Annals of Medicine & Surgery最新文献

{"title":"Hypokalemia in a young man…think Bartter syndrome type 3","authors":"Suaad Hamsho, Abdul Hadi Daher Alhussen, Hadi Alabdullah, Bilal Sleiay, Noor Kasem, Qussai Hassan","doi":"10.1097/ms9.0000000000001994","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001994","url":null,"abstract":"\u0000 \u0000 Bartter syndrome is an autosomal recessive salt reabsorption disorder that results in decreased extracellular fluid volume with low/normal blood pressure.\u0000 \u0000 \u0000 \u0000 A 17-year-old boy with polydipsia, polyuria, weakness in the lower limbs, and ataxic gait. His Laboratory test shows Hypokalemia; hypochloremia; hypomagnesemia and metabolic alkalosis. Our patient was managed by fluid and electrolyte replacement which is essential in emergency management.\u0000 \u0000 \u0000 \u0000 Bartter syndrome is difficult to treat and currently there is no complete cure. The overall prognosis depends on the extent of receptor dysfunction, and despite these facts, most patients can live a normal life if they strictly follow their treatment plan.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical removal of multiple xanthomas in familial hypercholesterolemia: a case report","authors":"M. A. Tolba, Anwar Mohamad, Youssef Z. Farhat, Mohammed A. Omar, Ahmed Mohamed Safy","doi":"10.1097/ms9.0000000000001997","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001997","url":null,"abstract":"\u0000 \u0000 Xanthomas are skin swellings that are caused by the accumulation of cholesterol and lipids in the body. They are associated with lipid disorders, such as familial hypercholesterolemia (FH). FH is a rare genetic disorder which is characterized mainly by high levels of LDL cholesterol.\u0000 \u0000 \u0000 \u0000 We report a case of an 11-year-old female who had multiple swellings all over the body with the largest measuring 7×4×3 cm in diameter. These lesions were gradually increasing in size since 4 years. She was being bullied by her school colleagues because of swellings appearance. Clinical examination revealed multiple yellowish masses on the patient’s elbows, knees, and buttocks which were painless, firm, and non-tender. Laboratory tests revealed elevated levels of serum cholesterol (512 mg/dL) and LDL cholesterol (469.2 mg/dL). Masses Ultrasound showed similar echogenicity to upper and lower extremities subcutaneous fat. Incisional biopsy microscopic images revealed clusters of foam cells. These findings led to a diagnosis of Homozygous FH (HoFH) and she underwent surgery to remove the xanthomas on her elbows.\u0000 \u0000 \u0000 \u0000 Xanthomas are small, yellowish skin swellings that form due to the presence of high lipids. As they are typically painless and small, this could lead to a late treatment or misdiagnosis. Drugs, life style changes and surgery represent treatment plan options.\u0000 \u0000 \u0000 \u0000 Xanthomas can be the first indication of an underlying hypercholesterolemia problem and this case report highlights the importance of early diagnosis of HoFH by providing the suitable management for this case in its early stages which can prevent developing serious complication.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti coauglants induced intracranial hemorrhage managed with decompressive craniectomy: A case report of lesson learned","authors":"Sagun Ghimire, Shikher Shrestha, Dinuj Shrestha, Ananta maharjan, Bibek Jaiswal, Prabin chaudhary, Sharon Sherpa","doi":"10.1097/ms9.0000000000001996","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001996","url":null,"abstract":"\u0000 \u0000 Intracerebral hemorrhage (ICH)secondary to use of anti-coagulants is one of the fearsome complications. Hemorrhage within the intracranial space due to such anti-coagulants results in expansion of the intracranial bleeding despite the reversal of anti-coagulants. Hence timely surgical intervention can be lifesaving.\u0000 \u0000 \u0000 \u0000 An elderly female who was undergoing management for her deranged coagulation parameters was found to be in a state of features suggestive of stroke. Patient was on regular anti-coagulants medication for her cardiology issues. CT scan showed intracranial hemorrhage which underwent expansion in same day hence decompressive craniectomy was done. In further stay in the ICU patient GCS was fluctuating but symptomatic improvement was noted. Anti-coagulants adjustment was done from cardiologist and further there was no expansion of intracranial bleeding with within normal coagulation parameters.\u0000 \u0000 \u0000 \u0000 Anti-coagulants are rampantly used in several cases . Despite the several complications there is desperate need of such medications for the betterment of the patient condition. Pharmacological management is major modality in reversal of OAC induced ICH but in rare cases in the background of OACs induced ICH there occurs expansion of hemorrhage. Hence the need for neurosurgical intervention whether be it minimal invasive surgery or decompressive craniectomy .\u0000 \u0000 \u0000 \u0000 In the background of less prevalence of OACs induced ICH, there is absence of robust guiding treatment protocol. Furthermore there exist minimal reported cases which underwent surgical intervention and resulted good prognosis.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized prediction of conditional survival for colorectal signet ring cell carcinoma patients","authors":"Jiani Gu, Lijun Zhang, Yanjin Zhang, Xia Chen, Ting Gu, Jidong Cai, Lifeng Yao, Lihua Yan","doi":"10.1097/ms9.0000000000001982","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001982","url":null,"abstract":"\u0000 \u0000 Conditional survival (CS) considers the time already survived after surgery and may provide additional survival information. We sought to construct and validate novel conditional survival nomograms for the prediction of conditional overall survival (OS) and cancer specific survival (CSS) of colorectal signet ring cell carcinoma (SRCC) patients.\u0000 \u0000 \u0000 \u0000 Patients diagnosed with stage I-III SRCC between 2010 and 2019 were identified from the Surveillance, Epidemiology, and End Results database. The formula calculating CS was: CS(x|y) = S(x+y)/S(x), where S(x) represents the survival at x years. CS nomograms were then constructed to predict the 5-year conditional OS and CSS, followed by internal validation.\u0000 \u0000 \u0000 \u0000 A total of 944 colorectal SRCC patients were finally identified in this study. The 5-year OS and CSS improved gradually with additional survival time. Univariate and multivariate Cox regression analysis conducted in training set revealed that age, race, T stage, LNR, and perineural invasion were independent risk factors for both OS and CSS. Two nomograms with considerable predictive ability were successfully constructed (AUC for OS: 0.788; AUC for CSS: 0.847) and validated (AUC for OS: 0.773; AUC for CSS: 0.799) for the prediction of 5-year OS and CSS, based on the duration of1-4 years post-surgery survival.\u0000 \u0000 \u0000 \u0000 The probability of achieving 5-year OS and 5-year CSS in colorectal SRCC patients improved gradually with additional time. Conditional nomograms considering survival time will be more reliable and informative for risk stratification and postoperative follow-up.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we improve therapeutic compliance in cancer patients? report of a cross-sectional case series study in Morocco","authors":"Khadija Mokhtari, B. Hajji, Hanane El oualy, Hamid Madani","doi":"10.1097/ms9.0000000000001869","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001869","url":null,"abstract":"Therapeutic compliance (TC) refers to the compliance of a patient to the prescriptions and recommendations of a doctor. Patients with cancer often exhibit unsatisfactory TC. The objective of our study was to assess TC levels in cancer patients and identify predictors of poor compliance. We conducted a cross-sectional study in March 2023 at the oncology center, where the vast majority of medical activity is performed in the day hospital. TC was measured using a questionnaire or survey. Various parameters were analyzed to identify predictive factors of poor therapeutic compliance. Our study included 175 cancer patients with a mean age of 55 years. The study revealed that 85% exhibited good compliance (GC) as indicated by the confidence interval [8.500 ± 0.075], signifying patients who consistently adhered to their medication schedule. Conversely, 15% demonstrated poor compliance (PC), as indicated by the confidence interval [0.825 ± 0.750]. Compliance status was assessed by considering patients who adhered to the prescribed medication timing as good compliance (GC) and those who did not adhere as poor compliance (PC). The analysis of our study results indicated that poor therapeutic compliance was associated with low socioeconomic and educational levels. Therefore, it is important to utilize all available resources to improve therapeutic compliance. The majority of factors contributing to poor compliance can be mitigated through effective coordination between the patient and their support network.","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethics in scientific research: a lens into its importance, history, and future","authors":"G. D. Miteu","doi":"10.1097/ms9.0000000000001959","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001959","url":null,"abstract":"","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the relationship between restless legs syndrome, mental status and sleep disorders among moroccan women during their third trimester of pregnancy","authors":"M. Guerroumi, A. Aquil, Ouassil El kherchi, Salma Ait bouighoulidne, Meryam Belhaj Haddou, A. Elgot","doi":"10.1097/ms9.0000000000001987","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001987","url":null,"abstract":"\u0000 \u0000 Restless legs syndrome (RLS) is a motor disorder encountered during pregnancy and leading to psychological and sleep impairments. The latter seems to be non-restorative and its occurrence alters the quality of life of pregnant woman. The objective of this study was to evaluate the prevalence of RLS and its relationship with both anxio-depressive symptoms and sleep disorders among a population of Moroccan pregnant women during their third trimester of pregnancy.\u0000 \u0000 \u0000 \u0000 A cross-sectional study was conducted in a population of pregnant women in their third trimester (n=178) admitted to two health facilities in the city of Marrakech: Youssef Ibn Tachafine and Oasis. The face-to-face questionnaire was used to collect data including, demographic and clinical characteristics, the four diagnostic criteria of RLS, the Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale (HADS). Patients were divided into two groups RLS+ (women with restless legs syndrome) and RLS- (women without restless legs syndrome).\u0000 \u0000 \u0000 \u0000 The prevalence of RLS was 59.5%, this syndrome was more common in the ninth month (74.15%) compared with the seventh and eighth months. Sleep impairment including sleep efficiency was significantly higher in RLS+ more than RLS- (P-value 0.05). Anxiety but not depression is significantly increased in RLS+ compared to RLS- (48.11% versus 38.8%, P = 0.000). No significant differences between RLS+ and RLS- in terms of socio-demographic and other clinical characteristics.\u0000 \u0000 \u0000 \u0000 RLS is encountered during the prenatal period, with a higher prevalence in the last trimester. During this stage of pregnancy, women suffering from RLS were vulnerable to anxiety and sleep disorders. Prevention and early diagnosis of RLS syndrome could be a proactive healthcare management leading to ensure better health outcomes and better conditions of pregnancy which precedes childbirth.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"115 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of retained metallic foreign body in liver - case report and review of literature","authors":"Santosh Dev, Manish Yadav, Newton Ashish Shah, Barsha Dev, Shishir Devkota, Laxman Khadka, Dhiraj Kumar Das, Samridhi Yadav, J. Sah, B. Ghimire","doi":"10.1097/ms9.0000000000001992","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001992","url":null,"abstract":"\u0000 \u0000 Foreign bodies in the liver are uncommon but can lead to severe conditions like liver abscess and sepsis. They typically enter through direct penetration, migration from the gastrointestinal tract, or through the blood. Common foreign objects include metal pins or sewing needles swallowed accidentally.\u0000 \u0000 \u0000 \u0000 A 25-year-old male presented to our OPD with pain over the right abdomen with a prior history of projectile injury causing laceration over the right anterior abdomen with primary suturing. On radiological investigation, a retained foreign body was revealed. The metallic foreign body was embedded in the liver for 5 months. Removal of the foreign body was performed without any complications.\u0000 \u0000 \u0000 \u0000 Intrahepatic foreign bodies (FBs) in the liver can result from penetrating injuries, iatrogenic causes, or ingestion, particularly in children. Clinical presentations vary, and complications such as abscess formation may occur. Diagnosis involves imaging modalities like X-rays, ultrasonography, and CT scans. The presented case highlights the importance of meticulous follow-up, as chronic pain manifested despite conservative management. The management of intrahepatic FBs depends on factors like size, location, and symptoms, with conservative approaches for stable patients. Surgical removal remains the mainstay of the treatment. Long-term monitoring is crucial to detect potential complications, and imaging studies play a key role in regular follow-up.\u0000 \u0000 \u0000 \u0000 Hepatic foreign bodies are rare, and symptoms vary based on size, type, and location, ranging from asymptomatic to complications such as abscess formation. Surgical removal is the main treatment, but in cases of noncomplicated hepatic foreign bodies, close follow up is necessary.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"91 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering access: the US’ first over-the-counter birth control pill revolutionizes contraception","authors":"Fatima Bint Sajid, Z. Mughal, Nabiha Syed, Abdul Maalik, Abdullah Mussarat, B. Rangwala, Syeda Mahrukh Fatima Zaidi, Hussain Sohail Rangwala, Mirha Ali, Asma Ahmed Farah","doi":"10.1097/ms9.0000000000001986","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001986","url":null,"abstract":"","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140221027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of needles distance of arteriovenous fistula cannulation on hemodialysis adequacy based on KT/V: a randomized controlled trial","authors":"Samad Karkhah, Majid Pourshaikhian, Saman Maroufizadeh, Pooyan Ghorbani Vajargah, P. Aghajanzadeh, Joseph Osuji, M. Moghadamnia","doi":"10.1097/ms9.0000000000001966","DOIUrl":"https://doi.org/10.1097/ms9.0000000000001966","url":null,"abstract":"\u0000 \u0000 This study aims to assess the effect of needle distance of arteriovenous fistula (AVF) cannulation on hemodialysis adequacy based on KT/V.\u0000 \u0000 \u0000 \u0000 This study was a parallel-group, randomized controlled trial. Patients who met the inclusion criteria were divided into two groups with 3 and 6 cm needle distances using block randomization. Data acquisition transpired through a comprehensive checklist encompassing demographic variables such as age and gender, alongside clinical metrics comprising actual weight, dry weight, average dialysis duration, fistula longevity, and KT/V rate.\u0000 \u0000 \u0000 \u0000 A total of 42 hemodialysis patients were enrolled in this investigation, with 21 allocated to the 3 cm needle distance group and another 21 to the 6 cm needle distance group. The mean post-hemodialysis KT/V values for the 3 cm and 6 cm needle distance groups were 1.25 (SD=0.25) and 1.42 (SD=0.24), respectively, demonstrating a statistically significant difference (P<0.001). While there was no significant difference in the average pre- and post-hemodialysis KT/V values within the 3 cm needle distance group (t=1.93, P=0.068), the corresponding values for the 6 cm needle distance group exhibited a notable discrepancy (t=9.66, P<0.001).\u0000 \u0000 \u0000 \u0000 In general, a needle distance of 6 cm between arteriovenous points yielded superior enhancements in dialysis adequacy compared to a 3 cm needle distance following hemodialysis. Consequently, health administrators and policymakers may consider instituting efficacious interventions to scrutinize the care and therapeutic protocols for hemodialysis patients, involving the development of policies and applications.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine &amp; Surgery","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140221950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}