Journal of Clinical Pediatric Dentistry最新文献

{"title":"Current Perspectives on Management Approaches for Molar Incisor Hypomineralization: Preliminary findings from the National Dental Practice-Based Research Network.","authors":"Azza Tagelsir Ahmed, Veerasathpurush Allareddy, David Avenetti, Joana Cunha-Cruz, Gregg H Gilbert","doi":"10.22514/jocpd.2026.027","DOIUrl":"10.22514/jocpd.2026.027","url":null,"abstract":"<p><strong>Purpose: </strong>To assess approaches used by National Dental Practice-Based Research Network dentists when they encounter newly erupted molars with molar incisor hypomineralization (MIH).</p><p><strong>Methods: </strong>A brief questionnaire (\"Quick Poll\") was administered to explore three early management areas of molars affected with MIH: (1) regularity of informing parents about these enamel defect; (2) frequency of using silver diamine fluoride (SDF) to treat MIH on molars, and (3) identifying which approaches dentists use when these molars present at a non-carious early stage of enamel breakdown.</p><p><strong>Results: </strong>Three-fourths (75%) of respondents would always inform patients of molar defects. There was no consensus about using SDF to manage MIH on molars; 26% said that they would never use SDF. There was substantial variation in recommendations for managing non-carious molars with MIH: 39% recommended routine preventive visits with topical fluoride application and only 1% recommended restorations.</p><p><strong>Conclusion: </strong>Although Network dentists would routinely inform patients of MIH, they exhibited little consensus about how best to manage it.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"50 1","pages":"301-306"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring child and family-level influences on oral hygiene practices (OHP)-a qualitative study from South India.","authors":"Muthu Murugan, Vineet Dhar, Latha Nirmal, Ankita M Saikia, Shuba Kumar, Rani Mohanraj, Umapathy Pasupathy, Kalpana Balakrishnan","doi":"10.22514/jocpd.2025.075","DOIUrl":"10.22514/jocpd.2025.075","url":null,"abstract":"<p><p>Early childhood caries (ECC) is an oral health concern prevalent globally, and can be effectively prevented via improved oral health literacy and practices. Parental beliefs, attitudes and cultural factors widely influence children's adoption of oral hygiene practices (OHP). Recent literature has demonstrated a knowledge gap in parents and caregivers regarding these practices. This qualitative study explored the traditional oral health beliefs, perspectives and practices among parents and caregivers of children aged 0-3 years, both with and without ECC via 24 semi-structured interviews and 2 focus group discussions. Moreover, information was collected regarding oral health practices and oral health-seeking behaviours to obtain in-depth insights into this phenomenon. The research process was guided by the Fisher-Owen's model focusing on child- and family-level influences. The audio recordings were entered into the NVivo software and analysed using the thematic analytical approach. The analysis unveiled two main themes under child-level and three under family-level influences. The findings revealed that child- and family-level determinants, such as the tender age of the child and poor cooperation in complying with OHP coupled with poor parental awareness of the importance of oral hygiene, specifically tooth brushing methods, use of toothpaste, the role of fluoride in the prevention of ECC, nighttime brushing and poor self-efficacy contributed to its inadequate practice. Preventing ECC requires an attitudinal and behavioural change among parents and caregivers. These observations indicate the lack of knowledge about oral health and OHP amongst parents and underscore the need for enhanced parental awareness and understanding of OHP via educational programs, and the development of effective oral health policies to improve oral health outcomes in young children.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"49 4","pages":"48-58"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147700089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICAM1 promotes the proliferation, migration, and odontoblast differentiation of human dental pulp stem cells by activating the TGF-β1/Smad pathway","authors":"","doi":"10.22514/jocpd.2025.117","DOIUrl":"https://doi.org/10.22514/jocpd.2025.117","url":null,"abstract":"Background: Intercellular adhesion molecule 1 (ICAM1) plays an important role in regulating cellular processes associated with tissue repair. Dental pulp stem cells (DPSCs) are essential for dental tissue regeneration, particularly in response to pulp injury. However, the regulatory mechanisms by which ICAM1 influences DPSC behavior remain to be fully elucidated. Methods: ICAM1 was overexpressed or silenced in DPSCs using viral transduction, and Transforming Growth Factor (TGF)-β1 expression was also knocked down to explore downstream effects. Cell proliferation was evaluated by Cell Counting Kit (CCK)-8 assay, while cell migration was evaluated via Transwell assays and Western blotting for Matrix Metalloproteinase (MMP)-2 and MMP-9. Odontoblastic differentiation was determined by Alkaline Phosphatase (ALP) activity assays, Alizarin Red S staining, and Western blot analysis of odontogenic markers including Dentin Sialophosphoprotein (DSPP), Osteocalcin (OCN), Runt-related transcription factor 2 (RUNX2), and Osterix (OSX). Activation of the TGF-β1/Mothers Against Decapentaplegic Homolog (Smad) pathway was examined through Western blotting of TGF-β1, Smad2, phosphorylated Smad2 (p-Smad2), Smad3, and phosphorylated Smad3 (p-Smad3). Results: Overexpression of ICAM1 enhanced DPSC proliferation, migration, and odontoblastic differentiation, which was accompanied by upregulation of the TGF-β1/Smad signaling pathway. Conversely, ICAM1 knockdown suppressed these cellular activities and attenuated pathway activation. Furthermore, TGF-β1 knockdown reversed the promotive effect of ICAM1 overexpression on odontoblastic differentiation, suggesting that ICAM1 exerts its effects in a TGF-β1-dependent manner. Conclusions: ICAM1 facilitates the proliferation, migration, and odontoblastic differentiation of DPSCs by activating the TGF-β1/Smad signaling pathway. These findings highlight the potential of ICAM1 as a regulatory target for enhancing dental pulp regeneration.","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"49 5","pages":"219-219"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-splenectomy permanent tooth extraction in a child with hereditary spherocytosis: a case report and guidelines care.","authors":"Patrick Pereira Garcia, Luenny Maria Moraes Pinheiro, Wellington José Alves Nunes, Rudys Rodolfo de Jesus Tavares, Cyrene Piazera Silva Costa","doi":"10.22514/jocpd.2024.143","DOIUrl":"10.22514/jocpd.2024.143","url":null,"abstract":"<p><p>Hereditary Spherocytosis (HS) is a type of hemolytic anemia characterized by a defect in the membrane of red blood cells, which causes them to assume a spherical shape, become osmotically fragile, and be prone to early hemolysis. While it is relatively well understood in the medical field, there is limited evidence regarding the dental management of patients with this condition. Therefore, this report aims to present a case involving the extraction of permanent teeth before splenectomy in a child with HS who had been hospitalized. Additionally, treatment guidelines for these patients are proposed and developed. The patient was scheduled to undergo a total splenectomy due to splenomegaly resulting from severe hemolytic anemia. Prior to the surgery, the child was referred to the hospital's dental clinic with a chief complaint of dental pain. An intraoral examination revealed carious lesions with pulpal involvement in the first molars, and extraction was recommended to minimize the risk of post-splenectomy infection. Hematological support was provided during dental treatment since partial control of the anemia was necessary for the extraction procedure. Developing dental treatment guidelines for patients with HS is essential to ensure their safety.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"48 6","pages":"221-224"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remineralization potential of a novel varnish: an <i>in vitro</i> comparative evaluation.","authors":"Ayse Nur Parlakyildiz Gokce, Ergun Kelesoglu, Kadir Sagır, Betul Kargul","doi":"10.22514/jocpd.2024.137","DOIUrl":"10.22514/jocpd.2024.137","url":null,"abstract":"<p><p>Despite fluoride's widespread use in preventing dental caries, it remains a significant oral disease with some drawbacks. Consequently, new preventative agents have emerged that can function independently of fluoride. Our aim is to demonstrate the efficacy of newly developed varnishes, 3% Rennou (theobromine calcium and phosphate) and 1% Rennou, in remineralizing initial caries. In our experiment, 40 human enamel samples were randomly allocated into four groups of 10 samples each as: Group 1 (G1): 5% NaF (Colgate PreviDent®), Group 2 (G2): 1% Rennou®, Group 3 (G3): 3% Rennou® and Group 4 (G4): Casein Phosphopeptide-Amorphous Calcium Phosphate + Fluoride (MI Varnish^TM GC). To produce an artificial carious lesion in the enamel, the samples were kept in a demineralizing solution for 72 hours. Samples underwent pH cycling for 6 days in order to induce remineralization. The means of the three measurements were compared, and the percentage of Surface Microhardness Recovery in (SMHR%) was calculated. Scanning Electron Microscopy (SEM) was used for qualitative assessment of surface changes. G1 had the highest SMHR% value, followed by G3, G2 and G4. The One-way ANOVA (Analysis of Variance) showed significant differences in the SMHR% values among the groups after six days of cycling (<i>p</i> < 0.001). In pairwise comparisons, groups did not show differences in means of SMHR% except for G1 and G4 (<i>p</i> = 0.006). In the SEM Images, after treatment within the NaF group, many flaky sediments were found on the enamel surface. Similarly, the maximum mineral gain was seen in the NaF and Rennou groups. SEM images of both varnish surfaces revealed a uniform layer interspersed with shapeless precipitates. All varnishes treated artificial enamel lesions to varying degrees. However, both concentrations of Rennou showed remineralization potential comparable to 5% NaF in acceptable statistical measurements. Thus, it could be used as a potentially effective preventive measure for pediatric patients.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"48 6","pages":"173-180"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Clearfil SE Bond 2 on restoring deciduous anterior teeth with ring caries and analysis of caries risk factors in children aged 3-8 years.","authors":"Jie Xiong, Qian Lv, Quqiuzi Wang, Xiaoyun Luo, Yujun Yang, Mengming Cao","doi":"10.22514/jocpd.2024.141","DOIUrl":"10.22514/jocpd.2024.141","url":null,"abstract":"<p><p>To investigate the impact of various self-acid corrosion adhesives in restoring ring caries in anterior deciduous teeth and the influencing factors of childhood caries. This study retrospectively analyzed the repair effect of two kinds of restoration schemes on the annular caries of children's deciduous anterior teeth. According to the repair scheme, 54 children with caries were divided into two groups. The children with 3M single bond repair were set as the control group, and the children with Clearfil SE Bond 2 repair were set as the study group. The repair effect of 6 months and 12 months of treatment and the treatment satisfaction of children were compared. Additionally, 50 children with no oral abnormalities were included as a healthy control group to analyze dental caries risk factors comparatively. The retention of dental restorations, marginal adaptation to dentin, and dental pulp vitality scores in the study group were significantly lower than those in the control group at both 6 and 12 months post-treatment, with statistically significant differences (<i>p</i> < 0.05). Moreover, satisfaction levels in the study group notably exceeded those in the control group (92.59% <i>vs.</i> 70.37%). Fisher exact test yielded a <i>p</i> value of 0.041. Binary logistic regression analysis revealed that daily tooth brushing habits and parental supervision were protective against dental caries occurrence. Conversely, plaque, dental calculus, proficiency in tooth brushing techniques, and post-brushing bedtime snacking emerged as independent risk factors for dental caries (<i>p</i> < 0.05). Compared to the conventional self-etching dentin adhesive filling regimen, the novel blended adhesive and composite resin filling significantly enhanced dental caries restoration outcomes and increased children's satisfaction. Notably, this approach was well-received by both children and their families. Further proactive measures targeting children with identified risk factors are warranted to reduce the incidence of dental caries.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"48 6","pages":"205-212"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eruption disturbance in first molar and primary second molar caused by multiple compound odontomas: a case report.","authors":"Tatsuya Akitomo, Yuko Iwamoto, Ami Kaneki, Taku Nishimura, Masashi Ogawa, Momoko Usuda, Mariko Kametani, Satoru Kusaka, Chieko Mitsuhata, Ryota Nomura","doi":"10.22514/jocpd.2024.144","DOIUrl":"10.22514/jocpd.2024.144","url":null,"abstract":"<p><p>Odontoma is an occasionally encountered condition that disturbs the eruption of adjacent teeth. Few reports have described multiple odontomas occurring at two adjacent sites, resulting in eruption disturbances of both primary and permanent teeth. An 8-year 2-month-old boy was referred to our hospital. Oral examination revealed that the maxillary left first molar and primary second molar were absent, and radiographic examination showed multiple compound odontomas in two regions near these unerupted teeth. The first molar gradually erupted after removal of the odontoma and excision of overlying gingiva around the tooth crown. The maxillary left second premolar spontaneously erupted at 9 years 6 months of age, but the impacted primary second molar and surrounding odontoma were located near the bottom of the maxillary sinus. The treatment plan was required to consider the completion of second premolar root development, followed by removal of the impacted primary second molar and remaining odontomas. In this case, the multiple odontomas were suspected to have disturbed the eruption of both primary and permanent teeth, and the degree of positional abnormality varied between the two teeth. This case report suggests the importance of early detection and treatment of teeth with odontoma-induced eruption disturbances.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"48 6","pages":"236-242"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large mandibular odontogenic keratocyst treated by decompression and secondary enucleation: a case report.","authors":"Jianfeng He, Huijing Wang, Jun Zeng, Libin Zhou","doi":"10.22514/jocpd.2024.142","DOIUrl":"10.22514/jocpd.2024.142","url":null,"abstract":"<p><p>Odontogenic keratocyst (OKC) is a common developmental odontogenic cyst in clinic patients. Odontogenic cysts are often treated by enucleation, curettage, marsupialization and decompression. With apparent advantages, marsupialization and decompression are often the preferred option for adolescents with large jaw cysts. This article aimed to report a case of large OKC involving the left mandibular second molar and third molar in a 13-year-old adolescent. Decompression was performed to preserve the second molar and inferior alveolar nerve, and the third molar was extracted. After ten months of follow-up, cyst volume decreased significantly, and the impacted second molar erupted spontaneously through the bony window. Subsequently, the residual cyst was removed by enucleation. After 18 months, the second molar erupted to the occlusal plane and played a normal function. No evidence of recurrence was found during the entire follow-up period.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"48 6","pages":"213-220"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is maxillary protraction the earlier the better? A retrospective study on early orthodontic treatment of Class III malocclusion with maxillary deficiency.","authors":"Yibo Li, Alimire Alifu, Yiran Peng","doi":"10.22514/jocpd.2024.133","DOIUrl":"10.22514/jocpd.2024.133","url":null,"abstract":"<p><p>To investigate the optimal timing of maxillary protraction in children with Class III malocclusion to aid comprehension of this still non-consensual topic. In all, the data of 97 children with Class III malocclusion treated by using the Delaire facemask with maxillary expansion were collected retrospectively and divided into three groups according to their dentition stages; those subjects in the mixed dentition group were further divided into three subgroups. All patients were regrouped by the cervical vertebral maturation index (CVMI) and observed closely by cephalograms at the beginning of treatment (T0) and after facemask removal (T1). Comparisons between subgroups, within groups, and the final evaluation of the increment of maxillary length were performed by different statistical methods. Similar favorable maxillary traction effects were achieved in all stages. Intragroup comparisons showed changes without significance in aspect ratio during the mixed dentition stage, while there was a significant decrease during the deciduous and permanent dentition stages. The largest increment of maxillary length was obtained when the maxillary protraction began at Cervical Stage (CS)2. However, no significant difference was found in all skeletal measurements among the three groups (deciduous, mixed and permanent dentition stages) and the three subgroups with mixed dentition. The univariable linear regression analysis also showed that CVMI and dentition stage at T1 did not have a significant impact on the increment of maxillary length. In our center, Class III malocclusion patients treated with the Delaire facemask achieved similar skeletal changes in short term, when they began the treatment at different dentition stages or CVMI stages. Starting the maxillary protraction at CS2 was likely a reliable choice for those who desired more maxillary advancement.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"48 6","pages":"133-143"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness and parental acceptance of silver diamine fluoride in preschool children: a non-randomized trial.","authors":"Burak Buldur, Betul Taskaya","doi":"10.22514/jocpd.2024.128","DOIUrl":"10.22514/jocpd.2024.128","url":null,"abstract":"<p><p>Silver diamine fluoride (SDF) presents a promising approach in pediatric dentistry, simplifying procedures by eliminating the need for sharp instruments or anesthesia. This study aimed to evaluate the effectiveness of 38% SDF application in arresting active caries lesions in preschool children and to assess parental acceptance of the treatment. This non-randomized, prospective, single-arm clinical study included 48 children, presenting with a total of 158 active caries lesions. The lesions were treated with 38% SDF, and their characteristics, including changes in dentin color and lesion texture, were evaluated at baseline and at a 6-month follow-up visit. The rate of lesion non-progression post-SDF application was calculated. Additionally, parents completed an oral health behavior form and the Parental Perceptions of Silver Diamine Fluoride Dental Color Changes Questionnaire to assess acceptance. The study observed a high rate of caries arrest in multi-surface teeth following SDF application. There was a statistically significant improvement in parental acceptance of SDF treatment. However, no significant interaction was observed between the treatment and either child- or parent-related variables regarding parental acceptability. The application of 38% SDF effectively arrested caries lesions in preschool children, with an observed increase in parental acceptance pre- and post-treatment.</p>","PeriodicalId":50235,"journal":{"name":"Journal of Clinical Pediatric Dentistry","volume":"48 6","pages":"78-88"},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}