International Journal of Biochemistry & Cell Biology最新文献

{"title":"Retraction notice to \"Activation-induced internalization differs for the tetraspanins CD9 and Tspan8: Impact on tumor cell motility\" [Intern. J. Biochem. Cell Biol., 43/1 (2011) 106-119].","authors":"Sanyukta Rana, Christoph Claas, Cosima C Kretz, Irina Nazarenko, Margot Zoeller","doi":"10.1016/j.biocel.2025.106818","DOIUrl":"https://doi.org/10.1016/j.biocel.2025.106818","url":null,"abstract":"","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":" ","pages":"106818"},"PeriodicalIF":3.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METTL5-mediated m⁶A modification of SLC7A11 promotes cervical cancer by inhibiting ferroptosis.","authors":"Yujin Dong, Wei Chang, Bei Lu, Yuanyuan Li, Yuanhua Liu","doi":"10.1016/j.biocel.2025.106822","DOIUrl":"https://doi.org/10.1016/j.biocel.2025.106822","url":null,"abstract":"<p><p>Ferroptosis could suppress the viability of cervical cancer cells and trigger their death, thereby offering a unique perspective for exploring novel therapeutic approach for cervical cancer. Here, this study tried to explore the role of N⁶-methyladenosine (m⁶A) methyltransferase methyltransferase-like 5 (METTL5) on cervical cancer ferroptosis. Elevated METTL5 functioned as an oncogene in cervical cancer tumorigenesis by inhibiting the ferroptosis. Mechanistically, METTL5 was verified to target SLC7A11 and installed the m⁶A methylation on SLC7A11 mRNA. Moreover, YTHDF3 bound with the m⁶A site of SLC7A11 mRNA to enhance SLC7A11 mRNA stability. Rescue assays confirmed that METTL5/YTHDF3/SLC7A11 axis inhibited the ferroptosis of cervical cancer cells. In vivo, METTL5 silencing repressed the tumor growth of cervical cancer cells, as well as reducing the SLC7A11. In conclusion, these data inspired that METTL5-mediated m⁶A modification of SLC7A11 promoted cervical cancer by inhibiting ferroptosis, providing a novel insight for cervical cancer.</p>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":" ","pages":"106822"},"PeriodicalIF":3.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal high-fat diet-induced obesity in offspring: Unraveling adipose tissue dysfunction mediated by increased heat shock proteins","authors":"Henry A. Paz ,&nbsp;Lasya Buddha ,&nbsp;Tianfu Lam ,&nbsp;Ying Zhong ,&nbsp;James D. Sikes ,&nbsp;Kartik Shankar ,&nbsp;Aline Andres ,&nbsp;Umesh D. Wankhade","doi":"10.1016/j.biocel.2025.106812","DOIUrl":"10.1016/j.biocel.2025.106812","url":null,"abstract":"<div><div>Maternal weight and diet before and during pregnancy have a substantial impact on offspring metabolic health, though sex-specific differences in metabolic and adipose tissue adaptations to maternal overnutrition remain insufficiently understood. Using a mouse model of maternal high-fat (HF) diet-induced obesity, this study assessed the sexually dimorphic responses on offspring adiposity, physiology, and adipose tissue function. Male offspring of HF diet-fed dams exhibited greater weight gain and adiposity, impaired glucose homeostasis, elevated serum levels of insulin, leptin, and cholesterol, along with increased adipogenic and heat shock proteins (HSPs) gene expression in white adipose tissue compared to female offspring. In established adipocyte cell lines independent of experimental animals, the expression of HSPs during differentiation was higher in white than in brown adipocytes. Also, expression of <em>Hsp90ab1</em> in human umbilical cord mesenchymal stem cells tended to positively correlate with maternal body mass index in male, but not in female infants. This finding was generated independently of the animal model and were intended to strengthen the translational perspective of our work. Together, these results suggest a potential link between maternal diet, HSPs, and adipose tissue function.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"186 ","pages":"Article 106812"},"PeriodicalIF":3.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cofilin is a key regulator of oxidative stress-induced intercellular tunneling nanotubes formation","authors":"Hongce Chen ,&nbsp;Zhirui Wu ,&nbsp;Lingyu Wang,&nbsp;Jingyao Zeng,&nbsp;Tongsheng Chen","doi":"10.1016/j.biocel.2025.106820","DOIUrl":"10.1016/j.biocel.2025.106820","url":null,"abstract":"<div><div>Tunneling nanotubes (TNTs) are open membranous channels between connected cells, TNTs-mediated substance transfer between tumor cells plays an important role in drug resistance, metastasis and recurrence of tumors. This study aims to explore the composition of TNTs between tumor cells and the function of cofilin in TNTs formation. Oxidative stress induces the formation of TNTs between tumor cells. The components of TNTs include microfilaments and cell membranes, some of which contain microtubules, as well as mitochondria, endoplasmic reticulum, lysosomes, lipid droplets, ions, etc. Förster resonance energy transfer (FRET) analysis of living cells showed that cofilin and actin only interact in TNTs, and inhibition of cofilin can suppress oxidative stress-induced TNTs production. Doxorubicin (DOX) induced senescent tumor cells (STC) can form TNTs, and TNTs mediated material transfer between STC can promote tumor cell survival, while inhibition of cofilin can promote STC death. In summary, our data suggests that cofilin plays an important role in the formation of TNTs, and targeted inhibition of TNTs mediated intercellular communication and material exchange holds significant potential as a novel cancer treatment strategy.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"186 ","pages":"Article 106820"},"PeriodicalIF":3.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabigerol – A potent regulator of insulin sensitivity in rat’s skeletal muscle via targeting the sphingolipid metabolism and PI3K/Akt/mTOR pathway?","authors":"Patrycja Bielawiec ,&nbsp;Lara Swierkot ,&nbsp;Karolina Konstantynowicz-Nowicka ,&nbsp;Adrian Chabowski ,&nbsp;Agnieszka Błachnio-Zabielska ,&nbsp;Ewa Harasim-Symbor","doi":"10.1016/j.biocel.2025.106819","DOIUrl":"10.1016/j.biocel.2025.106819","url":null,"abstract":"<div><div>Despite the great advances in medicine, there is a compelling need to develop alternative strategies to effectively treat obesity with the use of plant-origin therapeutics. Cannabigerol (CBG) appears to be a novel promising compound for managing this increasingly prevalent disease requiring multifaceted pharmacotherapy. Therefore, the herein study aimed to evaluate the potential therapeutic properties of 2-week CBG administration on the muscular metabolism of sphingolipids as well as insulin signal transduction pathway in a rat model of obesity and insulin resistance (IR) induced by high-fat, high-sucrose (HFHS) diet. The high-performance liquid chromatography (HPLC) and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC/MS/MS) were used to determine the sphingolipids content, while the multiplex assay kit was applied to measure the level of the phosphorylated form of proteins from the PI3K/Akt/mTOR pathway. The expression of various proteins engaged in the sphingolipid metabolism and insulin signaling was assessed using Western blotting. Our results showed that 2-week CBG treatment decreased the muscular content of most deleterious C16:0-Cer and C18:0-Cer ceramide species and reduced the intramuscular concentrations of sphinganine (SFA) and sphingosine (SFO), redirecting their metabolism toward phosphorylated derivatives, sphinganine-1-phosphate (SFA1P), and sphingosine-1-phosphate (S1P), respectively. Simultaneously, CBG counteracted S1P efflux in skeletal muscle, inhibiting the tissue-specific S1P/S1PR3 signaling. CBG also activated the PI3K/Akt/mTOR pathway, which increased the phosphorylation of protein kinase B (Akt) and its downstream targets in the myocytes of obese rats. These results suggest that CBG may play an essential homeostatic role in skeletal muscles and can protect from the development of obesity-associated metabolic derangements.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"186 ","pages":"Article 106819"},"PeriodicalIF":3.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifidobacterium apoptosis induction by measuring bax and caspases on SW948 human colon cancer cell line","authors":"Maryam Soraya ,&nbsp;Elham Moazamian ,&nbsp;Seyedeh Azra Shamsdin ,&nbsp;Mehdi Dehghani","doi":"10.1016/j.biocel.2025.106813","DOIUrl":"10.1016/j.biocel.2025.106813","url":null,"abstract":"<div><h3>Background</h3><div>Nowadays, probiotic bacteria have been considered as a factor in the prevention and treatment of cancer, especially by induction of apoptosis. The aim of study, the isolation and identification of <em>Bifidobacterium</em> SPP, and to investigate the effects of bacterial cell extract and cell free supernatants (CFS) was on normal cell line and colon cancer cell line through measuring caspases.</div></div><div><h3>Material and method</h3><div>In this study, dairy products were collected and After isolation and identification of <em>Bifidobacterium</em> via PCR method, the cytotoxicity effects of cell free supernatants (CFS) (<em>B.Bifidum</em> S2 and <em>B.Bifidum</em> S3) and bacterial cell extract (<em>B.Bifidum</em> P6 and <em>B.Bifidum</em> P17) on colon cancer cell line (SW948) and normal cell line (HEK-293) were evaluated using MTT assay. The effect of isolated bacterial strains on apoptotic cells was determined by measuring caspases 1, 3, 9 and Bax by using ELISA kit.</div></div><div><h3>Result</h3><div>The results showed that the cytotoxicity effect of CFS was higher than bacterial cell extract. CFS showed the highest cytotoxicity effect (about 95 %) on colon cancer cell line. Quantitative analysis of Caspase-1, −3, 9, and Bax expression demonstrated that CFS may exert anticancer effects through induced apoptosis.</div></div><div><h3>Conclusion</h3><div>The results of the present research indicate that probably <em>B.Bifidum</em> S2 and <em>B.Bifidum</em> S3 isolates may be prevent colon cancer by inducing apoptosis.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"186 ","pages":"Article 106813"},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144235797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medium-dose irradiation impairs long-term hematopoietic stem cell functionality and hematopoietic resilience to cytotoxic stress","authors":"Qinyu Zhang ,&nbsp;Anna Rydström ,&nbsp;Isabel Hidalgo ,&nbsp;Jörg Cammenga ,&nbsp;Alexandra Rundberg Nilsson","doi":"10.1016/j.biocel.2025.106814","DOIUrl":"10.1016/j.biocel.2025.106814","url":null,"abstract":"<div><div>Irradiation and 5-fluorouracil (5-FU) are widely utilized tools in hematopoietic research to generate myeloablation and assess blood recovery dynamics. A comprehensive understanding of their effects on the hematopoietic system is essential for optimizing therapeutic strategies, refining experimental models to modulate hematotoxicity, and interpreting research outcomes. Despite their widespread application, the long-term hematopoietic impacts of irradiation and 5-FU, particularly on hematopoietic stem cells (HSCs), remain incompletely characterized. In this study, we therefore examined the long-term effects of 2 Gy medium-dose ionizing radiation (MDIR) and 150 mg/kg 5-FU on HSCs and the hematopoietic system’s resilience to subsequent cytotoxic stress in mice. Our findings demonstrate that MDIR, but not 5-FU, induces sustained impairments in HSC function and results in the selective depletion of MHC class II^- HSCs – a subset characterized by high self-renewal potential and hypersensitivity to irradiation-induced ROS production. Furthermore, MDIR significantly compromised hematopoietic recovery following a subsequent 5-FU challenge, as evidenced by substantially reduced platelet and red blood cell (RBC) counts during the critical recovery phase. These findings highlight the distinct and persistent impacts of MDIR and 5-FU on HSCs and hematopoietic function, revealing crucial differences in their mechanisms of action and long-term consequences on the hematopoietic system.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"186 ","pages":"Article 106814"},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p38 MAPK–mediated upregulation of claudin-3 and claudin-4 by gemcitabine contributes to chemoresistance in ovarian cancer","authors":"Jiaxin Zhao ,&nbsp;Jianli Ke ,&nbsp;Xiaochao Cao ,&nbsp;Jie Li ,&nbsp;Mingzhen Gu ,&nbsp;Xiaoling Zhou ,&nbsp;Yinglu Yan ,&nbsp;Jiyuan Ke","doi":"10.1016/j.biocel.2025.106805","DOIUrl":"10.1016/j.biocel.2025.106805","url":null,"abstract":"<div><div>Chemotherapy is a primary therapeutic option in cancer treatment, but often associated with unwanted side effects and drug resistance. Claudin-3 (CLDN3) and claudin-4 (CLDN4) are essential components of tight junctions, frequently overexpressed in ovarian cancer, serve as potential therapeutic targets. In this study, we utilized flow cytometry, qPCR, Western blot, and animal experiments to investigate the regulation of CLDN3 and CLDN4 by chemotherapy drug, gemcitabine, in the ovarian cancer cell line A2780. We reported that gemcitabine can induce expression of CLDN3 and CLDN4 in ovarian cancer cells. Mechanistically, we showed that gemcitabine induces expression of CLDN3 and CLDN4 through p38 MAP kinase mediated transcriptional regulation. Overexpression of CLDN3 or CLDN4 functionally protected A2780 ovarian cancer from gemcitabine induced cell killing. It appears that gemcitabine induced expression of CLDN3/4 is a chemoresistance mechanism for cancer cells. Gemcitabine-induced upregulation of CLDN3/4 suggests that ovarian cancer cells may be more effectively targeted using claudin-3/4-specific antibodies or antibody-drug conjugates (ADCs) in combination with chemotherapy, which could have clinical implications for ovarian cancer treatment in the future.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"185 ","pages":"Article 106805"},"PeriodicalIF":3.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serine phosphorylation of protein arginine methyltransferase Hmt1 is critical for controlling its protein levels","authors":"Sai Wu ,&nbsp;Vincent Rossi ,&nbsp;Christopher A. Jackson ,&nbsp;Isabella Lonardo ,&nbsp;Joseph A. Ricottone ,&nbsp;Joan M. Hevel ,&nbsp;Michael C. Yu","doi":"10.1016/j.biocel.2025.106790","DOIUrl":"10.1016/j.biocel.2025.106790","url":null,"abstract":"<div><div>In eukaryotes, protein arginine methylation is a prevalent post-translational modification found in a multitude of proteins responsible for key biological processes, ranging from transcription to signaling. One model suggests that phosphorylation of serine 9 (S9) in the <em>Saccharomyces cerevisiae</em> major protein arginine methyltransferase Hmt1 is critical for its oligomerization and activity. In this study, we used classic biochemical approaches to demonstrate that neither the S9 phosphomimetic nor the non-phosphorylatable substitution mutants of Hmt1 affect its oligomerization. These mutants remain active <em>in vivo,</em> retaining their ability to methylate the SR-/hnRNP-like protein Npl3 and displaying a monomethylarginine and asymmetric dimethylarginine banding profile similar to that of the wild-type. In cells lacking Dbf2, the proposed kinase responsible for phosphorylating Hmt1 at S9, Npl3 remains methylated. Additionally, monomethylarginine and asymmetric dimethylarginine banding profiles in cells lacking Dbf2 mostly resemble those observed in the wild-type rather than in <em>hmt1Δ</em> cells. Synchronized yeast cells expressing either S9 substitution exhibit entry into the M phase of the cell cycle at a rate similar to that of both wild-type and <em>hmt1Δ</em> cells. Our results suggest that the C-terminal epitope tagging of Hmt1 is responsible for the previously observed loss of enzymatic activities, rather than the S9 phosphorylation status of Hmt1. Finally, we demonstrate that S9 phosphorylation plays a role in maintaining Hmt1 protein levels <em>in vivo</em>. Overall, our finding demonstrates a novel role for Hmt1 S9 phosphorylation in tuning its <em>in vivo</em> protein levels.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"185 ","pages":"Article 106790"},"PeriodicalIF":3.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridium butyricum protects the ileal barrier in mice by regulating the farnesoid X receptor signaling pathway","authors":"Hanfei Wang ,&nbsp;Li Hou ,&nbsp;Xintong Chen ,&nbsp;Linling Gui ,&nbsp;Weiwei Jiang ,&nbsp;Weibing Tang","doi":"10.1016/j.biocel.2025.106798","DOIUrl":"10.1016/j.biocel.2025.106798","url":null,"abstract":"<div><h3>Background</h3><div>The intestinal barrier has an important role in maintaining homeostasis. The aim of this study was to determine the protective effect of <em>Clostridium butyricum</em> (CBM) on small intestinal barrier damage in mice and the role of farnesoid X receptor (FXR) in regulating the intestinal barrier by <em>C. butyricum</em>.</div></div><div><h3>Methods and results</h3><div>A model of small intestinal injury induced by dextran sulfate sodium (DSS) was constructed to detect repair of intestinal barrier damage after feeding with <em>C. butyricum</em>. In the DSS model group, expression of the tight junction protein (TJP) was significantly decreased and expression of inflammatory factors was significantly increased. TJP expression was significantly increased and inflammatory factor expression was significantly decreased after <em>C. butyricum</em> feeding, which indicated that intestinal barrier function was repaired. In addition, inhibition of FXR expression as well as the downstream signaling pathways were demonstrated in the DSS model group. FXR and its downstream signaling pathways were significantly upregulated after feeding with <em>C. butyricum</em>. Then, intestinal barrier function was evaluated by constructing an intestinal-specific FXR knockout (KO) DSS model in mice. Suppression of TJP and upregulated expression of inflammatory factors were detected in the KO DSS group but there was no significant difference in the expression of TJP and inflammatory factors after <em>C. butyricum</em> feeding. Furthermore, there was no significant difference in FXR downstream signaling pathway expression after <em>C. butyricum</em> feeding compared to the KO DSS group. <em>C. butyricum</em> supernatants (CSs) upregulated the FXR signaling pathways <em>in vitro</em>. CSs did not activate the FXR signaling pathway when FXR was suppressed.</div></div><div><h3>Conclusions</h3><div><em>C. butyricum</em> supplementation effectively ameliorated DSS-induced intestinal barrier disruption. <em>C. butyricum</em> may have a protective effect on the small intestine through the FXR signaling pathway.</div></div>","PeriodicalId":50335,"journal":{"name":"International Journal of Biochemistry & Cell Biology","volume":"185 ","pages":"Article 106798"},"PeriodicalIF":3.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}