An efficient and expeditious synthesis of 1,2,4-triazolidine-3-thiones using meglumine as a reusable catalyst in water

IF 1.7 4区化学 Q3 Chemistry

Journal of Chemical Sciences Pub Date : 2022-09-03 DOI:10.1007/s12039-022-02087-5

Liklesha B Masram, Simren S Salim, Angad B Barkule, Yatin U Gadkari, Vikas N Telvekar

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引用次数: 3

Abstract

A simple, convenient, and eco-friendly procedure has been developed using meglumine (15 mol%) as a green catalyst for the synthesis of 1,2,4-triazolidine-3-thiones under one-pot condition. Variously substituted aldehydes or ketones reacted well with thiosemicarbazide to give desired compounds in extremely good quantity. The developed protocol offers several advantages such as shorter reaction times, mild reaction conditions, easy workup, simple purification procedures, water as a solvent, and wide substrate scope tolerance. Further, the catalyst was recycled (up to 4 cycles) without compromising the yield of the final products.

Graphical abstract

The current protocol demonstrates the synthesis of 1,2,4-triazolidine-3-thiones from variously substituted aldehydes or ketones with thiosemicarbazide under aqueous conditions. A simple stirring of the reaction at room temperature in the presence of the catalytic amount of meglumine quickly gave the desired product an excellent yield. The method is operationally simple and eco-friendly.

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以三聚氰胺为可重复使用催化剂在水中高效快速合成1,2,4-三唑烷-3-硫酮

研究了一种简单、方便、环保的新工艺，以十五摩尔%的三聚氨胺为绿色催化剂，在一锅条件下合成1,2,4-三唑烷-3-硫酮。各种取代的醛或酮与硫代氨基脲反应良好，得到大量所需的化合物。该方案具有反应时间短、反应条件温和、易于处理、纯化程序简单、水作为溶剂、底物范围宽等优点。此外，催化剂可循环使用(多达4次循环)，而不会影响最终产品的收率。图解摘要:目前的程序演示了在水条件下由不同取代的醛或酮与硫脲基氨基脲合成1,2,4-三唑烷-3-硫酮。在室温下，在催化量的聚氨胺的存在下，简单的搅拌反应，很快就得到了理想的产物，收率很高。该方法操作简单，环保。

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来源期刊

Journal of Chemical Sciences Chemistry-General Chemistry

CiteScore

2.90

自引率

5.90%

发文量

107

审稿时长

12 months

期刊介绍： Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.