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Molecular Therapy - Nucleic Acids最新文献

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Effective intravitreal gene delivery to retinal pigment epithelium with hyaluronic acid nanospheres 用透明质酸纳米球向视网膜色素上皮细胞进行有效的玻璃体内基因递送
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102222
Ryan Crane, Mustafa S Makia, Stephanie Zeibak, Lars Tebbe, Larissa Ikele, Christian Rutan Woods, Shannon M. Conley, Ghanashyam Acharya, M. Naash, M. Al-Ubaidi
{"title":"Effective intravitreal gene delivery to retinal pigment epithelium with hyaluronic acid nanospheres","authors":"Ryan Crane, Mustafa S Makia, Stephanie Zeibak, Lars Tebbe, Larissa Ikele, Christian Rutan Woods, Shannon M. Conley, Ghanashyam Acharya, M. Naash, M. Al-Ubaidi","doi":"10.1016/j.omtn.2024.102222","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102222","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"5 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel function and mechanism of ischemia-induced retinal astrocyte-derived exosomes for RGC apoptosis of ischemic retinopathy 缺血诱导的视网膜星形胶质细胞衍生外泌体在缺血性视网膜病变的 RGC 细胞凋亡中的新功能和机制
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102209
Xiaoyuan Ye, Yunfei Liu, Congying Chen, Yimeng Sun, Fan Li, Yunzhao Fu, Jiawen Luo, Lishi Su, Wei Chi
{"title":"A novel function and mechanism of ischemia-induced retinal astrocyte-derived exosomes for RGC apoptosis of ischemic retinopathy","authors":"Xiaoyuan Ye, Yunfei Liu, Congying Chen, Yimeng Sun, Fan Li, Yunzhao Fu, Jiawen Luo, Lishi Su, Wei Chi","doi":"10.1016/j.omtn.2024.102209","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102209","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"58 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141036605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Therapy and Nucleic Acid Adeno-associated virus-based gene therapy delivering combinations of two growth-associated genes to MPS IVA mice 分子疗法和核酸 基于腺相关病毒的基因疗法为 MPS IVA 小鼠提供两种生长相关基因的组合
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102211
Estera Rintz, Betul Celik, F. Nidhi, Angélica María Herreño-Pachón, Shaukat Khan, Eliana Benincore-Flórez, Shunji Tomatsu
{"title":"Molecular Therapy and Nucleic Acid Adeno-associated virus-based gene therapy delivering combinations of two growth-associated genes to MPS IVA mice","authors":"Estera Rintz, Betul Celik, F. Nidhi, Angélica María Herreño-Pachón, Shaukat Khan, Eliana Benincore-Flórez, Shunji Tomatsu","doi":"10.1016/j.omtn.2024.102211","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102211","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"26 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141053042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supercoiled DNA percentage, a key in-process control of linear DNA template for mRNA drug substance manufacturing 超卷曲 DNA 百分比--mRNA 药物生产过程中线性 DNA 模板的关键控制因素
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102223
Xijun Piao, Yujie Tang, Xiuzhi Li, Weicheng Zhang, Wei Yang, Xining Xu, Wenjing Wang, Jiajia Jiang, Jun Xu, Kunkun Hu, Meiling Xu, Mengjie Liu, Mengfei Sun, Lin Jin
{"title":"Supercoiled DNA percentage, a key in-process control of linear DNA template for mRNA drug substance manufacturing","authors":"Xijun Piao, Yujie Tang, Xiuzhi Li, Weicheng Zhang, Wei Yang, Xining Xu, Wenjing Wang, Jiajia Jiang, Jun Xu, Kunkun Hu, Meiling Xu, Mengjie Liu, Mengfei Sun, Lin Jin","doi":"10.1016/j.omtn.2024.102223","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102223","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"229 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141144842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LNA-i-miR-221 activity in Colorectal Cancer: A reverse translational Investigation 大肠癌中的 LNA-i-miR-221 活性：逆向转化研究
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102221
Ali Asad, Grillone Katia, Ascrizzi Serena, Caridà Giulio, Fiorillo Lucia, Ciliberto Domenico, Staropoli Nicoletta, Tagliaferri Pierosandro, Tassone Pierfrancesco, Di Martino Maria Teresa
{"title":"LNA-i-miR-221 activity in Colorectal Cancer: A reverse translational Investigation","authors":"Ali Asad, Grillone Katia, Ascrizzi Serena, Caridà Giulio, Fiorillo Lucia, Ciliberto Domenico, Staropoli Nicoletta, Tagliaferri Pierosandro, Tassone Pierfrancesco, Di Martino Maria Teresa","doi":"10.1016/j.omtn.2024.102221","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102221","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"66 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphocholine Headgroup Chemistry Alters the Extrahepatic Accumulation of Lipid Conjugated siRNA 磷酸胆碱头基化学改变脂质共轭 siRNA 的肝外积累
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102230
V. Hariharan, Takahiro Nakamura, Minwook Shin, Qi Tang, V. Sontakke, Jillian Caiazzi, S. Hildebrand, Anastasia Khvorova, Ken Yamada
{"title":"Phosphocholine Headgroup Chemistry Alters the Extrahepatic Accumulation of Lipid Conjugated siRNA","authors":"V. Hariharan, Takahiro Nakamura, Minwook Shin, Qi Tang, V. Sontakke, Jillian Caiazzi, S. Hildebrand, Anastasia Khvorova, Ken Yamada","doi":"10.1016/j.omtn.2024.102230","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102230","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141132919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell analysis for the survival mechanisms of fratricidal CAR-T targeting T-cell malignancies 针对 T 细胞恶性肿瘤的自相残杀 CAR-T 生存机制的单细胞分析
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102225
Hui-hua Hu, Ling Tang, Yuyan Zhao, Jiali Cheng, Mei Huang, Yong You, Ping Zou, Qian Lei, Xiaojian Zhu, An-Yuan Guo
{"title":"Single-cell analysis for the survival mechanisms of fratricidal CAR-T targeting T-cell malignancies","authors":"Hui-hua Hu, Ling Tang, Yuyan Zhao, Jiali Cheng, Mei Huang, Yong You, Ping Zou, Qian Lei, Xiaojian Zhu, An-Yuan Guo","doi":"10.1016/j.omtn.2024.102225","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102225","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"63 s239","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141134183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood pressure reduction through brain delivery of nanoparticles loaded with plasmid DNA encoding angiotensin receptor shRNA. 通过向大脑输送装有编码血管紧张素受体 shRNA 的 DNA 质粒的纳米颗粒降低血压。
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102210
Richard Nii Lante Lamptey, Chengwen Sun, Jagdish Singh
{"title":"Blood pressure reduction through brain delivery of nanoparticles loaded with plasmid DNA encoding angiotensin receptor shRNA.","authors":"Richard Nii Lante Lamptey, Chengwen Sun, Jagdish Singh","doi":"10.1016/j.omtn.2024.102210","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102210","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"35 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the Therapeutic Potential of Locked Nucleic Acids through Lipid Nanoparticle Delivery 通过脂质纳米颗粒递送释放锁定核酸的治疗潜力
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102224
Shahd Qassem, Dor Breier, G. Naidu, I. Hazan-Halevy, Dan Peer
{"title":"Unlocking the Therapeutic Potential of Locked Nucleic Acids through Lipid Nanoparticle Delivery","authors":"Shahd Qassem, Dor Breier, G. Naidu, I. Hazan-Halevy, Dan Peer","doi":"10.1016/j.omtn.2024.102224","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102224","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"32 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141137288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and viral replication 一种新型多靶点自组装多肽-siRNA 复合物，可同时抑制 SARS-CoV-2 与宿主细胞的相互作用和病毒复制
Molecular Therapy - Nucleic Acids Pub Date : 2024-05-01 DOI: 10.1016/j.omtn.2024.102227
Martina Tuttolomondo, Stephanie Thuy Duong Pham, Mikkel G Terp, Virginia Cendán Castillo, Nazmie Kalisi, Stefan Vogel, Niels Langkjær, Ulla Melchior Hansen, Helge Thisgaard, Henrik Daa Schrøder, Y. Palarasah, Henrik Jørn Ditzel
{"title":"A novel multitargeted self-assembling peptide-siRNA complex for simultaneous inhibition of SARS-CoV-2-host cell interaction and viral replication","authors":"Martina Tuttolomondo, Stephanie Thuy Duong Pham, Mikkel G Terp, Virginia Cendán Castillo, Nazmie Kalisi, Stefan Vogel, Niels Langkjær, Ulla Melchior Hansen, Helge Thisgaard, Henrik Daa Schrøder, Y. Palarasah, Henrik Jørn Ditzel","doi":"10.1016/j.omtn.2024.102227","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102227","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"23 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141139896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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