Journal of Buon最新文献_第4页

Is there any association between human papillomavirus amplification and ductal histology in invasive breast carcinoma? 人乳头瘤病毒扩增与浸润性乳腺癌导管组织学之间是否存在关联?

Journal of Buon Pub Date : 2021-09-01

Kadri Altundag

引用次数: 0

Application of dermal regenerative template in reconstructing skin defects after plantar malignant melanoma excision. 真皮再生模板在足底恶性黑色素瘤切除术后皮肤缺损重建中的应用。

Journal of Buon Pub Date : 2021-09-01

Xuanlong Zhang, Yute Sun, Zuoqiong Hou, Binlin Luo, Chujun Li, Keyu Jiang, Jinfang Liu, Gang Yao, Jian Tang

{"title":"Application of dermal regenerative template in reconstructing skin defects after plantar malignant melanoma excision.","authors":"Xuanlong Zhang, Yute Sun, Zuoqiong Hou, Binlin Luo, Chujun Li, Keyu Jiang, Jinfang Liu, Gang Yao, Jian Tang","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The excision of plantar malignant melanoma frequently leads to wide skin defects on the plantar surface. This study aimed to investigate the advantages and feasibility of dermal regenerative template reconstructing plantar blemishes caused by malignant melanoma.Methods: 28 patients identified with plantar malignant melanoma were included in this retrospective article. Eighteen patients received immediate skin grafts after wide excision skin graft (SG) group), whereas the remaining 10 patients were treated with dermal regenerative template (DRT) (Lando ®, Shenzhen TsingCare Medical Co. Ltd) 14 days before skin grafts (DRT group) and the postoperative survival rate in the two groups was analyzed. During the 6-month follow-up, we compared the scar index, plantar pain, and recurrent skin graft ulcer incidence on the skin grafts area.Results: Postoperative survival rate in the DRT group (91.75% ± 7.64%) was higher than in the SG group (80.51% ± 7.17%). The DRT group showed less scar formation on Vancouver scar scale (VSS index): 3.40 ± 1.07 than the SG group (VSS index: 6.33 ± 0.68). The dermal regenerative template alleviated plantar pain and decreased the incidence of ulcer on the skin grafts area.Conclusions: The dermal regenerative template not only improves the survival rate of skin grafts but also alleviates scar condition, plantar pain and recurrent skin graft ulcer. This study provides a new reconstructive strategy in plantar skin defects after the excision of malignant melanoma.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The landscape of angiogenesis subtypes for breast cancer: a comprehensive analysis based on the Cancer Genome Atlas. 乳腺癌血管生成亚型的景观:基于癌症基因组图谱的综合分析。

Journal of Buon Pub Date : 2021-09-01

Xiao-Fei Peng, Fang Lu Qin, Wen Jie Chen, Han Zhang, Zi Yue Mai, Jian Zeng

{"title":"The landscape of angiogenesis subtypes for breast cancer: a comprehensive analysis based on the Cancer Genome Atlas.","authors":"Xiao-Fei Peng, Fang Lu Qin, Wen Jie Chen, Han Zhang, Zi Yue Mai, Jian Zeng","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Breast cancer is a common malignant tumor in women with a poor prognosis. This study aimed to investigate angiogenesis subtypes of breast cancer and unveil the etiology and molecular features of breast cancer.Methods: Based on the angiogenesis gene set derived from AmiGO2, and breast cancer data in the Cancer Genome Atlas (TCGA), we define a novel cluster of angiogenesis subtypes for patients by consensus clustering. The gene regulation, immune landscape, molecular characteristics, and clinical features as well as enrichment pathways were explored in the angiogenesis subtypes of breast cancer.Results: Two angiogenesis subtypes were established through consensus clustering, among which subtype1 included 275 patients and subtype2 included 813 patients. A total of 643 differential expressed genes and 109 miRNAs were found between the two subtypes. The gene set enrichment analysis showed that the enriched hallmark pathways in subtype2 were related to the cancer tumorigenesis and breast cancer progression, including estrogen response early estrogen response late, epithelial-mesenchymal transition (EMT), especially angiogenesis. The mutant-allele tumor heterogeneity and tumor mutation burden of non-angiogenesis subtype were significantly higher than that in the angiogenesis subtype. The stroma score, immune score and ESTIMATE score were significantly higher in angiogenesis subtype, while the tumor purity in angiogenesis subtype was considerably lower. Finally, most immune checkpoints were expressed higher in the angiogenesis subtype.Conclusions: The omics analysis has established a novel angiogenesis subtype of breast cancer and identiﬁed the characteristics of the immune microenvironment and genomic alteration of breast cancer. Thus, this angiogenesis subtype might provide new evidence for inhibiting the progression and immunotherapy response in breast cancer.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39717877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cross-sectional study for assessing perceived symptoms, depression and quality of life in advanced lung cancer patients. 一项评估晚期肺癌患者感知症状、抑郁和生活质量的横断面研究。

Journal of Buon Pub Date : 2021-09-01

Maria Lavdaniti, Konstantina Patrikou, Paraskevi Maria Prapa, Maria Vastardi, Evangelos C Fradelos, Ioanna V Papathanasiou, Foteini Tzavella, Victoria Alikari, George Tzavelas

{"title":"A cross-sectional study for assessing perceived symptoms, depression and quality of life in advanced lung cancer patients.","authors":"Maria Lavdaniti, Konstantina Patrikou, Paraskevi Maria Prapa, Maria Vastardi, Evangelos C Fradelos, Ioanna V Papathanasiou, Foteini Tzavella, Victoria Alikari, George Tzavelas","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The purpose of the present study was to assess the perceived symptoms, depression and quality of life (QoL) in advanced lung cancer patients undergoing chemotherapy.Methods: The study was cross sectional and was conducted in the oncology department of General Hospital \"George Papanikolaou\", Thessaloniki, Greece. The sample was convenient and consisted of 76 advanced lung cancer patients. A questionnaire including instruments such as Center for Epidemiologic Studies Depression Scale- CES-D, Revised Edmonton Symptom Assessment Scale r-ESAS, EORTC QLQ-C30 and demographic and clinical information was used to collect data.Results: The most frequently observed symptoms were tiredness, shortness of breath, anxiety and well-being. The vast majority of patients (75.3%) had total score in CES-depression higher than 16. The type of residence affected ESAS emotional score (p=0.010). Gender affected the level of depression (p=0.014) and the type of lung cancer affected depression (p=0.036). The type of residence affected emotional functioning (p=0.010), the type of treatment influenced the score of global health status (p=0.007), the role functioning (p=0.032) and social functioning (p=0.024). Multivariate regression analysis was conducted to identify the predictors of overall QoL and depression. The statistically significant factors for QoL were pain (p<0.001) and tiredness (p=0.003), while the type of lung cancer (p<0.007), the type of insurance (p<0.025) and the type of treatment (p<0.041) influenced depression as well.Conclusions: Advanced lung cancer patients experienced moderate level in QoL and mild levels of symptoms. Demographic and clinical characteristics influenced depression and QoL.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10391380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity is a predictive biomarker of poor benefit from single-agent bevacizumab therapy in recurrent ovarian cancer patients. 肥胖是复发性卵巢癌患者从贝伐单抗单药治疗中获益较少的预测性生物标志物。

Journal of Buon Pub Date : 2021-09-01

Hiroyuki Yoshida, Daisuke Shintani, Keiichi Fujiwara

{"title":"Obesity is a predictive biomarker of poor benefit from single-agent bevacizumab therapy in recurrent ovarian cancer patients.","authors":"Hiroyuki Yoshida, Daisuke Shintani, Keiichi Fujiwara","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Bevacizumab, an anti-angiogenic agent targeting vascular endothelial growth factor (VEGF), is widely used for the treatment of ovarian cancer. However, no predictive biomarkers of clinical outcome for bevacizumab therapy have been identified. Adipose tissue secretes various growth factors, including VEGF, which may neutralize bevacizumab and attenuate its effects. Therefore, we evaluated whether obesity is a predictive biomarker of clinical outcome in ovarian cancer patients treated with single-agent bevacizumab.Methods: Thirty patients with recurrent ovarian cancer treated with single-agent bevacizumab were studied. Body mass index (BMI) and visceral fat area (VFA) were measured to assess the presence of obesity. VFA was measured using computed tomography volume-analyzing software. The association of BMI and VFA with clinical outcomes were evaluated.Results: High BMI and high VFA were significantly correlated with progressive disease (p=0.0195 and p=0.0352, respectively). A significant correlation was identified between high BMI and progressive disease in multivariate analysis (p=0.0459). Furthermore, there was a trend toward shorter progression-free survival and a significant shortening of overall survival in high-BMI patients compared with low-BMI patients (p=0.101 and p=0.0417, respectively).Conclusions: This study demonstrated that obesity is a predictive biomarker of poor benefit from single-agent bevacizumab therapy in recurrent ovarian cancer patients. Obesity may be a useful benchmark for the administration of bevacizumab in daily clinical practice.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between types of inflammatory cells located at the micro-environment of papillary thyroid microcarcinoma prognostic factors. 甲状腺乳头状微癌微环境炎性细胞类型与预后的关系。

Journal of Buon Pub Date : 2021-09-01

Sirin Kucuk, Pembe Oltulu

{"title":"The relationship between types of inflammatory cells located at the micro-environment of papillary thyroid microcarcinoma prognostic factors.","authors":"Sirin Kucuk, Pembe Oltulu","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To determine the relationship between inflammatory cell types in the microenvironment of papillary thyroid microcarcinoma (PTMC) and prognostic factors.Methods: The previous diagnoses and subtypes-variants of 163 patients with papillary thyroid microcarcinoma were re-evaluated according to the 2017 WHO classification. The peritumoral lymphocyte, plasma cell, neutrophil, eosinophil, and mast cell density were classified as none (0.24 mm2), mild (0-10/0.24 mm2), moderate (10-50/0.24 mm2), and severe (˃50/0.24 mm2) under 40x magnification and the relationship with prognostic factors was investigated.Results: There was a statistically significant relationship between tumor capsule invasion (p=0.024) and surgical margin (p=0.049) with mast cell infiltration. A statistically significant relationship was observed between tumor capsule invasion (p=0.0001) and the postoperative disease-free period (p=0.0001) with neutrophil cell infiltration. The postoperative disease-free period of those with neutrophil infiltration was statistically significantly shorter than that of those with no infiltration. The tumor diameter of those with no plasma cells was statistically significantly smaller than that of patients with plasma cells (p=0.003).Conclusions: Closer follow-up of patients with neutrophils, mast cells, and plasma cells, which have been found to be associated with poor prognostic factors in terms of recurrence, lymph node involvement, and distant metastasis, may increase survival.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39699300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The surgical challenge of oligometastatic pancreatic cancer: A systemic review of the literature. 寡转移胰腺癌的手术挑战：文献系统回顾。

Journal of Buon Pub Date : 2021-09-01

Gregory Christodoulidis, Dimitrios Magouliotis, Athina Samara, Theodoros Floros, Prokopis Andreas Zotos, Maria Tolia, Dimitris Zacharoulis

引用次数: 0

miR-34a-5p blocks cervical cancer growth and migration by downregulating CDC25A. miR-34a-5p通过下调CDC25A抑制宫颈癌的生长和迁移。

Journal of Buon Pub Date : 2021-09-01

Tao Jiang, Hongyan Cheng

引用次数: 0

BTBD7 accelerates the epithelial-mesenchymal transition, proliferation and invasion of prostate cancer cells. BTBD7促进前列腺癌细胞上皮-间质转化、增殖和侵袭。

Journal of Buon Pub Date : 2021-09-01

Bin Chen, Chang Liu, Guohui Bai, Yuhang Zhu, Houqiang Xu

引用次数: 0

MicroRNA-204-3p inhibits metastasis of pancreatic cancer via downregulating MGAT1. MicroRNA-204-3p通过下调MGAT1抑制胰腺癌转移

Journal of Buon Pub Date : 2021-09-01

Wei Liu, Xinglei Li, Xiao Tan, Xing Huang, Bole Tian

{"title":"MicroRNA-204-3p inhibits metastasis of pancreatic cancer via downregulating MGAT1.","authors":"Wei Liu, Xinglei Li, Xiao Tan, Xing Huang, Bole Tian","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: We aimed to clarify the relationship between microRNA-204-3p level and clinical indicators in pancreatic cancer patients, and to provide theoretical references for target therapy.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to detect relative levels of microRNA-204-3p and MGAT1 in 60 paired pancreatic cancer tissues and adjacent normal ones. The relationship between microRNA-204-3p level and clinical indicators in pancreatic cancer patients was analyzed. MicroRNA-204-3p overexpression model was established in AsPC-1 and CFPAC-1 cells. Transwell and wound healing assay were carried out to illustrate the influence of microRNA-204-3p on the migratory potential in pancreatic cancer. Lastly luciferase assay and rescue experiments were performed to demonstrate the potential mechanism between microRNA-204-3p and MGAT1.Results: MicroRNA-204-3p was lowly expressed in pancreatic cancer tissues. Low level of microRNA-204-3p predicted high rates of lymphatic metastasis and distant metastasis, as well as poor prognosis in pancreatic cancer patients. Overexpression of microRNA-204-3p inhibited pancreatic cancer cells to migrate in vitro. MicroRNA-204-3p could be targeted by MGAT1 through specific binding sites in the 3'UTR. A negative correlation between MGAT1 and microRNA-204-3p was identified in pancreatic cancer tissues. The interaction between MGAT1 and microRNA-204-3p was responsible for inhibiting metastasis of pancreatic cancer.Conclusions: MicroRNA-204-3p is closely linked to lymphatic metastasis, distant metastasis and prognosis in pancreatic cancer patients. It inhibits the migratory ability in pancreatic cancer cells via negatively regulating MGAT1 level.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39699298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0