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MRNACalc: An accurate RNA quantification tool in the era of modified nucleosides MRNACalc：修饰核苷时代的精确 RNA 定量工具
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102226
Sabine den Roover, J. Aerts
{"title":"MRNACalc: An accurate RNA quantification tool in the era of modified nucleosides","authors":"Sabine den Roover, J. Aerts","doi":"10.1016/j.omtn.2024.102226","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102226","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"26 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Large Language Model (LLM) to Multimodal Large Language Model (MLLM): A journey to shape the biological macromolecules to biological sciences and medicine 从大型语言模型（LLM）到多模态大型语言模型（MLLM）：从生物大分子到生物科学和医学的塑造之旅
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102255
M. Bhattacharya, S. Pal, S. Chatterjee, Sang-Soo Lee, C. Chakraborty
{"title":"Large Language Model (LLM) to Multimodal Large Language Model (MLLM): A journey to shape the biological macromolecules to biological sciences and medicine","authors":"M. Bhattacharya, S. Pal, S. Chatterjee, Sang-Soo Lee, C. Chakraborty","doi":"10.1016/j.omtn.2024.102255","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102255","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk-factors 利用预选的 RNA aptamer 池进行无偏血浆分析，预测 COVID-19 的死亡率并确定蛋白质风险因素
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102253
Asger Givskov Jørgensen, D. M. Dupont, Søren Fjelstrup, Claus Bus, C. Hansen, Thomas Benfield, Peter Garred, Peter M.H. Heegaard, Jørgen Kjems
{"title":"Unbiased plasma profiling using pre-selected RNA aptamer pools predicts mortality in COVID-19 and identifies protein risk-factors","authors":"Asger Givskov Jørgensen, D. M. Dupont, Søren Fjelstrup, Claus Bus, C. Hansen, Thomas Benfield, Peter Garred, Peter M.H. Heegaard, Jørgen Kjems","doi":"10.1016/j.omtn.2024.102253","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102253","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"4 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141394837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to improve the design of gapmer antisense oligonucleotide on allele-specific silencing 改进等位基因特异性沉默的间隙反义寡核苷酸设计的策略
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102237
S. Aguti, Shuzhi Cheng, Pierpaolo Ala, Sean Briggs, Francesco Muntoni, Haiyan Zhou
{"title":"Strategies to improve the design of gapmer antisense oligonucleotide on allele-specific silencing","authors":"S. Aguti, Shuzhi Cheng, Pierpaolo Ala, Sean Briggs, Francesco Muntoni, Haiyan Zhou","doi":"10.1016/j.omtn.2024.102237","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102237","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"130 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT 立体纯化反义寡核苷酸用于等位基因选择性降低突变型 HTT 的临床前评估
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102246
Naoki Iwamoto, Yuanjing Liu, M. Frank-Kamenetsky, Abbie Maguire, Wei Chou Tseng, Kristin Taborn, Nayantara Kothari, Ali Akhtar, K. Bowman, J. Shelke, A. Lamattina, X. Hu, Hyun Gyung Jang, P. Kandasamy, Fangjun Liu, K. Longo, Richard Looby, Meena, Jake Metterville, Qianli Pan, E. Purcell-Estabrook, M. Shimizu, Priyanka Shiva Prakasha, S. Standley, Hansini Upadhyay, Hailin Yang, Yuan Yin, Anderson Zhao, Christopher Francis, M. Byrne, Elena Dale, G. Verdine, C. Vargeese
{"title":"Preclinical evaluation of stereopure antisense oligonucleotides for allele-selective lowering of mutant HTT","authors":"Naoki Iwamoto, Yuanjing Liu, M. Frank-Kamenetsky, Abbie Maguire, Wei Chou Tseng, Kristin Taborn, Nayantara Kothari, Ali Akhtar, K. Bowman, J. Shelke, A. Lamattina, X. Hu, Hyun Gyung Jang, P. Kandasamy, Fangjun Liu, K. Longo, Richard Looby, Meena, Jake Metterville, Qianli Pan, E. Purcell-Estabrook, M. Shimizu, Priyanka Shiva Prakasha, S. Standley, Hansini Upadhyay, Hailin Yang, Yuan Yin, Anderson Zhao, Christopher Francis, M. Byrne, Elena Dale, G. Verdine, C. Vargeese","doi":"10.1016/j.omtn.2024.102246","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102246","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"56 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of DNA Minicircles for Delivery of Adenine and Cytosine Base Editors using Activatable Gene On “GO” Reporter Imaging Systems 利用可激活的基因 "GO "报告成像系统评估用于递送腺嘌呤和胞嘧啶碱基编辑器的 DNA 小环
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102248
Melissa M. Evans, Shirley Liu, Joshua S. Krautner, Caroline G. Seguin, Rajan Leung, John A. Ronald
{"title":"Evaluation of DNA Minicircles for Delivery of Adenine and Cytosine Base Editors using Activatable Gene On “GO” Reporter Imaging Systems","authors":"Melissa M. Evans, Shirley Liu, Joshua S. Krautner, Caroline G. Seguin, Rajan Leung, John A. Ronald","doi":"10.1016/j.omtn.2024.102248","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102248","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"498 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CircHTT(2,3,4,5,6) – co-evolving with the HTT CAG-repeat tract - modulates Huntington`s disease phenotypes CircHTT（2,3,4,5,6）--与 HTT CAG 重复序列共同进化--调节亨廷顿病的表型
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102234
Jasmin Morandell, A. Monziani, Martina Lazioli, Deborah Donzel, J. Döring, Claudio Oss Pegorar, Angela D’Anzi, M. Pellegrini, Andrea Mattiello, Dalia Bortolotti, G. Bergonzoni, T. Tripathi, Virginia B. Mattis, M. Kovalenko, Jessica Rosati, Christoph Dieterich, E. Dassi, V. Wheeler, Z. Ellederová, J. Wilusz, Gabriella Viero, M. Biagioli
{"title":"CircHTT(2,3,4,5,6) – co-evolving with the HTT CAG-repeat tract - modulates Huntington`s disease phenotypes","authors":"Jasmin Morandell, A. Monziani, Martina Lazioli, Deborah Donzel, J. Döring, Claudio Oss Pegorar, Angela D’Anzi, M. Pellegrini, Andrea Mattiello, Dalia Bortolotti, G. Bergonzoni, T. Tripathi, Virginia B. Mattis, M. Kovalenko, Jessica Rosati, Christoph Dieterich, E. Dassi, V. Wheeler, Z. Ellederová, J. Wilusz, Gabriella Viero, M. Biagioli","doi":"10.1016/j.omtn.2024.102234","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102234","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"125 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141282107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lowering an ER-stress-regulated long noncoding RNA protects mice from diabetes and isolated pancreatic islets from cell death. 降低ER应激调控的长非编码RNA可保护小鼠免受糖尿病和离体胰岛细胞死亡。
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102252
Mitsuo Kato, Maryam Abdollahi, Keiko Omori, Vajir Malek, L. Lanting, Fouad R. Kandeel, Jeffrey Rawson, Walter Tsark, Lingxiao Zhang, Mei Wang, Ragadeepthi Tunduguru, Rama Natarajan
{"title":"Lowering an ER-stress-regulated long noncoding RNA protects mice from diabetes and isolated pancreatic islets from cell death.","authors":"Mitsuo Kato, Maryam Abdollahi, Keiko Omori, Vajir Malek, L. Lanting, Fouad R. Kandeel, Jeffrey Rawson, Walter Tsark, Lingxiao Zhang, Mei Wang, Ragadeepthi Tunduguru, Rama Natarajan","doi":"10.1016/j.omtn.2024.102252","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102252","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"128 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selection of DNA aptamers that prevent the fibrillization of α-synuclein protein in cellular and mouse models 在细胞和小鼠模型中筛选出能阻止α-突触核蛋白纤维化的DNA适配体
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102251
E. McConnell, Dennis Chan, Katelyn Ventura, Joshua P. Callahan, Kathryn Harris, Vernon Hunt, Spencer Boisjoli, Daniel Knight, Evan T. Monk, Matthew R. Holahan, M. DeRosa
{"title":"Selection of DNA aptamers that prevent the fibrillization of α-synuclein protein in cellular and mouse models","authors":"E. McConnell, Dennis Chan, Katelyn Ventura, Joshua P. Callahan, Kathryn Harris, Vernon Hunt, Spencer Boisjoli, Daniel Knight, Evan T. Monk, Matthew R. Holahan, M. DeRosa","doi":"10.1016/j.omtn.2024.102251","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102251","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"11 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid Nanoparticle Technology-Mediated Therapeutic Gene Manipulation in the Eyes 脂质纳米粒子技术介导的眼部治疗基因操作
Molecular Therapy - Nucleic Acids Pub Date : 2024-06-01 DOI: 10.1016/j.omtn.2024.102236
Ting Wang, Tao Yu, Qian Liu, Tzu-Cheng Sung, Akon Higuchi
{"title":"Lipid Nanoparticle Technology-Mediated Therapeutic Gene Manipulation in the Eyes","authors":"Ting Wang, Tao Yu, Qian Liu, Tzu-Cheng Sung, Akon Higuchi","doi":"10.1016/j.omtn.2024.102236","DOIUrl":"https://doi.org/10.1016/j.omtn.2024.102236","url":null,"abstract":"","PeriodicalId":503104,"journal":{"name":"Molecular Therapy - Nucleic Acids","volume":"54 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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