Journal of Buon最新文献

Vitamin C through upregulating SYNPO2 level suppresses the proliferation and migration of glioma cells. 维生素 C 通过上调 SYNPO2 水平抑制胶质瘤细胞的增殖和迁移。

Journal of Buon Pub Date : 2021-11-01

Yishuo Zhu, Xuan Wang, Yujie Cui, Jin Bai, Junnian Zheng, Yuechao Fan

引用次数: 0

5G and human health. 5G与人类健康。

Journal of Buon Pub Date : 2021-09-01

Kiki Theodorou, Charis Tyrakis, Vasiliki Softa, Constantin Kappas

引用次数: 0

Chyle leak after major pancreatic surgery. Is this an underestimated complication? A narrative review of the literature. 胰腺大手术后乳糜漏。这是一种被低估的并发症吗?文学的叙事性评论。

Journal of Buon Pub Date : 2021-09-01

Michail Vailas, Maria Sotiropoulou, Nikolaos Benetatos, Francesk Mulita, Ioannis Maroulis, Stylianos Germanos

{"title":"Chyle leak after major pancreatic surgery. Is this an underestimated complication? A narrative review of the literature.","authors":"Michail Vailas, Maria Sotiropoulou, Nikolaos Benetatos, Francesk Mulita, Ioannis Maroulis, Stylianos Germanos","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Postoperative chyle leak, termed 'chylous ascites', is a rare complication with a reported frequency of only one in 20464 abdominal operations. The purpose of this study was to summarize the available scientific data reviewing the most relevant studies for this type of postoperative complication after pancreatic surgery, highlighting at the same time the necessity for pancreatic surgeons to retain a high level of clinical suspicion for the early diagnosis and its therapeutic management.Methods: A thorough literature search in Pubmed and Google Scholar, under the terms' chylous ascites OR chyle leak AND pancreas OR pancreatic', since the year of inception until 19th of February 2021 was conducted by the authors and the associated results are presented in this narrative review.Results: Chyle leak is a rare complication following pancreatic surgery. Patients may suffer from exudative enteropathy and malnutrition leading to repeated infections and impaired wound healing or even death secondary to sepsis. Several studies have highlighted the issue of increased hospital stay, while others failed to reach statistical significance as far as hospital stay or survival are concerned. Researchers found that patients with diffuse chyle leak tended to have a worse 3-year survival rate (18.8%), which can be attributed to postoperative complications and early demise due to immunosuppression associated with the leak, or delayed adjuvant chemotherapy Conclusion: Further clinical research is needed to enhance prevention, diagnosis, treatment and long-term prognosis of this relevant surgical problem that shows trends of increase due to the great number of major operations which are performed nowadays.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FAT10 stimulates the development of osteosarcoma by regulating the JAK/STAT signaling pathway. FAT10通过调控JAK/STAT信号通路刺激骨肉瘤的发展。

Journal of Buon Pub Date : 2021-09-01

Faliang Shi, Longyun Li, Yongjie Cheng

{"title":"FAT10 stimulates the development of osteosarcoma by regulating the JAK/STAT signaling pathway.","authors":"Faliang Shi, Longyun Li, Yongjie Cheng","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To investigate the potential function of FAT10 in the development of osteosarcoma (OS) and its mechanism.Methods: Relative level of FAT10 in OS specimens and cell lines was detected by qRT-PCR. The correlation between FAT10 level and clinical features of OS patients was assessed by χ2 test. After intervention of FAT10 in MG-63 and U2OS cells, changes of FAT10 level, cell viability, clonality and proliferative capacity were respectively detected by qRT-PCR, CCK-8, colony formation and EdU assay. Moreover, dynamic change of FAT10 in OS cells induced with pro-inflammatory factors was examined by qRT-PCR. Protein levels of FAT10, p-STAT1, p-STAT3 and p-STAT5 in OS cells induced with TNF-α were determined by Western blot. The JAK2 inhibitor AZ960 was used to further confirm the role of the JAK signaling in FAT10-regulated development of OS.Results: FAT10 was upregulated in OS specimens and cell lines, which was correlated to tumor size, WHO grade and distant metastasis of OS patients. Knockdown of FAT10 inhibited viability, clonality and proliferative capacity of MG-63 and U2OS cells. FAT10 was time-dependently upregulated in OS cells stimulated with IFN-γ and TNF-α, which was dose-dependently downregulated by the treatment of AZ960. Protein levels of FAT10, p-STAT1, p-STAT3 and p-STAT5 in OS cells induced with AZ960 were remarkably downregulated.Conclusion: FAT10 is upregulated in OS samples, which stimulates the development of OS by activating the JAK/STAT signaling pathway.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between post-progression survival and clinical characteristics of patients with metastatic colon cancer: A single center experience. 转移性结肠癌患者进展后生存与临床特征之间的关系:单中心经验。

Journal of Buon Pub Date : 2021-09-01

Mehmet Engin Ozekin, Ali Gokyer, Ahmet Kucukarda, Osman Kostek, Kubilay Issever, Bulent Erdogan

{"title":"The association between post-progression survival and clinical characteristics of patients with metastatic colon cancer: A single center experience.","authors":"Mehmet Engin Ozekin, Ali Gokyer, Ahmet Kucukarda, Osman Kostek, Kubilay Issever, Bulent Erdogan","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: In this study, we aimed to determine the factors which affect post-progression survival (PPS) and overall survival (OS) in patients with metastatic colorectal cancer.Methods: 87 patients with metastatic colorectal cancer had been followed up with palliative care due to disease progression or ECOG performance status after receiving at least two cycles of chemotherapy. PPS was estimated as the time between the last progression date and last control or death date in patients who were followed up with palliative care.Results: 87 patients with metastatic colorectal cancer were included in the study. Evaluation with multivariate analysis of factors affecting PPS revealed a significantly longer PPS (10.8 weeks) in patients with ECOG score 0 or 1 than the PPS of patients with ECOG score 2-5 (3 weeks) (p=0.01). It was also found that PPS was 14.4 weeks in patients with CEA levels <5ng/ml,while it was 6.7 weeks in patients with CEA levels ≥5 ng/ml (p=0.001) and PPS was 13.7 weeks in patients with controlled disease after first-line chemotherapy while it was 8 weeks in patients with progression (p=0.03); both were statistically significant. No significant association was found between PPS and age, gender, tumor location, sites of metastasis, and RAS status.Conclusion: ECOG performance status score of 0-1, CEA levels below 5 ng/ml, and disease control with first-line chemotherapy are related to longer PPS in patients with metastatic colorectal cancer.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Akt/GSK3β/β-catenin signaling regulated by ZCCHC14 is responsible for accelerating the proliferation of hepatocellular carcinoma. ZCCHC14调控的Akt/GSK3β/β-catenin信号转导是加速肝细胞癌增殖的罪魁祸首。

Journal of Buon Pub Date : 2021-09-01

Yujun Cui, Jijun Zhang, Chiyi Chen, Jinxuan Luo, Hao Yan, Wentao Jiang

引用次数: 0

LINC00355 triggers malignant progression of hepatocellular carcinoma via the sponge effect on miR-217-5p with the involvement of the Wnt/β-catenin signaling. LINC00355通过对miR-217-5p的海绵效应触发肝细胞癌的恶性进展，Wnt/β-catenin信号转导参与其中。

Journal of Buon Pub Date : 2021-09-01

Xuanming Luo, Miyesaier ABudureyimu, Guohuan Yang, Zhe Yan, Xiutao Fu, Pinxiang Lu, Dexiang Zhang, Shulong Zhang, Zhenbin Ding

{"title":"LINC00355 triggers malignant progression of hepatocellular carcinoma via the sponge effect on miR-217-5p with the involvement of the Wnt/β-catenin signaling.","authors":"Xuanming Luo, Miyesaier ABudureyimu, Guohuan Yang, Zhe Yan, Xiutao Fu, Pinxiang Lu, Dexiang Zhang, Shulong Zhang, Zhenbin Ding","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To uncover the biological role of LINC00355 in regulating the proliferative and apoptotic potentials in hepatocellular carcinoma (HCC), and the underlying mechanism.Methods: LINC00355 levels in HCC tissues and cell lines were detected by quantitative real-time polymerase chain reaction (qRT-PCR). After knockdown of LINC00355 or miR-217-5p in Hub7 and Hep3B cells, proliferative and apoptotic potentials were assessed by cell counting kit-8 (CCK-8), colony formation assay and flow cytometry. The interaction between LINC00355 and miR-217-5p was determined by dual-luciferase reporter assay and Pearson correlation test. Western blot analysis was conducted to illustrate the regulatory effects of LINC00355 and miR-217-5p on the Wnt/β-catenin signaling.Results: LINC00355 was upregulated in HCC tissues and cell lines. Knockdown of LINC00355 reduced viability in Hub7 and Hep3B cells, which was much pronounced on days 3 and 4. Clonality was attenuated by transfection of shLINC00355 as well. In addition, apoptosis rate increased by knockdown of LINC00355 in HCC cells. Protein levels of β-catenin, GSK3β, c-myc and cyclin D1 were downregulated in Hub7 and Hep3B cells transfected with shLINC00355. MiR-217-5p was the target gene binding LINC00355. It displayed exactly opposite regulations on HCC cell phenotypes and protein levels of vital genes in the Wnt/β-catenin signaling to those of LINC00355.Conclusions: LINC00355 is upregulated in HCC specimens, LINC00355 triggers proliferative rate and inhibits apoptosis in HCC cells by negatively regulating miR-217-5p and activating the Wnt/β-catenin signaling.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10690728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of oncology patients' satisfaction from intravenous chemotherapy. 肿瘤患者静脉化疗满意度评价。

Journal of Buon Pub Date : 2021-09-01

Christos Stylianou, Ioannis Kalemikerakis, Maria Vastardi, Anna Kavga, Nikoletta Margari, Eleni Dokoutsidou, Theocharis Konstantinidis, Ourania Govina

{"title":"Assessment of oncology patients' satisfaction from intravenous chemotherapy.","authors":"Christos Stylianou, Ioannis Kalemikerakis, Maria Vastardi, Anna Kavga, Nikoletta Margari, Eleni Dokoutsidou, Theocharis Konstantinidis, Ourania Govina","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To assess patient satisfaction from chemotherapy and investigate the effect of demographic factors, disease symptoms and treatment on satisfaction.Methods: A non-randomized cross-sectional survey was conducted on a sample of 100 patients undergoing chemotherapy at \"Metaxa\" Cancer Hospital, Piraeus, Greece for 6 months. A demographic data questionnaire, a Cancer Treatment Satisfaction Questionnaire (CTSQ) and visual analog scales were used to evaluate pain, anxiety, fatigue, and nausea while presence or absence of vomit were also assessed.Results: The majority of the patients in the sample were men (51%), with a mean age of 58.5 ± 10.82 years. The mean value of expectations from treatment was 60.55, from treatment's satisfaction was 75.86 and from feelings about treatment's side effects was 44.56. The most serious symptoms were fatigue and anxiety (7.2 ± 1.95 and 6.71 ± 2.5, respectively). Statistical tests have shown that sub-dimensions of CTSQ are associated with pain, anxiety, fatigue, and nausea.Conclusions: Generally, chemotherapy meets patients' expectations with cancer. Symptoms such as fatigue, anxiety, pain, and nausea affect their satisfaction. Treatment's satisfaction can be improved by evaluating symptoms, which will lead to appropriate interventions.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39699294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The place of Omalizumab in the treatment of Carboplatin hypersensitivity. 奥玛珠单抗在治疗卡铂过敏中的地位。

Journal of Buon Pub Date : 2021-09-01

Yasemin Benderli Cihan

引用次数: 0

Efficacy of endoscopic submucosal dissection in treating early colorectal cancer and precancerous lesions. 内镜下粘膜剥离术治疗早期结直肠癌及癌前病变的疗效观察。

Journal of Buon Pub Date : 2021-09-01

Lianlian Qu, Yifeng Cheng

{"title":"Efficacy of endoscopic submucosal dissection in treating early colorectal cancer and precancerous lesions.","authors":"Lianlian Qu, Yifeng Cheng","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To compare the efficacy and safety between endoscopic submucosal dissection (ESD) and conventional surgical treatment in the treatment of colorectal cancer (CRC) and the precancerous lesions.Methods: A retrospective analysis was performed on the clinical data of 65 patients with CRC or precancerous lesions (ESD group) and another 65 patients receiving surgical treatment at the same period (Surgery group). The surgical indicators, incidence of complications, and quality of life score were compared between the two groups, and the survival and tumor progression were followed up and recorded.Results: The rate of en bloc tumor resection was 89.2% (58/65) and 100% (65/65) and the rate of tumor curative resection was 92.3% (60/65) and 100% (65/65) in ESD group and Surgery group. Moreover, ESD group had markedly shorter operation time and mean hospital stay. After treatment, ESD group had higher scores of emotional functioning, fatigue, constipation, and diarrhea symptoms and general quality of life on the European Organization for Research and Treatment of Cancer quality of life questionnaire Core 30 (EORTC QLQ-C30) than Surgery group. The follow-up results showed no statistically significant difference in the 5-year recurrence rate between ESD group and Surgery group (7.7% vs. 0%, p=0.208).Conclusion: ESD and surgery have similar long-term clinical efficacy in treating early CRC and precancerous lesions, but ESD is more minimally invasive and safer, and is superior in accelerating postoperative recovery and improving the overall survival of patients.","PeriodicalId":50248,"journal":{"name":"Journal of Buon","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39877759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0