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Molecular Therapy - Nucleic Acids最新文献

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Effective AAV-mediated gene replacement therapy in retinal organoids modelling AIPL1-associated LCA4 在模拟 AIPL1 相关 LCA4 的视网膜器官组织中进行有效的 AAV 介导的基因替代治疗
Molecular Therapy - Nucleic Acids Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102148
Hali Sai, Bethany Ollington, Farah O. Rezek, Niuzheng Chai, Amelia Lane, Tassos Georgiadis, James Bainbridge, Michel Michaelides, Almudena Sacristán-Reviriego, P. Perdigão, Amy Leung, J. van der Spuy
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引用次数: 0
Effective AAV-mediated gene replacement therapy in retinal organoids modelling AIPL1-associated LCA4 在模拟 AIPL1 相关 LCA4 的视网膜器官组织中进行有效的 AAV 介导的基因替代治疗
Molecular Therapy - Nucleic Acids Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102148
Hali Sai, Bethany Ollington, Farah O. Rezek, Niuzheng Chai, Amelia Lane, Tassos Georgiadis, James Bainbridge, Michel Michaelides, Almudena Sacristán-Reviriego, P. Perdigão, Amy Leung, J. van der Spuy
{"title":"Effective AAV-mediated gene replacement therapy in retinal organoids modelling AIPL1-associated LCA4","authors":"Hali Sai, Bethany Ollington, Farah O. Rezek, Niuzheng Chai, Amelia Lane, Tassos Georgiadis, James Bainbridge, Michel Michaelides, Almudena Sacristán-Reviriego, P. Perdigão, Amy Leung, J. van der Spuy","doi":"10.1016/j.omtn.2024.102148","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102148","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"33 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139815885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-128-3p – a grey eminence of the human central nervous system MiR-128-3p--人类中枢神经系统的灰色突起
Molecular Therapy - Nucleic Acids Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102141
Klaudia Kiel, Sylwia Katarzyna Król, Agnieszka Bronisz, J. Godlewski
{"title":"MiR-128-3p – a grey eminence of the human central nervous system","authors":"Klaudia Kiel, Sylwia Katarzyna Król, Agnieszka Bronisz, J. Godlewski","doi":"10.1016/j.omtn.2024.102141","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102141","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139819608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic mRNA delivered to human cells leads to expression of Cpl-1 bacteriophage-endolysin with activity against Streptococcus pneumoniae 将合成的 mRNA 运送到人体细胞后，可表达具有抗肺炎链球菌活性的 Cpl-1 噬菌体内溶素
Molecular Therapy - Nucleic Acids Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102145
Moritz K. Jansson, Dat Tien Nguyen, Stefan Mikkat, Carolin Warnke, Marc Benjamin Janssen, Philipp Warnke, Bernd Kreikemeyer, N. Patenge
{"title":"Synthetic mRNA delivered to human cells leads to expression of Cpl-1 bacteriophage-endolysin with activity against Streptococcus pneumoniae","authors":"Moritz K. Jansson, Dat Tien Nguyen, Stefan Mikkat, Carolin Warnke, Marc Benjamin Janssen, Philipp Warnke, Bernd Kreikemeyer, N. Patenge","doi":"10.1016/j.omtn.2024.102145","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102145","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"238 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139821392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-449a ANTAGONIZES EMT THROUGH IL-6-MEDIATED TRANS- SIGNALING IN LARYNGEAL SQUAMOUS CANCER MiR-449a通过IL-6介导的信号转导抑制喉癌中的EMT
Molecular Therapy - Nucleic Acids Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102140
A. Cossu, Federica Melisi, Teresa Maria Rosaria Noviello, Lucia Stefania Pasquale, P. Grisolia, Carla Reale, Marco Bocchetti, Michela Falco, Chiara Tammaro, Nunzio Accardo, Francesco Longo, Salvatore Allosso, Massimo Mesolella, Raffaele Addeo, Francesco Perri, A. Ottaiano, Filippo Ricciardiello, Evžen Amler, C. Ambrosino, G. Misso, Michele Ceccarelli, M. Caraglia, M. Scrima
{"title":"MiR-449a ANTAGONIZES EMT THROUGH IL-6-MEDIATED TRANS- SIGNALING IN LARYNGEAL SQUAMOUS CANCER","authors":"A. Cossu, Federica Melisi, Teresa Maria Rosaria Noviello, Lucia Stefania Pasquale, P. Grisolia, Carla Reale, Marco Bocchetti, Michela Falco, Chiara Tammaro, Nunzio Accardo, Francesco Longo, Salvatore Allosso, Massimo Mesolella, Raffaele Addeo, Francesco Perri, A. Ottaiano, Filippo Ricciardiello, Evžen Amler, C. Ambrosino, G. Misso, Michele Ceccarelli, M. Caraglia, M. Scrima","doi":"10.1016/j.omtn.2024.102140","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102140","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"309 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-128-3p – a grey eminence of the human central nervous system MiR-128-3p--人类中枢神经系统的灰色突起
Molecular Therapy - Nucleic Acids Pub Date : 2024-02-01 DOI: 10.1016/j.omtn.2024.102141
Klaudia Kiel, Sylwia Katarzyna Król, Agnieszka Bronisz, J. Godlewski
{"title":"MiR-128-3p – a grey eminence of the human central nervous system","authors":"Klaudia Kiel, Sylwia Katarzyna Król, Agnieszka Bronisz, J. Godlewski","doi":"10.1016/j.omtn.2024.102141","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102141","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"22 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139879668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The function of tRNA-derived small RNAs in cardiovascular diseases tRNA 衍生的小 RNA 在心血管疾病中的功能
Molecular Therapy - Nucleic Acids Pub Date : 2024-01-01 DOI: 10.1016/j.omtn.2024.102114
Yan Zhao, Kai Wang, Chun Zhao, Ning Liu, Zhihong Wang, Wenting Yang, Zewei Cheng, Luyu Zhou, Kun Wang
{"title":"The function of tRNA-derived small RNAs in cardiovascular diseases","authors":"Yan Zhao, Kai Wang, Chun Zhao, Ning Liu, Zhihong Wang, Wenting Yang, Zewei Cheng, Luyu Zhou, Kun Wang","doi":"10.1016/j.omtn.2024.102114","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102114","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promising strategies employing nucleic acids as antimicrobial drugs 将核酸作为抗菌药物的前景战略
Molecular Therapy - Nucleic Acids Pub Date : 2024-01-01 DOI: 10.1016/j.omtn.2024.102122
Luís Moreira, N. Guimarães, Rita S. Santos, Joana A. Loureiro, Maria C. Pereira, Nuno F. Azevedo
{"title":"Promising strategies employing nucleic acids as antimicrobial drugs","authors":"Luís Moreira, N. Guimarães, Rita S. Santos, Joana A. Loureiro, Maria C. Pereira, Nuno F. Azevedo","doi":"10.1016/j.omtn.2024.102122","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102122","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"88 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139635481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multispecies-targeting siRNAs for the modulation of JAK1 in the skin 多物种靶向 siRNA 用于调节皮肤中的 JAK1
Molecular Therapy - Nucleic Acids Pub Date : 2024-01-01 DOI: 10.1016/j.omtn.2024.102117
Qi Tang, Katherine Y. Gross, H. Fakih, Samuel O. Jackson, Mohammad Zain Ui Abideen, Kathryn R. Monopoli, Carine Blanchard, Claire Bouix-Peter, Thibaud Portal, John E. Harris, Anastasia Khvorova, J. Alterman
{"title":"Multispecies-targeting siRNAs for the modulation of JAK1 in the skin","authors":"Qi Tang, Katherine Y. Gross, H. Fakih, Samuel O. Jackson, Mohammad Zain Ui Abideen, Kathryn R. Monopoli, Carine Blanchard, Claire Bouix-Peter, Thibaud Portal, John E. Harris, Anastasia Khvorova, J. Alterman","doi":"10.1016/j.omtn.2024.102117","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102117","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"50 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139456355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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