Efficacy of endoscopic submucosal dissection in treating early colorectal cancer and precancerous lesions.

Q2 Medicine
Journal of Buon Pub Date : 2021-09-01
Lianlian Qu, Yifeng Cheng
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引用次数: 0

Abstract

Purpose: To compare the efficacy and safety between endoscopic submucosal dissection (ESD) and conventional surgical treatment in the treatment of colorectal cancer (CRC) and the precancerous lesions.

Methods: A retrospective analysis was performed on the clinical data of 65 patients with CRC or precancerous lesions (ESD group) and another 65 patients receiving surgical treatment at the same period (Surgery group). The surgical indicators, incidence of complications, and quality of life score were compared between the two groups, and the survival and tumor progression were followed up and recorded.

Results: The rate of en bloc tumor resection was 89.2% (58/65) and 100% (65/65) and the rate of tumor curative resection was 92.3% (60/65) and 100% (65/65) in ESD group and Surgery group. Moreover, ESD group had markedly shorter operation time and mean hospital stay. After treatment, ESD group had higher scores of emotional functioning, fatigue, constipation, and diarrhea symptoms and general quality of life on the European Organization for Research and Treatment of Cancer quality of life questionnaire Core 30 (EORTC QLQ-C30) than Surgery group. The follow-up results showed no statistically significant difference in the 5-year recurrence rate between ESD group and Surgery group (7.7% vs. 0%, p=0.208).

Conclusion: ESD and surgery have similar long-term clinical efficacy in treating early CRC and precancerous lesions, but ESD is more minimally invasive and safer, and is superior in accelerating postoperative recovery and improving the overall survival of patients.

内镜下粘膜剥离术治疗早期结直肠癌及癌前病变的疗效观察。
目的:比较内镜下粘膜下剥离术(ESD)与常规手术治疗结直肠癌及癌前病变的疗效和安全性。方法:回顾性分析65例结直肠癌或癌前病变患者(ESD组)和同期接受手术治疗的65例患者(手术组)的临床资料。比较两组手术指标、并发症发生率、生活质量评分,并对两组患者的生存及肿瘤进展情况进行随访记录。结果:ESD组和手术组肿瘤整体切除率分别为89.2%(58/65)和100%(65/65),肿瘤根治性切除率分别为92.3%(60/65)和100%(65/65)。ESD组手术时间和平均住院时间明显缩短。治疗后,ESD组在欧洲癌症研究与治疗组织生活质量问卷Core 30 (EORTC QLQ-C30)中的情绪功能、疲劳、便秘、腹泻症状和一般生活质量得分均高于手术组。随访结果显示,ESD组与手术组5年复发率比较,差异无统计学意义(7.7% vs 0%, p=0.208)。结论:ESD与手术治疗早期结直肠癌及癌前病变的远期临床疗效相近,但ESD更具微创性和安全性,在加速患者术后恢复和提高患者总生存率方面具有优势。
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来源期刊
Journal of Buon
Journal of Buon 医学-肿瘤学
自引率
0.00%
发文量
0
审稿时长
4-8 weeks
期刊介绍: JBUON aims at the rapid diffusion of scientific knowledge in Oncology. Its character is multidisciplinary, therefore all aspects of oncologic activities are welcome including clinical research (medical oncology, radiation oncology, surgical oncology, nursing oncology, psycho-oncology, supportive care), as well as clinically-oriented basic and laboratory research, cancer epidemiology and social and ethical aspects of cancer. Experts of all these disciplines are included in the Editorial Board. With a rapidly increasing body of new discoveries in clinical therapeutics, the molecular mechanisms that contribute to carcinogenesis, advancements in accurate and early diagnosis etc, JBUON offers a free forum for clinicians and basic researchers to make known promptly their achievements around the world. With this aim JBUON accepts a broad spectrum of articles such as editorials, original articles, reviews, special articles, short communications, commentaries, letters to the editor and correspondence among authors and readers. JBUON keeps the characteristics of its former paper print edition and appears as a bimonthly e-published journal with continuous volume, issue and page numbers.
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