European Journal of Cardiovascular Prevention & Rehabilitation最新文献

{"title":"Oral Abstract Session: Epidemiology and sports cardiology","authors":"A. Hingorani, A. Jones, M. Charakida, D. Lawlor, Gd Smith, Sattar, J. Deanfield, C. Fischbacher, H. Brown, S. Capewell","doi":"10.1177/17418267100170s218","DOIUrl":"https://doi.org/10.1177/17418267100170s218","url":null,"abstract":"295 Prevalence and clinical significance of aortic root dilatation in highly-trained, competitive athletes B Di Giacinto, E De Blasiis, FM Di Paolo, FM Quattrini, C Pisicchio, E Guerra, R Ciardo, A Pelliccia Institute of Sport Medicine and Science, CONI, Rome, Italy Topic: Sports cardiology Purpose: Prevalence, clinical significance, and long-term consequences of aortic root (AoR) dilatation in competitive athletes are not yet investigated. Our aim was to assess the distribution and determinants of AoR size in a large population of competitive athletes. Methods: AoR dimension were assessed by echocardiography in 2,361 athletes participating in 48 different sports. Of them, 44 were excluded because aortic structural abnormalities, such as bicuspid aortic valve, Marfan s Syndrome, aortic prosthesis. The remaining 2,317, including 1,300 (56%) males and 1,017 (44%) females were the study population. Arbitrary cut-off of =40 mm, according to #36th Bethesda Conference, was used as upper normal limits for AoR. Results: In males AoR was 32.2 2.7 mm (range 23-44) and the 95th percentile was 37 mm. In females AoR was 27.5 2.6 mm (20-36) and the 95th percentile was 32 mm.Multiple regression and covariance analysis showed AoR dimension largely explained by body surface area, left ventricular mass and age (R21⁄4 0.61), with type of sports participation having only a modest effect. The AoR was<40 mm in 2,300 athletes (99%), and = 40 mm in only 17 (1%), all male. In this subset, aortic dimension increased over a 8 5 year follow-up (40.9 1.3 to 42.9 3.6 mm; p <0.01), including 3 former athletes in whomAoR become dilated (to 50mm, 50mm and 48mm) after 15-16 years, in the absence of symptoms or evidence of systemic disease. Conclusion:Dilatation of the aortic root ( =40 mm) is rare in highly trained athletes and is not a consistent feature of‘‘athlete s heart’’. Longitudinal assessment in athletes with AoR =40 mm showed further dimensional increase, which occasionally was very marked. Selective restriction from most intense competitive sports may be indicated in these athletes to reduce the risk associated with accelerated aortic enlargement.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"78 1","pages":"S59 - S60"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young Investigators Awards Session","authors":"S. Ramsay, P. Whincup, S. Hardoon, M. Thomas, R. Morris, -. SGWanna, Methee, P. Wohlfahrt, D. Palouš, M. Ingrischová, A. Krajčoviechová, J. Seidlerová, Adámková, J. Filipovský, R. Cífková","doi":"10.1177/17418267100170s220","DOIUrl":"https://doi.org/10.1177/17418267100170s220","url":null,"abstract":"419 Have socioeconomic differences in coronary risk factors changed over 20 years? Results from a population-based study of men between 1978-80 and 1998-2000 SE Ramsay, PH Whincup, SL Hardoon, MC Thomas, RW Morris, SG Wannamethee University College London, London, United Kingdom, St George’s, University of London, London, United Kingdom Topic: Cardiovascular epidemiology Background: Although CHD mortality has declined in the UK population since the late 1970s, the decline has been particularly marked among more affluent subjects. While the decline substantially reflects improvements in established coronary risk factors, little is known about how these have changed in different socioeconomic groups. Aim: To examine whether socioeconomic differences in coronary risk factors in Britain have changed over 20 years between 1978-80 and 1998-2000. Methods: A socioeconomically representative cohort of men aged 40-59 years from 24 British towns was followed-up from 1978-80. Data on blood pressure, cholesterol, body mass index (BMI), cigarette smoking and physical activity were collected at baseline (1978-80) and in 19982000. Social class was based on the longest-held occupation in middle-age. Results: Overall, the prevalence of cigarette smoking declined and mean blood pressure and non-HDL cholesterol levels fell, while mean HDL cholesterol and BMI, and physical activity increased. The higher odds of being a current smoker in manual (lower) compared with nonmanual (higher) social classes in 2000 (age-adjusted odds ratio1⁄42.04; 95%CI 1.68, 2.47) had not changed since 1978-80 (p for interaction social class time 0.51). Men in manual occupations became less likely to be physically inactive compared with non-manual groups (p for interaction 0.04) and more likely to be moderate-vigorously active (p for interaction 0.005). The 20-year increase in mean BMI was 2.34 kg/m2 in the manual compared with 2.01 kg/m2 in the nonmanual group (difference in mean change 0.33 kg/m2; 95%CI 0.14, 0.53; p for interaction 0.001). Mean systolic blood pressure declined more in manual than non-manual groups (difference in mean change 3.6; 95%CI 2.1, 5.3, p for interaction <0.0001). Non-manual groups had a greater mean decline in non-HDL cholesterol (difference in mean change 0.18 mmol/l; 95%CI 0.11, 0.25, p for interaction <0.0001) and a greater mean increase in HDL-cholesterol (difference in mean change 0.04 mmol/l; 95%CI 0.02, 0.06, p for interaction < 0.0001). Conclusions: Since the 1980s, socioeconomic differences in physical activity and blood pressure may have been reduced, while those in cigarette smoking have persisted. Socioeconomic differences in BMI, non-HDL and HDL-cholesterol levels appeared to have worsened, with more unfavourable changes in lower socioeconomic groups. Continuing priority is needed to improve adverse cardiovascular risk profiles in socially disadvantaged groups in the UK.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S63 - S64"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Session III: Sports cardiology","authors":"Nicole MPanhuyzen-Goedkoop, R. Terink, Jlrm Smeets, A. Kassim, KA Treusch, A. Fruend, C. Beller, M. Vlachojannis, K. Erdsiek, F. Van, Buuren, K.-P. Mellwig","doi":"10.1177/17418267100170s226","DOIUrl":"https://doi.org/10.1177/17418267100170s226","url":null,"abstract":"P398 Blood pressure response to exercise in young athletes associated with classification of sports N M Nicole MPanhuyzen-Goedkoop, R Terink, JLRM Smeets Radboud University Nijmegen Medical Centre, Heartlung Centre, Nijmegen, Netherlands, Sports Medical Center Papendal, Arnhem, Netherlands Topic: Sports cardiology Purpose: hemodynamic responses to maximal exercise testing cover the general population. Bloodpressure (BP) responses in athletes are reported at rest and during ambulatory BP monitoring. BP responses associated with different classes of sports are lacking. Purpose: To determine BP responses to exercise related to different classes of sports in young athletes (=35yr). Methods: Young athletes who had pre-participation cardiovascular screening, maximal exerciseECG, and were engaged in regular physical training and competition > previous 6 month were included in this retrospective study during 2000-2008. Bicycle exercise protocol until exertion, 75 watt (men) or 50 watt (women) during 4min, increment 25 watt / 2 min. BP and ECG at rest, each increment, and recovery phase was measured manually. Results: 475 athletes were included, 308 men and 167 women, age 9-35yr (mean 24yr). Number of training hours 1-30/wk. Mean resting BP was 122 mmHg systolic and 73.5 mmHg diastolic. Mean resting heart rate was 61.7 bpm on ECG. Mean BP responses to maximal exertion in different classes of sports (mmHg) are in table. Conclusion: this is the first study that demonstrates different BP responses associated with different classes of sports. The highest systolic and diastolic BP responses were recorded in moderate static-low dynamic sports. The lowest diastolic BP responses were recorded in moderate static-high dynamic sports. Values above the criteria for hypertension on exertion were in moderate static-low dynamic and high static-low dynamic classes of sports. Further studies are warranted to define ‘‘normal’’ blood pressure response to exercise in different classes of sports","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S88 - S88"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s226","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Session I: Cardiac rehabilitation and chronic heart failure","authors":"","doi":"10.1177/17418267100170s205","DOIUrl":"https://doi.org/10.1177/17418267100170s205","url":null,"abstract":"P85 The effect of high-intensity training on ventilatory efficiency in chronic heart failure MGJ Gademan, J Myers, K Brunner, W Kottman, C Boesch, P Dubach Palo Alto Veterans Affairs Medical Center / Stanford University, Palo Alto, United States of America, Kantosspital, Chur, Switzerland Topic: Cardiovascular rehabilitation Background: The oxygen uptake efficiency slope (OUES) is a relatively new measure of ventilatory efficiency which has prognostic value in chronic heart failure (CHF) patients. The OUES has the advantage that it is independent of exercise capacity achieved. Little is known regarding the effects of exercise training on OUES in CHF. Hypothesis: High-intensity training improves the OUES in patients with CHF. Methods: Fifty CHF patients were randomized to a 2-month high-intensity residential exercise training program (EXTR, N1⁄424) or to a control group (CTRL, N1⁄426). Before and after the study period, maximal cardiopulmonary exercise testing was performed. Peak oxygen uptake (VO2peak), VE/VCO2 slope, OUES, and minute-by-minute lactate responses were measured. Results: Exercise training significantly increased VO2peak (23%), peak minute ventilation (23%), exercise time (29%) andpeakworkload (28%),whereasno improvementswereobserved in controls (p<0.05). These responses also improved at the lactate threshold (VO2peak 44%, minute ventilation 44%, exercise time 71% and workload 69%). The OUES increased by 11% in the EXTR group and 4% in the CTRL group (p1⁄40.46 between groups). However, the within group change in the EXTR group was highly significant (p1⁄40.003). At baseline, EXTR patients had an OUES that was 69% of the predicted value, and this improved to 78% after finishing the program (p within group1⁄40.004). Conversely, no differences were observed in the VE/VCO2 slope. Conclusions: In these relatively healthy CHF patients, high intensity training resulted in marked improvements inVO2peak, exercise time andworkload.Trainingalso improved theOUESbut not the VE/VCO2 slope. Among measures of ventilatory inefficiency, the OUES may respond more favorably to exercise training than the VE/VCO2 slope. Therefore, an improvement in the OUES may be a more achievable outcome from exercise training in relatively healthy CHF patients.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S19 - S23"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Abstract Session: Translational science","authors":"V. Dao, M. Oppermann, N. Mangner, G. Schuler, M. Thomis, S. Onkelinx, JJ Prompers, B. Wessels, W. D. Vries, M.L. Zonderland, Nicolay, G. Schep, P. Doevendans","doi":"10.1177/17418267100170s219","DOIUrl":"https://doi.org/10.1177/17418267100170s219","url":null,"abstract":"301 Sustained Hypertension Despite Endothelium-Specific Reintroduction of Functionally Active eNOS in eNOS-Deficient Mice T Suvorava, VT Dao, M Oppermann, G Kojda Institute of Pharmacology and Clinical Pharmacology, University Hospital, Duesseldorf, Germany Topic: Hypertension Purpose: Several studies have shown that eNOS-deficient mice (eNOS-/-) have higher blood pressure than wild-type mice. It is frequently assumed that hypertension in eNOS-/is caused by the lack of endothelium-derived nitric oxide and the resulting increase in arterial tone and peripheral resistance. We sought to investigate whether endothelial-specific targeting of eNOS introduced in eNOS-/can normalize aortic reactivity and blood pressure. Methods:Transgenic mice carrying bovine eNOS (eNOSbovþ) have been generated on C57Bl/ 6 background using the endothelium-specific Tie-2 promotor. By breeding these mice with eNOS knockouts (eNOS-/-), mice that only express eNOSbov (eNOS-/-/eNOSbovþ) were obtained. Results: Western blot analysis confirmed eNOS protein expression in aorta (67.7 12.6), myocardium (49.9 5.4), lung (124.5 2.5) and skeletal muscle (87.0 25.1) of eNOS-/-/ eNOSbovþ as compared to C57Bl/6 (100%, n1⁄43-6). Aortas of eNOS-/-/eNOSbovþ showed complete restoration of endothelium-dependent relaxation to acetylcholine. The doseresponse-patterns to acetylcholine did not differ significantly (P1⁄40.562, n1⁄47-11, two-way ANOVA), and the maximal relaxations were similar in eNOS-/-/eNOSbovþ (98.3 2.14 %, n1⁄47) and C57Bl/6 mice (92.4 3.6 %, n1⁄411) while no relaxation was observed in eNOS-/(137.5 12.1, n1⁄411). Hypersensitivity to phenylephrine observed in eNOS-/mice (maximal contraction 15.2 0.7 mN, n1⁄46, P<0.0001) vs C57Bl/6 (4.6 1.1mN, n1⁄45) was blunted by endothelium-targeted reintroduction of eNOS (2.9 0.8, mN, n1⁄46). Likewise, there was a significant increase in aortic sensitivity to NO-donors S-nitroso-N-acetyl-penicillamine and diethylamine/NO in eNOS-/as compared to C57Bl/6 (n1⁄44-5, P<0.05) and this was completely abolished in eNOS-/-/eNOSbovþ (n1⁄44-5, P1⁄4 0.0278). The expression of both sGC-alpha1 and sGC-beta1 did not reveal any significant difference between eNOS-/-, eNOS-/-/eNOSbovþ and C57Bl/6 (n1⁄44, each P>0.05, ANOVA). Despite complete restoration of aortic reactivity, eNOS-/-/eNOSbovþ mice have strongly elevated systolic blood pressure (n1⁄4137.1 2.26 mmHg, n1⁄48) as compared to C57Bl/6 (118.4 3.1 mmHg, n1⁄46, P<0.05), but not to eNOS-/(135.9 2.07, n1⁄48, P1⁄40.7). Conclusions: Endothelium-specific reintroduction of functionally active eNOS in eNOSdeficient mice resulted in complete normalization of aortic reactivity but not blood pressure. These data suggest that eNOS appears to have limited effect on systemic blood pressure.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S61 - S62"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Session IV. Sports cardiology","authors":"","doi":"10.1177/17418267100170s232","DOIUrl":"https://doi.org/10.1177/17418267100170s232","url":null,"abstract":"","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S111 - S111"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s232","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Session IV. Epidemiology and public health","authors":"Y. Chan, C. Siu, K. Yiu, Sw Li, S. Tam, Th Lam, C. Lau, H. Tse, N. Smeeton, S. Allender, S. Yamada, K. Kamisaka, A. Araki, Y. Fujioka, K. Yasui, Y. Hasegawa, Koike","doi":"10.1177/17418267100170s230","DOIUrl":"https://doi.org/10.1177/17418267100170s230","url":null,"abstract":"P475 Secondary prevention of stroke in Czech patients in the EUROASPIRE III Study Stroke Specific Module J Bruthans, O Mayer, J Simon, M Galovcova, J Hrbkova, J Belohoubek, R Cifkova, H Rosolova Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Charles University School of Medicine, Pilsen, Czech Republic Topic: Stroke Aims of study: To assess the prevalence of major risk factors for ischemic stroke, to determine implementation of the secondary prevention of stroke in clinical practice. Methods: A total of 507 consecutive patients aged < 80 years and hospitalized for their first ischemic stroke in the respective district hospital (Praha 4 and Plzen-mesto) were selected retrospectively. Data were obtained from patients hospital medical records and subsequent patients history including the completion of structured questionnaires. Outpatient examination including fasting blood sampling was performed at 636 months post-stroke. The survey was carried out as part of a European study using the protocol of the EUROASPIRE III study Stroke Specific Module. Results: A total of 341 men and women were examined. Of these, at the time of examination, 636 months post stroke, 14.9% were current smokers, 38.8% were obese, 81% had blood pressure levels> 130/80 mmHg, 71.1% had increased LDL-cholesterol (> 2.5 mmol/L), 32.3% had overt diabetes (fasting blood glucose > 7 mmol/L or treatment with oral hypoglycemic agents or insulin), with only 5.5% of patients with diabetes showing satisfactory diabetes control (fasting blood glucose< 6.1 mmol/L). At the time of this examination, 78.9% of patients were receiving antiplatelet drugs or anticoagulants, 52.2% statins, 85.9% antihypertensive medication (43.1% beta-blockers, 68.9% ACE inhibitors or angiotensin II receptor blockers, 39.9% diuretics, and 32.6% calcium-channel blockers). Only a small proportion of patients were compliant with nonpharmacologic measures of secondary prevention (exercise and diet in particular). While signs of depression were possibly or likely present in 33.3% of patients, 21% of patients showed likely or probable anxiety. Conclusion: Secondary preventive lifestyle measures are inadequately implemented, with only a small proportion of patients achieving goal values of risk factors despite widely used drug therapy. The role of post-stroke rehabilitation and psychotherapy is largely underestimated.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S105 - S98"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Session II: Epidemiology and public health","authors":"JS Mindell, P. Zaninotto, E. Falaschetti, M. Aresu, N. Poulter, G. Flores-Mateo, M. O’flaherty, K. Nnoaham, F. Lloyd-Williams, M. Rayner, Capewell, S. GWannamethee, L. T. Lennon, M. C. Thomas, P. HWhincup, G. Kopec, B. Sobien, M. Podolec, H. Dziedzic, M. Sobien, M. Brozda, A. Pajak, Podolec","doi":"10.1177/17418267100170s212","DOIUrl":"https://doi.org/10.1177/17418267100170s212","url":null,"abstract":"P190 The Italian Health Examination Survey: time trends of CVD risk factors S Giampaoli, C Lo Noce, L Iacoviello, D Vanuzzo, L Palmieri, C Donfrancesco, J Stamler Instituto Superiore di Sanita, Rome, Italy, Catholic University of the Sacred Heart, Campobasso, Italy, Center for Cardiovascular Prevention, Udine, Italy, Northwestern University, Feinberg School of Medicine, Chicago, United States of America Topic: Risk factors and risk prediction Purpose: A periodic Health Examination Survey (HES)-Osservatorio Epidemiologico Cardiovascolare (OEC) has been implemented in Italy. The aim of this analysis is to present initial results for 2008-09 and compare them with those collected in 1998, the previous HES. Methods: Randomized population samples stratified by age and sex were examined (participation rate 63%). Risk factor data were collected using MONICA Project standardized methodologies; biochemical levels were assayed in a central laboratory. In 1998, about 10,000 men and women ages 35-74 years were enrolled throughout the country (200 persons from each 1,5 million of resident population). The new screening is enrolling the same sample size, age range 35-79 years. All data are age-standardized using the European standard population. Results: Data here are from 7 regions, for a total of 1,454 men and women in 1998 and 1,864 persons in 2008-09. Data comparison shows a decrease for systolic blood pressure (men: from 139 to 135 mmHg; women: from 130 to 125 mmHg) and diastolic blood pressure (men: from 87 to 82 mmHg; women: from 82 to 78 mmHg); an increase for serum total cholesterol (men: from 209 to 217 mg/dl; women: from 206 to 218 mg/dl), while HDL-cholesterol remained stable (men: 52 and 51 mg/dl; women: 59 and 60 mg/dl); body mass index also was stable for men and women (average 28 kg/m2 and 27 kg/m2); glycemia increased in both genders (men: from 92 to 97mg/dl; women: from 87 to 89 mg/dl). Prevalence of obesity increased from 21% to 26% in men, and did not change in women (26%); prevalence of diabetes did not change in men (12%) and decreased slightly in women (from 8% to 7%); smoking habit decreased in men (from 33% to 26%) but not in women (22% in both surveys). Conclusions: Although these are only preliminary results, HES trends show troublesome increases in total cholesterol, glycemia, and obesity; improvements in blood pressure. In combination with other information sources, the OEC can contribute greatly to evaluation of the efficacy of community actions (the Italian smoking ban regulation, introduction of risk assessment in clinical practice) and to elaboration of needed next efforts.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S38 - S46"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s212","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65490884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderated Poster Session II: Epidemiology and public health","authors":"K. Ueshima, K. Oba, A. Fujimoto, T. Ogihara, T. Saruta, K. Nakao, F. Farahati","doi":"10.1177/17418267100170s202","DOIUrl":"https://doi.org/10.1177/17418267100170s202","url":null,"abstract":"P22 C-reactive protein in prepubertal children with abdominal obesity as a marker of cardiovascular and metabolic risk S Galcheva, Y Yotov, V Iotova Medical University, Varna, Bulgaria Topic: Risk factors and risk prediction High sensitivity C-reactive protein (hsCRP) is a marker of inflammation and is found to be a significant predictor of cardiovascular diseases (CVD). Metabolic syndrome and abdominal obesity are associated with earlier and more severe presentation of atherosclerosis. Aim: To evaluate the level of hsCRP in children aged below 10 years according to overweight/ obesity status and in relation to cardiovascular parameters and other risk factors. Participants and methods:We evaluated 168 healthy children (78 boys and 90 girls) at the mean age 8.1 1.2 years divided in three groups normal (NW, 31.5%), overweight (OW, 27.4%) or obese (OB, 41.1%) according to bodymass index (BMI) international reference (Cole, 2000) and waist circumference (WC). Their blood pressure (BP) and heart rate (HR) were measured and blood tests for fasting blood glucose (BG), immunoreactive insulin (IRI), lipids, liver enzymes, hsCRP, and other proinflammatory and hormonal markers were drawn. HOMA-IR was calculated according to the standard formula. Log transformation of data for the hsCRP, BMI and other variables was performed where appropriate because of skewed distribution. Results: The hsCRP was significantly higher in the OB 7.53 0.91 (mean SE) compared with the OW 4.11 0.9 (p1⁄40.029) and NW 3.17 0.88 mg/l (p1⁄40.001) children, without important gender differences. The inflammation marker displayed significant linear increase with both BMI andWC. The hsCRP was positively correlated with IRI (r1⁄40.237, p1⁄4 0.004), with HOMAIR (r1⁄40.279, p1⁄40.001), with systolic BP (r1⁄40.396, p<0.0001) and diastolic BP (r1⁄40.299, p <0.0001), and negatively with HDL-cholesterol (r1⁄4-0.202, p1⁄40.013). In multivariable linear regression model, the hsCRP increased with 1.84 mg/l (95%CI1⁄41.50-2.26, p<0.0001) per WC quartile after adjustment for age, gender, BMI, birth weight, BG, HOMA-IR. For BMI, the significance of the relation with hsCRP which was present in the univariate analysis disappeared after adjusting for WC in the multivariate model. Conclusions: The hsCRP is elevated in healthy overweight and obese children already in prepuberty. It correlates with higher BP and other important risk factors for CVD. At this age, waist circumference is a better predictor of the hsCRP levels than is BMI. The prevention of CVD through weight control has to start early in life.","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S3 - S4"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderated Poster Session VI: Cardiac rehabilitation","authors":"F. Cesari, R. Marcucci, F. Sofi, C. Burgisser, S. Luly, R. Abbate, G. Gensini, Fattirolli","doi":"10.1177/17418267100170s222","DOIUrl":"https://doi.org/10.1177/17418267100170s222","url":null,"abstract":"P316 Endothelial progenitor cells mobilization and inflammation after cardiac rehabilitation on patients undergoing percutaneous coronary intervention after acute coronary sindrome F Cesari, R Marcucci, F Sofi, C Burgisser, S Luly, R Abbate, GF Gensini, F Fattirolli Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Florence, Italy, Cardiac Rehabilitation Center , Unit of Gerontology and Geriatrics , University of Florence, Florence, Italy Topic: Cardiovascular rehabilitation Background: Endothelial progenitor cells (EPCs) are bone marrow-derived progenitor cells which support vascular endothelium, so playing a crucial role in the beginning and progression of atherosclerosis. It has been previously demonstrated that a potent trigger for EPCs mobilization is regular physical exercise. However, few data regarding the possible effect of cardiac rehabilitation (CR) program after primary percutaneous coronary intervention (PCI) on EPCs are available. We performed this study in order to assess the variations of EPCs in relation to inflammatory markers in patients who performed a four weeks CR after PCI. Methods: 55 patients [45 M/10 F; mean age 58 (41-74) years] were admitted in an four weeks execise-based CR program after acute coronary syndrome and PCI. The numbers of EPCs and the sera levels of NT-ProBNP and high sensitivity C-reactive protein (CRP) were determined at the beginning (T1) and at the end (T2) of the CR program. All patients were under HMG-CoA reductase inhibitor therapy and performed a cardiopulmonary exercise test at T1 and at T2. Peripheral blood EPCs were measured by using flow cytometry and were defined as CD34þKDRþ, CD133þKDRþ and CD34þCD133þKDRþ. CRP and NT-ProBNP were measured by using a nephelometric and an immunometric method, respectively. Results: With regards to EPCs, we observed a significantly increase at T2 with respect to T1 [CD34þKDRþ: 7 (0-27) vs. 13 (0-37) cells/106 events p1⁄40.010; CD133þKDRþ: 7(0-27 vs. 10 (0-33) ) cells/106 events p1⁄40.018; CD34þCD133þKDRþ: 7 (0-27) vs. 10 (0-33) cells/106 events p1⁄40.014]. As expected, a significantly increase at T2 was observed for cardiopulmonary parameters (VO2max andWatt) whereas hsCRP andNT-ProBNP levels significantly decreased at T2 with respect to T1 values. By diving our patients populations in relation to the increase of EPCs, patients with an increase of EPCs were significantly younger with respect to the others [56 (42-74) vs. 61 (41-74) p<0.05], showed significantly lower baseline levels of CRP [2.5 (0.4-9.0) vs. 6.3 (0.3-9.1) mg/L p<0.05] and a better exercise tolerance with higher basal VO2max [21.0 (10.0-30.7) vs. 17.9 (10.0-28.0) ml/Kg/min]. Moreover, among cardiovascular risk factors the presence of smoking habit and obesity negatively influenced the increase of EPCs. Conclusion: A four weeks exercise-based CR program after ACS and PCI, is able to determine an increase of EPCs number with a contemporary decrease of CRP","PeriodicalId":50492,"journal":{"name":"European Journal of Cardiovascular Prevention & Rehabilitation","volume":"17 1","pages":"S67 - S68"},"PeriodicalIF":0.0,"publicationDate":"2010-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/17418267100170s222","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65491439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}