Medical & Clinical Research最新文献

{"title":"Real World Effectiveness of Orphenadrine citrate 50 mg + Paracetamol 650 mg (Norgesic ® Forte ) on Low Back Pain of Filipino Patients","authors":"","doi":"10.33140/mcr.09.01.05","DOIUrl":"https://doi.org/10.33140/mcr.09.01.05","url":null,"abstract":"Introduction: Low back pain is a common musculoskeletal disorder, estimated to affect up to 84% of adults at some point in their lives. It is one of the leading causes of activity limitation, work absenteeism, and lost productivity, inflicting substantial costs on health, social, and economic systems. Globally, back pain causes more disability than any other condition. The study aimed to determine the effectiveness of a combination drug: Orphenadrine citrate 50 mg + paracetamol 650 mg (Norgesic ® Forte) in alleviating low back pain of adult Filipino patients who are presenting with acute non-specific moderate to severe low back pain. Methods: This is a real-world, uncontrolled, longitudinal, observational study on the effectiveness of a combination drug: Orphenadrine citrate 50 mg + paracetamol 650 mg (Norgesic ® Forte). Patients with acute low back pain were prescribed by participating physicians with said drugs according to local prescribing information and routine clinical practice. The pain was assessed using the Visual Analogue Scale (VAS), and the Roland-Morris Disability Questionnaire (RMDQ) was used to evaluate for self-rated physical disability. Patients were followed up until the total resolution of the low back pain or up to a maximum of ten (10) days. The study also documented any adverse effects for ten (10) days. Results: In the 181 participants, the median onset of pain relief occurred an hour after the first dose; the fastest occurred at 5 minutes, and the slowest at 8 hours. At baseline, the median VAS score was 7, the lowest was 2, and the highest was 10. Generally, a decreasing trend was observed on subsequent time points compared to baseline (p<0.0001). By day 5, VAS scores dropped to 0 until day 10. The mean duration of symptoms before total resolution of low back pain was 4.3 SD ± 2.0 days. As much as 72.4% of the participants’ VAS scores decreased by 2 points from baseline as early as day 1. The highest observed proportion of respondents with at least two 2-point decreases from baseline VAS scores was on day 3. Using the RMDQ with scores ranging from 0 (no disability) to 24 (severe disability), the median physical disability score on day 1 was 9, with a minimum value of 1 and a maximum of 23. On day 11, this significantly decreased to 1, with values ranging from 0 to 11 (p<0.0001). Thirteen participants developed adverse events, which were generally mild. Conclusion: Results indicate that Orphenadrine citrate 50 mg + Paracetamol 650 mg (Norgesic ® Forte) provides pain relief compared to the baseline. In addition to its analgesic effects, there is an improvement in physical function, as evidenced by the significant decrease in the physical disability scores and, subsequently, an improvement in the quality of life (QoL) of these patients.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"31 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140496193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing Leishmania donovani Metabolism in 3D Culture: New Perspectives on Drug Targets","authors":"","doi":"10.33140/mcr.09.01.03","DOIUrl":"https://doi.org/10.33140/mcr.09.01.03","url":null,"abstract":"Objective: The goal of the research was to investigate Leishmania donovani (L. donovani) metabolism in a 3D culture environment and find possible targets for metabolic drugs. Methods: Different metabolic experiments were performed on two strains of L. donovani (LD1S and LD2B) that were cultivated in 3D spheroids. In order to comprehend the metabolic processes of L. donovani, glucose intake, lactate generation, and lipid utilization were evaluated. Hexokinase (HK) and fatty acid synthase (FAS), two important enzymes implicated in these metabolic pathways, were recognized as potential therapeutic targets. HK and FAS were knocked down in the parasite using CRISPR-Cas9 technology to validate these targets, and the effects on growth and viability were statistically evaluated. Results: In the 3D culture, L. donovani showed a strong growth pattern and significantly increased in diameter over the course of 14 days (p<0.001). When compared to earlier 2D investigations, metabolic tests revealed that 3D cells consumed much more glucose and used lipids (p<0.001). In comparison to wild-type strains, HK and FAS knockdown strains drastically decreased their use of lipids and glucose, respectively (p<0.001). In comparison to the wild-type strains, both knockdown variants demonstrated significantly less growth and vitality (p<0.001). Conclusion: Our results demonstrate the value of 3D culture for investigating the metabolism of L. donovani, and they also identify and verify HK and FAS as prospective therapeutic targets. These discoveries could open the door for the creation of novel treatment approaches to treat L. donovani infection. The parasite's considerable growth and survival decrease when these metabolic pathways are interrupted is supported by statistical evidence, opening the door for future therapeutic development.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Low-Dose Dexmedetomidine on Intestinal Barrier and Functional Recovery in Elderly Patients Undergoing Orthopedic Surgery for Lower Limbs","authors":"","doi":"10.33140/mcr.09.01.04","DOIUrl":"https://doi.org/10.33140/mcr.09.01.04","url":null,"abstract":"Objective: This study used the minimum recommended clinical dose of dexmedetomidine to investigate whether it can protect the intestinal barrier and the effects on intestinal function recovery in elderly patients undergoing lower limb orthopedic surgery. Methods: 56 patients, who underwent elective lower limb orthopedic surgery in our hospital from November 1, 2019 to November 1, 2021, were divided into control group (saline group) and DEX group (dexmedetomidine group) by random numbers method. The DEX group received dexmedetomidine at 0.5 μg/kg, pumped within 15 min and then maintained at 0.1 μg/kg/h until 30 min before the skin suture. The control group performed the same procedure with normal saline instead. The primary outcomes included the time of first hepatic gate exhaust, serum diamine oxidase, and D-lactate levels. Secondary outcomes include total amount of sufentanil, mean arterial pressure, heart rate, duration of anesthesia, duration of surgery, tumor necrosis factor- α, C-reactive protein, lipopolysaccharide levels. Results: The time of first anal exhaust in the DEX group was significantly shorter compared with the control group (13.23 ± 4.98 hours vs19.67±5.16 hours; p<0.001), and the total amount of sufentanyl in the DEX group was significantly lower than that in the control group (35.32±10.23ug vs 42.33±12.19ug; p=0.002). At 24 hours after surgery, serum diamine oxidase, tumor necrosis factor-α, and C-reactive protein levels increased in both groups, but no difference was statistically significant (p>0.05), and there was no significant difference in LPS levels in the two groups before and 24 hours after surgery (p>0.05). D-lactate was increased in both groups at 24 hours after surgery, but the D-lactate increased more in control patients than in the DEX group (36.17±14.69 mg/L vs 29.10±12.19 mg/L;p=0.017). Correlation analysis showed that diamine oxidase, D lactate, age, APACHE II score, total amount, and time to first anal discharge in the DEX group (p<0.05). Conclusion: The intraoperative administration of dexmedetomidine can accelerate the recovery of gastrointestinal function, which may be related to the protective effect of DEx on the gastrointestinal barrier.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and Management of Cancer Recurrence","authors":"","doi":"10.33140/mcr.09.01.01","DOIUrl":"https://doi.org/10.33140/mcr.09.01.01","url":null,"abstract":"Cancer recurrence is defined as the re-establishment of tumor burden following previous eradication of primary cancer by various treatments. Once this event takes place, the prognosis of the patient often becomes grim, signaling the end of life. Compared to the management of initially diagnosed cases, clinical dealing of recurred cancer has been in a state of chaos without consensus and guidelines. The reason for this lack of consensus in dealing with recurred cancer comes from highly variable outcomes to the same treatment in individual case, thus no defined treatments can be planned in advance. Why is recurred cancer more deadly than primary cancer? Why do some cancer cases recur while others don’t? Why is it more difficult to deal with recurred cancer than primary cancer? These are challenging clinically relevant questions, the answer to which may help us to understand the mechanism behind tumor recurrence and provide strategy to deal with this deadly event more efficiently. Here, using a few cases, we present our analyses on this issue with focus on the status of antitumor immunity, the most critical factor influencing the outcome of each recurrence. Our analyses and experiences with cancer recurrence indicate that although appearing complicated than initially diagnosed cancer, recurred cancer could be reasonably managed like initially diagnosed cancer as long as its reason for recurrence is clearly identified.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"14 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139451520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Breast Enlargement And Psychological Stress In Women: Mediating Effects Of Coping Styles","authors":"","doi":"10.33140/mcr.08.12.06","DOIUrl":"https://doi.org/10.33140/mcr.08.12.06","url":null,"abstract":"Aim: To study the interactions between breast hyperplasia and psychological stress and coping styles in women. Methods: A total of 230 women were examined, and 130 subjects with breast hyperplasia and 100 subjects without breast hyperplasia were selected and administered the Adult Version of the Coping Methods Questionnaire and the Health Perceptions and Behaviors Questionnaire. Results: There was a significant positive correlation between breast hyperplasia and psychological stress scores in women (R=0.177, P<0.01), a significant negative correlation with positive coping style scores for coping methods (R=-0.153, P<0.05), and a significant negative correlation between psychological stress and positive coping style (R=-0.268, P<0.01). In the mediation effect test, it was found that women with breast enlargement not only acted directly on their psychological stress of health behaviors, but also indirectly through positive coping of coping styles. Conclusion: The use of positive coping styles in patients suffering from breast enlargement is able to reduce their level of psychological stress.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"65 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparity of Cell Death Attributes in Primary Adult Human Glioblastoma: A Review","authors":"","doi":"10.33140/mcr.08.12.05","DOIUrl":"https://doi.org/10.33140/mcr.08.12.05","url":null,"abstract":"Primary adult glioblastoma is a malignant tumor of the neuroaxis, throughout which it will spread widely. The survival rate of the patients is inferior to 15 months. A poor outcome is related to drug resistance, as well as to the blood-brain-barrier permeability. A major mechanism of the drug impediment is based on an apoptotic blockade, but also, increasingly, of nonapoptotic cell death, the various forms of which may be manipulated to a level that may initiate some degree of improvement in the clinical features. But these molecules, for example, those responsible for autophagic or paraptotic cell death, have reacted so far by obscure processes that are just starting to be elucidated. The goal of this review is to display the diverse variants of cell death involved in glioblastoma and to highlight the relevance of molecules and processes to the mechanism and therapy of this malignancy. Moreover, attempts will be made to trace the data concerning the repair manipulations performed on the original defects inherent in this cancer","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"60 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Between Tamsulosin and Oxybutynin in Relieving Ureteral Stent Related Symptoms","authors":"","doi":"10.33140/mcr.08.11.08","DOIUrl":"https://doi.org/10.33140/mcr.08.11.08","url":null,"abstract":"One handred cases with unilateral ureteral stent insertion were randomized into four groups; given placebo (25 patients), Oxybutynin 5mg once daily (25 patients), Tamsulosin 0.4mg once daily (25 patients) or combination respectively. All patients received the drugs for three weeks and completed the symptom questionnaire and quality of life questionnaire one week after stent insertion and one week after stent removal. There was no significant difference in the efficacy between Tamsulosin and Oxybutynin in relieving urgency (9 patients, 9 patients respectively), frequency (7 patients, 9 patients respectively) and dysuria (11 patients, 9 patients respectively) with the superiority of combination therapy (12 patients, 16 patients, 17 patients respectively)( P-values: 0.01, 0.001, 0.001 respectively). For relieving abdominal pain, Tamsulosin was more efficacious than Oxybutynin (8 patients versus 5 patients) with the superiority of the combination therapy (12 patients) (P-value: 0.001). For relieving hematuria, Tamsulosin and combination therapy were comparable and both superior to Oxybutynin with a P-value 0.001. For improving quality of life, both Tamsulosin and Oxybutynin were comparable (9 patients, 9 patients) with superiority of combination therapy (15 patients) with a P-value 0.001.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139197602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal for a New Sports Talent Identification System Based on the Tracking Phenomenon of Height","authors":"","doi":"10.33140/mcr.08.11.09","DOIUrl":"https://doi.org/10.33140/mcr.08.11.09","url":null,"abstract":"In sports talent discovery in Japan, a system has been built to effectively support athletes with contact maintained between regional and central sports organizations. However, while a certain effect has been achieved with this system, much still depends on tacit knowledge. That is, a discovery system based on scientific evidence has not yet been established. The system is especially lagging in terms of approaches from the field of growth and development research. The only such approach, as found by Fujii, is that height and athletic ability are independent phenomena, and if one wants to discover exceptional sports talent it is necessary to think about height and athletic ability independently. In this study, we attempted to analyze the tracking of tall and short heights in the junior (school-age) period from the perspective of physical growth science, by applying the application of the wavelet interpolation model. The results showed that a tracking phenomenon is seen with a high probability (about 90%) for both tall and short heights. This makes it possible to identify who will be tall and short in the future. Assessing the athletic ability of tall and short people independently and proposing a system that screens for people with high athletic ability can contribute to building a new system for the discovery of sports talent.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"26 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139206333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CD147 Epitope on SARS CoV2 and the Spike in Cancer, Autoimmunity and Organ Fibrosis","authors":"","doi":"10.33140/mcr.07.051","DOIUrl":"https://doi.org/10.33140/mcr.07.051","url":null,"abstract":"TNFα in partnership with glycosylated CD147 conspires to create the fertile soil for de novo and recurrent cancer. CD147 is present on the spike protein S (virus or vaccine) [1], despite claims to the contrary [2,3]. These claims have been discredited [4]. Pro and con arguments for the connection between cancer and Covid-19 or its vaccines continue to rage. But the physiologic implications involving TNFα and CD147 discussed in this article are worrisome. A deep dive into the tumor microenvironment (TME) created by the high mannose high glycosylation of CD147 is undertaken. Angiotensin II type 1 receptor antibodies and TNFα generated by the virus and/or the vaccine are biomarkers for future LC. Their presence in POTS is 70%. These activate AT1Rs and ADAM17 aka TACE, the enzyme that produces TNFα. This cytokine inhibits mannosidase and leads to the high mannose glycosylation of CD147, TNFα, IL-6, and TGF beta or their receptors, which appears to redirect their pleiotropic functions. High mannose glycosylation of CD147 drives the production of IL-17 and IFN gamma closely linked to autoimmune disease. TGF beta is linked to organ fibrosis. The TME created by these redirected cytokines spawns epithelial mesenchymal transition (EMT), cancer associated fibrosis (CAF), tumorigenesis, and metastasis. TNFα is associated with aggressive forms of colon cancer and Triple negative breast cancer (TNBC) and levels are elevated when vitamin D and magnesium are deficient. TNBC (15% of breast cancers, but the most aggressive form) is especially prominent in the obese and in young (less than 40) African American and Hispanic women. Specific recommendations for prevention and therapy include D-mannose.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"53 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139265352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Consanguineous Marriages on Arab Offspring in the Arab Community","authors":"","doi":"10.33140/mcr.08.11.05","DOIUrl":"https://doi.org/10.33140/mcr.08.11.05","url":null,"abstract":"To better understand the effect of intergenerational consanguineous marriages on the onset and severity of dyslexia, this study focused on investigating the frequency of dyslexia in diverse family backgrounds, including consanguineous and non-consanguineous spouses. Despite the advance of modernization and globalization, certain cultures that are mainly focused in North Africa, the Middle East and South Asia, continue to prioritize and practice family marriage and this is despite the warnings and recommendations of global health organizations. Dyslexia is a common learning disability that affects the development of language, and its main effect appears as difficulties in reading, spelling and decoding. This disability is related to phonological problems and not to intellectual ability. The reading and spelling errors are strongly influenced by heredity and genetics, with approximately 50% hereditary influence and genetic variables that contribute to the appearance of the disability among the offspring. The study compares the ability to deal with phonological and orthographic challenges in dyslexic children born from marriages from different marriage backgrounds, relatives and non-relatives, to peers. Phonological coding, spoken language abilities, working memory and reading comprehension are among the genetic and neurological aspects that have been studied.","PeriodicalId":503698,"journal":{"name":"Medical &amp; Clinical Research","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139272140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}