Tạp chí Y học Quân sự最新文献_第2页

STUDY ON THE ANTAGONISTIC ACTIVITY AGAINST TWO PATHOGENIC BACTERIA IN HUMANS OF STREPTOMYCES MIP_L26 ISOLATED FROM SOIL IN THE ROOT ZONE OF THE MAY CHANG TREE (LITSEA CUBEB) 从五常树根部土壤中分离出的链霉菌 mip_l26 对人类两种病原菌的拮抗活性研究

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.377

Chu Thanh Binh, Le Huu Hiep, Truong Minh Noel, Vu Van Duyen, Nguyen Xuan Dinh, Pham Thi Kim Nhung, Tran Minh Tam

{"title":"STUDY ON THE ANTAGONISTIC ACTIVITY AGAINST TWO PATHOGENIC BACTERIA IN HUMANS OF STREPTOMYCES MIP_L26 ISOLATED FROM SOIL IN THE ROOT ZONE OF THE MAY CHANG TREE (LITSEA CUBEB)","authors":"Chu Thanh Binh, Le Huu Hiep, Truong Minh Noel, Vu Van Duyen, Nguyen Xuan Dinh, Pham Thi Kim Nhung, Tran Minh Tam","doi":"10.59459/1859-1655/jmm.377","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.377","url":null,"abstract":"Purpose: Study on the antagonistic activity against two pathogenic bacteria in humans (Staphylococcus aureus and Streptococcus pneumoniae) of the Streptomyces MIP_L26 (Called MIP_L26), isolated from the soil in the root zone of the May Chang tree; to investigate the biological characteristics of MIP_L26 \u0000Subjects and methods: Experimental study, determine the antimicrobial activity against two pathogenic bacteria in humans (Staphylococcus aureus and Streptococcus pneumoniae), and some biological characteristics of MIP_L26.\u0000Results: MIP_L26 was identified as having a strong antagonistic ability against the two bacteria causing Staphylococcus aureus and Streptococcus pneumoniae with an antibacterial ring diameter of 18 ± 5 mm and 13 ± 5 mm, respectively. Based on classification according to morphological, physiological, and biochemical characteristics, combined with the results of 16S rRNA gene sequencing, MIP_L26 was identified as Streptomyces gancidicus MIP_L26. The fermentation medium for the biosynthesis of antibacterial substances was ISP6 and the recovery time for antimicrobial substances was after 72 hours of fermentation.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALGESIC EFFECT OF “DINH THONG PHONG” CAPSULES ON EXPERIMENTAL ANIMALS dinh thong phong "胶囊对实验动物的镇痛作用

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.278

Tran Thanh Tuan, Vu Ngoc Thang, Dao Nguyen Manh, Quach Thi Quynh, Nguyen Hai Duong, Dang Thi Minh

{"title":"ANALGESIC EFFECT OF “DINH THONG PHONG” CAPSULES ON EXPERIMENTAL ANIMALS","authors":"Tran Thanh Tuan, Vu Ngoc Thang, Dao Nguyen Manh, Quach Thi Quynh, Nguyen Hai Duong, Dang Thi Minh","doi":"10.59459/1859-1655/jmm.278","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.278","url":null,"abstract":"Purpose: Evaluate the analgesic effect of “Dinh Thong Phong” capsules on experimental animals.\u0000Subjects and Methods: “Dinh Thong Phong” capsules, meeting the standard criteria, were evaluated for analgesic effect on white mice. In particular, the central analgesic effect was assessed using the hot plate model, peripheral analgesic effect was assessed using the writhing pain model.\u0000Results: In the hot plate model, “Dinh Thong Phong” capsules at a dosage of 860 mg/kg and 2,580 mg/kg significantly increased the reaction time to heat (p < 0.001) compared to the control group. The difference in reaction time to heat between the groups using “Dinh Thong Phong” capsules and the group using codeine phosphate at a dose of 20 mg/kg was not statistically significant (p > 0.05). In the writhing model, “Dinh Thong Phong” capsules at a dose of 860 mg/kg and 2,580 mg/kg significantly reduced the number of writhing episodes (p < 0.001) compared to the control group. The difference in the number of writhing episodes between the groups using “Dinh Thong Phong” capsules and the group using aspirin at a dose of 150 mg/kg was not statistically significant (p > 0.05).","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"79 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACUTE AND SUB-CHRONIC TOXICITY ASSESSMENT OF PYRIDOSTIGMINE BROMIDE 90 MG EXTENDED- ELEASE TABLETS IN EXPERIMENTAL ANIMALS 吡啶斯的明溴化物 90 毫克缓释片对实验动物的急性和亚慢性毒性评估

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.402

Do Phong Tue, To Minh Hung, Le Quoc Hung, Nguyen Hai Duong, Nguyen Van Thinh, Vu Thi Que

{"title":"ACUTE AND SUB-CHRONIC TOXICITY ASSESSMENT OF PYRIDOSTIGMINE BROMIDE 90 MG EXTENDED- ELEASE TABLETS IN EXPERIMENTAL ANIMALS","authors":"Do Phong Tue, To Minh Hung, Le Quoc Hung, Nguyen Hai Duong, Nguyen Van Thinh, Vu Thi Que","doi":"10.59459/1859-1655/jmm.402","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.402","url":null,"abstract":"Purpose: This study aimed to assess the acute and subchronic toxicity of Pyridostigmine bromide 90 mg extended-release tablets in experimental animals. \u0000Subjects and methods: Pyridostigmine bromide 90 mg extended-release tablets were prepared complying in-house specifications. Acute oral toxicity (LD50) was determined in white mice using the Litchfield-Wilcoxon method. Subchronic toxicity was assessed in rabbits following OECD guidelines. \u0000Results: The acute toxicity study revealed an LD50 of 17.9 mg/kg when Pyridostigmine bromide 90 mg extended-release tablets were orally administered to mice. In the subchronic toxicity assessment, rabbits were treated with Pyridostigmine bromide tablets for 28 days. Doses of 7.2 mg/kg/day and 21.6 mg/kg/day showed no significant alterations in hematological parameters (red blood cells, hemoglobin, hematocrit, mean corpuscular volume, white blood cells, platelets), blood biochemical parameters (AST, ALT, total protein, creatinine, urea), and did not cause damage to the histopathology of the liver, spleen, and kidneys in rabbits. However, the dose of 21.6 mg/kg/day resulted in a statistically significant difference in rabbit weight gain compared to those administered a dose of 7.2 mg/kg/day and those in the control group.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF SURGICAL OUTCOMES OF OSTEOPOROTIC VERTEBRAL COMPRESSION FRACTURE PATIENTS TREATED BY KYPHOPLASTY, AT MILITARY HOSPITAL 105 军事医院对接受椎体后凸成形术治疗的骨质疏松性椎体压缩骨折患者的手术效果评估 105

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.396

Nguyen Thanh Bac, Dao Van Thuy

引用次数: 0

THE INITIAL TREATMENT RESULTS OF 6 PATIENTS WITH NON-SMALL CELL LUNG CANCER WITH EGFR AND ALK CONCURRENT MUTATIONS, AT THE CENTRAL LUNG HOSPITAL 中央肺科医院对 6 名 Egfr 和 alk 并发突变的非小细胞肺癌患者的初步治疗结果

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.293

Le Tu Linh, Nguyen Viet Nhung, Nguyen Hoang Anh, Le Ngoc Minh Thu, Hoang Huy Anh, Nguyen Dieu My, Nguyen Thi Trang

{"title":"THE INITIAL TREATMENT RESULTS OF 6 PATIENTS WITH NON-SMALL CELL LUNG CANCER WITH EGFR AND ALK CONCURRENT MUTATIONS, AT THE CENTRAL LUNG HOSPITAL","authors":"Le Tu Linh, Nguyen Viet Nhung, Nguyen Hoang Anh, Le Ngoc Minh Thu, Hoang Huy Anh, Nguyen Dieu My, Nguyen Thi Trang","doi":"10.59459/1859-1655/jmm.293","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.293","url":null,"abstract":"Purpose: Evaluate the initial treatment results of non-small cell lung cancer with EGFR and ALK concurrent mutations.\u0000Subjects and methods: A prospective study, non-controlled description, and longitudinal follow-up of 6 patients with stage IIIB-IV non-small cell lung cancer, with EGFR and ALK concurrent mutations, at the National Lung Hospital, from January 2022 to July 2023.\u0000Results: The average age of patients was 65.5 years, the male/female gender ratio was 5/1, and the proportion of patients who smoked was 83.3%. Patients were mainly admitted to the hospital due to symptoms of cough (100%), chest pain (50.0%), and dyspnea (33.3%); the majority of patients with stage IV cancer (83.3%); all patients had adenocarcinoma (100%). The average disease-free survival time was 11.36 months. The common unwanted effects were mainly skin rash (83.3%) and diarrhea (66.7%). Elevated liver enzymes and renal failure occurred in the group of patients using a combination of EGFR-TKIs and ALK-TKIs and were the reasons for discontinuation of ALK-TKIs.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"83 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASSESSMENT OF UNWANTED EFFECTS OF CONCURRENT CHEMORADIOTHERAPY FOR NASOPHARYNGEAL CARCINOMA, AT THE NATIONAL OTORHINOLARYNGOLOGY HOSPITAL OF VIETNAM, FROM 2019 TO 2023 2019年至2023年越南国立耳鼻喉科医院鼻咽癌同期化疗放疗不良反应评估

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.330

Le Van Thanh, Nguyen Quang Trung, Pham Dinh Khanh, Hoang Thi Thao

引用次数: 0

STUDY ON THE ACTUAL SITUATION OF DOMESTIC WATER IN 24 MILITARY UNITS IN THE NORTHERN REGION IN 2022 关于 2022 年北部地区 24 个军事单位生活用水实际情况的研究

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.258

Tran Quoc Luat, Cao Thi Minh Ngoc, Pham Van Son

{"title":"STUDY ON THE ACTUAL SITUATION OF DOMESTIC WATER IN 24 MILITARY UNITS IN THE NORTHERN REGION IN 2022","authors":"Tran Quoc Luat, Cao Thi Minh Ngoc, Pham Van Son","doi":"10.59459/1859-1655/jmm.258","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.258","url":null,"abstract":"Purpose: Study on the actual situation of domestic water in some military units in the Northern region in 2022.\u0000Subjects and Methods: A cross-sectional descriptive study with analysis and evaluation of seven basic physical, chemical and microbiological indicators on 113 samples of domestic water collected at 24 military units stationed in the Northern Region from July to October, 2022.\u0000Results: The water used for consumption and daily activities in the studied units accounted for 58.4% from drilled wells and dug wells and 35.4% from water supplied by factories, in which 61.1% of the water was untreated before use. The proportion of water sources that did not meet the standards according to QCVN 01:2018/BYT for pH indicator was 29/113 samples (25.7%), and for turbidity was 10/113 samples (8.8%). A comparison of nitrite and ammonia standards between treated and untreated water sources showed approximate equality. The difference in permanganate criteria between treated and untreated water sources and the proportion of samples meeting standards according to QCVN 01-1: 2018/BYT was statistically significant with p < 0.05.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CIRCULATING PROTEINS AS DIAGNOSTIC BIOMARKERS IN BREAST CANCER 作为乳腺癌诊断生物标志物的循环蛋白

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.345

Dinh Thi Thao, Nguyen Cam Thach, Vu Van Tuyen, Tran Quang Huy, Nguyen Thi Anh Tuyet, Nguyen Van Tuyen, Tran Thai Ha

引用次数: 0

EVALUATION OF TREATMENT RESULTS IN 10 PATIENTS WITH SOFT TISSUE DEFECTS IN THE WRIST-HAND REGION USING RADIAL ARTERY PERFORATOR FLAPS 使用桡动脉穿孔皮瓣对 10 名腕部软组织缺损患者的治疗效果进行评估

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.246

Vu Quoc Khanh, Hoang Thanh Tuan, Vu Quang Vinh, Tran Van Anh, Do Trung Quyet, Hoang Tuan Hoang

引用次数: 0

EVALUATION OF THE INITIAL RESULTS OF APPLYING INFORMATION TECHNOLOGY TO PREVENT CONTRAINDICATED DRUG INTERACTIONS IN PRESCRIPTIONS AT THE MILITARY HOSPITAL 7, MILITARY REGION 3 评估第 3 军区第 7 军人医院应用信息技术防止处方中药物相互作用禁忌的初步成果

Tạp chí Y học Quân sự Pub Date : 2024-02-28 DOI: 10.59459/1859-1655/jmm.376

Nguyen Phuong Dong, Nhu Thi Ly

{"title":"EVALUATION OF THE INITIAL RESULTS OF APPLYING INFORMATION TECHNOLOGY TO PREVENT CONTRAINDICATED DRUG INTERACTIONS IN PRESCRIPTIONS AT THE MILITARY HOSPITAL 7, MILITARY REGION 3","authors":"Nguyen Phuong Dong, Nhu Thi Ly","doi":"10.59459/1859-1655/jmm.376","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.376","url":null,"abstract":"Purpose: Building a list of contraindicated drug interactions and evaluating the initial results of applying information technology to prevent contraindicated drug interactions in prescriptions at the Military hospital 7.\u0000Subjects and Methods: A retrospective, descriptive study evaluated 158,213 prescriptions before integrating the drug interaction warning utility and 18,222 prescriptions after integrating the drug interaction at the Military hospital 7.\u0000Results: Successfully built and integrated 82 pairs of contraindicated drug interactions in Hospital information system (HIS) software, including 54 pairs with contraindicated drug interactions in combination and 28 pairs of contraindicated drug interactions in specific clinical contexts. In 158,213 prescriptions before integrating the drug interaction warning utility, 45 prescriptions with contraindicated drug interactions were identified (including nine prescriptions with contraindicated drug interactions in combination, with two pairs of drug interactions, and 36 prescriptions with contraindicated drug interactions in specific clinical contexts, with seven pairs of drug interactions). In 18,222 prescriptions after integrating real-time contraindicated drug interaction warnings on HIS software, no prescriptions with contraindicated drug interactions detected.\u0000Conclusions: The initial application of information technology has improved a positive effect in preventing contraindicated drug interactions in prescriptions at Military hospital 7.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"40 S25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0