The Open Cardiovascular Medicine Journal最新文献_第7页

Evaluating the role of perceived stress on the likelihood of having a non - fatal acute coronary syndrome: a case-control study. 评估感知压力对非致死性急性冠状动脉综合征可能性的作用:一项病例对照研究。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-07-25 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010068

Alexia Katsarou, Filippos Triposkiadis, John Skoularigis, Emmanuela Griva, George Neroutsos, Georgios Karayannis, Charalabos Papageorgiou, Demosthenes Panagiotakos

{"title":"Evaluating the role of perceived stress on the likelihood of having a non - fatal acute coronary syndrome: a case-control study.","authors":"Alexia Katsarou, Filippos Triposkiadis, John Skoularigis, Emmanuela Griva, George Neroutsos, Georgios Karayannis, Charalabos Papageorgiou, Demosthenes Panagiotakos","doi":"10.2174/1874192401408010068","DOIUrl":"https://doi.org/10.2174/1874192401408010068","url":null,"abstract":"Objectives: The aim of the current study was to evaluate the independent role of perceived stress, measured by the PSS-14, on the likelihood of having acute coronary syndrome (ACS).Conclusion: This is a case-control study with individual matching by age and sex. During 2010-2012, 250 consecutive patients (60±11 years, 78% men) with a first ACS and 250 population-based, control subjects (60±8.6 years, 77.6% men), were enrolled. Perceived stress levels were evaluated with the PSS-14 scale, depression status was assessed with the Zung Depression Rating Scale, anxiety status with the STAI scale and adherence to the Mediterranean diet was assessed by the MedDietScore.Conclusion: Higher perceived stress was associated with increased likelihood of having an ACS, after adjusting for various factors (OR=1.15, %CI 1.11, 1.18). STAI and ZUNG scale were positively associated with the likelihood of having an ACS (OR: 1.27 %CI 1.20-1.34, p<0.001 and OR: 1.49 %CI 1.36-1.63, p<0.001 respectively). Stratified analysis by sex showed a greater impact of perceived stress in men, compared with women (Wald test value 45.65 vs 18.56, respectively). When stratifying by depression levels, the effect of perceived stress on ACS was not significant among depressed individuals. When stratifying by level of anxiety, higher odds of having an ACS was found in the low anxiety group (OR: 1.129, %CI 1.047-1.218).Conclusion: Perceived stress appears as an independent ACS risk factor, although no causal relationship can be extracted due to the nature of the study. Early recognition and treatment of perceived stress may lead to ACS risk reduction.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"68-75"},"PeriodicalIF":0.8,"publicationDate":"2014-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/24/3f/TOCMJ-8-68.PMC4141169.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32610287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Comparative Effect of Atorvastatin and Rosuvastatin on 25-hydroxy-Vitamin D Levels in Non-diabetic Patients with Dyslipidaemia: A Prospective Randomized Open-label Pilot Study. 阿托伐他汀和瑞舒伐他汀对非糖尿病血脂异常患者25-羟基维生素D水平的影响比较:一项前瞻性随机开放标签试点研究

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The Open Cardiovascular Medicine Journal Pub Date : 2014-07-11 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010055

Panagiotis Anagnostis, Fotini Adamidou, Aristidis Slavakis, Stergios A Polyzos, Despina Selalmatzidou, Athanasios Panagiotou, Vasilios G Athyros, Asterios Karagiannis, Marina Kita

{"title":"Comparative Effect of Atorvastatin and Rosuvastatin on 25-hydroxy-Vitamin D Levels in Non-diabetic Patients with Dyslipidaemia: A Prospective Randomized Open-label Pilot Study.","authors":"Panagiotis Anagnostis, Fotini Adamidou, Aristidis Slavakis, Stergios A Polyzos, Despina Selalmatzidou, Athanasios Panagiotou, Vasilios G Athyros, Asterios Karagiannis, Marina Kita","doi":"10.2174/1874192401408010055","DOIUrl":"https://doi.org/10.2174/1874192401408010055","url":null,"abstract":"Aims: Low 25-hydroxy-vitamin D [25(ΟΗ)D] levels have been associated with increased risk for cardiovascular disease. Conflicting data exist regarding the effect of statins on [25(OH)D] levels. The aim of this study was to compare the effect of atorvastatin and rosuvastatin on 25(OH)D levels in non-diabetic patients with dyslipidaemia. Methods: This was a prospective randomized open-label study. Patients were assigned to atorvastatin 20 mg⁄day (n=28, age: 56.1±2.2 years, 22 females) or rosuvastatin 10 mg⁄day (n=24, age: 57.4±1.9 years, 20 females). Total cholesterol (TC), low- (LDL-C) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting plasma glucose, insulin, glycosylated haemoglobin A1c (HbA1c) and high sensitivity C-reactive protein (hsCRP) levels were measured, and homeostatic model of assessment insulin resistance (HOMA-IR) was calculated at baseline and 12 weeks post-treatment. Results: There were no within or between group significant differences in 25(OH)D levels (atorvastatin: 21.7±1.9 ng/ml at baseline and 23.5±2.3 ng/ml at week 12; rosuvastatin: 25.3±1.8 and 27.0±2.4 ng/ml, respectively; p=0.172 and p=0.306 for between groups, respectively). Both statins significantly reduced TC, TG and LDL-C levels, with a greater LDL-C reduction being observed by rosuvastatin. Conclusion: Atorvastatin and rosuvastatin did not significantly affect 25(OH)D levels in this study.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"55-60"},"PeriodicalIF":0.8,"publicationDate":"2014-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/8e/TOCMJ-8-55.PMC4126186.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32574343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Quality of diabetes care in primary health centres in north Al-batinah of oman. 阿曼阿尔巴蒂纳北部初级保健中心的糖尿病护理质量。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-06-13 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010048

Mohammed Al-Shafaee, Yousuf Al-Farsi, Yousuf Al-Kaabi, Yajnavalka Banerjee, Najat Al-Zadjali, Ibrahim Al-Zakwani

{"title":"Quality of diabetes care in primary health centres in north Al-batinah of oman.","authors":"Mohammed Al-Shafaee, Yousuf Al-Farsi, Yousuf Al-Kaabi, Yajnavalka Banerjee, Najat Al-Zadjali, Ibrahim Al-Zakwani","doi":"10.2174/1874192401408010048","DOIUrl":"https://doi.org/10.2174/1874192401408010048","url":null,"abstract":"Objective: To assess the quality of diabetic care provided in primary health care settings in Oman.Methods: This was a cross-sectional study of randomly selected 500 patients with diabetes mellitus (DM) attending 6 primary care diabetic clinics in the north Al-Batinah region of Oman from January to December 2010. Nine standards on the quality of diabetes care were audited.Results: The mean age of the sample was 51±13 years, ranging from 15 to 87 years; the majority (61%) were females. The mean duration of DM was 4±3 years, ranging from 1 to 18 years. Seventy-seven percent of the patients attended diabetic clinics at least 4 times per year. Of the 9 assessed diabetic standards, HbA1c was documented in 33% of the patients, body mass index in 12%, low-density lipoprotein cholesterol (LDL-C) in 40%, urinary albumin:creatinine ratio in 28%, creatinine in 63% and blood pressure (BP) in 96%. Optimal control among the documented indicators was noted in 32, 21, 25, 85, 95 and 19%, respectively. Twenty percent of the patients had their ECGs done while only 39% of the patients had foot examination. No patient had attained control in all of HbA1c., BP and LDL-C.Conclusion: There is a gap between the recommended DM care guidelines and current practice with consequent poor quality of care in these patients.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"48-54"},"PeriodicalIF":0.8,"publicationDate":"2014-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/f3/TOCMJ-8-48.PMC4093660.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32505402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

New insights into the management of hypertension and cardiovascular risk with Angiotensin receptor blockers: observational studies help us? 血管紧张素受体阻滞剂对高血压和心血管风险管理的新见解:观察性研究帮助我们?

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The Open Cardiovascular Medicine Journal Pub Date : 2014-04-04 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010035

Assen Goudev

{"title":"New insights into the management of hypertension and cardiovascular risk with Angiotensin receptor blockers: observational studies help us?","authors":"Assen Goudev","doi":"10.2174/1874192401408010035","DOIUrl":"https://doi.org/10.2174/1874192401408010035","url":null,"abstract":"Post-marketing observational studies are valuable for establishing the real-world effectiveness of treatment regimens in routine clinical practice as they typically monitor a diverse population of patients over many months. This article reviews recent observational studies of angiotensin receptor blockers (ARBs) for the management of hypertension: the 6-month eprosartan POWER study (n~29,400), the 3-month valsartan translational research programme (n~19,500), the 9-month irbesartan Treat to Target study (n=14,200), the 6-month irbesartan DO-IT survey (n~3300) and the 12-week candesartan CHILI survey programme (n=4600). Reduction in blood pressure with ARBs reported across these studies appears to be comparable for the different agents, although direct comparisons between studies cannot be made owing to different treatment durations and baseline patient demographics. Of these studies, the eprosartan POWER study, 2 of the 7 studies in the valsartan translational research programme, and the candesartan CHILI Triple T study measured total cardiovascular risk, as recommended in the 2013 European Society of Cardiology-European Society of Hypertension guidelines. The POWER study confirmed the value of the Systemic Coronary Risk Evaluation (SCORE) to accurately assess total cardiovascular risk. With the advent of new healthcare practices, such as the use of electronic health records (EHRs), observational studies in larger patient populations will become possible. In the future, algorithms embedded in EHR systems could evolve as decision support tools to inform on patient care. ","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"35-42"},"PeriodicalIF":0.8,"publicationDate":"2014-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d7/83/TOCMJ-8-35.PMC4021208.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32357558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ex-vivo Assessment of Coronary Artery Atherosclerosis by Magnetic Resonance Imaging: Correlation with Histopathology. 磁共振成像在体外评估冠状动脉粥样硬化:与组织病理学的相关性。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-04-04 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010026

Everli P S Gonçalves Gomes, Carlos Eduardo Rochitte, Clerio F Azevedo, Pedro A Lemos, Paulo Sampaio Gutierrez, Luiz Antonio M César

{"title":"Ex-vivo Assessment of Coronary Artery Atherosclerosis by Magnetic Resonance Imaging: Correlation with Histopathology.","authors":"Everli P S Gonçalves Gomes, Carlos Eduardo Rochitte, Clerio F Azevedo, Pedro A Lemos, Paulo Sampaio Gutierrez, Luiz Antonio M César","doi":"10.2174/1874192401408010026","DOIUrl":"https://doi.org/10.2174/1874192401408010026","url":null,"abstract":"Introduction: In recent years, high-resolution magnetic resonance imaging (MRI) has emerged as a very promising technique for studying atherosclerotic disease in humans.Aim: In the present study we sought to determine whether MRI allowed for the morphological characterization of the coronary vessel wall and atherosclerotic plaques using histopathological assessment as the reference standard.Methods: The study population consisted of 13 patients who died of acute myocardial infarction and underwent autopsy. The proximal portions of the coronary arteries were excised and were evaluated both by MRI and by histopathology. For each arterial segment, the following parameters were calculated through manual planimetry: 1. total vessel area (TVA); 2. luminal area (LA) and 3. plaque area (PA).Results: A total of 207 coronary artery cross-sections were found to be suitable for analysis by both MRI and histopathology and were included in the final analyses. Both methods demonstrated moderate to good agreement for the quantification of TVA (mean difference = 2.4±2.4 mm(2), 95‰ limits of agreement from -2.4 to +7.2 mm(2); CCC = 0.69, 95‰ CI from 0.63 to 0.75), LA (mean difference = 0.0±1.7 mm(2), 95‰ limits of agreement from -3.3 to + 3.3 mm(2); CCC = 0.84, 95‰ CI from 0.80 to 0.88) and PA (mean difference = 2.4±2.4 mm(2), 95‰ limits of agreement from -2.3 to + 7.1 mm(2); CCC = 0.64, 95‰ CI from 0.58 to 0.71).Conclusion: In this ex vivo experimental model we demonstrated good agreement between coronary artery morphometrical measurements obtained by high-resolution MRI and by histopathology.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"26-34"},"PeriodicalIF":0.8,"publicationDate":"2014-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/8f/TOCMJ-8-26.PMC4021207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32357557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Type F Congenital Quadricuspid Aortic Valve: A Very Rare Case Diagnosed by 3-dimenional Transoesophageal Echocardiography. 经食道三维超声心动图诊断F型先天性四尖瓣主动脉瓣一例。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-03-07 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010023

Pankaj Garg, Hazlyna Kamaruddin, Rachel Orme, Victoria Watt

引用次数: 4

The effect of concomitant cardiac resynchronization therapy on quality of life in patients with heart failure undergoing cardiac surgery. 合并心脏再同步化治疗对心衰手术患者生活质量的影响。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-02-21 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010018

Emma Thorén, Milos Kesek, Lena Jidéus

{"title":"The effect of concomitant cardiac resynchronization therapy on quality of life in patients with heart failure undergoing cardiac surgery.","authors":"Emma Thorén, Milos Kesek, Lena Jidéus","doi":"10.2174/1874192401408010018","DOIUrl":"https://doi.org/10.2174/1874192401408010018","url":null,"abstract":"Objectives: To evaluate the effect of concomitant cardiac resynchronization therapy (CRT) on health related quality of life (QoL) in patients with heart failure (HF) and ventricular dyssynchrony undergoing cardiac surgery.Methods: Twenty-eight patients received permanent epicardial CRT in connection to coronary artery bypass grafting (CABG) and/or aortic valve replacement (AVR) (CRT group). Thirty-seven HF patients without concomitant CRT served as a comparison group (non-CRT group). SF-36 was used to assess QoL in the two groups and was also compared with the general Swedish population.Results: The median follow-up time was 28 months after surgery (range 8 to 44 months). No difference in QoL could be shown between the CRT group and the comparison group. Several subscales of QoL in the CRT group were in range with the general Swedish population.Conclusion: Concomitant CRT for patients with HF and ventricular dyssynchrony undergoing CABG and/or AVR did not result in a higher estimated QoL compared to HF patients without CRT.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"18-22"},"PeriodicalIF":0.8,"publicationDate":"2014-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/99/TOCMJ-8-18.PMC3963133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32205733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Impact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin. CYP3A5基因多态性对辛伐他汀疗效的影响。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-02-07 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010012

Genovefa Kolovou, Georgia Ragia, Vana Kolovou, Constantinos Mihas, Niki Katsiki, Ioannis Vasiliadis, Sophie Mavrogeni, Vassiliki Vartela, Anna Tavridou, Vangelis G Manolopoulos

{"title":"Impact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin.","authors":"Genovefa Kolovou, Georgia Ragia, Vana Kolovou, Constantinos Mihas, Niki Katsiki, Ioannis Vasiliadis, Sophie Mavrogeni, Vassiliki Vartela, Anna Tavridou, Vangelis G Manolopoulos","doi":"10.2174/1874192401408010012","DOIUrl":"https://doi.org/10.2174/1874192401408010012","url":null,"abstract":"Background: One of the promises of human genetics is individualized therapy. Therefore, we evaluated the impact of CYP3A5 gene polymorphism on the effectiveness of simvastatin (a HMG-CoA reductase inhibitor).Methods: Patients (n = 191) with hypercholesterolemia were treated with simvastatin for at least 6 months and were genotyped for the CYP3A5 polymorphism.Results: The frequency of CYP3A5 polymorphism was 0.5% for WT (wild-type), 15.6% for HT (heterozygous, expressors) and 83.9% for HM (homozygous, non-expressors). Differences in lipid profile before and after dose-response of simvastatin treatment were described as % difference {[(variable after-variable before)/variable before]*100}. There was a trend towards the decrease of low density lipoprotein cholesterol (LDL-C) in HT individuals who had a -35.2% reduction with a dose of 20 mg simvastatin and HM individuals who had a slightly higher decrease (-37.5%) despite the lower dose of simvastatin (10 mg, p = 0.07). Furthermore, HT genotype individuals had significantly higher than expected (6-8%) LDL-C % difference between 20 and 40 mg of simvastatin (-35.2 vs -49.2%, p = 0.037). In individuals with HM genotype a significant LDL-C % difference was found between 10 and 40 mg of simvastatin (-37.5 vs -48.4%, p = 0.023).Conclusion: The individuals with HM polymorphism display a trend towards higher LDL-C reductions compared with HT polymorphism. Within the same genotype, differences between doses were also observed. These findings need to be confirmed in larger studies.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"12-7"},"PeriodicalIF":0.8,"publicationDate":"2014-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/25/TOCMJ-8-12.PMC3959175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32195769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Clinical Implication of the Renin-angiotensin-aldosterone Blockers in Chronic Kidney Disease Undergoing Hemodialysis. 肾素-血管紧张素-醛固酮阻滞剂在慢性肾病血液透析中的临床意义。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-02-07 eCollection Date: 2014-01-01 DOI: 10.2174/1874192401408010006

Yoshiyuki Morishita, Eiji Kusano, Daisuke Nagata

引用次数: 1

Continuous heliox breathing and the extent of anatomic zone of noreflow and necrosis following ischemia/reperfusion in the rabbit heart. 兔心脏缺血再灌注后连续螺旋呼吸与无血流坏死解剖区范围的关系。

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The Open Cardiovascular Medicine Journal Pub Date : 2014-01-24 eCollection Date: 2013-01-01 DOI: 10.2174/1874192401408010001

Sharon L Hale, Donald R Vanderipe, Robert A Kloner

{"title":"Continuous heliox breathing and the extent of anatomic zone of noreflow and necrosis following ischemia/reperfusion in the rabbit heart.","authors":"Sharon L Hale, Donald R Vanderipe, Robert A Kloner","doi":"10.2174/1874192401408010001","DOIUrl":"https://doi.org/10.2174/1874192401408010001","url":null,"abstract":"Background: Nitrogen may contribute to reperfusion injury. Some studies have shown that helium as a replacement for nitrogen in breathing gas (heliox) reduces cell necrosis after ischemia/reperfusion when used in a preconditioning fashion (intermittent heliox exposure). Our aim was to test whether heliox, breathed continuously throughout the ischemic and reperfusion periods, reduced necrosis and a marker of reperfusion injury, the no-reflow phenomenon.Methods and results: Anesthetized, open-chest rabbits received 30 min coronary artery occlusion/3 hrs reperfusion. Before CAO rabbits were randomized to heliox (30% oxygen + 70% helium, n=8) or air supplemented with oxygen to achieve blood gas values within physiologic range (n = 8). Rabbits received the appropriate mix during ischemic and reperfusion periods. Infarct size (% risk zone) and no-reflow defect were measured at the end of the reperfusion period. The ischemic risk zone was similar in both groups (28% of left ventricle in heliox and 29% in control). Heliox breathing did not reduce necrosis; infarct size, expressed as a percentage of the risk region was 44±4% in the heliox group and 49±5% in controls, p = 0.68. The extent of the no-reflow defect was not altered by heliox, either expressed as a percent of the risk region (29±4% in heliox and 28±3% in control) or as a percent of the necrotic zone (65±5% in heliox and 59±8% in control).Heliox treatment had no effect on hemodynamic parameters or arterial blood gas values.Conclusion: Continuous heliox breathing does not appear to be cardioprotective in the setting of acute myocardial infarction in the rabbit model. Heliox respiration administered during 30 minutes of ischemia and 180 minutes of reperfusion did not alter infarct size or the extent of no-reflow.","PeriodicalId":504447,"journal":{"name":"The Open Cardiovascular Medicine Journal","volume":"8 ","pages":"1-5"},"PeriodicalIF":0.8,"publicationDate":"2014-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fd/ed/TOCMJ-8-1.PMC3937439.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32169120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9