Chu Thanh Binh, Le Huu Hiep, Truong Minh Noel, Vu Van Duyen, Nguyen Xuan Dinh, Pham Thi Kim Nhung, Tran Minh Tam
{"title":"STUDY ON THE ANTAGONISTIC ACTIVITY AGAINST TWO PATHOGENIC BACTERIA IN HUMANS OF STREPTOMYCES MIP_L26 ISOLATED FROM SOIL IN THE ROOT ZONE OF THE MAY CHANG TREE (LITSEA CUBEB)","authors":"Chu Thanh Binh, Le Huu Hiep, Truong Minh Noel, Vu Van Duyen, Nguyen Xuan Dinh, Pham Thi Kim Nhung, Tran Minh Tam","doi":"10.59459/1859-1655/jmm.377","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.377","url":null,"abstract":"Purpose: Study on the antagonistic activity against two pathogenic bacteria in humans (Staphylococcus aureus and Streptococcus pneumoniae) of the Streptomyces MIP_L26 (Called MIP_L26), isolated from the soil in the root zone of the May Chang tree; to investigate the biological characteristics of MIP_L26 \u0000Subjects and methods: Experimental study, determine the antimicrobial activity against two pathogenic bacteria in humans (Staphylococcus aureus and Streptococcus pneumoniae), and some biological characteristics of MIP_L26.\u0000Results: MIP_L26 was identified as having a strong antagonistic ability against the two bacteria causing Staphylococcus aureus and Streptococcus pneumoniae with an antibacterial ring diameter of 18 ± 5 mm and 13 ± 5 mm, respectively. Based on classification according to morphological, physiological, and biochemical characteristics, combined with the results of 16S rRNA gene sequencing, MIP_L26 was identified as Streptomyces gancidicus MIP_L26. The fermentation medium for the biosynthesis of antibacterial substances was ISP6 and the recovery time for antimicrobial substances was after 72 hours of fermentation.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tran Thanh Tuan, Vu Ngoc Thang, Dao Nguyen Manh, Quach Thi Quynh, Nguyen Hai Duong, Dang Thi Minh
{"title":"ANALGESIC EFFECT OF “DINH THONG PHONG” CAPSULES ON EXPERIMENTAL ANIMALS","authors":"Tran Thanh Tuan, Vu Ngoc Thang, Dao Nguyen Manh, Quach Thi Quynh, Nguyen Hai Duong, Dang Thi Minh","doi":"10.59459/1859-1655/jmm.278","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.278","url":null,"abstract":"Purpose: Evaluate the analgesic effect of “Dinh Thong Phong” capsules on experimental animals.\u0000Subjects and Methods: “Dinh Thong Phong” capsules, meeting the standard criteria, were evaluated for analgesic effect on white mice. In particular, the central analgesic effect was assessed using the hot plate model, peripheral analgesic effect was assessed using the writhing pain model.\u0000Results: In the hot plate model, “Dinh Thong Phong” capsules at a dosage of 860 mg/kg and 2,580 mg/kg significantly increased the reaction time to heat (p < 0.001) compared to the control group. The difference in reaction time to heat between the groups using “Dinh Thong Phong” capsules and the group using codeine phosphate at a dose of 20 mg/kg was not statistically significant (p > 0.05). In the writhing model, “Dinh Thong Phong” capsules at a dose of 860 mg/kg and 2,580 mg/kg significantly reduced the number of writhing episodes (p < 0.001) compared to the control group. The difference in the number of writhing episodes between the groups using “Dinh Thong Phong” capsules and the group using aspirin at a dose of 150 mg/kg was not statistically significant (p > 0.05).","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"79 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Do Phong Tue, To Minh Hung, Le Quoc Hung, Nguyen Hai Duong, Nguyen Van Thinh, Vu Thi Que
{"title":"ACUTE AND SUB-CHRONIC TOXICITY ASSESSMENT OF PYRIDOSTIGMINE BROMIDE 90 MG EXTENDED- ELEASE TABLETS IN EXPERIMENTAL ANIMALS","authors":"Do Phong Tue, To Minh Hung, Le Quoc Hung, Nguyen Hai Duong, Nguyen Van Thinh, Vu Thi Que","doi":"10.59459/1859-1655/jmm.402","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.402","url":null,"abstract":"Purpose: This study aimed to assess the acute and subchronic toxicity of Pyridostigmine bromide 90 mg extended-release tablets in experimental animals. \u0000Subjects and methods: Pyridostigmine bromide 90 mg extended-release tablets were prepared complying in-house specifications. Acute oral toxicity (LD50) was determined in white mice using the Litchfield-Wilcoxon method. Subchronic toxicity was assessed in rabbits following OECD guidelines. \u0000Results: The acute toxicity study revealed an LD50 of 17.9 mg/kg when Pyridostigmine bromide 90 mg extended-release tablets were orally administered to mice. In the subchronic toxicity assessment, rabbits were treated with Pyridostigmine bromide tablets for 28 days. Doses of 7.2 mg/kg/day and 21.6 mg/kg/day showed no significant alterations in hematological parameters (red blood cells, hemoglobin, hematocrit, mean corpuscular volume, white blood cells, platelets), blood biochemical parameters (AST, ALT, total protein, creatinine, urea), and did not cause damage to the histopathology of the liver, spleen, and kidneys in rabbits. However, the dose of 21.6 mg/kg/day resulted in a statistically significant difference in rabbit weight gain compared to those administered a dose of 7.2 mg/kg/day and those in the control group.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"13 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EVALUATION OF SURGICAL OUTCOMES OF OSTEOPOROTIC VERTEBRAL COMPRESSION FRACTURE PATIENTS TREATED BY KYPHOPLASTY, AT MILITARY HOSPITAL 105","authors":"Nguyen Thanh Bac, Dao Van Thuy","doi":"10.59459/1859-1655/jmm.396","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.396","url":null,"abstract":"Purpose: To evaluate the surgical outcomes of osteoporotic vertebral fracture patients treated by kyphoplasty at Military Hospital 105.\u0000Subjects and Methods: A descriptive, retrospective study of 34 osteoporotic fractures patients who were treated by kyphoplasty at Military Hospital 105 from January 2021 to December 2021.\u0000Results: Immediately post operation, 100% of patients had significant pain relief compared to preoperation (average VAS score after surgery 1.91 ± 1.22); 100% of patients had vertebral body height restored (with moderate level 36.4%, good level 39.4%); The kyphosis corrected spine has statistical significance compared to before treatment (with p < 0.05).","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"66 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Tu Linh, Nguyen Viet Nhung, Nguyen Hoang Anh, Le Ngoc Minh Thu, Hoang Huy Anh, Nguyen Dieu My, Nguyen Thi Trang
{"title":"THE INITIAL TREATMENT RESULTS OF 6 PATIENTS WITH NON-SMALL CELL LUNG CANCER WITH EGFR AND ALK CONCURRENT MUTATIONS, AT THE CENTRAL LUNG HOSPITAL","authors":"Le Tu Linh, Nguyen Viet Nhung, Nguyen Hoang Anh, Le Ngoc Minh Thu, Hoang Huy Anh, Nguyen Dieu My, Nguyen Thi Trang","doi":"10.59459/1859-1655/jmm.293","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.293","url":null,"abstract":"Purpose: Evaluate the initial treatment results of non-small cell lung cancer with EGFR and ALK concurrent mutations.\u0000Subjects and methods: A prospective study, non-controlled description, and longitudinal follow-up of 6 patients with stage IIIB-IV non-small cell lung cancer, with EGFR and ALK concurrent mutations, at the National Lung Hospital, from January 2022 to July 2023.\u0000Results: The average age of patients was 65.5 years, the male/female gender ratio was 5/1, and the proportion of patients who smoked was 83.3%. Patients were mainly admitted to the hospital due to symptoms of cough (100%), chest pain (50.0%), and dyspnea (33.3%); the majority of patients with stage IV cancer (83.3%); all patients had adenocarcinoma (100%). The average disease-free survival time was 11.36 months. The common unwanted effects were mainly skin rash (83.3%) and diarrhea (66.7%). Elevated liver enzymes and renal failure occurred in the group of patients using a combination of EGFR-TKIs and ALK-TKIs and were the reasons for discontinuation of ALK-TKIs.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"83 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Le Van Thanh, Nguyen Quang Trung, Pham Dinh Khanh, Hoang Thi Thao
{"title":"ASSESSMENT OF UNWANTED EFFECTS OF CONCURRENT CHEMORADIOTHERAPY FOR NASOPHARYNGEAL CARCINOMA, AT THE NATIONAL OTORHINOLARYNGOLOGY HOSPITAL OF VIETNAM, FROM 2019 TO 2023","authors":"Le Van Thanh, Nguyen Quang Trung, Pham Dinh Khanh, Hoang Thi Thao","doi":"10.59459/1859-1655/jmm.330","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.330","url":null,"abstract":"Purpose: Assessment of the unwanted effects of concurrent chemoradiotherapy for nasopharyngeal carcinoma.\u0000Subjects and methods: A retrospective combined prospective study and description of 53 patients with stage II-IVA nasopharyngeal carcinoma, treated with concurrent chemoradiotherapy by the cisplatin regimen on days 1, 22 and 43 at the National Otorhinolaryngology Hospital of Vietnam from 2019 to 2023.\u0000Results: The incidence of grade 3 toxicity on the hematopoietic and non-hematopoietic systems, and late complications occurred at a low rate. Specifically: toxicities of leukopenia and granulocytopenia at grade 3 were 17.0%, and 7.5% respectively; toxicity: dermatitis, mucositis, and, nausea at grade 3 were 3.8%, 18.9%, and 5.7%, respectively. Late complications of xerostoma and skin fibrosis at grade 3 were 18.9% and 1.9%, respectively.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"282 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"STUDY ON THE ACTUAL SITUATION OF DOMESTIC WATER IN 24 MILITARY UNITS IN THE NORTHERN REGION IN 2022","authors":"Tran Quoc Luat, Cao Thi Minh Ngoc, Pham Van Son","doi":"10.59459/1859-1655/jmm.258","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.258","url":null,"abstract":"Purpose: Study on the actual situation of domestic water in some military units in the Northern region in 2022.\u0000Subjects and Methods: A cross-sectional descriptive study with analysis and evaluation of seven basic physical, chemical and microbiological indicators on 113 samples of domestic water collected at 24 military units stationed in the Northern Region from July to October, 2022.\u0000Results: The water used for consumption and daily activities in the studied units accounted for 58.4% from drilled wells and dug wells and 35.4% from water supplied by factories, in which 61.1% of the water was untreated before use. The proportion of water sources that did not meet the standards according to QCVN 01:2018/BYT for pH indicator was 29/113 samples (25.7%), and for turbidity was 10/113 samples (8.8%). A comparison of nitrite and ammonia standards between treated and untreated water sources showed approximate equality. The difference in permanganate criteria between treated and untreated water sources and the proportion of samples meeting standards according to QCVN 01-1: 2018/BYT was statistically significant with p < 0.05.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dinh Thi Thao, Nguyen Cam Thach, Vu Van Tuyen, Tran Quang Huy, Nguyen Thi Anh Tuyet, Nguyen Van Tuyen, Tran Thai Ha
{"title":"CIRCULATING PROTEINS AS DIAGNOSTIC BIOMARKERS IN BREAST CANCER","authors":"Dinh Thi Thao, Nguyen Cam Thach, Vu Van Tuyen, Tran Quang Huy, Nguyen Thi Anh Tuyet, Nguyen Van Tuyen, Tran Thai Ha","doi":"10.59459/1859-1655/jmm.345","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.345","url":null,"abstract":"Purpose: Summary of tumor-produced circulating proteins as biomarkers in breast cancer (BC) detection.\u0000Subjects and method: A meta-analysis of 50 researches on protein biomarkers in BC diagnosis.\u0000Results: Many studies have shown that tumors continuously release components such as protein, RNA, and DNA into the bloodstream during apotosis. There are different protein markers, as tissue markers and serum markers involved assisting diagnosis, but none of them can independently establish the final diagnotic BC at an early stage. Therefore, scientific communities have been putting lots of effort to discover biomarkers for better identifying this malignant disease at earlier stages.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"26 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vu Quoc Khanh, Hoang Thanh Tuan, Vu Quang Vinh, Tran Van Anh, Do Trung Quyet, Hoang Tuan Hoang
{"title":"EVALUATION OF TREATMENT RESULTS IN 10 PATIENTS WITH SOFT TISSUE DEFECTS IN THE WRIST-HAND REGION USING RADIAL ARTERY PERFORATOR FLAPS","authors":"Vu Quoc Khanh, Hoang Thanh Tuan, Vu Quang Vinh, Tran Van Anh, Do Trung Quyet, Hoang Tuan Hoang","doi":"10.59459/1859-1655/jmm.246","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.246","url":null,"abstract":"Purpose: Evaluate the treatment results of soft-tissue defects in the wrist-hand region by radial artery perforator flaps.\u0000Subjects and methods: A prospective, non-controlled study and cross-sectional description of 10 patients with soft-tissue defects in the wrist-hand region due to burns, indicated for reconstructive treatment using radial artery perforator flaps at the Center for Plastic and Aesthetic Surgery, Le Huu Trac National Burn Hospital, from January to September, 2021.\u0000Results: Patients aged between 17 and 69, mean age of 37.3 ± 14.5 years; ratio of male patients to female patients was 4/1. Regarding the location of injuries: 9 patients had soft-tissue defects in the dorsum of the wrist-hand; 1 patient had a soft-tissue defect in the volar aspect of the wrist-hand. Regarding treatment results: 8 patients showed excellent treatment results, 2 patients had satisfactory results, and there were no cases of treatment failure.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"39 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EVALUATION OF THE INITIAL RESULTS OF APPLYING INFORMATION TECHNOLOGY TO PREVENT CONTRAINDICATED DRUG INTERACTIONS IN PRESCRIPTIONS AT THE MILITARY HOSPITAL 7, MILITARY REGION 3","authors":"Nguyen Phuong Dong, Nhu Thi Ly","doi":"10.59459/1859-1655/jmm.376","DOIUrl":"https://doi.org/10.59459/1859-1655/jmm.376","url":null,"abstract":"Purpose: Building a list of contraindicated drug interactions and evaluating the initial results of applying information technology to prevent contraindicated drug interactions in prescriptions at the Military hospital 7.\u0000Subjects and Methods: A retrospective, descriptive study evaluated 158,213 prescriptions before integrating the drug interaction warning utility and 18,222 prescriptions after integrating the drug interaction at the Military hospital 7.\u0000Results: Successfully built and integrated 82 pairs of contraindicated drug interactions in Hospital information system (HIS) software, including 54 pairs with contraindicated drug interactions in combination and 28 pairs of contraindicated drug interactions in specific clinical contexts. In 158,213 prescriptions before integrating the drug interaction warning utility, 45 prescriptions with contraindicated drug interactions were identified (including nine prescriptions with contraindicated drug interactions in combination, with two pairs of drug interactions, and 36 prescriptions with contraindicated drug interactions in specific clinical contexts, with seven pairs of drug interactions). In 18,222 prescriptions after integrating real-time contraindicated drug interaction warnings on HIS software, no prescriptions with contraindicated drug interactions detected.\u0000Conclusions: The initial application of information technology has improved a positive effect in preventing contraindicated drug interactions in prescriptions at Military hospital 7.","PeriodicalId":504443,"journal":{"name":"Tạp chí Y học Quân sự","volume":"40 S25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}