INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES最新文献

{"title":"Unveiling the Potential of VELScope in Potentially Malignant Oral Lesion Early Detection for Future Dental Diagnosis Technology","authors":"Daniel Adhie Saputra, Dea Permata, Amar Raikhan Qodri, Amandia Dew i Permana Shita","doi":"10.47191/ijmscrs/v4-i03-09","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-09","url":null,"abstract":"Introduction: Oral lesions range from innocuous to possibly dangerous, including oral cancer, which is the world's 16th most common malignancy. Early detection of oral cancer can enhance a patient's life expectancy by a decade, emphasizing the need of diagnostic instruments like VELScope. VELScope is a portable device that employs blue light to examine oral tissue, exposing natural fluorescence and emphasizing aberrant regions that would otherwise be invisible without the use of specialized equipment. Objectives: This review looks at the possibility of the VELScope for identifying oral lesions, since it has the potential to be a future dental diagnostic tool. Method: We began with 88 findings and reduced them down to 33 research regarding VELScope technology published in the previous five years. Following screening, we chose ten articles using the same criteria for all research. Results: VELScope uses fluorescence to identify both obvious and concealed oral lesions, which is especially useful when collagen loss occurs in normal tissues. While using autofluorescence requires knowledge, it assists in analyzing margins in probable pre- malignant oral conditions. VELScope, despite its limitations, has promise for early cancer diagnosis as technology develops. Conclusion: When utilized for early diagnosis, VELScope helps to reduce oral cancer mortality, reaching an 83% 5-year survival rate. While it has limits, continuous technical improvements have the potential to improve its accuracy, making it a vital tool for accurate early diagnosis and lowering oral cancer mortality.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"286 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140255665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gracilis Muscle Flap Technique is an Aesthetic and Functional Option in Fournier's Gangrene: Clinical Case","authors":"Sergio Heinar Rodríguez-Sosa, Gerardo Salvador Rea-Martínez, Edgar Efraín Hernandez-Luna, Eduardo Navarro-Becerra, Ana Fernanda Espinoza de los Monteros-Kelley, Alexis Emir Noguera Echeverría, Fernanda Ramírez- Amado, Héctor Armando Rubio-Zapata, Guillermo Padrón-Arredondo","doi":"10.47191/ijmscrs/v4-i03-07","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-07","url":null,"abstract":"Introduction. The scrotum is a covering of skin that covers and protects the testicles. Although it is not common, some bacterial infections of this skin can extend to deep tissues and produce a severe entity known as Fournier's gangrene. Clinical case. A 62-year-old male patient arrives at the Emergency Department due to increased scrotal volume with extension to the perineal region associated with purulent discharge and fever for one week. The patient has type 2 diabetes mellitus of 10 years duration, with poor control despite consuming oral hypoglycemic agents. He has also had high blood pressure for two years, managed with Losartan 50 mg/day. They observed secretion from perianal fistula drainage and uncomplicated external hemorrhoids. Laboratories: Glucose 260 mg/dL, BUN 23 mg/dL, Urea 49.5 mg/dL, Cr 1.50 mg/dL, Leukocytosis 33.39 x 109/L, Hb 9.9 g/dL, Hct. 30.3%. Discussion. The management of Fournier's gangrene includes both pharmacological measures, such as the use of antibiotic therapy and surgical management. Autologous partial skin graft is one of the most used techniques due to its safety and versatility and the extensive availability of donor areas. The process consists of obtaining a portion of skin taken from a donor area, preferably the thighs, which is obtained with a dermatome, after which the graft is meshed, increasing its extension and increasing the surface to be covered. As for negative aspects, there is possibly an unaesthetic result and possible retractions. Despite this, most authors point to a good result with this technique.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"24 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tranexamic Acid in the Treatment of Melasma: A Comprehensive Review of Topical, Intradermal, and Oral Administration","authors":"Zahraa Nasser Abdul Ghani, Mohammed Khalid Abbood","doi":"10.47191/ijmscrs/v4-i03-05","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-05","url":null,"abstract":"A malfunction in human melanogenesis called melasma causes the epidermis to become hyperpigmented in certain regions of the body gradually. It significantly affects physical appearance, results in psychological and physiological distress, and diminishes those impacted individuals' quality of living. In order to restrict blood loss, tranexamic acid (TA), a plasmin inhibitor, is used for stopping unusual fibrinolysis. It works by permanently inhibiting lysine binding sites on plasminogen molecules, which prohibits plasminogen activator (PA) from converting plasminogen to plasmin. It seems sense that tranexamic acid might have an impact on keratinocyte association and function because plasminogen is additionally found in human epidermis basal cells and owing to the fact that PA has been shown to be produced by cultivated human keratinocytes. A comprehensive review of the literature demonstrates that although TA is administered by topical, oral, and intradermal injection as well as utilized as an adjuvant therapy Added to the laser therapy to treat melasma, its effectiveness has not been sufficiently proved. To fully understand the function of TA in the management of melasma, additional investigation is required.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Molecular Insights into Hypertrophic Scars and Keloids: A Literature Review","authors":"Naina Banun Turobi, Fadel Rahman, Nathasya Fernanda, A. Fawzy","doi":"10.47191/ijmscrs/v4-i03-06","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-06","url":null,"abstract":"Background: Hypertrophic scars and keloids represent two distinct forms of abnormal wound healing, characterized by excessive fibrous tissue formation. Despite their prevalence, the pathophysiological mechanisms underlying their development and persistence remain incompletely understood. This literature review synthesizes current clinical and molecular insights into hypertrophic scars and keloids, aiming to highlight differences in their etiology, pathogenesis, and therapeutic responses. Methods: A comprehensive review of the literature was conducted, focusing on articles that provided significant insights into the clinical manifestations, genetic predispositions, molecular pathways, and treatment strategies related to hypertrophic scars and keloids. Experimental studies and clinical trials were included to encompass a wide range of data sources. Results: Hypertrophic scars are confined to the original wound boundary and may regress over time, whereas keloids extend beyond the wound margins and do not regress. Clinically, hypertrophic scars and keloids differ in their appearance, texture, and predilection sites. At the molecular level, these differences are underscored by distinct profiles of cytokine expression, growth factor activity, and extracellular matrix composition. Genetic studies have identified several predisposing factors, including specific gene mutations and polymorphisms. Treatment strategies vary; however, intralesional corticosteroids remain the first-line treatment for both conditions. Emerging therapies targeting specific molecular pathways offer potential for improved outcomes. Conclusion: Hypertrophic scars and keloids are complex conditions with distinct clinical and molecular characteristics. Understanding these differences is crucial for developing targeted and effective therapies. Future research should focus on unraveling the genetic basis of these conditions and exploring novel therapeutic targets. Enhanced knowledge of the pathogenic mechanisms will facilitate the advancement of personalized medicine approaches in the management of hypertrophic scars and keloids.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"28 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140259689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Reproductive Technologies (ART) and Controlled Ovarian Hyperstimulation","authors":"L. Mettler, Anupama Dasari –Mettler, Soeren von Otte","doi":"10.47191/ijmscrs/v4-i03-04","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-04","url":null,"abstract":"If a couple cannot conceive and carry out a baby we speak of “infertility Infertility ,as an unwanted condition, that has been well known since ancient times. However, the first known gynecologic medical text, the Kahoun papyrus (2200-1950 B.C), describes infertility as a disruption in the continuity between the reproductive organs and the digestive tract.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"26 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstructive Paradigms: Unraveling the Interplay between Plastic Surgery and Rehabilitation in the Aftermath of Severe Burn Injuries","authors":"Ivonne Alejandra Perales Soto, Jennifer Maribel Llamas Medrano, Edgar Eduardo Camacho Flores, Patricia Leonor Olea Oliva, Sebastián Martínez Pinedo, Indira Anelly Reyes Ureña","doi":"10.47191/ijmscrs/v4-i03-02","DOIUrl":"https://doi.org/10.47191/ijmscrs/v4-i03-02","url":null,"abstract":"The contemporary landscape of burn care and rehabilitation stands at the nexus of medical innovation and interdisciplinary collaboration. This article delves into the tangled web of implications arising from the integration of plastic surgery within the rehabilitative continuum for victims of extensive burn injuries. Through a comprehensive exploration of cutting-edge surgical techniques, patient outcomes, and the symbiotic relationship between plastic surgery and rehabilitation, this discourse aims to illuminate the transformative potential of reconstructive interventions. By elucidating the dynamic interplay between surgical innovation and rehabilitative strategies, our investigation seeks to contribute to the evolving paradigm in the holistic management of victims enduring the aftermath of severe burns.","PeriodicalId":502774,"journal":{"name":"INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES","volume":"24 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140265971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}