INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES最新文献

{"title":"Endocardial Fibroelastosis: A Comprehensive Review of Pathogenesis, Clinical Manifestations, Diagnostic Modalities, and Management Strategies","authors":"Donaldo Emiliano Silva López, Oyuky Yumary Citlalli Flores Alamos, Saúl Villaseñor Angulo, Diana Marisol Perales Rivera, Verónica Guadalupe Vázquez Rubio, Domingo Antonio Manriquez Vazquez","doi":"10.47191/ijmscrs/v4-i05-09","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i05-09","url":null,"abstract":"Endocardial fibroelastosis (EFE) is a rare and enigmatic myocardial disease characterized by the abnormal accumulation of collagen and elastin fibers in the endocardium, predominantly affecting the left ventricle. This comprehensive review aims to elucidate the pathogenesis, clinical manifestations, diagnostic modalities, and management strategies of EFE. EFE typically presents in infants and young children, although adult cases have been reported. The etiology of EFE remains elusive, with theories implicating genetic, infectious, and autoimmune factors. Clinically, EFE may manifest with symptoms of heart failure, arrhythmias, or sudden cardiac death. Diagnosis often involves echocardiography, cardiac magnetic resonance imaging, and endomyocardial biopsy. Management strategies for EFE are primarily supportive, focusing on the management of heart failure symptoms and arrhythmias, with advanced cases necessitating heart transplantation. This review provides a comprehensive overview of EFE, highlighting the challenges in diagnosis and management and underscoring the need for further research to elucidate its pathogenesis and improve outcomes.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"44 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141118972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causes of Infant Choking (Children up to 1 Year of Age) and Strategies for Prevention: Systematic Review","authors":"Cristianne Confessor Castilho Lopes, Larissa Silva Guimarães, Eduardo Barbosa Lopes, F. H. Pitanga, L. Lopes, Maria Eduarda Castilho Lopes, Joacir Ferreira Júnior, M. M. da Costa, Joely Athina Martins Rocha, Sandra Maria Alves de Sousa Lima, Kennedy Ferreira Lales, Rayssa Figueiredo Magalhães Santiago","doi":"10.47191/ijmscrs/v4-i03-26","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-26","url":null,"abstract":"Introduction: Choking in babies is not only a health issue, but also a source of anxiety for parents and caregivers, as it can lead to serious consequences, including serious injuries and, in extreme cases, death. Objective: Offer a thorough analysis of the existing literature on this critical topic. Methods: This study constitutes a systematic review, classified as exploratory and descriptive. The preparation of the research was a bibliographical search in electronic databases on methods associated with RSL (Systematic Literature Review) and the applications of SMARTER (Simple Multi-Attribute Rating Technique using Exploiting Rankings). Results: A comprehensive systematically search of the literature yielded a total of 423 articles referring I'm the main causes of choking in children under 1 year of age, of which 11 articles were eligible I'm be included in this systematic review. Conclusion: Continued research and public education efforts are important in mitigating the risks associated with choking in infants. Implementing evidence-based prevention strategies is crucial to ensuring the safety and well-being of newborns and young infants.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140211028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Back Pain and the Rural Worker","authors":"Cristianne Confessor Castilho Lopes, Larissa Silva Guimarães, E. B. Lopes, F. H. Pitanga, L. Lopes, Maria Eduarda Castilho Lopes, Nicoly Carolina Fachin, Raul Souto, Daniel Furlan, Kennedy Ferreira Lales, Joely Athina Martins Rocha","doi":"10.47191/ijmscrs/v4-i03-27","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-27","url":null,"abstract":"Introduction: The rural worker, in his work activity, uses the extensor muscles of the lumbar spine in a large number of his actions, and when the abdominal muscles reduce their strength and an imbalance occurs between the flexor and extensor muscles of the trunk, which can result in a backache. Objective: To demonstrate the correlation between the work activity of rural workers and low back pain. Methods: This study constitutes a systematic review, classified as exploratory and descriptive. The preparation of the research was a bibliographical search in electronic databases on methods associated with RSL (Systematic Literature Review) and the applications of SMARTER ( Simple Multi-Attribute Rating Technique using Exploiting Rankings ). Results: A comprehensive systematic search of the literature yielded a total of 852 articles referring to the correlation between low back pain and rural workers, of which 14 articles were eligible to be included in this systematic review. Conclusion: The conclusion of this study highlights the importance of integrated and personalized approaches to reduce the risks and impacts of this condition on the health and well-being of rural workers.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":" 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140215797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open Lumbar Sympathectomy on Buerger’s Disease: A Case Report","authors":"Auzan Qostholani Al Khoiri, Taufan Hidayat","doi":"10.47191/ijmscrs/v4-i03-25","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-25","url":null,"abstract":"Thromboangiitis obliterans known as Buerger's disease is a nonatherosclerotic, progressive inflammatory disease that affects small and medium arteries in the upper and lower extremities. Strong relationship was found between the development of this disease and the patient's history of smoking. We reported a case of 50-year-old male with progressive pain in fingers of right leg with darkened ulcer. Open lumbar sympathectomy is a procedure that is rarely performed nowadays, but progressive pain in buerger’s disease patients can be managed with this procedure. The aim of sympathectomy is to reduce sympathetic response causing vasodilation effect which will reduce rest pain.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"10 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140225536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Chronotropic Incompetence and Correlation with Exercise Tolerance in Patients with Implantable Cardiac Devices Undergoing a Phase II Cardiac Rehabilitation Program Article Sidebar","authors":"José L. Martínez-Paniagua, Jorge A Lara-Vargas, Erik E. Briceño-Gómez, Hugo A . Radillo-Alba","doi":"10.47191/ijmscrs/v4-i03-23","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-23","url":null,"abstract":"Objective: Since patients with implantable cardiac devices tend to develop chronotropic incompetence (CI) associated with the effect of the device itself or the pharmacological effect of the underlying disease, CI could act as a limiting factor in improving exercise tolerance in patients undergoing cardiac rehabilitation program, since an increase in HR is a crucial part in improving cardiac output as a central component of oxygen consumption (VO2). However, it has been observed that there could be other factors contributing to the improvement in exercise tolerance in these patients regardless of the presence of CI. The aim of this research is to clarify the effect of chronotropic incompetence on the improvement in exercise capacity in patients with implantable cardiac devices after a phase II cardiac rehabilitation program (CRP). Methods: Quasi-experimental study applied to patients with implantable cardiac devices (ICDs, CRT, pacemakers) undergoing a supervised concurrent CRP, lasting 4-6 weeks, at an intensity between 65-80% of heart rate reserve (HRR), associated with kinesiotherapy sessions (with strength and endurance training and other biomotor qualities) and interdisciplinary intervention, education, and counseling. CI was calculated using the chronotropic response index, and METs-load measurement was performed at the beginning and at the end of the intervention. Results: Forty patients with a mean age of 61.4 years were included, mostly male (29) 72.5%, (23) 57.5% diagnosed with heart failure, and regarding the type of device, pacemakers (20) 50%, implantable cardioverter-defibrillator (ICD) (12) 30%, and cardiac resynchronization therapy with defibrillator (CRT-D) (20) 8%, of the total patients (35) 87.5% presented chronotropic incompetence and only (5) 12.5% with normal chronotropic response at the end of the intervention. A significant decrease in the chronotropic response index from 0.70 to 0.47 (p <0.001) and a significant increase in METs-load from 5.47 to 9.35 (p <0.001) were found. The value of the differential between initial and final METs (delta-METs) was obtained for both groups, observing a significant increase between initial and final METs in favor of patients with CI (3.8 Vs 3.5, p<0.012) at the end of the intervention. A significant moderate negative correlation (r=-0.395, Spearman, p<0.012) was determined between the degree of CI and final METs-load. Conclusions: It was observed that patients with implantable cardiac devices undergoing a CRP show an increase in exercise tolerance measured in METs, with an inversely proportional correlation to chronotropic incompetence.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"8 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI Models for Chest Radiograph Analysis: Internal Clinical Trial vs. Gold Standards","authors":"Mr. Pritam Dhalla, Mr. Soham Pal, Mr. Amar Saish","doi":"10.47191/ijmscrs/v4-i03-24","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-24","url":null,"abstract":"Our vision is to develop an AI-based software which is capable of analyzing frontal PA chest X-rays for disease diagnosis, detection, and prediction through the analysis of several different X-ray manifestations and findings which are inter-correlated to arrive to a final result. We utilize state of-the-art AI, thereby facilitating in empowering of the world through our med-tech ecosystem. It is being developed with the intention of enhanced cardiopulmonary care, bridging the gaps in healthcare, by giving conclusive and comprehensive diagnosis at lower costs and reducing the number of unnecessary diagnostic tests which, often, serve as the main cause of the delay between diagnosis and treatment. Why X-rays? X-rays have been chosen as the input because it is Non-invasive mode of diagnostic test, affordable, accessible and has much lesser radiation exposure compared to other imaging methods of CT, MRI, PET.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"56 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140231064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Cardiorespiratory Fitness and Quality of Life in Women with Chronic Heart Failure after a Cardiac Rehabilitation Program","authors":"Erik Eduardo Briceño Gómez, Jorge A. Lara Vargas, José Leonardo Martínez Paniagua, Hugo A. Radillo Alba","doi":"10.47191/ijmscrs/v4-i03-19","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-19","url":null,"abstract":"Introduction: Women with heart failure (HF) tend to experience a greater symptom burden and lower quality of life, possibly due to phenotypic differences and unique gender-associated risk factors. Despite evidence on the effects of cardiac rehabilitation programs (CRP) in the general population, there is underrepresentation of women in these programs. Additionally, the impact of CRP on cardiorespiratory variables obtained through cardiopulmonary exercise testing (CPET) and health-related quality of life (HRQoL) in women with HF remains unknown. Objective: To assess the impact of a CRP on cardiorespiratory fitness (CRF) in cardiorespiratory variables obtained through CPET and HRQoL in women with HF. Methods: A quasi-experimental study included HF patients who completed a CRP from June 2019 to December 2023. The CRP involved nutritional assessment, psychosocial evaluation, educational sessions, and concurrent training. It comprised 30 minutes of aerobic resistance training at 65-80% of heart rate reserve (HRR) and 30 minutes of strength training at 30-50% of 1-repetition maximum (1RM), with a frequency of 3 sessions per week for 4 to 6 weeks. CPET was conducted at the beginning and end of the program, analyzing cardiorespiratory variables. HRQoL was assessed using the SF-36 questionnaire. Gains in CRF and HRQoL at the end of the program in both men and women were analyzed. Results: Out of 217 included patients, 29.9% were women. At the program's onset, women showed lower exercise tolerance than men (workload 5.4±2.57 METs vs. 6.62±2.53 METs) and worse HRQoL (62.03%±18.37 vs. 68.38%±18.37). However, post-intervention, they optimized their CRF (%predicted VO2 [%VO2p] initial 56.62%±20.11 vs final 80.12%±30.32, p=<0.001). Significant improvements in cardiorespiratory variables were observed in both cases: delta METs-load 3.02, p=<0.001, delta peak oxygen consumption (VO2peak) 1.83 ml/kg/min, p=<0.001, delta oxygen pulse (PO2) 1.21, p=0.021, delta cardiac power output (CPO) 1917, p=0.004, with a rightward shift in ventilatory thresholds and improvement in HRQoL (62.03%±18.37 vs. 78.81%±12.9, p=<0.001) post-CRP. The only variable with no significant changes in either case was VE/VCO2 slope (delta -0.51, p=0.736). Additionally, in women with reduced left ventricular ejection fraction (<50%), variables with no significant improvement included CPO (delta 959.22, p=0.283) and time to recovery of VO2 kinetics (TRCVO2) (delta -0.74, p=0.957). In patients with preserved left ventricular ejection fraction (≥50%), variables with no significant change included PO2 (delta 1.08, p=0.173), TRCVO2 (delta 26.82, p=0.099), and the first ventilatory threshold (VT1) (delta 0.09, p=0.504). Program attendance was 87.5% in both groups. Conclusion: Implementing a CRP in women with HF resulted in significant improvements in all evaluated cardiorespiratory variables (except for VE/VCO2 slope) and quality of life. These findings support the importance of ensuring women's access","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"139 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140235540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracerebral Haemorrhage after Illicit Use of Sildenafil: A Case Report","authors":"Arti Shukla, Raghavendra Vagyannavar","doi":"10.47191/ijmscrs/v4-i03-22","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-22","url":null,"abstract":"Sildenafil(viagra) has become one of the top selling over the counter product for the treatment of male erectile dysfunction.(1) We report a case of 34year male patient admitted in our ICU with history of severe headache followed by sudden loss of consciousness after ingestion of two tablets of sildenafil(50mg) land up intracerebral bleed and died. There are many cases in the literature reporting intracerebral or subarachnoid haemorrhage associated with use of sildenafil while sexual contact.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"65 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathomechanisms, Pathophysiology and Biomechanics of Degenerative Spine Disease: A Review of Literature","authors":"Ogunleye Oo, Adamu A, Baffah Am, Essien Ob, Bwala Kj, Ballah Am, Kirfi Am, Abdul Mm, Duke R","doi":"10.47191/ijmscrs/v4-i03-21","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-21","url":null,"abstract":"The intervertebral disc in human being is a complex structure and is made up of fibrous and cartilaginous tissues. It is characterized as tension-resisting structure while it allows limited range of motion in axial, bending or rotational posture. Degenerative process of this structure present with clinical morbidity to the patients and possess great challenges to the clinicians while offering care for disc’s pathology. Degeneration begins with imbalance of homeostasis maintained by content of nucleus pulposus and annulus fibrosus. Numerous factors; genetic, mechanical and nutritional, can initiate and or accelerate this degeneration process which ultimately alter the biomechanics of the spine. The aim of this review is to give an overview on the degeneration process, causes and factors influencing disc degeneration, the mechanisms of degeneration and the changes resulted from intervertebral disc degeneration.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Advanced Reproductive Medicine on Female Fertility: Clinical and Technological Perspectives","authors":"Bolívar Leonardo Saquinga Pujos, Alex David Noroña Pilataxi, Jamie Patricia Celi Andrade, Michael Roberto Flores, Ginger Vanessa Miranda Alburquerque, Miriam Elizabeth Tierra Vargas","doi":"10.47191/ijmscrs/v4-i03-20","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-20","url":null,"abstract":"Background: Infertility is defined as failure to be pregnant after 12 months of unprotected intercourse. This condition affects millions of individuals worldwide. It is not only a personal problem, causing stress and anxiety amongst individuals and couples, but it has become a community issue. One in every 6 couples will experience infertility in their lifetime. It is affecting both male and female reproductive systems, with causes ranging from hormonal imbalances to obstructive disorders. Despite its prevalence, fertility care is unequal and, for those in low and middle-income countries, virtually non-existent and a long overdue topic for global attention and action. Method: We followed a systematic approach to select articles related to recent developments in female fertility and reproductive medicine. Keywords such as “female fertility” and “advanced reproductive medicine” were used for getting targeted articles. We used only peer-reviewed articles published from 2019 to 2024. Only high-quality data was extracted for general public information. Result: Our findings show that Assisted Reproductive Technologies (ART), microfluidic devices, and innovations like CoQ10 therapies have significantly improved fertility treatment outcomes. AI-driven personalized medicine has enhanced accessibility and effectiveness, democratizing fertility care. Stem cell therapy and platelet-rich plasma techniques are another breakthrough in reproductive medicine. Conclusion: It is concluded that medical advancements have revolutionized reproductive medicine. There is now a ray of new hope for those couple who are experiencing infertility. The future promises further improvements in success rates and patient experience with continued progress.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}