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[Physical activity for knee osteoarthritis.] [膝关节骨关节炎的体育锻炼。]
Clinical calcium Pub Date : 2017-01-01
Masashi Nagao, Muneaki Ishijima, Haruka Kaneko, Yuji Takazawa, Hiroshi Ikeda, Kazuo Kaneko
{"title":"[Physical activity for knee osteoarthritis.]","authors":"Masashi Nagao, Muneaki Ishijima, Haruka Kaneko, Yuji Takazawa, Hiroshi Ikeda, Kazuo Kaneko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Elder populations have been increasing in Japan and estimated 24 million people have knee osteoarthritis(OA). Recently, people have diverse sociological background and demand for participating sports has been growing. People may participate sports to prevent some diseases such as locomotive syndrome. According to the recent studies, excessive high impact sports increase the risk of OA, while daily life exercise decrease the risk. Epidemiological approach demonstrated that reduced knee extension muscle strength increases the risk of OA. We reviewed and discussed the recent topics including efficacy of physical therapy for knee OA and how much sports activities could be beneficial after knee surgery.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 1","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The significance of exercises and sports in the locomotive syndrome prevention.] 体育锻炼在预防机车综合征中的意义
Clinical calcium Pub Date : 2017-01-01
Hideaki Ishibashi
{"title":"[The significance of exercises and sports in the locomotive syndrome prevention.]","authors":"Hideaki Ishibashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Japan, the world's fastest aging country, the locomotive syndrome that shows a decrease in the mobility due to dysfunctions of the locomotor organs is a major risk factor of long-term care need in the old age. Exercises and sports habits are well reviewed to lead to the improvement and maintenance of motor function, and exercises are also useful in the prevention of a number of musculoskeletal diseases. In addition, several trials with the exercise intervention indicated improvement in motor function, suggesting exercises could prevent the locomotive syndrome. In future, prevalence of exercise habits may lead to decrease the prevalence of locomotive syndrome, resulting in elongation of the healthy life span.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Topics for basic research(osteoclast and bone resorption)in ASBMR 2016.] 【ASBMR 2016基础研究主题（破骨细胞与骨吸收）】
Clinical calcium Pub Date : 2017-01-01
Nobuyuki Udagawa
{"title":"[Topics for basic research(osteoclast and bone resorption)in ASBMR 2016.]","authors":"Nobuyuki Udagawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a brief report summarizing topics in ASBMR 2016 held at Georgia World Congress Center in Atlanta on September 16-19th. In this paper, I report some topics from presentation of basic research(especially osteoclast and bone resorption)in ASBMR 2016.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 1","pages":"128-132"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Efficacy of zoledronic acid for osteoporosis:evidence from studies abroad.] [唑来膦酸治疗骨质疏松症的疗效：国外研究证据]
Clinical calcium Pub Date : 2017-01-01
Daisuke Inoue
{"title":"[Efficacy of zoledronic acid for osteoporosis:evidence from studies abroad.]","authors":"Daisuke Inoue","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Zoledronic acid is a nitrogen-containing bisphosphonate that has the strongest and the most persistent anti-resorptive activity. Once-yearly zoledronic acid has recently been approved for the treatment of osteoporosis in Japan. This overview summarizes abundant evidence of zoledronic acid, obtained from studies abroad, for its efficacy for postmenopausal, male and glucocorticoid-induced osteoporosis.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 2","pages":"247-255"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of zoledronic acid on osteoporosis patients in Japan.] [唑来膦酸对日本骨质疏松症患者的影响]
Clinical calcium Pub Date : 2017-01-01
Sakae Tanaka
{"title":"[Effects of zoledronic acid on osteoporosis patients in Japan.]","authors":"Sakae Tanaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Zoledronic acid is a bisphosphonate with the most potent anti-bone resorbing activity. Several previous studies demonstrated that zoledronic acid once a year significantly reduced the risk of vertebral, non-vertebral, and hip fractures in postmenopausal women. In a phase Ⅲ 2-year placebo-controlled, randomized, double-blind comparative study in Japan(ZONE study)demonstrated that once-yearly infusion of zoledronic acid 5 mg increased lumbar spine and proximal femoral BMD, and reduced the incidence of vertebral and non-vertebral fractures in Japanese patients with primary osteoporosis compared to placebo.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 2","pages":"257-261"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Drug selection and treatment goal in osteoporosis therapy.] 骨质疏松症的药物选择与治疗目标
Clinical calcium Pub Date : 2017-01-01
Mika Yamauchi, Toshitsugu Sugimoto
{"title":"[Drug selection and treatment goal in osteoporosis therapy.]","authors":"Mika Yamauchi, Toshitsugu Sugimoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>\u0000 The goal of treatment for osteoporosis is to reduce the risk of fracture. Achieving effective reductions in the risk of fracture requires evidence-based drug selection and careful consideration of patient background, including concomitant diseases and drug adherence. Selective estrogen receptor modulators(SERM)and active vitamin D\u0000 <sub>3</sub>\u0000 such as eldecalcitol are well indicated in early menopausal women with no history of fragility fractures. Moreover, elderly individuals with a history of fragility fractures are at high risk of vertebral and hip fractures, so bisphosphonates, denosumab and teriparatide are well indicated in these patients. Although no well-established goal has been devised for the treatment of osteoporosis in Japan, the strategy of goal-directed treatment of osteoporosis has been reported in the United States.\u0000 </p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 2","pages":"189-196"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathological state or cause of sarcopenia.] [肌肉减少症的病理状态或原因]
Clinical calcium Pub Date : 2017-01-01
Yasumoto Matsui
{"title":"[Pathological state or cause of sarcopenia.]","authors":"Yasumoto Matsui","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Skeletal muscle atrophy by aging(Sarcopenia)is more likely to occur in lower limbs rather than upper ones, and in the thigh rather than in the lower leg, and in the anterior side of thigh rather than posterior, faster in men than in women. It differs from disuse muscle atrophy in that it occurs slowly and gradually, hard to be recovered, or fast twitch fibers are mainly involved. Many factors or phenomena are known to contribute to proceed sarcopenia. In the aged skeletal muscle tissue, the number of satellite cells or motor neurons decrease and the function of the neuro-muscular junction declines. Oxidative stress and chronic inflammation increase as aging which relate with sarcopenia. Inflammatory cytokines, such IL-6, TNF-α, IL-5 play the roles Muscle protein breakdown is up regulated through ubiquitin-dependent proteolysis. Oxidative stress influences mitochondrial dysfunction or induces apoptosis. Also as aging, anabolic factors which are preferable to protein synthesis, such as IGF-1, sex hormones, vitamin D, or branched chain amino acid.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 1","pages":"45-52"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Innovation of bisphosphonates for improvement of adherence.] [创新双膦酸盐改善依从性]
Clinical calcium Pub Date : 2017-01-01
Yasuhiro Takeuchi
{"title":"[Innovation of bisphosphonates for improvement of adherence.]","authors":"Yasuhiro Takeuchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bisphosphonates are standard medicine for treatment of osteoporosis, and have been inovated to overcome complicated rules for their appropriate administration or their poor intestinal absorption. Not only weekly but also monthly oral bisphosphonates have been available. Furthermore, we are now allowed to choose intravenous administration of bisphosphonates for osteorporosis. Good persistance and adherence is another critical and essential issue to be solved to achive the aim of osteoprosis treatment with bisphosphonates. Variable formulations of bisphosphonate are now able to bring patients closer to a goal of reduction in fragile fracture due to osteoporosis.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 2","pages":"197-202"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Osteoporosis in Super-aged society.] [老年社会中的骨质疏松症]
Clinical calcium Pub Date : 2017-01-01
Atsushi Suzuki
{"title":"[Osteoporosis in Super-aged society.]","authors":"Atsushi Suzuki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteoporosis could contribute to increase other chronic diseases such as cardiovascular events, resulting in higher mortality in these patients. Antiresorptive agents such as bisphosphonates has been reported to reduce not only the number of fragile fracture but also all causes mortality. These agents are also expected to improve quality of life and activity of daily life with longer life expectancy.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 2","pages":"183-187"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Influences of resistance training on bone.] [抗阻训练对骨骼的影响]
Clinical calcium Pub Date : 2017-01-01
Naoyuki Kawao, Hiroshi Kaji
{"title":"[Influences of resistance training on bone.]","authors":"Naoyuki Kawao, Hiroshi Kaji","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Resistance training has been known to be effective to maintain and improve bone mineral density(BMD)and bone strength. Resistance training in combination with other types of exercise might be effective for maintaining BMD in patients with osteoporosis. Resistance training improves a decrease in BMD through an enhancement of bone formation and a suppression of bone resorption. It is thought that resistance training might affect bone metabolism through direct biomechanical force on bone cells and endocrinological factors as well as the nervous system.</p>","PeriodicalId":502100,"journal":{"name":"Clinical calcium","volume":"27 1","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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