Expert Review of Proteomics最新文献_第6页

Proteomics applications in next generation induced pluripotent stem cell models. 蛋白质组学在新一代诱导多能干细胞模型中的应用。

IF 3.8 3区生物学

Expert Review of Proteomics Pub Date : 2024-04-01 Epub Date: 2024-03-27 DOI: 10.1080/14789450.2024.2334033

Vyshnavi Manda, Jay Pavelka, Edward Lau

引用次数: 0

Bringing proteomics to bear on male fertility: key lessons. 将蛋白质组学应用于男性生育：关键经验。

IF 3.8 3区生物学

Expert Review of Proteomics Pub Date : 2024-04-01 Epub Date: 2024-04-10 DOI: 10.1080/14789450.2024.2327553

Rachel Parkes, Thomas X Garcia

{"title":"Bringing proteomics to bear on male fertility: key lessons.","authors":"Rachel Parkes, Thomas X Garcia","doi":"10.1080/14789450.2024.2327553","DOIUrl":"10.1080/14789450.2024.2327553","url":null,"abstract":"Introduction: Male infertility is a major public health concern globally. Proteomics has revolutionized our comprehension of male fertility by identifying potential infertility biomarkers and reproductive defects. Studies comparing sperm proteome with other male reproductive tissues have the potential to refine fertility diagnostics and guide infertility treatment development.Areas covered: This review encapsulates literature using proteomic approaches to progress male reproductive biology. Our search methodology included systematic searches of databases such as PubMed, Scopus, and Web of Science for articles up to 2023. Keywords used included 'male fertility proteomics,' 'spermatozoa proteome,' 'testis proteomics,' 'epididymal proteomics,' and 'non-hormonal male contraception.' Inclusion criteria were robust experimental design, significant contributions to male fertility, and novel use of proteomic technologies.Expert opinion: Expert analysis shows a shift from traditional research to an integrative approach that clarifies male reproductive health's molecular intricacies. A gap exists between proteomic discoveries and clinical application. The expert opinions consolidated here not only navigate the current findings but also chart the future proteomic applications for scientific and clinical breakthroughs. We underscore the need for continued investment in proteomic research - both in the technological and collaborative arenas - to further unravel the secrets of male fertility, which will be central to resolving fertility issues in the coming era.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"181-203"},"PeriodicalIF":3.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11426281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The method developer's guide to oligonucleotide design. 方法开发人员的寡核苷酸设计指南。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-16 DOI: 10.1080/14789450.2024.2318565

Leonie Wenson, Mattias Leino, Malin Jarvius, Johan Heldin, Björn Koos, Ola Söderberg

引用次数: 0

Quantitative analysis of proteostasis networks: are there applications for dementia? 蛋白稳态网络定量分析：是否适用于痴呆症？

IF 3.8 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-23 DOI: 10.1080/14789450.2024.2320807

Daniel B McClatchy

引用次数: 0

How can proteomics be incorporated into the management of atrial fibrillation? 如何将蛋白质组学纳入心房颤动的治疗中？

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI: 10.1080/14789450.2024.2312099

Haiyu Zhang, Jing Shi

引用次数: 0

Recent advances in mass spectrometry for the detection of doping. 质谱法检测兴奋剂的最新进展。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-01-17 DOI: 10.1080/14789450.2024.2305432

Andreas Thomas, Mario Thevis

{"title":"Recent advances in mass spectrometry for the detection of doping.","authors":"Andreas Thomas, Mario Thevis","doi":"10.1080/14789450.2024.2305432","DOIUrl":"10.1080/14789450.2024.2305432","url":null,"abstract":"Introduction: The analysis of doping control samples is preferably performed by mass spectrometry, because obtained results meet the highest analytical standards and ensure an impressive degree of reliability. The advancement in mass spectrometry and all its associated technologies thus allow for continuous improvements in doping control analysis.Areas covered: Modern mass spectrometric systems have reached a status of increased sensitivity, robustness, and specificity within the last decade. The improved sensitivity in particular has, on the other hand, also led to the detection of drug residues that were attributable to scenarios where the prohibited substances were not administered consciously but rather by the unconscious ingestion of or exposure to contaminated products. These scenarios and their doubtless clarification represent a great challenge. Here, too, modern MS systems and their applications can provide good insights in the interpretation of dose-related metabolism of prohibited substances. In addition to the development of new instruments itself, software-assisted analysis of the sometimes highly complex data is playing an increasingly important role and facilitating the work of doping control laboratories.Expert opinion: The sensitive analysis and evaluation of a higher number of samples in a shorter time is made possible by the ongoing developments in mass spectrometry.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"27-39"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139425907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of proteomics in acute pancreatitis: new and old knowledge. 蛋白质组学在急性胰腺炎中的作用：新旧知识。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-23 DOI: 10.1080/14789450.2024.2320810

Peng Ge, Yalan Luo, Guixin Zhang, Hailong Chen

{"title":"The role of proteomics in acute pancreatitis: new and old knowledge.","authors":"Peng Ge, Yalan Luo, Guixin Zhang, Hailong Chen","doi":"10.1080/14789450.2024.2320810","DOIUrl":"10.1080/14789450.2024.2320810","url":null,"abstract":"Introduction: Around 20% of individuals diagnosed with acute pancreatitis (AP) may develop severe acute pancreatitis (SAP), possibly resulting in a mortality rate ranging from 15% to 35%. There is an urgent need to thoroughly understand the molecular phenotypes of SAP resulting from diverse etiologies. The field of translational research on AP has seen the use of several innovative proteomic methodologies via the ongoing improvement of isolation, tagging, and quantification methods.Areas covered: This paper provides a comprehensive overview of differentially abundant proteins (DAPs) identified in AP by searching the PubMed/MEDLINE database (2003-2023) and adds significantly to the current theoretical framework.Expert opinion: DAPs for potentially diagnosing AP based on proteomic identification need to be confirmed by multi-center studies that include larger samples. The discovery of DAPs in various organs at different AP stages via proteomic technologies is essential better to understand the pathophysiology of AP-related multiple organ dysfunction syndrome. Regarding the translational research of AP, novel approaches like single-cell proteomics and imaging using mass spectrometry may be used as soon as they become available.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"115-123"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the human brain proteome: opportunities, challenges, and clinical potential. 绘制人脑蛋白质组图谱：机遇、挑战和临床潜力。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.1080/14789450.2024.2313073

Paz Cartas-Cejudo, Adriana Cortés, Mercedes Lachén-Montes, Elena Anaya-Cubero, Erika Peral, Karina Ausín, Ramón Díaz-Peña, Joaquín Fernández-Irigoyen, Enrique Santamaría

{"title":"Mapping the human brain proteome: opportunities, challenges, and clinical potential.","authors":"Paz Cartas-Cejudo, Adriana Cortés, Mercedes Lachén-Montes, Elena Anaya-Cubero, Erika Peral, Karina Ausín, Ramón Díaz-Peña, Joaquín Fernández-Irigoyen, Enrique Santamaría","doi":"10.1080/14789450.2024.2313073","DOIUrl":"10.1080/14789450.2024.2313073","url":null,"abstract":"Introduction: Due to the segmented functions and complexity of the human brain, the characterization of molecular profiles within specific areas such as brain structures and biofluids is essential to unveil the molecular basis for structure specialization as well as the molecular imbalance associated with neurodegenerative and psychiatric diseases.Areas covered: Much of our knowledge about brain functionality derives from neurophysiological, anatomical, and transcriptomic approaches. More recently, laser capture and imaging proteomics, technological and computational developments in LC-MS/MS, as well as antibody/aptamer-based platforms have allowed the generation of novel cellular, spatial, and posttranslational dimensions as well as innovative facets in biomarker validation and druggable target identification.Expert opinion: Proteomics is a powerful toolbox to functionally characterize, quantify, and localize the extensive protein catalog of the human brain across physiological and pathological states. Brain function depends on multi-dimensional protein homeostasis, and its elucidation will help us to characterize biological pathways that are essential to properly maintain cognitive functions. In addition, comprehensive human brain pathological proteomes may be the basis in computational drug-repositioning methods as a strategy for unveiling potential new therapies in neurodegenerative and psychiatric disorders.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"55-63"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic signatures of suicide attempt behavior: insights and applications. 自杀未遂行为的基因特征：见解与应用。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-08 DOI: 10.1080/14789450.2024.2314143

Antonio Drago

{"title":"Genetic signatures of suicide attempt behavior: insights and applications.","authors":"Antonio Drago","doi":"10.1080/14789450.2024.2314143","DOIUrl":"10.1080/14789450.2024.2314143","url":null,"abstract":"Introduction: Every year about 800,000 complete suicide events occur. The identification of biologic markers to identify subjects at risk would be helpful in targeting specific support treatments.Area covered: A narrative review defines the meta-analytic level of current evidence about the biologic markers of suicide behavior (SB). The meta-analytic evidence gathered so far indicates that the hypothesis-driven research largely failed to identify the biologic markers of suicide. The most consistent and replicated result was reported for: 1) 5-HTR2A T102C, associated with SB in patients with schizophrenia (OR = 1.73 (1.11-2.69)) and 2) BDNF Val66Met (rs6265), with the Met-Val + Val-Val carriers found to be at risk for suicide in the Caucasian population (OR: 1.96 (1.58-2.43)), while Val-Val vs. Val-Met + Met carriers found to be at risk for suicide in the Asian populations (OR: 1.36 (1.04-1.78)). GWAS-based meta-analyses indicate some positive replicated findings regarding the DRD2, Neuroligin gene, estrogen-related genes, and genes involved in gene expression.Expert opinion: Most consistent results were obtained when analyzing sub-samples of patients. Some promising results come from the implementation of the polygenic risk score. There is no current consensus about an implementable biomarker for SB.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"41-53"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tackling reproducibility: lessons for the proteomics community. 解决可重复性问题：蛋白质组学界的经验教训。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2024-01-01 Epub Date: 2024-02-26 DOI: 10.1080/14789450.2024.2320166

Julian Uszkoreit, Magnus Palmblad, Veit Schwämmle

引用次数: 0