抑制tim-3在癌症、病毒感染和自身免疫性疾病中的治疗潜力。

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Biochemistry & Cell Biology Pub Date : 2025-07-01 DOI:10.1016/j.biocel.2025.106826

Ashira Manzoor, Khaled Barakat

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引用次数: 0

摘要

TIM-3 （T细胞免疫球蛋白和粘蛋白结构域蛋白-3）是一种有效的检查点受体，可作为免疫反应的负调节因子。许多免疫细胞，包括单核细胞、TH17 （T辅助性17）细胞、肥大细胞、骨髓细胞和Treg（调节性T）细胞，都表达TIM-3。它由四种配体组成：HMGB1（高迁移基团蛋白B1）、PtdSer（磷脂酰丝氨酸）、半乳糖凝集素-9和CEACAM-1（癌胚抗原细胞粘附分子1）。研究表明TIM-3在癌症、慢性病毒感染和自身免疫性疾病中的作用。因此，抑制TIM-3是目前免疫治疗的一种治疗方法，特别是与其他免疫检查点抑制剂联合使用时。现就其在不同疾病中的作用及其潜在的信号机制作一综述。

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Therapeutic potential of TIM-3 inhibition in cancer, viral infections, and autoimmune disorders

TIM-3 (T cell immunoglobulin and mucin domain protein-3) is a potent checkpoint receptor that functions as a negative regulator of the immune response. Numerous immune cells, including monocytes, TH17 (T helper 17) cells, mast cells, myeloid cells, and Treg (regulatory T) cells, express TIM-3. It consists of four ligands: HMGB1 (High Mobility Group Protein B1), PtdSer (Phosphatidylserine), Galectin-9, and CEACAM-1 (Carcinoembryonic Antigen Cell Adhesion Molecule 1). Research has shown TIM-3's role in cancers, chronic viral infections, and autoimmune disorders. Inhibiting TIM-3, therefore, is a therapeutic approach in the current immunotherapy, particularly when combined with other immune checkpoint inhibitors. The review summarizes its function in different disorders and its potential signaling mechanisms.

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来源期刊

International Journal of Biochemistry & Cell Biology 生物-生化与分子生物学

CiteScore

8.10

自引率

0.00%

发文量

124

审稿时长

19 days

期刊介绍： IJBCB publishes original research articles, invited reviews and in-focus articles in all areas of cell and molecular biology and biomedical research. Topics of interest include, but are not limited to: -Mechanistic studies of cells, cell organelles, sub-cellular molecular pathways and metabolism -Novel insights into disease pathogenesis -Nanotechnology with implication to biological and medical processes -Genomics and bioinformatics