FEBS LettersPub Date : 2022-04-19DOI: 10.1038/s41467-022-29757-9
Mihael S Grbić, Eoin C T O'Farrell, Yosuke Matsumoto, Kentaro Kuga, Manuel Brando, Robert Küchler, Andriy H Nevidomskyy, Makoto Yoshida, Toshiro Sakakibara, Yohei Kono, Yasuyuki Shimura, Michael L Sutherland, Masashi Takigawa, Satoru Nakatsuji
{"title":"Anisotropy-driven quantum criticality in an intermediate valence system.","authors":"Mihael S Grbić, Eoin C T O'Farrell, Yosuke Matsumoto, Kentaro Kuga, Manuel Brando, Robert Küchler, Andriy H Nevidomskyy, Makoto Yoshida, Toshiro Sakakibara, Yohei Kono, Yasuyuki Shimura, Michael L Sutherland, Masashi Takigawa, Satoru Nakatsuji","doi":"10.1038/s41467-022-29757-9","DOIUrl":"10.1038/s41467-022-29757-9","url":null,"abstract":"<p><p>Intermetallic compounds containing f-electron elements have been prototypical materials for investigating strong electron correlations and quantum criticality (QC). Their heavy fermion ground state evoked by the magnetic f-electrons is susceptible to the onset of quantum phases, such as magnetism or superconductivity, due to the enhanced effective mass (m<sup>*</sup>) and a corresponding decrease of the Fermi temperature. However, the presence of f-electron valence fluctuations to a non-magnetic state is regarded an anathema to QC, as it usually generates a paramagnetic Fermi-liquid state with quasiparticles of moderate m<sup>*</sup>. Such systems are typically isotropic, with a characteristic energy scale T<sub>0</sub> of the order of hundreds of kelvins that require large magnetic fields or pressures to promote a valence or magnetic instability. Here we show the discovery of a quantum critical behaviour and a Lifshitz transition under low magnetic field in an intermediate valence compound α-YbAlB<sub>4</sub>. The QC origin is attributed to the anisotropic hybridization between the conduction and localized f-electrons. These findings suggest a new route to bypass the large valence energy scale in developing the QC.</p>","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":"9 1","pages":"2141"},"PeriodicalIF":14.7,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74609216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2022-03-29DOI: 10.1002/1873-3468.14331
D. Ruffell
{"title":"GENIGMA: an app to map the 3D genome of cancer cell lines through extreme citizen science","authors":"D. Ruffell","doi":"10.1002/1873-3468.14331","DOIUrl":"https://doi.org/10.1002/1873-3468.14331","url":null,"abstract":"In this Scientists' Forum article, we present a new app, GENIGMA, launched by structural genomics specialist Marc A. Marti‐Renom and his team, aimed at mapping the 3D genome of cancer cell lines. GENIGMA is a digital game, which was designed and tested through a co‐creation process with citizens. Finally, by playing the game, citizens produce data, reaching beyond the capacity of artificial intelligence. This is an exceptional experiment of extreme citizen science, which broadens the implications of open science.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44749506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2022-03-28DOI: 10.1002/1873-3468.14342
Maiko Furubayashi, T. Maoka, Y. Mitani
{"title":"Promiscuous activity of β‐carotene hydroxylase CrtZ on epoxycarotenoids leads to the formation of rare carotenoids with 6‐hydroxy‐3‐keto‐ε‐ends","authors":"Maiko Furubayashi, T. Maoka, Y. Mitani","doi":"10.1002/1873-3468.14342","DOIUrl":"https://doi.org/10.1002/1873-3468.14342","url":null,"abstract":"Carotenoids with rare 6‐hydroxy‐3‐keto‐ε‐end groups, such as piprixanthin, vitixanthin, or cochloxanthin, found in manakin birds or plants, are rare carotenoids with high antioxidant activity. The same chemical structure is found in abscisic acid or blumenol, apocarotenoids found in plants or fungi. In this study, we serendipitously discovered that the promiscuous activity of the β‐carotene hydroxylase CrtZ, a diiron‐containing membrane protein, can catalyze the formation of 6‐hydroxy‐3‐keto‐ε‐end by using epoxycarotenoids antheraxanthin or violaxanthin as substrate. We suggest that the reaction mechanism is similar to that of a rhodoxanthin biosynthetic enzyme. Our results provide a further understanding of the reaction mechanism of diiron‐containing β‐carotene hydroxylases, as well as insight into the biosynthesis of natural compounds with 6‐hydroxy‐3‐keto‐ε‐end carotenoid derivatives.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45512275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2022-03-09DOI: 10.1002/1873-3468.14328
A. Mohr, M. Crawford, P. Jasbi, S. Fessler, K. Sweazea
{"title":"Lipopolysaccharide and the gut microbiota: considering structural variation","authors":"A. Mohr, M. Crawford, P. Jasbi, S. Fessler, K. Sweazea","doi":"10.1002/1873-3468.14328","DOIUrl":"https://doi.org/10.1002/1873-3468.14328","url":null,"abstract":"Systemic inflammation is associated with chronic disease and is purported to be a main pathogenic mechanism underlying metabolic conditions. Microbes harbored in the host gastrointestinal tract release signaling byproducts from their cell wall, such as lipopolysaccharides (LPS), which can act locally and, after crossing the gut barrier and entering circulation, also systemically. Defined as metabolic endotoxemia, elevated concentrations of LPS in circulation are associated with metabolic conditions and chronic disease. As such, measurement of LPS is highly prevalent in animal and human research investigating these states. Indeed, LPS can be a potent stimulant of host immunity, but this response depends on the microbial species’ origin, a parameter often overlooked in both preclinical and clinical investigations. Indeed, the lipid A portion of LPS is mutable and comprises the main virulence and endotoxic component, thus contributing to the structural and functional diversity among LPSs from microbial species. In this review, we discuss how such structural differences in LPS can induce differential immunological responses in the host.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45684737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2022-03-06DOI: 10.1002/1873-3468.14327
Kazuo Kobayashi, J. Igarashi, T. Kozawa
{"title":"Interdomain electron transfer in flavohaemoglobin from Candida norvegensis with antibiotic azole compounds","authors":"Kazuo Kobayashi, J. Igarashi, T. Kozawa","doi":"10.1002/1873-3468.14327","DOIUrl":"https://doi.org/10.1002/1873-3468.14327","url":null,"abstract":"Flavohaemoglobins (FlavoHbs) function as nitric oxide dioxygenases, oxidizing nitric oxide with nitrite and shuttling electrons from NAD(P)H via FAD and O2. Here, using pulse radiolysis, we investigate intramolecular electron transfer between FAD and haem b in FlavoHbs. We found that reduction of FlavoHb with hydrated electrons proceeded via two phases: an initial fast phase and a second slower process. Absorbance measured at 600 nm revealed fast flavin reduction followed by a slower decrease corresponding to reoxidation of FAD. The slower process was partially lost in FlavoHbs lacking FAD. These results suggest that the slower phase is attributable to intramolecular electron transfer from FAD to the haem iron. The rate constant in the absence of azole compound (3.3 × 103 s‐1) was accelerated ~ 10‐fold (2.7 × 104 s‐1) by the binding of econazole, reflecting a conformational change in the open‐to‐closed transition.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46127173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2022-03-01DOI: 10.1002/1873-3468.14284
M. Brunner
{"title":"Retraction statement: miR‐96/HBP1/Wnt/β‐catenin regulatory circuitry promotes glioma growth","authors":"M. Brunner","doi":"10.1002/1873-3468.14284","DOIUrl":"https://doi.org/10.1002/1873-3468.14284","url":null,"abstract":"Retraction statement: Zhiyong Yan, Jianpeng Wang, Chao Wang, Yingbing Jiao, Weiguo Qi, Shusheng Che (2014), miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth, FEBS Letters, 588: 3038-3046. https://doi.org/10.1016/j.febslet.2014.06.017 The above article from FEBS Letters, published online on 12 June 2014 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editor-in-Chief, Michael Brunner, the FEBS Press and John Wiley & Sons Ltd. The retraction has been agreed due to concerns raised about Figures 4C, 6A and 6C. There is evidence of image manipulation and the duplication of image elements from four subsequently published articles. The authors and the authors' institution failed to reply to the journal's requests to provide original data confirming that the images arose from the reported experiments are genuine, unmodified and suitable for publication. Reference 1 Yan Z, Wang J, Wang C, Jiao Y, Qi W, Che S. miR-96/HBP1/Wnt/β-catenin regulatory circuitry promotes glioma growth. FEBS Lett. 2014;588:3038-46.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41496392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
FEBS LettersPub Date : 2021-10-07DOI: 10.1002/1873-3468.14324
Alberto Blanch Jover, Nicola de Franceschi, D. Fenel, W. Weissenhorn, C. Dekker
{"title":"The archaeal division protein CdvB1 assembles into polymers that are depolymerized by CdvC","authors":"Alberto Blanch Jover, Nicola de Franceschi, D. Fenel, W. Weissenhorn, C. Dekker","doi":"10.1002/1873-3468.14324","DOIUrl":"https://doi.org/10.1002/1873-3468.14324","url":null,"abstract":"The Cdv proteins constitute the cell-division system of the Crenarchaea, in a protein machinery that is closely related to the ESCRT system of eukaryotes. The CdvB paralog CdvB1 is believed to play a major role in the constricting ring that is the central actor in cell division in the crenarchaea. Here, we present an in vitro study of purified CdvB1 from the crenarchaeon M. sedula with a combination of TEM imaging and biochemical assays. We show that CdvB1 self-assembles into filamentous polymers that are depolymerized by the action of the Vps4-homolog ATPase CdvC. Using liposome flotation assays, we show that CdvB1 binds to negatively charged lipid membranes and can be detached from the membrane by the action of CdvC. Interestingly, we find that the polymerization and the membrane binding are mutually exclusive properties of the protein. Our findings provide novel insight into one of the main components of the archaeal cell division machinery.","PeriodicalId":50454,"journal":{"name":"FEBS Letters","volume":"596 1","pages":"958 - 969"},"PeriodicalIF":3.5,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45665732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}