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Lipopolysaccharide and the gut microbiota: considering structural variation 脂多糖与肠道菌群:考虑结构变异
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2022-03-09 DOI: 10.1002/1873-3468.14328
A. Mohr, M. Crawford, P. Jasbi, S. Fessler, K. Sweazea
{"title":"Lipopolysaccharide and the gut microbiota: considering structural variation","authors":"A. Mohr, M. Crawford, P. Jasbi, S. Fessler, K. Sweazea","doi":"10.1002/1873-3468.14328","DOIUrl":"https://doi.org/10.1002/1873-3468.14328","url":null,"abstract":"Systemic inflammation is associated with chronic disease and is purported to be a main pathogenic mechanism underlying metabolic conditions. Microbes harbored in the host gastrointestinal tract release signaling byproducts from their cell wall, such as lipopolysaccharides (LPS), which can act locally and, after crossing the gut barrier and entering circulation, also systemically. Defined as metabolic endotoxemia, elevated concentrations of LPS in circulation are associated with metabolic conditions and chronic disease. As such, measurement of LPS is highly prevalent in animal and human research investigating these states. Indeed, LPS can be a potent stimulant of host immunity, but this response depends on the microbial species’ origin, a parameter often overlooked in both preclinical and clinical investigations. Indeed, the lipid A portion of LPS is mutable and comprises the main virulence and endotoxic component, thus contributing to the structural and functional diversity among LPSs from microbial species. In this review, we discuss how such structural differences in LPS can induce differential immunological responses in the host.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45684737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Interdomain electron transfer in flavohaemoglobin from Candida norvegensis with antibiotic azole compounds 抗生素唑类化合物对北假丝酵母黄血红蛋白结构域间电子转移的影响
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2022-03-06 DOI: 10.1002/1873-3468.14327
Kazuo Kobayashi, J. Igarashi, T. Kozawa
{"title":"Interdomain electron transfer in flavohaemoglobin from Candida norvegensis with antibiotic azole compounds","authors":"Kazuo Kobayashi, J. Igarashi, T. Kozawa","doi":"10.1002/1873-3468.14327","DOIUrl":"https://doi.org/10.1002/1873-3468.14327","url":null,"abstract":"Flavohaemoglobins (FlavoHbs) function as nitric oxide dioxygenases, oxidizing nitric oxide with nitrite and shuttling electrons from NAD(P)H via FAD and O2. Here, using pulse radiolysis, we investigate intramolecular electron transfer between FAD and haem b in FlavoHbs. We found that reduction of FlavoHb with hydrated electrons proceeded via two phases: an initial fast phase and a second slower process. Absorbance measured at 600 nm revealed fast flavin reduction followed by a slower decrease corresponding to reoxidation of FAD. The slower process was partially lost in FlavoHbs lacking FAD. These results suggest that the slower phase is attributable to intramolecular electron transfer from FAD to the haem iron. The rate constant in the absence of azole compound (3.3 × 103 s‐1) was accelerated ~ 10‐fold (2.7 × 104 s‐1) by the binding of econazole, reflecting a conformational change in the open‐to‐closed transition.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46127173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction statement: miR‐96/HBP1/Wnt/β‐catenin regulatory circuitry promotes glioma growth 撤回声明:miR‐96/HBP1/Wnt/β‐catenin调控回路促进胶质瘤生长
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2022-03-01 DOI: 10.1002/1873-3468.14284
M. Brunner
{"title":"Retraction statement: miR‐96/HBP1/Wnt/β‐catenin regulatory circuitry promotes glioma growth","authors":"M. Brunner","doi":"10.1002/1873-3468.14284","DOIUrl":"https://doi.org/10.1002/1873-3468.14284","url":null,"abstract":"Retraction statement: Zhiyong Yan, Jianpeng Wang, Chao Wang, Yingbing Jiao, Weiguo Qi, Shusheng Che (2014), miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth, FEBS Letters, 588: 3038-3046. https://doi.org/10.1016/j.febslet.2014.06.017 The above article from FEBS Letters, published online on 12 June 2014 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editor-in-Chief, Michael Brunner, the FEBS Press and John Wiley & Sons Ltd. The retraction has been agreed due to concerns raised about Figures 4C, 6A and 6C. There is evidence of image manipulation and the duplication of image elements from four subsequently published articles. The authors and the authors' institution failed to reply to the journal's requests to provide original data confirming that the images arose from the reported experiments are genuine, unmodified and suitable for publication. Reference 1 Yan Z, Wang J, Wang C, Jiao Y, Qi W, Che S. miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth. FEBS Lett. 2014;588:3038-46.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41496392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover 封面
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2021-11-24 DOI: 10.1109/maes.2022.3145207
{"title":"Front Cover","authors":"","doi":"10.1109/maes.2022.3145207","DOIUrl":"https://doi.org/10.1109/maes.2022.3145207","url":null,"abstract":"","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48390430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover 封面
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2021-10-20 DOI: 10.1109/emctech53459.2021.9618981
{"title":"Front Cover","authors":"","doi":"10.1109/emctech53459.2021.9618981","DOIUrl":"https://doi.org/10.1109/emctech53459.2021.9618981","url":null,"abstract":"","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49181049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The archaeal division protein CdvB1 assembles into polymers that are depolymerized by CdvC 古菌分裂蛋白CdvB1组装成被CdvC解聚的聚合物
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2021-10-07 DOI: 10.1002/1873-3468.14324
Alberto Blanch Jover, Nicola de Franceschi, D. Fenel, W. Weissenhorn, C. Dekker
{"title":"The archaeal division protein CdvB1 assembles into polymers that are depolymerized by CdvC","authors":"Alberto Blanch Jover, Nicola de Franceschi, D. Fenel, W. Weissenhorn, C. Dekker","doi":"10.1002/1873-3468.14324","DOIUrl":"https://doi.org/10.1002/1873-3468.14324","url":null,"abstract":"The Cdv proteins constitute the cell-division system of the Crenarchaea, in a protein machinery that is closely related to the ESCRT system of eukaryotes. The CdvB paralog CdvB1 is believed to play a major role in the constricting ring that is the central actor in cell division in the crenarchaea. Here, we present an in vitro study of purified CdvB1 from the crenarchaeon M. sedula with a combination of TEM imaging and biochemical assays. We show that CdvB1 self-assembles into filamentous polymers that are depolymerized by the action of the Vps4-homolog ATPase CdvC. Using liposome flotation assays, we show that CdvB1 binds to negatively charged lipid membranes and can be detached from the membrane by the action of CdvC. Interestingly, we find that the polymerization and the membrane binding are mutually exclusive properties of the protein. Our findings provide novel insight into one of the main components of the archaeal cell division machinery.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45665732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Front Cover 封面
IF 3.5 4区 生物学
FEBS Letters Pub Date : 2021-08-01 DOI: 10.1002/1873-3468.13833
{"title":"Front Cover","authors":"","doi":"10.1002/1873-3468.13833","DOIUrl":"https://doi.org/10.1002/1873-3468.13833","url":null,"abstract":"","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/1873-3468.13833","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42343508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells. 膜蛋白的聚集和流动性与 T 细胞质膜中的局部脂质秩序相互作用。
IF 3 4区 生物学
FEBS Letters Pub Date : 2021-08-01 Epub Date: 2021-07-07 DOI: 10.1002/1873-3468.14153
Iztok Urbančič, Lisa Schiffelers, Edward Jenkins, Weijian Gong, Ana Mafalda Santos, Falk Schneider, Caitlin O'Brien-Ball, Mai Tuyet Vuong, Nicole Ashman, Erdinc Sezgin, Christian Eggeling
{"title":"Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells.","authors":"Iztok Urbančič, Lisa Schiffelers, Edward Jenkins, Weijian Gong, Ana Mafalda Santos, Falk Schneider, Caitlin O'Brien-Ball, Mai Tuyet Vuong, Nicole Ashman, Erdinc Sezgin, Christian Eggeling","doi":"10.1002/1873-3468.14153","DOIUrl":"10.1002/1873-3468.14153","url":null,"abstract":"<p><p>To disentangle the elusive lipid-protein interactions in T-cell activation, we investigate how externally imposed variations in mobility of key membrane proteins (T-cell receptor [TCR], kinase Lck, and phosphatase CD45) affect the local lipid order and protein colocalisation. Using spectral imaging with polarity-sensitive membrane probes in model membranes and live Jurkat T cells, we find that partial immobilisation of proteins (including TCR) by aggregation or ligand binding changes their preference towards a more ordered lipid environment, which can recruit Lck. Our data suggest that the cellular membrane is poised to modulate the frequency of protein encounters upon alterations of their mobility, for example in ligand binding, which offers new mechanistic insight into the involvement of lipid-mediated interactions in membrane-hosted signalling events.</p>","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39018058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation. 人类脂肪细胞在肾上腺素能刺激下的高效生热反应需要依赖 ASC-1 转运体的氨基酸摄取。
IF 3 4区 生物学
FEBS Letters Pub Date : 2021-08-01 Epub Date: 2021-07-23 DOI: 10.1002/1873-3468.14155
Rini Arianti, Boglárka Ágnes Vinnai, Beáta B Tóth, Abhirup Shaw, Éva Csősz, Attila Vámos, Ferenc Győry, Pamela Fischer-Posovszky, Martin Wabitsch, Endre Kristóf, László Fésüs
{"title":"ASC-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation.","authors":"Rini Arianti, Boglárka Ágnes Vinnai, Beáta B Tóth, Abhirup Shaw, Éva Csősz, Attila Vámos, Ferenc Győry, Pamela Fischer-Posovszky, Martin Wabitsch, Endre Kristóf, László Fésüs","doi":"10.1002/1873-3468.14155","DOIUrl":"10.1002/1873-3468.14155","url":null,"abstract":"<p><p>Brown and beige adipocytes dissipate energy by uncoupling protein 1 (UCP1)-dependent and UCP1-independent thermogenesis, which may be utilized to develop treatments against obesity. We have found that mRNA and protein expression of the alanine/serine/cysteine transporter-1 (ASC-1) was induced during adipocyte differentiation of human brown-prone deep neck and beige-competent subcutaneous neck progenitors, and SGBS preadipocytes. cAMP stimulation of differentiated adipocytes led to elevated uptake of serine, cysteine, and glycine, in parallel with increased oxygen consumption, augmented UCP1-dependent proton leak, increased creatine-driven substrate cycle-coupled respiration, and upregulation of thermogenesis marker genes and several respiratory complex subunits; these outcomes were impeded in the presence of the specific ASC-1 inhibitor, BMS-466442. Our data suggest that ASC-1-dependent consumption of serine, cysteine, and glycine is required for efficient thermogenic stimulation of human adipocytes.</p>","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39150599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periostin deficiency attenuates lipopolysaccharide- and obesity-induced adipose tissue fibrosis. 包膜组织蛋白缺乏症可减轻脂多糖和肥胖诱导的脂肪组织纤维化。
IF 3 4区 生物学
FEBS Letters Pub Date : 2021-08-01 Epub Date: 2021-07-03 DOI: 10.1002/1873-3468.14154
Yuhan Yang, Yanfei Zhang, Xueliang Zhou, Dandan Chen, Gaoliang Ouyang, Yingfu Liu, Dan Cui
{"title":"Periostin deficiency attenuates lipopolysaccharide- and obesity-induced adipose tissue fibrosis.","authors":"Yuhan Yang, Yanfei Zhang, Xueliang Zhou, Dandan Chen, Gaoliang Ouyang, Yingfu Liu, Dan Cui","doi":"10.1002/1873-3468.14154","DOIUrl":"10.1002/1873-3468.14154","url":null,"abstract":"<p><p>Periostin (POSTN) is a type of matricellular protein, but its functions in adipose fibrosis remain unclear. Here, we found that POSTN expression is significantly increased in mouse adipose tissue after treatment with lipopolysaccharide (LPS) or a high-fat diet (HFD) and that adipose progenitor cells are the main source of POSTN. In our mouse model of fibrosis, POSTN deletion protected mice from adipose fibrosis, probably through reducing the accumulation of macrophages and promoting adipocyte differentiation of progenitor cells. Taken together, our study demonstrates that POSTN deficiency attenuates adipose tissue fibrosis and improves insulin resistance, providing new insights into the diagnosis and treatment of type II diabetes by targeting adipose tissue fibrosis.</p>","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39103532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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