy control groups (p < .05). Trauma profiles varied by severity: sexual abuse was more frequently reported in mild PNES, whereas physical abuse and emotional neglect were significantly higher in severe PNES (p < .05). Mild PNES patients also exhibited higher dissociation, somatization, and total alexithymia scores compared with severe PNES and healthy controls (all p < .05).</p><p><strong>Significance: </strong>Severity-linked clinical characteristics in PNES were associated with distinct trauma profiles and psychological symptom patterns. These exploratory findings highlighted the relevance of individualized psychological assessment and support the need for further research to validate severity-based distinctions.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The second unprovoked seizure in a cohort of treated patients with a first unprovoked seizure.","authors":"Revital Gandelman-Marton, Jacques Theitler","doi":"10.1002/epd2.70234","DOIUrl":"https://doi.org/10.1002/epd2.70234","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the rate of a second unprovoked seizure in antiseizure medications (ASMs)-treated patients following a first unprovoked seizure and to identify potential risk factors associated with its occurrence.</p><p><strong>Methods: </strong>A retrospective review of the computerized database and the medical records of all the patients who presented to our outpatient epilepsy clinic following admission and ASM initiation due to a first unprovoked seizure during a decade (2012-2021).</p><p><strong>Results: </strong>The study group included 60 patients aged 18-84 years (mean: 40.8 years), 35 (58.3%) men. A second unprovoked seizure occurred in 43% of the patients at last observation. Seventy-five percent of the recurrences occurred at 3 years. Patients with a second unprovoked seizure were younger (32.9 vs. 46.9 years) (p = 0.010) and more likely to be women (64% vs. 28.6%) (p = 0.009) compared to patients without recurrent seizures.</p><p><strong>Significance: </strong>Women and younger patients may deserve closer monitoring following a first unprovoked seizure. Further studies are needed to assess the efficacy of specific treatment strategies among all people with a first unprovoked seizure, with emphasis on younger adults and especially women.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Translational considerations in epilepsy surgery: Linking longitudinal cognitive phenotyping with epigenetic hypotheses.","authors":"Mary Lou Smith","doi":"10.1002/epd2.70243","DOIUrl":"https://doi.org/10.1002/epd2.70243","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blink-induced epileptic negative myoclonus in CHD2-related epilepsy: A novel seizure semiology linked to visual transient hyperexcitability.","authors":"Wen Wang, Lin Wan, Linyan Hu, Jian Chen, Yan Zhao, Zhichao Li, Guang Yang","doi":"10.1002/epd2.70227","DOIUrl":"https://doi.org/10.1002/epd2.70227","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsia partialis continua as the presenting manifestation of Creutzfeldt-Jakob disease: A video-polygraphic clinical vignette.","authors":"Roberta Cutellè, Angelo Pascarella, Ada Santoro, Vittoria Cianci, Anna Mammì, Giovanbattista Gaspare Tripodi, Caterina Prestandrea, Sara Gasparini, Edoardo Ferlazzo","doi":"10.1002/epd2.70238","DOIUrl":"https://doi.org/10.1002/epd2.70238","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of human status epilepticus in organophosphate poisoning: A real-world Stage 1 Plus model?","authors":"Giuseppe Magro, Oreste Marsico","doi":"10.1002/epd2.70240","DOIUrl":"https://doi.org/10.1002/epd2.70240","url":null,"abstract":"<p><strong>Objective: </strong>To describe clinical phenotypes of organophosphate (OP)-related status epilepticus (SE) and to determine whether they could represent a real-world model of Stage 1 Plus SE, a stage possibly requiring early polytherapy from the start.</p><p><strong>Methods: </strong>We conducted a systematic review, searching PubMed and Scopus, complemented by Google Scholar and reference/citation screening to find human OP-related SE. Two reviewers independently screened records, extracted patient-level data, and appraised methodological quality following the PRISMA guidelines; disagreements were resolved by consensus. Studies including single epileptic seizures not meeting the International League Against Epilepsy (ILAE) criteria for SE were excluded.</p><p><strong>Results: </strong>Twelve cases met the inclusion criteria. A specific OP agent was identified in 7/12. Convulsive SE was reported in 8/12, while nonconvulsive and myoclonic SE were documented in a minority of cases; phenotypes could overlap. SE onset after exposure ranged from 2 to 36 h, with one case linked to chronic intoxication. Concomitant cholinergic features were reported in almost all cases (11/12). Seizure persistence after an initial benzodiazepine (BDZ) bolus was reported in all cases in which a first-line BDZ bolus was administered (7/7), prompting a sequential shift to antiseizure medications or anesthetic agents. Mechanical ventilation was required in 11/12; reported outcomes were favorable in 11/12.</p><p><strong>Significance: </strong>OP poisoning is a polymorphic entity including several cholinergic features and a broad SE spectrum, mainly convulsive SE. Ongoing seizures after early BDZ therapy suggest a possible direction toward a Stage 1 Plus phenotype, mirroring experimental evidence from preclinical animal models of OP-induced SE, possibly requiring early polytherapy.</p>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A star in the daylight clinical vignette: Lesional focal epilepsy with cerebral accessory falx.","authors":"Kyle McGrath, Joel Kaye, John Paul Sheehy, Heather Ravvin McKee","doi":"10.1002/epd2.70235","DOIUrl":"https://doi.org/10.1002/epd2.70235","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super-refractory multifocal subtle status epilepticus during coma in anti-NMDA receptor antibody encephalitis.","authors":"Anahita Jafari, Toni Betiku, Andy Shar, Brin Freund, Anteneh Feyissa, Seyed Mirsattari, Alicia Kissinger-Knox, Dawn Radford, Aybuke Acar, William O Tatum","doi":"10.1002/epd2.70171","DOIUrl":"10.1002/epd2.70171","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":"551-558"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical vignette: Generalized epilepsy associated with TRMT1 mutation in two siblings.","authors":"Nuria Lamagrande Casanova, Mario Iglesias Rodríguez, Valentina Ortiz-Cabrera, Elena González-Alguacil, Juan José García Peñas, Rita Valero Pertegal, Cristina Benítez Provedo, Anna Duat Rodríguez, Víctor Soto-Insuga","doi":"10.1002/epd2.70159","DOIUrl":"10.1002/epd2.70159","url":null,"abstract":"","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":" ","pages":"535-538"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}