International Journal of Nursing Studies最新文献

{"title":"Authors' response to \"Comment on Zhang et al. (2025) 'Effectiveness of exercise-based interventions in preventing cancer therapy-related cardiac dysfunction in patients with breast cancer: A systematic review and network meta-analysis'\".","authors":"Dandan Zhang, Hexiao Ding, Ruisi Ma, Ting Liu","doi":"10.1016/j.ijnurstu.2025.105107","DOIUrl":"https://doi.org/10.1016/j.ijnurstu.2025.105107","url":null,"abstract":"","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":" ","pages":"105107"},"PeriodicalIF":7.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driving behavior and driving outcomes after acute and critical illness: A systematic review","authors":"Valerie Danesh ,&nbsp;Anthony D. McDonald ,&nbsp;Kellia J. Hansmann ,&nbsp;Leanne M. Boehm ,&nbsp;Han Su ,&nbsp;Tammy L. Eaton ,&nbsp;Kelly M. Toth ,&nbsp;Alejandro C. Arroliga ,&nbsp;Brittany D. Work ,&nbsp;Joanne McPeake","doi":"10.1016/j.ijnurstu.2025.105105","DOIUrl":"10.1016/j.ijnurstu.2025.105105","url":null,"abstract":"<div><h3>Background</h3><div>Adults recovering from hospitalization for acute or critical illnesses often face new or worsening physical and cognitive impairments, which can impact their driving abilities and safety. The purpose of this review is to synthesize evidence on driving behaviors and outcomes in the six months following hospitalization for acute or critical illness to guide patient care, provider recommendations, and future research.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted on PubMed, CINAHL, PsycINFO, and Cochrane databases from 1997 to October 20, 2023 with forward and backward searches.</div><div>Primary empirical research involving vehicle drivers was included. Studies were excluded if they involved fewer than five participants, or if they focused on acute medical conditions with established driving rehabilitation programs. Two reviewers screened abstracts and full texts, resolving discrepancies through discussion.</div></div><div><h3>Results</h3><div>Nineteen studies met the inclusion criteria. Driving behavior and safety data from these studies were derived from simulators (n = 10), self-reports (n = 8) and administrative/regulatory datasets (n = 1). Simulation studies primarily focused on post-surgical populations, and brake reaction times. Self-report studies highlighted driving suspension, cessation, and perceived safety issues. The heterogeneity of study designs and populations limited formal meta-analyses.</div></div><div><h3>Discussion</h3><div>The evidence on driving safety and behavior post-hospitalization is heterogeneous and sparse, with some studies indicating no significant change in collision rates and others showing increased risks. Consequently, clinicians face challenges in recommendations on return to driving. There is a need for robust study designs and naturalistic driving studies to examine the specific impacts of hospitalization on driving safety and to develop evidence-based guidelines to address discharge planning to answer questions of “when should I return to driving?”</div></div><div><h3>Registration</h3><div>PROSPERO identifier CRD42023464876.</div></div>","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"168 ","pages":"Article 105105"},"PeriodicalIF":7.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Zhang et al. (2025) 'Effectiveness of exercise-based interventions in preventing cancer therapy-related cardiac dysfunction in patients with breast cancer: A systematic review and network meta-analysis'.","authors":"Da Qian,Haotian Su,Xuli Meng","doi":"10.1016/j.ijnurstu.2025.105106","DOIUrl":"https://doi.org/10.1016/j.ijnurstu.2025.105106","url":null,"abstract":"","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"19 1","pages":"105106"},"PeriodicalIF":8.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'They never listen' - Normalised deviance in nursing and midwifery staffing.","authors":"Stuart Tuckwood,Peter Griffiths","doi":"10.1016/j.ijnurstu.2025.105110","DOIUrl":"https://doi.org/10.1016/j.ijnurstu.2025.105110","url":null,"abstract":"","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"19 1","pages":"105110"},"PeriodicalIF":8.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nurse-led interventions on enhancing patient-related outcomes in colorectal cancer management throughout the cancer care continuum: A systematic review and meta-analysis","authors":"Yitong Han,&nbsp;Yujie Han,&nbsp;Wenshan Huang,&nbsp;Yantong Liu,&nbsp;Ziqi Wang,&nbsp;Wei Zhao,&nbsp;Wei Zhang","doi":"10.1016/j.ijnurstu.2025.105100","DOIUrl":"10.1016/j.ijnurstu.2025.105100","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Colorectal cancer ranks third in global incidence and second in cancer-related mortality worldwide. Despite persistent challenges across the care continuum, nurses play a pivotal role in optimizing patient outcomes through tailored interventions. However, robust evidence on the clinical efficacy and optimal delivery of nurse-led interventions remains limited.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To describe the health problems of the participants and nurse-led interventions in accordance with the Omaha System and summarize evidence on the effects of these interventions throughout the continuum from colorectal cancer screening to survivorship.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Eight databases, namely, Web of Science, the Cochrane Library, the Cumulative Index to Nursing and Allied Health Literature, EMBASE, PubMed, Scopus, China National Knowledge Infrastructure and Wanfang Data, were searched from their inception to May 2024. Additionally, the reference lists of the included studies were examined. Content analysis was applied to identify problems and interventions based on the Omaha System. Meta-analysis and descriptive analysis were adopted. Subgroup analyses were conducted on the basis of the study design, treatment history and mode of intervention delivery.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Twenty-eight studies identified problems and types of nurse-led interventions. There were 13 problems in the psychosocial, physiological and health-related behaviors domains. The nurse-led interventions included teaching, guidance and counseling; case management; and treatments and procedures. Nurse-led interventions improved screening rates for colonoscopy and fecal occult blood testing (odds ratio [OR] = 2.51; 95 % confidence interval [CI]: 2.16 to 2.92; p &lt; 0.001; OR = 6.14; 95 % CI: 1.93 to 19.47; p = 0.002), the adequacy of bowel preparation (OR = 1.69; 95 % CI: 1.40 to 2.03; p &lt; 0.001), stoma self-efficacy (standardized mean difference [SMD] = 2.48; 95 % CI: 0.71 to 4.25; p = 0.006), and quality of life (SMD = 0.72; 95 % CI: 0.21 to 1.22; p = 0.005), and reduced the incidence of stoma complications (OR = 0.28; 95 % CI: 0.18 to 0.42; p &lt; 0.001), anxiety (SMD = −&lt;!--&gt; &lt;!--&gt;1.19; 95 % CI: −&lt;!--&gt; &lt;!--&gt;1.40 to −&lt;!--&gt; &lt;!--&gt;0.99; p &lt; 0.001), and depression (SMD = −&lt;!--&gt; &lt;!--&gt;1.00; 95 % CI: −&lt;!--&gt; &lt;!--&gt;1.20 to −&lt;!--&gt; &lt;!--&gt;0.79; p &lt; 0.001). However, nurse-led interventions were ineffective in reducing distress and addressing unmet supportive care needs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Nurse-led interventions can reduce stoma complications, anxiety and depression and increase the screening rate for colorectal cancer, the adequacy of bowel preparation, stoma self-efficiency and quality of life. Nevertheless, future rigorous research is needed to validate their effects and inform wider implementation.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Registration&lt;/h3&gt;&lt;div&gt;PROSPERO (CRD42024505730) registered on February 18, 2024.&lt;/di","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"168 ","pages":"Article 105100"},"PeriodicalIF":7.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different frequencies of ventilator circuit changes on the incidence of ventilator-associated pneumonia: A network meta-analysis","authors":"Kangle Guo ,&nbsp;Xue Shang ,&nbsp;Yinghua Zhang ,&nbsp;Xiuxia Li ,&nbsp;Kehu Yang ,&nbsp;Yan Wang","doi":"10.1016/j.ijnurstu.2025.105099","DOIUrl":"10.1016/j.ijnurstu.2025.105099","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effect of different frequencies of ventilator circuit changes on the occurrence of ventilation-associated pneumonia using network meta-analysis.</div></div><div><h3>Methods</h3><div>Chinese and English databases were systematically searched to collect eligible studies on the relationship between ventilator circuit changes and ventilation-associated pneumonia. The incidence of pneumonia for each change frequency was pooled using R software, and network meta-analysis was performed using Stata software to determine the optimal change frequency.</div></div><div><h3>Results</h3><div>A total of 23 studies were included, including nine ventilator circuit changes with different frequencies. The meta-analysis showed that the combined incidence of pneumonia was 25 %. Network meta-analysis showed 3-day circuit changes significantly reduced ventilation-associated pneumonia incidence compared with 1 day (odds ratio (OR) = 0.26, 95 % confidence interval (CI) [0.10, 0.69]), 2 days (OR = 0.41, 95 % CI [0.20, 0.87]), 4 days (OR = 0.17, 95 % CI [0.04, 0.72]), and 14 days (OR = 0.11, 95 % CI [0.02, 0.50]). Direct meta-analysis showed no significant difference in 3-day circuit changes versus 1 day, 3-day circuit changes versus 14 days, and 7-day circuit changes versus 14 days. The probability ranking indicated that a 3-day frequency of ventilator circuit changes had the greatest probability of being the optimal intervention, followed by 5 days and 7 days.</div></div><div><h3>Conclusion</h3><div>The meta-analysis showed that ventilator circuit changes every 3 days had the best effect, but once a week also showed a positive preventive effect, with no significant effect on ventilation-associated pneumonia occurrence. These findings combined with existing evidence indicate that high frequency changes in the ventilator circuit should be avoided.</div></div>","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"168 ","pages":"Article 105099"},"PeriodicalIF":7.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asking the tough questions and having crucial conversations: promoting the value and quality of healthcare simultaneously.","authors":"Patricia M Davidson,David C Currow,Steven Z Pantilat,Kenneth Hillman","doi":"10.1016/j.ijnurstu.2025.105098","DOIUrl":"https://doi.org/10.1016/j.ijnurstu.2025.105098","url":null,"abstract":"","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"8 1","pages":"105098"},"PeriodicalIF":8.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of advance care planning for patients with advanced cancer: A meta-analysis of randomized controlled studies","authors":"Shu Zhang ,&nbsp;Juejin Li ,&nbsp;Yun Zhang ,&nbsp;Xiaolin Hu","doi":"10.1016/j.ijnurstu.2025.105096","DOIUrl":"10.1016/j.ijnurstu.2025.105096","url":null,"abstract":"<div><h3>Background</h3><div>Patients with advanced cancer often have to make difficult end-of-life decisions, which are closely associated with their access to anticipated care after loss of mental capacity. Advance care planning, an approach of discussing, documenting, and deciding on end-of-life preferences, helps with better decision-making. However, despite being recommended for oncology care, its efficacy for patients with advanced cancer remains unclear.</div></div><div><h3>Objective</h3><div>To explore the effects of advance care planning in patients with advanced cancer.</div></div><div><h3>Design</h3><div>Systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>Twelve electronic databases, including Embase, Medline, the Cochrane Central Register of Controlled Trials, PsycINFO, Web of Science, CINAHL complete, CBM, CNKI, VIP, Wanfang, Google Scholar and Proguest Dissertations and Theses, were searched from inception to December 2024. The Cochrane Risk of Bias Tool 2.0 was used to evaluate the quality of the included studies. Meta-analysis was performed with R software, and outcomes not amenable to meta-analysis were narratively synthesized.</div></div><div><h3>Results</h3><div>Fourteen studies were included. The results of the meta-analysis implied that advance care planning significantly improved the completion of advance directives (OR = 7.93, 95 % CI: 2.76–22.77, P = 0.0001) and palliative care utilization (OR = 1.39, 95 % CI: 1.08–1.78, P = 0.0009). Anxiety (SMD = −<!--> <!-->0.14, 95 % CI: −<!--> <!-->0.52–0.23, P = 0.45), depression (SMD = −<!--> <!-->0.10, 95 % CI: −<!--> <!-->0.55–0.34, P = 0.66), decisional conflicts (MD = −<!--> <!-->1.25, 95 % CI: −<!--> <!-->3.67–1.18, P = 0.31), patient satisfaction (SMD = 0.19, 95 % CI: −<!--> <!-->0.23–0.70, P = 0.47), and quality of life (SMD = 0.32, 95 % CI: −<!--> <!-->0.83–1.48, P = 0.58) were not improved. In the narrative synthesis, dignity was enhanced, but the effects of concordance between actual care received and preferences were inconsistent. In general, existing advance care planning is primarily delivered in a face-to-face format in hospitals and focuses on older patients.</div></div><div><h3>Conclusions</h3><div>Advance care planning may have desirable impacts on improving the completion of advance directives and palliative care utilization for patients with advanced cancer. It was not effective in improving anxiety, depression, decisional conflicts, patient satisfaction, and quality of life. The effects of dignity and care concordance need to be further validated. Young patient-specific, digital technology-based, and in-home advance care planning is encouraged, and the optimal timing of interventions also needs to be clarified.</div></div>","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"168 ","pages":"Article 105096"},"PeriodicalIF":7.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk prediction model for chemotherapy-induced nausea and vomiting in cancer patients: a systematic review","authors":"Yongjian Wang ,&nbsp;Ruishuang Zheng ,&nbsp;Yunting Wu ,&nbsp;Ting Liu ,&nbsp;Liqian Hao ,&nbsp;Jue Liu ,&nbsp;Lili Shi ,&nbsp;Qing Guo","doi":"10.1016/j.ijnurstu.2025.105094","DOIUrl":"10.1016/j.ijnurstu.2025.105094","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Chemotherapy-induced nausea and vomiting increase the healthcare burden and lead to adverse clinical outcomes in cancer patients. Although many risk prediction models for chemotherapy-induced nausea and vomiting have been developed, their methodological quality and applicability remain uncertain.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;To systematically review and evaluate existing studies on risk prediction models for chemotherapy-induced nausea and vomiting in cancer patients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;PubMed, the Cochrane Library, Embase, Web of science, CINAHL, Scopus, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database, Chinese Biomedical literature Database (CBM) were systematically searched from inception to October 1, 2024. Studies were appraised critically and data extracted by two authors independently based on the Prediction Model Risk of Bias Assessment Tool (PROBAST) and Data Extraction for Systematic Reviews of Prediction Modeling Studies (CHARMS).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 4195 articles were retrieved, ultimately including 17 studies with 62 models for chemotherapy-induced nausea and vomiting. The sample size of the included studies ranged from 137 to 2215, with areas under the curve ranging from 0.602 to 0.850. In this study, the deep forest model demonstrated strong discrimination and calibration, outperforming conventional machine learning and traditional regression models. The five most important predictors in the deep forest model were creatinine clearance, age, sex, anticipatory nausea and vomiting, and antiemetic regimen. Across all included studies, age, chemotherapy regimens, cycles of chemotherapy, history of alcohol consumption, prior episodes of chemotherapy-induced nausea and vomiting, sleep quality before chemotherapy, sex, antiemetic regimens, history of morning sickness, anticipatory nausea and vomiting, were the most frequently reported predictors. All studies were rated as high risk of bias mainly due to poor reporting of the participants and analysis domains, with high concerns regarding applicability in 9 studies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The research on prediction models for chemotherapy-induced nausea and vomiting model is in its developing stage, with both commonalities and differences in predictors. Despite the overall acceptable performance of chemotherapy-induced nausea and vomiting models, most studies have methodological shortcomings, and few models have been validated. Future studies should refer to the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) guideline for model design, implementation, and reporting. Moreover, studies with larger sample sizes and multicenter external validation are necessary to enhance the robustness of predictive models.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Registration&lt;/h3&gt;&lt;div&gt;The protocol for th","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"168 ","pages":"Article 105094"},"PeriodicalIF":7.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for women undergoing in vitro fertilization: An updated systematic review and meta-analysis with trial sequential analysis","authors":"Qin-Wei Fu ,&nbsp;Shao-Mi Zhu ,&nbsp;Ji Chen ,&nbsp;Yong-Qin Liu ,&nbsp;Chang-Hao Liang ,&nbsp;Lin-Jiang Song ,&nbsp;Jing Zhuang ,&nbsp;Xin Tan ,&nbsp;Li-Zhou Liu ,&nbsp;Ling Luo ,&nbsp;Hai-Yan Yin ,&nbsp;Wing-Fai Yeung ,&nbsp;Shu-Cheng Chen ,&nbsp;Wei-Ting Liu ,&nbsp;Qin-Xiu Zhang ,&nbsp;Yong Tang","doi":"10.1016/j.ijnurstu.2025.105097","DOIUrl":"10.1016/j.ijnurstu.2025.105097","url":null,"abstract":"<div><h3>Background</h3><div>In vitro fertilization (IVF) is a widely utilized assisted reproductive technology, but its success rates remain suboptimal due to various physiological and psychological factors. Acupuncture, as a complementary therapy, has been proposed to improve reproductive outcomes and alleviate associated pain and anxiety.</div></div><div><h3>Objective</h3><div>To evaluate the effectiveness and safety of acupuncture as an adjunctive treatment for women undergoing IVF, focusing on reproductive outcomes, pain reduction, and anxiety alleviation.</div></div><div><h3>Methods</h3><div>Five English databases were searched up to June 20th, 2024. Manual acupuncture or electro-acupuncture was used solely as a complementary adjuvant in the experimental groups, and control interventions were sham acupuncture or blank (wait-list) control. Systematic reviews and meta-analyses were conducted based on the Cochrane systematic review method, and trial sequential analyses were performed. Meta-influence analyses, meta-regression and subgroup-analyses were performed for exploration of heterogeneity and related variables. Egger’s together with trim and fill tests were conducted for evaluation of publication bias. The quality of the results was assessed, and correlation coefficient and cluster analyses were also performed.</div></div><div><h3>Results</h3><div>Finally, 42 trials identified from 37 published articles, involving 7400 participants, were included, representing diverse populations worldwide. Compared to sham acupuncture and blank controls, acupuncture significantly (P &lt; 0.05) improved biochemical pregnancy rate (RR = 1.28, 95 % CI: 1.04-1.57) and clinical pregnancy rates (RR = 1.19, 95 % CI: 1.06-1.34). Additionally, acupuncture was associated with better pain management during surgery and reduced anxiety levels. Acupuncture-specific adverse events were reported in eight of 42 trials, primarily mild to moderate local reactions. However, a significantly higher early miscarriage rate was observed in the acupuncture groups (RR = 1.51, 95 % CI: 1.10-2.08).</div></div><div><h3>Conclusions</h3><div>Acupuncture may improve certain reproductive outcomes and alleviate pain and anxiety in women undergoing IVF. However, the potential risk of early miscarriage warrants caution, and further rigorous trials are needed to confirm these findings.</div></div><div><h3>Registration</h3><div>PROSPERO registration number CRD42020206012.</div></div>","PeriodicalId":50299,"journal":{"name":"International Journal of Nursing Studies","volume":"168 ","pages":"Article 105097"},"PeriodicalIF":7.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}