European Journal of Cardiovascular Prevention & Rehabilitation最新文献

{"title":"Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease.","authors":"Yap-Hang Chan,&nbsp;Tai-Hing Lam,&nbsp;Kui-Kai Lau,&nbsp;Kai-Hang Yiu,&nbsp;Chung-Wah Siu,&nbsp;Sheung-Wai Li,&nbsp;Hiu-Ting Chan,&nbsp;Sidney Tam,&nbsp;Chu-Pak Lau,&nbsp;Hung-Fat Tse","doi":"10.1177/1741826710389385","DOIUrl":"https://doi.org/10.1177/1741826710389385","url":null,"abstract":"<p><p>Endogenous estrogen is known to positively influence the level and functionality of endothelial progenitor cells (EPC). However, the effect of phytoestrogen on EPC is unknown. Isoflavone is a major component of phytoestrogen. This study aims to investigate if the intake of isoflavone has any impact on the circulating level of EPC. We studied 102 consecutive patients (mean age: 66.5 ± 9.5 years, 78% male, all female post-menopausal) with cardiovascular disease (atherothrombotic stroke 62%, coronary artery disease 38%). Circulating levels of CD133(+) EPC were determined by flow cytometry. Non-invasive pulse wave velocity (PWV) was measured. Long-term intake of isoflavone was determined by a validated food frequency questionnaire. Isoflavone intake was positively associated with circulating CD133(+) EPC (r = 0.31, p = 0.001). Patients with circulating CD133(+) EPC <10th percentile had significantly lower isoflavone intake than patients with CD133(+)EPC ≥10th percentile (4.6 ± 3.7 mg/day versus 19.3 ± 30.2 mg/day, p < 0.001). A significant overall linear trend of circulating EPC across increasing tertiles of isoflavone intake was observed (p = 0.004). Adjusted for potential confounders, increased isoflavone intake from the 1st to the 3rd tertile independently predicted increased circulating CD133(+) EPC level by 221 cells/µl (95%CI: 71.4 to 369.8, relative increase 160%, p = 0.004). Gender was not a significant factor (p > 0.05). Furthermore, circulating CD133(+) EPC <10th percentile was independently predictive of increased PWV by 261.7 cm/s (95% CI: 37.1 to 486.2, p = 0.024). The study demonstrated that circulating EPC increased by more than one fold in patients with cardiovascular disease who had higher intake of isoflavone, suggesting that isoflavone may confer vascular protection through enhanced endothelial repair.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-month programme on lifestyle changes in primary cardiovascular prevention: a telemedicine pilot study.","authors":"Palmira Bernocchi,&nbsp;Doriana Baratti,&nbsp;Emanuela Zanelli,&nbsp;Silvana Rocchi,&nbsp;Massimo Salvetti,&nbsp;Anna Paini,&nbsp;Simonetta Scalvini","doi":"10.1177/1741826710389364","DOIUrl":"https://doi.org/10.1177/1741826710389364","url":null,"abstract":"<p><strong>Background: </strong>Technology and information systems enabling transmission of patients' data and ability to provide and exchange professional support remotely to the general practitioners can improve quality and continuity of care.</p><p><strong>Design: </strong>We set up a programme of primary prevention in 27 patients at risk for cardiovascular diseases by using Telemedicine Service for 6 months.</p><p><strong>Methods: </strong>Telemedicine Service enlisted the involvement of physicians and nurse-tutors. The following cardiovascular activity markers were assessed: (i) cardiovascular risk cards (Framingham Study and Progetto CUORE); (ii) blood pressure; (iii) physical activity (three sessions of bicycle exercise training and calisthenic exercises a week); and (iv) questionnaires on stress and quality of life.</p><p><strong>Results: </strong>Both cardiovascular risk cards showed a statistically significant reduction of the score (p < 0.05). Systolic and diastolic blood pressures showed a statistically significant reduction (128 ± 10 mmHg vs. 121 ± 9 mmHg, p = 0.04; 80 ± 8 mmHg vs. 73 ± 7 mmHg, p = 0.001). There was a noticeable increase in patient compliance for reporting blood pressure data. 89% of patients complied with the physical activity programme. Effort test significantly increased from 11.4 ± 3.5 to 12.7 ± 3.4 min (p = 0.02). There was a significant improvement in physical health (p = 0.04) and 85% of patients were satisfied with the service.</p><p><strong>Conclusions: </strong>A home multidisciplinary programme for primary cardiovascular disease prevention is simple, efficacious, and very well accepted by the patients with the majority of patients showing reduction in cardiovascular risk scores.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29780015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The oxygen uptake efficiency slope in children with congenital heart disease: construct and group validity.","authors":"B C Bongers,&nbsp;H J Hulzebos,&nbsp;A C Blank,&nbsp;M van Brussel,&nbsp;T Takken","doi":"10.1177/1741826710389390","DOIUrl":"https://doi.org/10.1177/1741826710389390","url":null,"abstract":"<p><strong>Objective: </strong>The oxygen uptake efficiency slope (OUES) has been proposed as an independent and objective alternative to the peak oxygen uptake (VO(2peak)), which does not require maximal exercise. The aim of this study was to investigate the construct and group validity of the OUES in children with congenital heart disease (CHD).</p><p><strong>Methods: </strong>Thirty-one patients with CHD, of which 16 patients (mean age ± SD 11.2 ± 2.7 years) with a Fontan repair and 15 patients (mean age ± SD 13.2 ± 3.6 years) with surgical repair of tetralogy of Fallot (ToF) completed a symptom-limited cardiopulmonary exercise test. The OUES was calculated and normalized for body surface area at three different exercise intensities: (1) using 100% of the exercise data; (2) using the first 75% of the exercise data; and (3) using exercise data up to the ventilatory threshold (VT). Furthermore, peak oxygen uptake (VO(2peak)), VT, ventilatory efficiency (V(E)/VO(2)-slope), and ventilatory drive (V(E)/VCO(2)-slope) were calculated and compared with values of 46 healthy children (mean age ± SD 12.2 ± 2.4 years).</p><p><strong>Results: </strong>In all three groups, the OUES values determined at the three different exercise intensities were not significantly different from each other. Moreover, the OUES was significantly reduced in the children with CHD, with significantly lower values in the Fontan patients compared to ToF. Strong correlations were found between the OUES and both the VO(2peak) and VT in Fontan and ToF patients.</p><p><strong>Discussion: </strong>The OUES provides a valid measure of cardiopulmonary fitness in children with CHD, which is independent of exercise intensity and strongly correlated with VO(2peak) and VT (construct validity). Furthermore, the OUES is capable of differentiating between healthy children and children with CHD and between Fontan and ToF patients (group validity). Therefore, the OUES may be a valid, effort-independent parameter of cardiopulmonary fitness in children with CHD.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International data on supportive therapies at 1 year in acute coronary syndrome patients undergoing PCI: results from the APTOR study.","authors":"Ameet Bakhai,&nbsp;Jean Ferrieres,&nbsp;Andres Iñiguez,&nbsp;Claude Schmitt,&nbsp;Magali Sartral,&nbsp;Mark Belger,&nbsp;Uwe Zeymer","doi":"10.1177/1741826710389382","DOIUrl":"https://doi.org/10.1177/1741826710389382","url":null,"abstract":"<p><strong>Background: </strong>Supportive therapies of exercise and diet-modifying secondary prevention programmes are associated with reduced morbidity and mortality in acute coronary syndrome (ACS) patients. We sought to evaluate the frequency and correlates of referral to these supportive therapies, and their impact on concordance with prescribed secondary prevention medications at 1 year among ACS patients undergoing percutaneous coronary intervention (PCI) in three European countries.</p><p><strong>Design/methods: </strong>Data on referral for exercise and diet supportive therapies were collected at discharge through to 1 year in the Antiplatelet Therapy Observational Registry (APTOR) prospective observational study conducted in France, Spain and the UK in 1335 patients.</p><p><strong>Results: </strong>40% of patients received referral for exercise or diet, while three out of five patients received neither, with large variation between countries. Predictors of recommendation for either diet or exercise when excluding country were enrolment in a non-teaching centre (odds ratio [OR] 1.62, 95% CI [confidence interval] 1.33-1.97, p < 0.0001) and use of only a bare metal stent during PCI (OR 1.59, 95% CI 1.30-1.92, p = 0.0002), while weight and BMI had no bearing. Patients recommended either diet or exercise programmes had significantly more secondary prevention medication rates for each of the five predefined evidence-based BASIC (beta-blockers, aspirin, statins, ACE-inhibitors/ARBs and clopidogrel) medication therapies at 1 year.</p><p><strong>Conclusion: </strong>Following an ACS treated with PCI, by 1 year the majority of European patients were not recommended supportive therapies of exercise and dietary secondary prevention programmes, which have previously been associated with reduced morbidity and mortality and are recommended in the guidelines. Those recommended such therapies had considerably improved concordance with evidence-based therapies such as aspirin, clopidogrel and statins prescribed at 1 year. These data show a need for greater adherence to the European guidelines to ensure ACS patients are recommended such therapies.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary model for cardiovascular risk prediction in people with type 2 diabetes.","authors":"Andre Pascal Kengne,&nbsp;Anushka Patel,&nbsp;Michel Marre,&nbsp;Florence Travert,&nbsp;Michel Lievre,&nbsp;Sophia Zoungas,&nbsp;John Chalmers,&nbsp;Stephen Colagiuri,&nbsp;Diederick E Grobbee,&nbsp;Pavel Hamet,&nbsp;Simon Heller,&nbsp;Bruce Neal,&nbsp;Mark Woodward","doi":"10.1177/1741826710394270","DOIUrl":"https://doi.org/10.1177/1741826710394270","url":null,"abstract":"<p><strong>Background: </strong>Existing cardiovascular risk prediction equations perform non-optimally in different populations with diabetes. Thus, there is a continuing need to develop new equations that will reliably estimate cardiovascular disease (CVD) risk and offer flexibility for adaptation in various settings. This report presents a contemporary model for predicting cardiovascular risk in people with type 2 diabetes mellitus.</p><p><strong>Design and methods: </strong>A 4.5-year follow-up of the Action in Diabetes and Vascular disease: preterax and diamicron-MR controlled evaluation (ADVANCE) cohort was used to estimate coefficients for significant predictors of CVD using Cox models. Similar Cox models were used to fit the 4-year risk of CVD in 7168 participants without previous CVD. The model's applicability was tested on the same sample and another dataset.</p><p><strong>Results: </strong>A total of 473 major cardiovascular events were recorded during follow-up. Age at diagnosis, known duration of diabetes, sex, pulse pressure, treated hypertension, atrial fibrillation, retinopathy, HbA1c, urinary albumin/creatinine ratio and non-HDL cholesterol at baseline were significant predictors of cardiovascular events. The model developed using these predictors displayed an acceptable discrimination (c-statistic: 0.70) and good calibration during internal validation. The external applicability of the model was tested on an independent cohort of individuals with type 2 diabetes, where similar discrimination was demonstrated (c-statistic: 0.69).</p><p><strong>Conclusions: </strong>Major cardiovascular events in contemporary populations with type 2 diabetes can be predicted on the basis of routinely measured clinical and biological variables. The model presented here can be used to quantify risk and guide the intensity of treatment in people with diabetes.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710394270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking habits and the risk of non-fatal acute myocardial infarction in Costa Rica.","authors":"Marta Rossi,&nbsp;Eva Negri,&nbsp;Carlo La Vecchia,&nbsp;Hannia Campos","doi":"10.1177/1741826710389381","DOIUrl":"https://doi.org/10.1177/1741826710389381","url":null,"abstract":"<p><strong>Background: </strong>Smoking is a major risk factor for cardiovascular diseases, but there is little information on Latin America.</p><p><strong>Methods: </strong>We used data from a case-control study comprising 2094 cases with a first acute non-fatal myocardial infarction (MI) and 2094 matched controls (by age, sex, and area of residence) living in Costa Rica between 1994 and 2004. Relative risks (RRs) were obtained from conditional logistic regression models.</p><p><strong>Results: </strong>Compared to never smokers, the risk of MI was not higher in ex-smokers, but the RR was 2.71 for current smokers, and increased with the number of cigarettes smoked per day. Smoking ≥25 cigarettes per day was associated with an eight-fold risk of MI. The RR was higher for women (4.39) than for men (2.38). There was no trend in risk with duration and age at starting smoking. RRs were respectively 4.8, 5.6 and 6.1 for smokers of ≥15 cigarettes per day with obesity, diabetes or hypertension compared to non-smokers. Subjects living with a smoker had a 23% higher MI risk. Active and passive smoking accounted for 38% and 8% of MI cases. It explained 25% and 9% of female and 42% and 7% of male cases, 47% and 15% of cases below age 50, and 35% and 5% cases above age 50 years. Stopping smoking reduced the risk of MI already after one year, and after five years the risk approached that of never smokers.</p><p><strong>Conclusion: </strong>In Costa Rica, like elsewhere, inducing smokers to stop is a public health priority.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29780009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct renin inhibition: update on clinical investigations with aliskiren.","authors":"Natale Daniele Brunetti,&nbsp;Luisa De Gennaro,&nbsp;Pier Luigi Pellegrino,&nbsp;Andrea Cuculo,&nbsp;Luigi Ziccardi,&nbsp;Antonio Gaglione,&nbsp;Matteo Di Biase","doi":"10.1177/1741826710389387","DOIUrl":"https://doi.org/10.1177/1741826710389387","url":null,"abstract":"<p><p>The renin–angiotensin–aldosterone system (RAAS) plays a pivotal role in regulating blood pressure, volume, and electrolytes. The final product of RAAS cascade is angiotensin II, which exerts diverse biological activities via binding to one of three known receptor types, with different binding consequences. Despite the success with conventional strategies to limit angiotensin II production and action, these agents promote a reflex rise in plasma renin activity, which is thought to be associated with an increased incidence of cardiovascular events. Several renin inhibitors have been synthesized in order to counteract deleterious consequences of renin activity and RAAS activation; aliskiren is the first of these new non-peptide direct renin inhibitors to be approved for the treatment of hypertension. The paper reviews pharmacokinetics of aliskiren and its role in hypertension, with particular regard to those studies that compared clinical efficacy of aliskiren in comparison and in addition to other antihypertensive drug strategies.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389387","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of cardiovascular risk factors and concentration of C-reactive protein in Type D personality persons without cardiovascular disease.","authors":"Gunnar Einvik,&nbsp;Toril Dammen,&nbsp;Harald Hrubos-Strøm,&nbsp;Silje K Namtvedt,&nbsp;Anna Randby,&nbsp;Håvard A Kristiansen,&nbsp;Virend K Somers,&nbsp;Inger H Nordhus,&nbsp;Torbjørn Omland","doi":"10.1177/1741826710389383","DOIUrl":"https://doi.org/10.1177/1741826710389383","url":null,"abstract":"<p><strong>Background: </strong>Type D personality is associated with poor cardiovascular outcome in patients with coronary or peripheral arterial disease. Whether Type D personality is associated with cardiovascular risk in persons without overt cardiovascular disease remains unknown. We hypothesized that Type D personality is associated with higher prevalence of traditional cardiovascular risk factors and higher concentration of C-reactive protein.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Type D personality was assessed in 453 participants without cardiovascular disease derived from an epidemiological study of obstructive sleep apnoea. An evaluation of obesity, lipid status, diabetes, blood pressure, heart rate, smoking, leisure-time physical activity and high-sensitivity C-reactive protein was performed.</p><p><strong>Results: </strong>Smoking (43% vs. 21%, P < 0.001) and low leisure-time physical activity (<3 hours/week, 57% vs. 40%, P = 0.003) were more prevalent, and heart rate (mean (standard deviation), 75 (10) vs. 71 (9), P = 0.001) and body mass index was higher (29.8 (6.0) vs. 28.4 (4.5) kg/m2, P = 0.009) in Type D compared to non-Type D participants. The total number of risk factors was significantly higher in Type D than non-Type D participants (3.4 (1.3) vs. 3.0 (1.2), P = 0.004). The concentration of C-reactive protein was higher in participants with Type D personality (median, interquartile range 1.6, 0.7-3.4 vs. 1.1, 0.6-2.6, P = 0.047), although not statistically significant after adjustment for possible mediating factors.</p><p><strong>Conclusions: </strong>Among participants at high risk of cardiovascular disease, presence of Type D personality was associated with elevated body mass index and unhealthy behaviour such as smoking and low physical activity, which may have mediated the elevated concentration of C-reactive protein.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time trends in cardiovascular and all-cause mortality in the 'old' and 'new' European Union countries.","authors":"Eftyhia Helis,&nbsp;Lana Augustincic,&nbsp;Sabine Steiner,&nbsp;Li Chen,&nbsp;Penelope Turton,&nbsp;J George Fodor","doi":"10.1177/1741826710389361","DOIUrl":"https://doi.org/10.1177/1741826710389361","url":null,"abstract":"<p><strong>Aims: </strong>There are large differences in all-cause and cardiovascular disease (CVD) mortality between eastern and western countries in Europe. We reviewed the development of these mortality trends in countries of the European Union (EU) over the past 40 years and evaluated available data regarding possible determinants of these differences.</p><p><strong>Methods and results: </strong>We summarized all-cause mortality and specific cardiovascular mortality for two country groups - 10 countries that joined the European Union (EU) after 2004 (East), and 15 countries that joined before 2004 (West). Standardized mortality rates were retrieved from the World Health Organization \"European Health for All\" database for each country between 1970 and 2007. Currently (in the 2000s), mortality due to circulatory system disease, ischemic heart disease (IHD), cerebrovascular disease (CBVD), and all-causes in the 'new' EU countries (East) is approximately twice that in the 'old' EU countries (West). These differences were much smaller in the 1970s. The increasing gap in mortality between West and East is primarily the result of a continuous and rapid improvement in the West.</p><p><strong>Conclusion: </strong>Differences in lifestyle (i.e. diet, alcohol consumption, physical activity, and smoking) provide insufficient explanation for the observed mortality gap in these two groups of EU countries. Higher expenditures on health, better access to invasive and acute cardiac care, and better pharmacological control of hypertension and hypercholesterolemia in the West are well documented. Socioeconomic and psychosocial factors may also contribute to the changes in mortality trends.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389361","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29781518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity, metabolic syndrome, and coronary risk: the EPIC-Norfolk prospective population study.","authors":"Lysette N Broekhuizen,&nbsp;S Matthijs Boekholdt,&nbsp;Benoit J Arsenault,&nbsp;Jean-Pierre Despres,&nbsp;Erik S G Stroes,&nbsp;John J P Kastelein,&nbsp;Kay-Tee Khaw,&nbsp;Nicholas J Wareham","doi":"10.1177/1741826710389397","DOIUrl":"https://doi.org/10.1177/1741826710389397","url":null,"abstract":"<p><strong>Objective: </strong>We investigated the association between physical activity, metabolic syndrome (MS), and the risk of future coronary heart disease (CHD) and mortality due to CHD in middle-aged men and women.</p><p><strong>Design: </strong>Prospective cohort study.</p><p><strong>Subjects: </strong>A total of 10,134 men and women aged 45-79 years at baseline, were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. Cardiovascular risk factors and physical activity levels were recorded at baseline. Rates of CHD and CHD mortality were recorded during a follow-up of 10.9 years.</p><p><strong>Results: </strong>The prevalence of MS was 37.6% in men and 30.2% in women. Hazard ratios (HRs) for future CHD were 1.95 (95% CI 1.65-2.31) for men with MS and 3.17 (95% CI 2.53-3, 97) for women with MS, compared to those without MS. HRs adjusted for age and smoking were 1.52 (95% CI 1.29-1.81) for men and 1.76 (95% CI 1.39-2.23) for women. Additional adjustment for physical activity did not attenuate these risk estimates further [HRs 1.51 (95% CI 1.27-1.79) and 1.74 (95% CI 1.38-2.21), respectively]. CHD risk associated with MS was substantially lower among participants who were physically active. There was no longer a significant difference in CHD event rate between men with MS who were active and men without MS who were inactive (11.5% vs. 12.8%). For women, similar associations were observed (5.3% vs. 5.6%). We found evidence for significant effect modification (p for interaction = 0.006) such that physical activity affected the association between MS and CHD risk.</p><p><strong>Conclusion: </strong>Middle-aged men and women with MS have an increased risk for future CHD. This CHD risk associated with MS is substantially lower among those who are physically active. Participants with MS who were physically active had a lower CHD risk than people without MS who were physically inactive.</p>","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1741826710389397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29779932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}