Qeios Pub Date : 2024-06-11 DOI: 10.32388/dvwq2l

Rakesh Bharath, Ajay Vidyarthi, Neeti Dharamwat, Saumyta Mishra, Nirdhum Shikha, Nishit Kakka

{"title":"Clinical Implications of EMT in HNSCC: A Review of the Factors and Pathways at Play","authors":"Rakesh Bharath, Ajay Vidyarthi, Neeti Dharamwat, Saumyta Mishra, Nirdhum Shikha, Nishit Kakka","doi":"10.32388/dvwq2l","DOIUrl":"https://doi.org/10.32388/dvwq2l","url":null,"abstract":"_Background: _Epithelial–mesenchymal transition (EMT) is effected in squamous cell cancers via activation of the cadherin switch. Activation of the switch results in decreased expression of E-cadherin and increased expression of N-cadherin. This results in loss of cell-cell adhesion and cellular polarity and allows the tumour cells to metastasise.\u0000\u0000_Aims_ _&_ _Objectives:_ This systematic review was carried out to find the clinical implications of EMT in HNSCC and bring together the molecular, genetic, and epigenetic pathways found to be acting on the cadherin switch.\u0000\u0000_Materials & Methods: _An extensive search for relevant papers was made on PubMed, Medline, and Google Search. Only good-quality studies pertaining to epithelial–mesenchymal transition in oral cavity cancers in humans were selected. Furthermore, all selected papers were assessed for their clinical relevance.\u0000\u0000_Results: _The cadherin switch is regulated by transcription factors like Snail, SLUG, ZEB1, and ZEB2. It is also acted on by epigenetic modifiers. These transcription factors are regulated by multiple pathways like Wnt/β–catenin, PI3K/AKT, MAPK, etc. These pathways are in turn regulated by molecular and external agents like NNK from tobacco smoke, hypoxia, the DDB2 gene, reactive oxygen species (ROS), and melatonin.\u0000","PeriodicalId":503632,"journal":{"name":"Qeios","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Educational Leadership Practices on Education Quality in Secondary Schools in South Sudan 教育领导实践对南苏丹中学教育质量的影响

Qeios Pub Date : 2024-06-11 DOI: 10.32388/plfwh0

James Ajuong Arou, Kanbiro Orkaido Deyganto

{"title":"Effect of Educational Leadership Practices on Education Quality in Secondary Schools in South Sudan","authors":"James Ajuong Arou, Kanbiro Orkaido Deyganto","doi":"10.32388/plfwh0","DOIUrl":"https://doi.org/10.32388/plfwh0","url":null,"abstract":"This study examines the effect of educational leadership practices on the education quality of secondary schools in South Sudan. A mixed-methods approach, combining qualitative and quantitative research methods, was employed to gather data from 350 students through questionnaires and interviews. The results of the regression analysis revealed a significant positive relationship between educational leadership practices and education quality. Specifically, strong communication skills, an effective decision-making style, instructional leadership, and a positive school climate and culture on the part of the educational leadership were associated with higher levels of education quality. The study underscores the importance of educational leaders prioritizing the development and enhancement of their leadership practices to support education quality for student success. Recommendations include providing targeted training and professional development opportunities for leaders to improve their leadership skills and creating a supportive and collaborative school environment that values effective educational leadership practices. By investing in educational leadership development and ensuring they have the necessary skills and resources, all stakeholders can help improve education quality for the best academic outcomes for students in South Sudan. The findings of this study contribute valuable insights for educational institutions and policymakers aiming to enhance education quality through effective educational leadership practices.\u0000","PeriodicalId":503632,"journal":{"name":"Qeios","volume":"123 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141360726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical Implicative Analysis of Students’ Algebra Performance 学生代数成绩的统计意义分析

Qeios Pub Date : 2024-06-10 DOI: 10.32388/fl8eng

Reinhard Oldenburg, Kaye Stacey

引用次数: 0

Possible Tetraquark Explanation for the J/ψK0S Structure Observed in Proton-Proton Collision Data at Center-of-Mass Energies of 7, 8, and 13 TeV 质心能量为 7、8 和 13 TeV 时质子-质子对撞数据中观测到的 J/ψK0S 结构的可能四夸克解释

Qeios Pub Date : 2024-06-08 DOI: 10.32388/yft8l5

J. Bevelacqua

引用次数: 0

On the Same Page: Providing Theoretical Context for the Critical List of Variables for Sustaining the Commons 同心协力：为维持公域的关键变量清单提供理论背景

Qeios Pub Date : 2024-06-08 DOI: 10.32388/5i2ucv

Miramanni Mishkin

{"title":"On the Same Page: Providing Theoretical Context for the Critical List of Variables for Sustaining the Commons","authors":"Miramanni Mishkin","doi":"10.32388/5i2ucv","DOIUrl":"https://doi.org/10.32388/5i2ucv","url":null,"abstract":"Elinor Ostrom pioneered common pool resource management theory. Her work was advanced by other contemporaries in the field. The result was a list of enabling variables for sustaining common pool resource systems. However, the interpretation of the qualifiers for the variables has been somewhat inconsistent among researchers, rendering meta-analysis and cross-case comparisons less robust. As the basis for CPR system theory, the importance of context for consistency becomes more significant with the pressures for effective analyses and subsequent policy— increasing with the impacts of climate change on the world’s CPR systems. This variable context must be preserved in the operationalizing process to ensure more robust comparability in data collection and, ultimately, a more effective evolution of theory. This review paper presents a reference where each variable is discussed in the context of its nascence and application in CPR theory by the researcher who flagged its importance. The goal of providing a reference for the theoretical context for the critical list of variables is to maintain the variables' theoretical integrity. The goal is to enable more informative and robust results in singular and comparative CPR analyses. Additional variables are defined and recommended for inclusion.\u0000","PeriodicalId":503632,"journal":{"name":"Qeios","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141369557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Intellectual Capital Efficiency Translate into Financial Performance for Islamic Banks in Indonesia? Evidence from the Pre-Pandemic Period 印度尼西亚伊斯兰银行的知识资本效率是否转化为财务绩效？大流行前时期的证据

Qeios Pub Date : 2024-06-05 DOI: 10.32388/chbtcm.2

Azharsyah Ibrahim, Rosniar Rosniar

引用次数: 0

Possible Description of the Excited States of the Neutral Charmed Omega in Terms of a First-Order Pentaquark Mass Formula 用一阶五夸克质量公式描述中性魅力欧米茄激发态的可能性

Qeios Pub Date : 2024-06-05 DOI: 10.32388/mu0id5

J. Bevelacqua

{"title":"Possible Description of the Excited States of the Neutral Charmed Omega in Terms of a First-Order Pentaquark Mass Formula","authors":"J. Bevelacqua","doi":"10.32388/mu0id5","DOIUrl":"https://doi.org/10.32388/mu0id5","url":null,"abstract":"Bevelacqua Resources, 7531 Flint Crossing Circle SE, Owens Cross Roads, AL 35763 USA bevelresou@aol.com\u0000\u0000 Recently proposed sscqq-bar pentaquark structures for the excited states of the neutral charmed omega are investigated using a first-order mass formula incorporating weakly interacting qq-bar meson and Ω0c baryon clusters. The results are compared to the predictions of the LHCb Collaboration. \u0000\u0000 The first-order pentaquark mass formula has typically yielded results within about 10% of the experimental mass values. Using this criterion, the Ω0c(2770), Ω0c(3000), Ω0c(3050), Ω0c(3065), Ω0c(3090), Ω0c(3119), and Ω0c(3185) states could be described by the ssc + uu-bar and ssc + dd-bar pentaquarks with the meson clusters uu-bar and dd-bar having a pseudoscalar configuration. The Ω0c(3185) is also described by the ssc + ss-bar with the ss-bar in a pseudoscalar state. In a similar manner, the Ω0c(3327) state could be described by the ssc + uu-bar and ssc + dd-bar pentaquarks with the meson clusters uu-bar and dd-bar having a vector configuration, and a ssc + ss-bar pentaquark with the meson cluster ss-bar having a pseudoscalar configuration. The model is not sufficiently refined to distinguish between these states.\u0000\u0000 The only state with a specified Jπ assignment is the Ω0c(2770). The Particle Data Group specifies a 3/2+ assignment. The first-order pentaquark allows both 1/2+ and 3/2+ values for all Ω0c excited states.\u0000\u0000KEYWORDS: Pentaquark, first-order mass formula, quark model, excited states of the neutral charmed omega\u0000","PeriodicalId":503632,"journal":{"name":"Qeios","volume":"75 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141385378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Polypropylene Wastes on the Compressive Strength of Grade 25 Concrete 聚丙烯废料对 25 级混凝土抗压强度的影响

Qeios Pub Date : 2024-06-05 DOI: 10.32388/frvq7i.2

R. Umasabor, Oluwadamilola Ayomikun Longe

引用次数: 0

Decay Characteristics of Neutron Excess Scandium Nuclei 中子过剩钪核的衰变特性

Qeios Pub Date : 2024-05-24 DOI: 10.32388/25ngqr

J. Bevelacqua

引用次数: 0

Review of: "preparation of nanodevice layers, nanopatterning of materials, and circuit editing" 回顾："纳米器件层的制备、材料的纳米图案化和电路编辑"

Qeios Pub Date : 2024-05-24 DOI: 10.32388/m2t0nh

Melina Parker