Journal of Environmental Pathology Toxicology and Oncology最新文献_第3页

Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape 基于凋亡和缺氧相关基因的胃癌预后模型的开发：对生存和免疫格局的预测性洞察力

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2024-03-01 DOI: 10.1615/jenvironpatholtoxicoloncol.2024050455

Jian Zhu, Yao Ma

{"title":"Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape","authors":"Jian Zhu, Yao Ma","doi":"10.1615/jenvironpatholtoxicoloncol.2024050455","DOIUrl":"https://doi.org/10.1615/jenvironpatholtoxicoloncol.2024050455","url":null,"abstract":"Background: Gastric cancer (GC) stands as the fifth most prevalent malignancy worldwide and the fourth primary contributor to cancer-associated fatalities worldwide. The search for pivotal prognostic biomarkers and elucidation of underlying mechanisms driving GC progression necessitate innovative approaches. Apoptosis and hypoxia were intricately associated and interdependent in tumorigenesis. This work investigated the potential value of apoptosis- and hypoxia-related genes (AHRGs) in GC prognosis, with implications for immune therapy in GC patients.\u0000Methods: Differential expression analysis was performed on GC transcriptomic data from TCGA. Apoptosis-related genes (ARGs) and hypoxia-related genes (HRGs) were obtained from the MSigDB database, followed by intersection analysis with differentially expressed genes (DEGs) in GC. A prognostic model was constructed using univariate Cox regression, LASSO analysis, and multivariate Cox regression analyses. The model was validated using a GEO dataset, and DEGs between high- and low-risk groups were subjected to enrichment analysis. A nomogram was created by incorporating clinical information. Non-negative matrix factorization based on core prognostic genes from the multifactorial model was employed to cluster tumor samples. The subsequent analyses encompassed immune landscape, immunophenoscore, TIDE score, as well as chemosensitivity for distinct subtypes.\u0000Results: A prognostic model based on AHRGs was established, and its robust predictive capability was validated in external cohorts. Riskscore was determined as an independent prognostic factor, augmenting prognostic nomogram in conjunction with other clinical features.","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"15 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140125410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment strategy for breast benign intraductal papilloma: A Meta-Analysis 乳腺良性导管内乳头状瘤的治疗策略：元分析

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2024-03-01 DOI: 10.1615/jenvironpatholtoxicoloncol.2024052888

Congkun Lou, Wenxin Wang, Binggang Zhou

{"title":"Treatment strategy for breast benign intraductal papilloma: A Meta-Analysis","authors":"Congkun Lou, Wenxin Wang, Binggang Zhou","doi":"10.1615/jenvironpatholtoxicoloncol.2024052888","DOIUrl":"https://doi.org/10.1615/jenvironpatholtoxicoloncol.2024052888","url":null,"abstract":"Background: Currently, the optimal treatment approach for breast benign intraductal papilloma (IDP) diagnosed via biopsy remains uncertain. There is ongoing debate regarding the feasibility of clinical follow-up and the criteria for selective surgical excision.\u0000Objective: This study aims to conduct a meta-analysis to determine the rate of upgrade from breast benign IDP and identify predictive factors associated with the conversion of benign IDP to high-risk lesions or carcinoma, which could guide healthcare practitioners in selecting the appropriate clinical treatment strategy.\u0000Methods: We conducted a comprehensive search across multiple databases (PubMed, Web Of Science, Cochrane Library, and Embase) for studies published between 2012 and 2023 that evaluated upgrade rates and predictive factors of breast benign IDP diagnosed via biopsy. In addition, we included studies that reported on the clinical follow-up of patients with breast benign IDP.\u0000Results: In total, 32 studies comprising 7,371 cases of biopsy-diagnosed breast benign IDP were included. Among these cases, 720 demonstrated an upgrade to high-risk lesions or carcinoma, resulting in an upgrade rate of 6.94% (95% confidence interval: 3.0-8.0%). A subgroup of 1,713 patients was clinically followed up, demonstrating an average follow-up duration of 30.95 months. Among them, 26 cases experienced an upgrade to high-risk lesions or carcinoma, yielding an upgrade rate of 1.51% (95% CI 0.00-2.00%). Furthermore, we identified nine predictive factors associated with the upgrading of breast benign IDP, which included age at diagnosis, personal history of breast cancer, family history of breast cancer, multiple IDPs, lesi","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"24 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140054960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on protease inhibitors of herbal origin to combat malignancy 草药蛋白酶抑制剂抗击恶性肿瘤综述

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2024-03-01 DOI: 10.1615/jenvironpatholtoxicoloncol.2024052872

Sanjib Bhattacharya

引用次数: 0

Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma 铁代谢和免疫相关基因作为肝细胞癌风险标志物的预后意义

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2024-03-01 DOI: 10.1615/jenvironpatholtoxicoloncol.2024050167

Shijing Tang, Hao Chen

{"title":"Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma","authors":"Shijing Tang, Hao Chen","doi":"10.1615/jenvironpatholtoxicoloncol.2024050167","DOIUrl":"https://doi.org/10.1615/jenvironpatholtoxicoloncol.2024050167","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with significant heterogeneity, which poses challenges in predicting prognosis and treatment outcomes. The impact of iron metabolism and immune-related genes (IMRGs) on HCC patient prognoses remains elusive. We utilized The Cancer Genome Atlas (TCGA) dataset to obtain mRNA expression data and clinical information from HCC patients. Through the application of LASSO regression and univariate/multivariate Cox regression analyses, we identified five IMRGs significantly associated with survival of HCC patients. We constructed a prognostic model comprising these five genes. The model demonstrated excellent predictive performance, not only within TCGA dataset but also when validated using the Gene Expression Omnibus (GEO) dataset. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses presented significant variations in functional categories, such as apical plasma membrane and collagen-containing extracellular matrix. Several pathways, including the PI3K-AKT signaling pathway and the calcium signaling pathway, exhibited significant variations among HCC patients with varying prognoses (P<0.05). Immune infiltration analysis indicated significantly lower levels of various immune cells, immune functions, and immune checkpoints, such as B cells, CD8+ T cells, and TILs, in the high-risk group (P<0.05). Immunophenoscore results suggested that the low-risk group may exhibit a more favorable response to immune therapy. Furthermore, the CellMiner database predicted anti-tumor drugs significantly associated with prognostic genes (P<0.001). In conclusion, our findings highlight the predictive r","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"27 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140045704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNF20 reduced cell proliferation and Warburg effect of Liver cancer by the promotion of NLRP3 Ubiquitination in liver cancer RNF20 通过促进 NLRP3 泛素化减少肝癌细胞增殖和沃伯格效应

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2024-03-01 DOI: 10.1615/jenvironpatholtoxicoloncol.2024053012

Deqin Liu, Renyin Luo, Qian Zhou, Mei Li

{"title":"RNF20 reduced cell proliferation and Warburg effect of Liver cancer by the promotion of NLRP3 Ubiquitination in liver cancer","authors":"Deqin Liu, Renyin Luo, Qian Zhou, Mei Li","doi":"10.1615/jenvironpatholtoxicoloncol.2024053012","DOIUrl":"https://doi.org/10.1615/jenvironpatholtoxicoloncol.2024053012","url":null,"abstract":"Background: The present study explored that the effects and its possible mechanisms of ring finger protein 20 (RNF20) in Postoperative survival rate of Liver cancer in clinical.\u0000Methods: All the serum samples were collected from our hospital. Quantitative polymerase chain reaction (PCR) and Microarray analysis, and RNA pull down assay were used in this study.\u0000Results: We found that the serum RNF20 mRNA expression level in patients with liver cancer were down-regulated. Postoperative survival rate of RNF20 high expression was higher than that of RNF20 low expression. Then, over-expression of RNF20 diminished liver cancer cell proliferation and metastasis. RNF20 reduced Warburg effect of Liver cancer. RNF20 expression regulated NOD-like receptor protein 3 (NLRP3) expression and increased NLRP3 Ubiquitination. NLRP3 participated in the effects of RNF20 on cell proliferation, and not affected on Warburg effect of Liver cancer.\u0000Conclusions: Our study demonstrated that the serum RNF20 expression level was down-regulated in Liver cancer, and promoted postoperative survival rate. RNF20 can reduce cancer progression of Liver cancer by NLRP3 signal pathway, suggesting that it may prove to be a potential therapeutic target for postoperative survival rate of Liver cancer.","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"84 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140152958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotics and Cancer : A Review on the anti-cancer activity of probiotics 益生菌与癌症：益生菌抗癌活性综述

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2024-01-01 DOI: 10.1615/jenvironpatholtoxicoloncol.2023049792

Akhil Nair, Kanchanlata Tungare, Ameyota De, Renitta Jobby

{"title":"Probiotics and Cancer : A Review on the anti-cancer activity of probiotics","authors":"Akhil Nair, Kanchanlata Tungare, Ameyota De, Renitta Jobby","doi":"10.1615/jenvironpatholtoxicoloncol.2023049792","DOIUrl":"https://doi.org/10.1615/jenvironpatholtoxicoloncol.2023049792","url":null,"abstract":"Among the most prominent diseases in the world, the number of cancer cases has steadily increased over the last few decades. It has also developed into a significant global issue as a result of its increasing mortality. Even though various anti-cancer medications exist, we have not been able to eradicate cancer totally. The numerous undesirable effects associated with cancer therapy further emphasize the importance of developing an alternative technique of cancer treatment. Recent research has established the beneficial effects of a probiotic diet or supplementation against cancer without displaying any detrimental consequences. In humans, an imbalance in the gut microbiome can act as a trigger for the onset of a variety of diseases, including cancer. Probiotics play a critical role in re-establishing the composition of the gut flora, which can aid in cancer prevention. Additionally, they can limit the invasion and spread of infections that have the potential to cause cancer. Probiotics can combat cancer in a variety of ways, including by eliciting and boosting the immune response, secreting metabolites, preventing cancer cells from metastasizing, inhibiting carcinogenic chemicals and mitigating their toxicity, etc. This review aims to summarize the role of probiotics and their mechanisms of action against the different types of cancers. Additionally, this review highlights the benefits of probiotic use in pre- and post-operative cancer patients","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"39 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139103846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Janus Kinase-Signal Transducer and Activator of Transcription Inhibitors for the Treatment and Management of Cancer. Janus激酶信号转导子和转录抑制剂激活子用于癌症的治疗和管理。

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2023-01-01 DOI: 10.1615/JEnvironPatholToxicolOncol.2023045403

Fahim Anwar Rizwi, Md Abubakar, Eswara Rao Puppala, Ahsas Goyal, Ch Veera Bhadrawamy, V G M Naidu, S Roshan, B Tazneem, Waleed Hassan Almalki, Vetriselvan Subramaniyan, Sushama Rawat, Gaurav Gupta

{"title":"Janus Kinase-Signal Transducer and Activator of Transcription Inhibitors for the Treatment and Management of Cancer.","authors":"Fahim Anwar Rizwi, Md Abubakar, Eswara Rao Puppala, Ahsas Goyal, Ch Veera Bhadrawamy, V G M Naidu, S Roshan, B Tazneem, Waleed Hassan Almalki, Vetriselvan Subramaniyan, Sushama Rawat, Gaurav Gupta","doi":"10.1615/JEnvironPatholToxicolOncol.2023045403","DOIUrl":"10.1615/JEnvironPatholToxicolOncol.2023045403","url":null,"abstract":"According to the World Health Organization (WHO), cancer is the second-highest cause of mortality worldwide, killing nearly 9.6 million people annually. Despite the advances in diagnosis and treatment during the last couple of decades, it remains a serious concern due to the limitations of currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. In addition, many etiological factors such as environmental and genetic factors initiate the activation of the Janus kinase (JAK)-signal transducer and activator of the transcription (STAT) pathway. This aberrant activation of the JAK-STAT pathway has been reported in various disease states, including inflammatory conditions, hematologic malignancies, and cancer. For instance, many patients with myeloproliferative neoplasms carry the acquired gain-of-function JAK2 V617F somatic mutation. This knowledge has dramatically improved our understanding of pathogenesis and has facilitated the development of therapeutics capable of suppressing the constitutive activation of the JAK-STAT pathway. Our aim is not to be expansive but to highlight emerging ideas towards preventive therapy in a modern view of JAK-STAT inhibitors. A series of agents with different specificities against different members of the JAK family of proteins is currently undergoing evaluation in clinical trials. Here we give a summary of how JAK-STAT inhibitors function and a detailed review of current clinical drugs for managing cancer as a new therapeutic approach.","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"42 4","pages":"15-29"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9898043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Differences between Urban and Rural Environments on Cardiovascular Health: A Systematic Review. 城乡环境对心血管健康的影响:一项系统综述。

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2023-01-01 DOI: 10.1615/JEnvironPatholToxicolOncol.2023047649

Venetia Notara, Stamatia Kokkou, Emanouil Bindakos, Evanthia Sakellari, Constantina Skanavis

{"title":"Differences between Urban and Rural Environments on Cardiovascular Health: A Systematic Review.","authors":"Venetia Notara, Stamatia Kokkou, Emanouil Bindakos, Evanthia Sakellari, Constantina Skanavis","doi":"10.1615/JEnvironPatholToxicolOncol.2023047649","DOIUrl":"https://doi.org/10.1615/JEnvironPatholToxicolOncol.2023047649","url":null,"abstract":"The effect of the urban vs. rural environment on cardiovascular health is an extremely significant issue, nowadays. Up to date, there is a number of studies revealing that there is environmental impact on the prevalence of cardiovascular disease (CVD). The aim of the current systematic review was to investigate the relationship between the natural environment and cardiovascular health, through the differences between urban and rural environments. A literature search was conducted during July 2022-November 2022 using the databases PubMed/Medline, Scopus and Google Scholar (limited to the last 10 years). The search identified four studies that fulfilled the main aim of the present review. Regardless of the limited number of studies, it was shown that the different environments have a great impact on cardiovascular health. Specifically, various factors seem to affect the occurrence of CVDs in both urban and rural environments. The present review highlights the effect of urban vs. rural environment in relation to cardiovascular risk factors. However, there is a necessity for further investigation in this field in order to shed more light on the environmental components with the most significant impact.","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"42 4","pages":"87-94"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9910760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma. 基于免疫组织化学和原位杂交的胃癌分子分类的临床病理特征及预后意义。

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2023-01-01 DOI: 10.1615/JEnvironPatholToxicolOncol.2023047662

Gizem Issin, İlyas Sayar, Fatih Demir, İrem Güvendir Bakkaloğlu, Mehmet Gamsizkan, Zeliha Yildiz, Ismail Yilmaz, Sevilay Akalp Özmen, Diren Vuslat Çağatay, Itır Ebru Zemheri, Murat Demiriz, Armağan Günal

{"title":"Clinicopathologic Features and Prognostic Significance of Immunohistochemistry and In Situ Hybridization Based Molecular Classification in Gastric Carcinoma.","authors":"Gizem Issin, İlyas Sayar, Fatih Demir, İrem Güvendir Bakkaloğlu, Mehmet Gamsizkan, Zeliha Yildiz, Ismail Yilmaz, Sevilay Akalp Özmen, Diren Vuslat Çağatay, Itır Ebru Zemheri, Murat Demiriz, Armağan Günal","doi":"10.1615/JEnvironPatholToxicolOncol.2023047662","DOIUrl":"https://doi.org/10.1615/JEnvironPatholToxicolOncol.2023047662","url":null,"abstract":"Background/aim: Gastric carcinoma (GC) is a highly heterogeneous disease with many subtypes that have different morphologic and molecular characteristics. In the current study, we analyzed immunohistochemical (IHC) and in situ hybridization (ISH) features of GCs and evaluated their association with prognosis and clinicopathological features.Materials and methods: Three hundred cases analyzed by IHC and ISH for microsatellite stability, p53, e-cadherin, HER2, PD-L1 expression, and Epstein-Barr virus (EBV) status. Cases were classified into five subgroups based on expression profile. The relationships between subgroups, clinicopathological features, and survival were determined.Results: Ten (3.3%) cases were classified as EBV-associated, 45 (15%) as microsatellite instable (MSI), 73 (24.3%) as EBV-/microsatellite-stable (MSS)/epithelial-mesenchymal-transformation (EMT)-like, 75 (25%) as EBV-/MSS/ non-EMT-like/p53+, and 97 (32.3%) as EBV-/MSS/non-EMT-like/p53-. The MSI subtype had the best overall survival (OS). In contrast, the EBV-/MSS/EMT-like subtype had the poorest OS. The MSI subtype was also related with old age of the patient and antrum-corpus localized tumors, whereas the EBV-/MSS/EMT-like was associated with young age, larger tumor size, and advanced stage presentation. PD-L1 positivity is highly correlated with MSI and EBV-associated subtypes.Conclusion: Our data demonstrated a link between IHC/ISH characteristics of GC and clinical outcomes. IHC/ISH based molecular classification may be helpful in predicting the survival.","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"42 4","pages":"1-14"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9910761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines. 抗癌植物化学纳米制剂:对癌细胞系的治疗干预。

IF 2.4 4区医学

Journal of Environmental Pathology Toxicology and Oncology Pub Date : 2023-01-01 DOI: 10.1615/JEnvironPatholToxicolOncol.2022044317

Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M Balaramnavar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Gaurav Gupta, Madan Mohan Gupta

{"title":"Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines.","authors":"Debjyoti Talukdar, Parveen Kumar, Deepak Sharma, Vishal M Balaramnavar, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Imran Kazmi, Fahad A Al-Abbasi, Sami I Alzarea, Gaurav Gupta, Madan Mohan Gupta","doi":"10.1615/JEnvironPatholToxicolOncol.2022044317","DOIUrl":"https://doi.org/10.1615/JEnvironPatholToxicolOncol.2022044317","url":null,"abstract":"Phytochemicals have the potential to treat resistant cancer. They are delivered to the target site via nano-based carriers. Promising results are seen in preclinical and in vitro models, as phytochemical-based nanoformulations have improved cell cytotoxicity compared to single agents. They can synergistically inhibit cancer cell growth through p53 apoptosis in MCF-7 breast cancer cell lines. Moreover, synergic viability in reproducible glioma models at half inhibitory concentrations has been shown. Through caspase activation, phytochemical-based nanoformulations also increase cell death in 4T1 breast cancer cell lines. They have shown improved cytotoxicity at half inhibitory concentrations compared to single-agent drugs in cervical cancer. In terms of colorectal cancer, they have the potential to arrest cells in the S phase of the cell cycle and synergistically inhibit cell proliferation. In squamous cell carcinoma of the tongue, they inhibit protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathways. This review reports on developments in the therapeutic management of various cancers using phytochemical-based nanoformulations, which have shown potential benefits in the clinical management of cancer patients, halting/slowing the progression of the disease and ameliorating chemotherapy-induced toxicities.","PeriodicalId":50201,"journal":{"name":"Journal of Environmental Pathology Toxicology and Oncology","volume":"42 1","pages":"79-93"},"PeriodicalIF":2.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9212614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3