不同数字干预对轻度认知障碍或痴呆患者的疗效：系统综述和网络荟萃分析

IF 7.1 1区医学 Q1 NURSING

International Journal of Nursing Studies Pub Date : 2025-05-29 DOI:10.1016/j.ijnurstu.2025.105129

Xin Lin , Guangyi Xu , Mengjiao Zhao , Yunxia Jiang

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引用次数: 0

摘要

认知障碍患者的数量正在迅速增加。先前的研究表明，数字认知训练是一种有前途、安全、有效的非药物治疗方法，但目前尚不清楚哪种数字干预最有效。本研究的目的是比较不同数字干预对认知功能轻度认知障碍（MCI）或痴呆的有效性。目的本研究通过网络荟萃分析评估不同数字干预对MCI或痴呆患者的疗效。方法系统检索Pubmed、Web of science、Embase、Cochrane中央对照试验注册库、中国知网（CNKI）、VIP Journal、万方数据库，检索时间为2025年1月1日至2025年1月1日，纳入评价计算机化认知干预对MCI或痴呆患者整体认知、执行功能和记忆功能影响的随机对照试验（RCTs）。采用一致性模型进行网络元分析。结果共纳入文献57篇，纳入受试者3182人。网络荟萃分析显示，基于移动设备的电子游戏是减缓全球认知能力下降(标准平均差（SMD) = 5.09, 95%置信区间（95% CI） 2.17, 11.91）和执行功能下降（SMD = 0.17, 95% CI 0.03, 0.90）的最有效干预措施。在记忆功能方面，沉浸式虚拟现实技术是减缓记忆衰退最有效的认知干预（SMD = 2.71, 95% CI 1.35, 5.46）。结论数字认知干预效果优于常规治疗，移动视频游戏和沉浸式虚拟现实可能是减缓认知衰退的最佳数字认知干预手段。

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Efficacy of different digital interventions in patients with mild cognitive impairment or dementia: A systematic review and network meta-analysis

Background

The number of people living with cognitive impairment is increasing rapidly. Previous research has shown that digital cognitive training is a promising, safe, and efficacious non-pharmacological treatment, but it is unclear which digital intervention is most effective. The purpose of this study was to compare the effectiveness of different digital interventions on cognitive function mild cognitive impairment (MCI) or dementia.

Objective

This study evaluated the efficacy of different digital interventions for patients with MCI or dementia through a network meta-analysis.

Methods

We systematically searched Pubmed, Web of science, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure (CNKI),VIP Journal, and Wanfang Database from inception to 1 January 2025 and included randomized controlled trials (RCTs) that evaluated efficacy of computerized cognitive intervention on global cognition, executive function, and memory function in patients with MCI or dementia. The consistency model was used to conduct a network meta-analysis.

Results

A total of 57 articles were included in the review, including 3182 participants. Network meta-analysis showed that mobile device-based electronic games were the most effective intervention in slowing the decline of global cognition (standard mean difference (SMD) = 5.09, 95 % confidence interval (95 % CI) 2.17, 11.91) and the decline of executive function (SMD = 0.17, 95 % CI 0.03, 0.90) in the most effective interventions. As for memory function, immersive virtual reality technology was the most effective cognitive intervention to slow down memory decline (SMD = 2.71, 95 % CI 1.35, 5.46).

Conclusions

Digital cognitive interventions have better efficacy compared to conventional therapies, and mobile video games and immersive virtual reality may be the best digital cognitive interventions to slow cognitive decline.

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来源期刊

International Journal of Nursing Studies 医学-护理

CiteScore

15.00

自引率

2.50%

发文量

181

审稿时长

21 days

期刊介绍： The International Journal of Nursing Studies (IJNS) is a highly respected journal that has been publishing original peer-reviewed articles since 1963. It provides a forum for original research and scholarship about health care delivery, organisation, management, workforce, policy, and research methods relevant to nursing, midwifery, and other health related professions. The journal aims to support evidence informed policy and practice by publishing research, systematic and other scholarly reviews, critical discussion, and commentary of the highest standard. The IJNS is indexed in major databases including PubMed, Medline, Thomson Reuters - Science Citation Index, Scopus, Thomson Reuters - Social Science Citation Index, CINAHL, and the BNI (British Nursing Index).