Yasemin M Akay, Andrei Dragomir, Chuanze Song, Jie Wu, Metin Akay
{"title":"Hippocampal gamma oscillations in rats.","authors":"Yasemin M Akay, Andrei Dragomir, Chuanze Song, Jie Wu, Metin Akay","doi":"10.1109/MEMB.2009.934619","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934619","url":null,"abstract":"<p><p>Previous studies suggested that gamma oscillations in the brain are associated with higher order cognitive functions, including selective visual attention, motor task planning, sensory perception, working memory, and dreaming rapid eye movement (REM) sleep. These oscillations are mainly observed in the cortical regions and also occur in neocortical and subcortical areas and hippocampus. These oscillations may occur under certain pathological conditions, such as epilepsy, and are mainly observed in the cortical regions and hippocampus. The previous studies have suggested that epilepsy may be associated with disturbances of autonomic nervous system(ANS) and with changes in autonomic cardioregulatory function. In this article, we investigate the influence of acute exposure to 2-aminoethoxy-diphenylborate (2-APB), a membrane-permeable inositol 1,4,5-trisphosphate (IP) receptor, and store-operated Ca(2+) channel (SOC) blocker on the complexity of hippocampal gamma oscillations. Our central hypothesis is that acute exposure to 2-APB significantly reduces the hippocampal gamma oscillations. To test this hypothesis, we use brain-slice recordings and the advanced nonlinear dynamical analysis method based on the Lempel-Ziv (LZ) estimator. Our nonlinear dynamical analysis results estimated from brain-slice recordings suggested that 2-APB exposure significantly reduces the hippocampal gamma oscillations.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 6","pages":"92-5"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28509552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tuning of the sequence technique.","authors":"Dominique Laude, V Baudrie, Jean-Luc Elghozi","doi":"10.1109/MEMB.2009.934630","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934630","url":null,"abstract":"<p><p>The sequence method was first described by Di Rienzo in cats and applied in different species including humans. Until now, no systematic study of spontaneous baroreflex sensitivity (BRS) has been performed by the sequence method in mice. This study aimed to characterize the best estimates of BRS using the sequence method by tuning all the possible parameters, specifically, the number of beats involved in a sequence, the minimal changes in blood-pressure (BP) ramps, and the minimal changes in pulse-interval (PI) ramps. Also, the relevance to set a minimal correlation coefficient in the regression line between BP and PI was tested. An important point was the delay to be applied between BP and PI. This delay represents the physiological time for the baroreflex loop to efficiently correct the BP variations.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 6","pages":"30-4"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934630","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28509629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgios D Mitsis, Rong Zhang, Benjamin D Levine, Efthalia Tzanalaridou, Demosthenes G Katritsis, Vasilis Z Marmarelis
{"title":"Autonomic neural control of cerebral hemodynamics.","authors":"Georgios D Mitsis, Rong Zhang, Benjamin D Levine, Efthalia Tzanalaridou, Demosthenes G Katritsis, Vasilis Z Marmarelis","doi":"10.1109/MEMB.2009.934908","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934908","url":null,"abstract":"<p><p>Despite the rich innervation of the cerebral vasculature by both sympathetic and parasympathetic nerves, the role of autonomic control in cerebral circulation and, particularly, cerebral hemodynamics is not entirely clear. Previous animal studies have reported inconsistent results regarding the effects of electrical stimulation or denervation on cerebral blood flow (CBF), cerebral pressure-flow relationship, and cerebral vessel response to metabolic stimuli. Moreover, with the advance of transcranial Doppler ultrasound (TCD), which yields accurate measurements of CBF velocity (CBFV) with high time resolution, it has been found that in humans CBFV in the middle cerebral artery decreased substantially during lower body negative pressure (LBNP) and head-up tilt in the absence of systemic hypotension, which suggests the presence of cerebral vasoconstriction associated with augmented sympathetic nerve activity during orthostatic stress. These observations were based on assessing static measures of cerebral circulation, i.e., mean values of artevial blood pressure (ABP) and CBF with a low time resolution.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 6","pages":"54-62"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28509545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jan J Zebrowski, Pawel Kuklik, Teodor Buchner, Rafał Baranowski
{"title":"Concealed conduction effects in the atrium.","authors":"Jan J Zebrowski, Pawel Kuklik, Teodor Buchner, Rafał Baranowski","doi":"10.1109/MEMB.2009.934628","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934628","url":null,"abstract":"<p><p>A one-dimensional (1-D) model of the atrium together with the sinoatrial (SA) and atrioventricular (AV) nodes is presented in this article. The two nodes are each modeled by 15-element, diffusively coupled, modified van der Pol oscillator chains, while the atrium tissue is represented by a 90-element chain of diffusively coupled FitzHugh-Nagumo (FHN) equations. The modified van der Pol oscillators are able to reproduce physiologically important properties, such as the refraction period, phase-sensitivity properties, and modes of change of the action potential frequency. The activity of both branches of the autonomous nervous system may be introduced into the model in a simplified way. The model enables the study of the effect of the magnitude of the action potential conduction rate in the nodes on interspike intervals (ISIs; equivalent of RR intervals) and explains the occurrence of RR-interval alternans in certain patients. The effect of breathing modulation of heart rate and of a single deep breath can also be modeled. Finally, concealed conduction effects in the atrium are studied, yielding results comparable with recorded heart rate variability data.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 6","pages":"24-9"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28509628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jose F Valencia, Montserrat Vallverdú, Rico Schroeder, Andreas Voss, Rafael Vázquez, Antonio Bayés de Luna, Pere Caminal
{"title":"Complexity of the short-term heart-rate variability.","authors":"Jose F Valencia, Montserrat Vallverdú, Rico Schroeder, Andreas Voss, Rafael Vázquez, Antonio Bayés de Luna, Pere Caminal","doi":"10.1109/MEMB.2009.934621","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934621","url":null,"abstract":"<p><p>This work has proposed a methodology based on the concept of entropy rates to study the complexity of the short-term heart-rate variability (HRV) for improving risk stratification to predict sudden cardiac death (SCD) of patients with established ischemic-dilated cardiomyopathy (IDC). The short-term HRV was analyzed during daytime and nighttime by means of RR series. An entropy rate was calculated on the RR series, previously transformed to symbol sequences by means of an alphabet. A statistical analysis permitted to stratify high- and low-risk patients of suffering SCD, with a specificity (SP) of 95% and sensitivity (SE) of 83.3%.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 6","pages":"72-8"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28509546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Introductory Text to Bioengineering (Advanced Series in Biomechanics, Vol. 4) (Chien, S. et al; 2008) [Book reviews]","authors":"H. Sung","doi":"10.1109/MEMB.2009.934241","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934241","url":null,"abstract":"This textbook provides a very comprehensive overview of the issues that bioengineers deal with, such as biomechanics, tissue engineering, nanotechnology, and systems biology.","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 1","pages":"66-67"},"PeriodicalIF":0.0,"publicationDate":"2009-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62475598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Attorneys' fees for the winner [Patents]","authors":"M. Klee","doi":"10.1109/MEMB.2009.934251","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934251","url":null,"abstract":"In the United States, the normal rule is that each party to a lawsuit pays its own attorneys' fees. However, some statutes, including the Copyright Act, give the trial judge the authority to make the loser pay some or all of the winner's attorneys' fees when the loser, in one way or another, has acted badly. The question then becomes what constitutes sufficiently bad behavior so as to justify an award of attorneys' fees. That was the question before the court in the recent case of Asset Marketing Systems (AMS) v. Gagnon.","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 1","pages":"58-58"},"PeriodicalIF":0.0,"publicationDate":"2009-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934251","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62475669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Normal versus pathological voice signals.","authors":"Everthon Fonseca, Jose Pereira","doi":"10.1109/MEMB.2009.934248","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934248","url":null,"abstract":"In this work, a method to analyze the time-frequency characteristics to distinguish pathological voices from patients with Reinke's edema and nodules in vocal folds was developed. Daubechies discrete wavelet transform (DWT) components of approximation and detail in convenient scales of frequency for different voice signals were used to analyze the time-frequency signal characteristics. In this work, 71 voice signals were used from subjects of different ages, both male and female: 30 with no pathology in vocal folds, 25 from patients with nodules in vocal folds, and 16 from patients with Reinke's edema. Least squares support-vector machines (LS- SVM) classifier leads to more than 90% of classification accuracy between normal voices and voices from patients with nodules in vocal folds, more than 85% between normal voices and voices from patients with Reinke's edema, and more than 80% between the two different pathological voice signals.","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 5","pages":"44-8"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40031711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Don't play it again, Sam.","authors":"Michael R Neuman","doi":"10.1109/memb.2009.934237","DOIUrl":"https://doi.org/10.1109/memb.2009.934237","url":null,"abstract":"","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 5","pages":"3-4"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/memb.2009.934237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40035679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pressure-detection algorithms.","authors":"J C Perfetto, A G Ruiz, R O Sirne, C E D'Attellis","doi":"10.1109/MEMB.2009.934246","DOIUrl":"https://doi.org/10.1109/MEMB.2009.934246","url":null,"abstract":"Our approach is based on identifying specific characteristics of the arterial blood pressure (ABP) signal. During the development of the algorithm, we examined the signals and tried to extract the features that signals always share with other signals of the same type. These features permit acceptance of a portion of the signal as being part of arterial pressure or reject it as being an artifact. The algorithm first detects the occurrence of the systolic point and, thereafter, the diastolic point. The method we present here is designed to be used in adaptation mechanisms of the cardiovascular system assessment.","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":"28 5","pages":"35-40"},"PeriodicalIF":0.0,"publicationDate":"2009-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.934246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40031708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}