Journal of Chemical Sciences最新文献

{"title":"Thermoresponsive sustainable release of anticancer drugs using cyto-compatible pyrenylated hydrogel as vehicle","authors":"Dipen Biswakarma,&nbsp;Nilanjan Dey,&nbsp;Santanu Bhattacharya","doi":"10.1007/s12039-022-02124-3","DOIUrl":"10.1007/s12039-022-02124-3","url":null,"abstract":"<div><p>Pyrene-based fluorogenic amphiphilic probe (1) has been synthesized, which can form a thixotropic (injectable) hydrogel in the aqueous medium. The biocompatible hydrogel, so formed, is involved in the thermoresponsive, sustainable delivery of two anticancer drugs, Doxorubicin (DOX) and Mitoxantrone (MT). A substantial difference in the extent of drug release is noticed at 25 and 37 °C, even at physiological pH. The cumulative releases of ~80% and ~70% for DOX and MT, respectively, from the drug-loaded hydrogel samples, are observed for 72 h. In both cases, drug molecule release follows zero-order kinetics and non-Fickian diffusion pathways. The excellent stability of 1 against proteinase enzyme suggests that the present system can be used for sustainable, targeted release of drug molecules under in-vivo conditions. As expected, DOX-loaded hydrogels kill cancer cells more efficiently than the free drug (i.e., DOX).</p><h3>Graphical abstract</h3><p>A pyrene-based amphiphilic probe has been synthesized, which can form a thixotropic hydrogel in the aqueous medium. The biocompatible hydrogel was involved in the thermoresponsive, sustainable delivery of two anticancer drugs, Doxorubicin (DOX) and Mitoxantrone (MT). Moreover, the DOX-loaded hydrogel could kill cancer cells more efficiently than the free drug.\u0000</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"135 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12039-022-02124-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4718696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophobic Hydration: A Theoretical Investigation of Structure and Dynamics","authors":"Kambham Devendra Reddy,&nbsp;Rajib Biswas","doi":"10.1007/s12039-022-02123-4","DOIUrl":"10.1007/s12039-022-02123-4","url":null,"abstract":"<p>The presence of external solutes alters the local structures, and dynamics of water. The nature and extent of these structural modifications depend on several factors. Particularly, the chemical nature of the solute is very crucial. The alteration of water structure and dynamics in the presence of hydrophobic substances draws considerable attention in biological systems. The present work is focused on exploring the microscopic arrangement of solvation shells of tiny hydrophobic solute methane. We explore the tetrahedral order, local structural index, and van Hove self-correlation function to get a quantitative understanding. We observe a slight increase in the structural order of water molecules in methane’s first solvation shell, similar to that of the low-temperature water. We also find that water facing the methane have lower structural order than bulk water. Furthermore, the water molecules in the first solvation shell around methane show relatively slower orientational relaxation.</p><p>The hydrophobicity-induced alterations of water structural and dynamical properties are investigated using solvation shell decomposition. We observe the slower relaxation of selected water molecules staying longer time in methane first solvation shell. We find enhanced structural order in the methane first solvation shell and some dangling water molecules.</p>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"135 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4496416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-free C(sp3)-H Bromination: Synthesis of Phenacyl bromide and Benzyl bromide derivatives","authors":"Sourav Mal,&nbsp;Satinath Sarkar,&nbsp;Manoranjan Jana","doi":"10.1007/s12039-022-02107-4","DOIUrl":"10.1007/s12039-022-02107-4","url":null,"abstract":"<div><p>A metal-free C(sp³)-H bromination methodology has been developed for aromatic ketones and some substituted toluenes under ambient conditions. The reaction for the toluenes is mediated by PhI(OAc)₂ (iodobenzene diacetate) in presence of KBr, while the bromination in aromatic ketones requires additional assistance of <i>p</i>-TsOH.H₂O and BF₃.Et₂O.</p><h3>Graphical abstract</h3><p>Synopsis: Synthesis of phenacyl bromides has been achieved under transition metal-free conditions. Some observations on substituted toluene systems have also been reported. In both cases, C(sp³)-H bromination has taken place at room temperature in the presence of phenyliodine diacetate (PIDA).</p>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4113329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally stable complexes of Fe(III), Co(II), Ni(II) and Cu(II) with Schiff base derived from 4-aminoacetophenone and salicylaldehyde","authors":"Rasheeda M Ansari,&nbsp;Dileep Ramakrishna,&nbsp;Badekai Ramachandra Bhat","doi":"10.1007/s12039-022-02113-6","DOIUrl":"10.1007/s12039-022-02113-6","url":null,"abstract":"<div><p>The Schiff base ligand 1-(4-((2-hydroxybenzylidene)amino)phenyl)ethan-1-one, obtained from 4-aminoacetophenone and salicylaldehyde, and its complexes with Fe(III), Co(II), Ni(II) and Cu(II) have been synthesized. These complexes were characterized by FTIR spectroscopy, elemental, and SCXRD analysis. FTIR spectra of complexes show the bidentate coordination of metal ions with ligands where O and N are electron-donating sites of the azomethine group. The electronic absorption spectra of these complexes show the characteristics of absorption bands involved in the Fe, Co, and Ni complexes due to their π→π*, n→π* transitions. Further, the geometry of the complexes was deduced from the calculated magnetic moment values and single crystal XRD analysis.</p><h3>Graphical abstract</h3><p>A Schiff base derived from the condensation reaction between 2-aminoacetophenone and salicylaldehyde was involved in the formation of four different metal complexes, i.e., with Nickel, Cobalt, Iron, and Copper. The synthetic route to forming these complexes followed an easy process, and the complexes were obtained in good yields.\u0000</p><figure><div><div><div><picture><img></picture></div></div></div></figure></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4980269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of refinery cracked naphtha stream into efficient lubricity improvers for ULSD","authors":"H SRUTHI,&nbsp;D UDAYA KUMAR,&nbsp;PRAMOD HEGDE,&nbsp;M G MANJUNATHA,&nbsp;R KARTHICK,&nbsp;V NANDAKUMAR","doi":"10.1007/s12039-022-02102-9","DOIUrl":"10.1007/s12039-022-02102-9","url":null,"abstract":"<div><p>A new route for the conversion of refinery light cracked naphtha (LCN) stream into lubricity improvers for ultra-low sulphur diesel (ULSD) was developed through a simple chemical process involving olefin epoxidation and esterification reactions. Two different methods<i> viz.,</i> H₂O₂/glacial acetic acid and m-chloroperbenzoic acid (m-CPBA), were found to be suitable for the epoxidation of LCN. The LCN epoxide was subjected to an esterification reaction <i>via</i> epoxide ring opening using different long chain (C₄ - C₁₈ alkyl groups) organic acids to get the hydroxy ester derivatives of LCN. The lubricating property of the newly synthesized hydroxy esters was studied by dosing them with ULSD at 300 and 150 ppm (wt/vol) concentrations. Amongst them, LCN hydroxy ester derived from stearic acid showed the best lubrication-enhancing property at both dosage levels. The scanning electron microscope (SEM) image and energy dispersive spectra (EDS) of the high-frequency reciprocating rig (HFRR) specimen support the lubricating action of the LCN esters through the formation of a protective layer between the metallic surfaces. The synergy of simple chemical processes and efficient lubricity action makes these LCN esters as promising materials for low-cost and scalable additives for ULSD.</p><h3>Graphical abstract</h3><p>The olefin-rich light cracked naphtha obtained from the fluidized catalytic cracker unit of the oil refinery was converted into hydroxy esters through an epoxidation reaction followed by the esterification with different carboxylic acids. The hydroxy esters at low dosage levels (150/300 ppm) enhance the lubricating property of ultra-low sulfur diesel.</p>\u0000 <figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\u0000 </div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4510750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico studies of 6-phenyl-3-(pyridin-2-yl)-1,2,4-triazine as a corrosion inhibitor for some important metals used in implants","authors":"Maria G Babashkina,&nbsp;Tatyana M Burkhanova,&nbsp;Damir A Safin","doi":"10.1007/s12039-022-02104-7","DOIUrl":"10.1007/s12039-022-02104-7","url":null,"abstract":"<div><p>In this work detailed DFT-based computational studies of 6-phenyl-3-(pyridin-2-yl)-1,2,4-triazine (<b>PhPyTrz</b>) are reported. The global reactivity descriptors and molecular electrostatic potential (MEP) were also revealed to probe the reactivity and determine the reactive centers of <b>PhPyTrz</b>. Some biological properties of <b>PhPyTrz</b> were evaluated using online tools. Corrosion inhibition properties of <b>PhPyTrz</b> both in the gas phase and in the aqueous medium for some important metals used in implants were also estimated by means of DFT calculations. It was established that <b>PhPyTrz</b> exhibits the best corrosion inhibition towards Ni and Co. It was also revealed that the corrosion inhibition power of <b>PhPyTrz</b> decreases in water.</p><h3>Graphical abstract</h3><p>We report DFT-based computational studies of 6-phenyl-3-(pyridin-2-yl)-1,2,4-triazine (<b>PhPyTrz</b>). Some biological properties of <b>PhPyTrz</b> were predicted. Corrosion inhibition properties of <b>PhPyTrz</b> both in gas phase and in the aqueous medium for some important metals used in implants were also estimated by DFT calculations.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4478462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium(II) complex bearing benzothiazole based O,N,S donor pincer ligand: Study of in-vitro cytotoxicity, interaction with CT-DNA and BSA protein","authors":"RAHUL NASKAR,&nbsp;PARAMITA GHOSH,&nbsp;SUBRATA MANDAL,&nbsp;SUBRATA JANA,&nbsp;NABENDU MURMU,&nbsp;TAPAN KUMAR MONDAL","doi":"10.1007/s12039-022-02101-w","DOIUrl":"10.1007/s12039-022-02101-w","url":null,"abstract":"<div><p>A new palladium(II) complex, [Pd(LS^Et)Cl] (<b>C1</b>) with benzothiazole based ONS donor pincer ligand (HLS^Et) was synthesized (where, HLS^Et = 2-(benzothiazol-2-yl)-6-(((2-(ethylthio)phenyl)imino)methyl)phenol). Interaction of <b>C1</b> with CT DNA was investigated, and its binding constant was found to be 4.0×10⁵ M⁻¹. The proficiency of ethidium bromide (EB) displacement from its EB-CTDNA complex by <b>C1</b> was performed by the fluorescence quenching method, and Stern-Volmer quenching constant (K_sv) was found to be 4.3×10⁵ M⁻¹. Similarly, the interaction of <b>C1</b> with BSA protein was investigated by UV-Vis and fluorescence methods. The apparent association constant (K_a) and K_sv were determined (K_a = 2.8×10⁴ M⁻¹ and K_sv = 5.5×10⁴ M⁻¹). In vitro cytotoxicity of the complex, [Pd(LS^Et)Cl] (<b>C1</b>), towards human gastric cancer cell lines (AGS) was assessed by the MTT assay method. The half maximal inhibitory concentration (IC₅₀) of <b>C1</b> (9.55 ± 1.23 µM) towards AGS cancer lines was found to be lower than cisplatin (23.13 ± 1.03 µM).</p><h3>Graphical abstract</h3><p>Herein, new palladium(II) complex, [Pd(LS^Et)Cl] (<b>C1</b>) with benzothiazole-based ONS donor pincer ligand (HLS^Et) was synthesized and characterized by several spectroscopic techniques. Interaction of <b>C1</b> with CT DNA and BSA protein was investigated by UV-Vis and fluorescence methods. In vitro cytotoxicity of the complex toward human gastric cancer cell lines (AGS) was evaluated by the MTT assay method. The half maximal inhibitory concentration (IC₅₀) of the palladium(II) complex (9.55±1.23 µM) was found to be less compared to cisplatin (23.13±1.03 µM) towards AGS cancer lines.\u0000</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12039-022-02101-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5166547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New cyclam based Zn(II) complexes: effect of flexibility and para substitution on DNA binding, in vitro cytotoxic studies and antimicrobial activities","authors":"B Archana,&nbsp;S Sreedaran","doi":"10.1007/s12039-022-02091-9","DOIUrl":"10.1007/s12039-022-02091-9","url":null,"abstract":"<div><p>A series of macrobicyclic binuclear Zn(II) complexes were synthesized from their macrocyclic ligand (L¹ and L²) by Schiff base condensation with appropriate aliphatic or aromatic diamines, ZnCl₂.4H₂O, and triethylamine. All the complexes were characterized by elemental and spectral analysis. The enhanced DNA binding affinity of complexes [Zn₂L^1a], [Zn₂L^1c], and [Zn₂L^1d] is due to the existence of the electron-donating CH₃ group, which leads to hydrophobic interaction with the hydrophobic DNA surface. The existence of electron-withdrawing Br atom in complex [Zn₂L^2a], [Zn₂L^2c], and [Zn₂L^2e] leads to lesser DNA binding affinity. The fluorescence quenching of the Zn(II) complex at 370 nm indicates the strong coordination of metal ions with N and O atoms of the ligand. The 3D fluorescence spectrum of [Zn₂L^2d] complex has been quenched more compared to [Zn₂L^2a] due to the planarity of aromatic system. DNA cleavage of Zn(II) complexes begins at a low concentration (25 μM) and reaches the maximum cleavage with a successive increase in concentration (100 μM). All the complexes were screened for antimicrobial and anticancer activity.</p><h3>Graphical abstract</h3><p>\u0000Macrobicyclic binuclear zinc(II) complexes synthesized from their macrocyclic ligands by Schiff base condensation were characterized by elemental and spectral analysis. The enhanced DNA binding affinity (CH₃ group) and lesser DNA binding affinity (Br group) have been explained. The 3D fluorescence spectrum shows quenching due to the planarity of aromatic system. DNA cleavage and <i>in vitro</i> activities have been discussed.</p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12039-022-02091-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5132584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient and expeditious synthesis of 1,2,4-triazolidine-3-thiones using meglumine as a reusable catalyst in water","authors":"Liklesha B Masram,&nbsp;Simren S Salim,&nbsp;Angad B Barkule,&nbsp;Yatin U Gadkari,&nbsp;Vikas N Telvekar","doi":"10.1007/s12039-022-02087-5","DOIUrl":"10.1007/s12039-022-02087-5","url":null,"abstract":"<div><p>A simple, convenient, and eco-friendly procedure has been developed using meglumine (15 mol%) as a green catalyst for the synthesis of 1,2,4-triazolidine-3-thiones under one-pot condition. Variously substituted aldehydes or ketones reacted well with thiosemicarbazide to give desired compounds in extremely good quantity. The developed protocol offers several advantages such as shorter reaction times, mild reaction conditions, easy workup, simple purification procedures, water as a solvent, and wide substrate scope tolerance. Further, the catalyst was recycled (up to 4 cycles) without compromising the yield of the final products.</p><h3>Graphical abstract</h3><p>The current protocol demonstrates the synthesis of 1,2,4-triazolidine-3-thiones from variously substituted aldehydes or ketones with thiosemicarbazide under aqueous conditions. A simple stirring of the reaction at room temperature in the presence of the catalytic amount of meglumine quickly gave the desired product an excellent yield. The method is operationally simple and eco-friendly.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12039-022-02087-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77252757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disodium Anacardate: A Bio-based Catalyst for Room Temperature Synthesis of New, Fluorescent 1, 4-Benzoxazinone and Benzophenoxazinone Derivatives","authors":"Rahul A Nagarkar,&nbsp;Sudhir E Dapurkar","doi":"10.1007/s12039-022-02082-w","DOIUrl":"10.1007/s12039-022-02082-w","url":null,"abstract":"<div><p>The first report of room temperature synthesis of new, fluorescent 1, 4-benzoxazinone derivatives using disodium anacardate as a bio-based catalyst is discussed here. Disodium anacardate was derived from cashew nut shell liquid (CNSL) which is a renewable but underutilized agro by-product of the cashew industry. The synthesis of 1, 4-benzoxazinone derivatives were derived through a one-pot three-component reaction of 2-aminophenol, diethyl acetylenedicarboxylate, and trans 1, 2-dibenzoylethylene. Further, the utility of disodium anacardate as a base catalyst is tested effectively for the room temperature synthesis of benzophenoxazinone derivatives synthesized from 2-aminophenol and dichloro-1,4-naphthoquinones. In a solvent effect study, the catalyst activity of disodium anacardate was found excellent in green solvents. The fluorescence activity was studied for the synthesized molecules. Our efforts through this study are to explore the novel applications of anacardic acid in organic transformations and establish its utility in new synthetic methodologies.</p><h3>Graphical abstract</h3><p>Herein, we report room temperature synthesis of new fluorescent 1,4-benzoxazinone and benzophenoxazinones derivatives using disodium anacardate as a bio-based catalyst which was also synthesized at room temperature from Cashew nut shell liquid (CNSL). The fluorescence activity was studied for the synthesized molecules.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":50242,"journal":{"name":"Journal of Chemical Sciences","volume":"134 3","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88397330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}