{"title":"新生儿癫痫发作：在儿科转诊中心的队列评估。","authors":"Joana Amaral, Inês Silva Costa, Joana Ribeiro, Cármen Costa, Filipe Palavra, Cristina Pereira, Conceição Robalo","doi":"10.1002/epd2.20331","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Neonatal seizures have an incidence of 1–5/1000 newborns. Their clinical, etiology, and therapeutic characterization is a clinical challenge.</p>\n \n <p>The objective of this study was to characterize neonatal seizures recorded over 6 years, considering the clinical presentation, management, and follow-up.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A retrospective analysis of clinical, neurophysiological (video-electroencephalogram), and imaging data of all newborns who had suspected neonatal seizures with electroencephalographic findings (paroxysmal activity, electrographic-only seizures, and/or electroclinical seizures) was performed. The study considered all cases that occurred between January 2010 and December 2015, with the respective follow-up equal to or longer than 7 years.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Seizures were diagnosed in 85 newborns, 87.1% within the first 48 h of life. In 72.9% of suspected cases, only paroxysmal activity in the v-EEG was recorded, in another 16.5% electrical-only seizures were found, and in 10.6% there were electroclinical seizures. Epilepsy was diagnosed in 23.5% of cases, with 14% currently maintaining therapy. Motor sequelae occurred in 44.3% of children and 41.4% had normal neurological examination. There were also 11.4% of deaths in the neonatal period.</p>\n </section>\n \n <section>\n \n <h3> Significance</h3>\n \n <p>Neonatal seizures occur mostly in the first 48 h of life and mainly due to hypoxic–ischemic injuries. During follow-up, we recorded epilepsy in ¼ of patients.</p>\n </section>\n </div>","PeriodicalId":50508,"journal":{"name":"Epileptic Disorders","volume":"27 2","pages":"255-263"},"PeriodicalIF":1.9000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neonatal seizures: A cohort evaluation at a pediatric referral center\",\"authors\":\"Joana Amaral, Inês Silva Costa, Joana Ribeiro, Cármen Costa, Filipe Palavra, Cristina Pereira, Conceição Robalo\",\"doi\":\"10.1002/epd2.20331\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Neonatal seizures have an incidence of 1–5/1000 newborns. Their clinical, etiology, and therapeutic characterization is a clinical challenge.</p>\\n \\n <p>The objective of this study was to characterize neonatal seizures recorded over 6 years, considering the clinical presentation, management, and follow-up.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A retrospective analysis of clinical, neurophysiological (video-electroencephalogram), and imaging data of all newborns who had suspected neonatal seizures with electroencephalographic findings (paroxysmal activity, electrographic-only seizures, and/or electroclinical seizures) was performed. The study considered all cases that occurred between January 2010 and December 2015, with the respective follow-up equal to or longer than 7 years.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Seizures were diagnosed in 85 newborns, 87.1% within the first 48 h of life. In 72.9% of suspected cases, only paroxysmal activity in the v-EEG was recorded, in another 16.5% electrical-only seizures were found, and in 10.6% there were electroclinical seizures. Epilepsy was diagnosed in 23.5% of cases, with 14% currently maintaining therapy. Motor sequelae occurred in 44.3% of children and 41.4% had normal neurological examination. There were also 11.4% of deaths in the neonatal period.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Significance</h3>\\n \\n <p>Neonatal seizures occur mostly in the first 48 h of life and mainly due to hypoxic–ischemic injuries. During follow-up, we recorded epilepsy in ¼ of patients.</p>\\n </section>\\n </div>\",\"PeriodicalId\":50508,\"journal\":{\"name\":\"Epileptic Disorders\",\"volume\":\"27 2\",\"pages\":\"255-263\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epileptic Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/epd2.20331\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epileptic Disorders","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/epd2.20331","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Neonatal seizures: A cohort evaluation at a pediatric referral center
Objective
Neonatal seizures have an incidence of 1–5/1000 newborns. Their clinical, etiology, and therapeutic characterization is a clinical challenge.
The objective of this study was to characterize neonatal seizures recorded over 6 years, considering the clinical presentation, management, and follow-up.
Methods
A retrospective analysis of clinical, neurophysiological (video-electroencephalogram), and imaging data of all newborns who had suspected neonatal seizures with electroencephalographic findings (paroxysmal activity, electrographic-only seizures, and/or electroclinical seizures) was performed. The study considered all cases that occurred between January 2010 and December 2015, with the respective follow-up equal to or longer than 7 years.
Results
Seizures were diagnosed in 85 newborns, 87.1% within the first 48 h of life. In 72.9% of suspected cases, only paroxysmal activity in the v-EEG was recorded, in another 16.5% electrical-only seizures were found, and in 10.6% there were electroclinical seizures. Epilepsy was diagnosed in 23.5% of cases, with 14% currently maintaining therapy. Motor sequelae occurred in 44.3% of children and 41.4% had normal neurological examination. There were also 11.4% of deaths in the neonatal period.
Significance
Neonatal seizures occur mostly in the first 48 h of life and mainly due to hypoxic–ischemic injuries. During follow-up, we recorded epilepsy in ¼ of patients.
期刊介绍：
Epileptic Disorders is the leading forum where all experts and medical studentswho wish to improve their understanding of epilepsy and related disorders can share practical experiences surrounding diagnosis and care, natural history, and management of seizures.
Epileptic Disorders is the official E-journal of the International League Against Epilepsy for educational communication. As the journal celebrates its 20th anniversary, it will now be available only as an online version. Its mission is to create educational links between epileptologists and other health professionals in clinical practice and scientists or physicians in research-based institutions. This change is accompanied by an increase in the number of issues per year, from 4 to 6, to ensure regular diffusion of recently published material (high quality Review and Seminar in Epileptology papers; Original Research articles or Case reports of educational value; MultiMedia Teaching Material), to serve the global medical community that cares for those affected by epilepsy.
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