{"title":"Sagamicin and the related aminoglycosides: fermentation and biosynthesis. I. Biosynthetic studies with the blocked mutants of Micromonospora sagamiensis.","authors":"H Kase, Y Odakura, K Nakayama","doi":"10.7164/antibiotics.35.1","DOIUrl":"https://doi.org/10.7164/antibiotics.35.1","url":null,"abstract":"<p><p>The mutants blocked in the gentamicin C1 production were derived from a sagamicin producing strain of Micromonospora sagamiensis. The intermediates produced by these mutants were isolated and properly identified. Comparing the biotransformation activities in the resting cells of the mutants with those of a DOS idiotroph, KY 11525, the blocked steps in sagamicin and gentamicin biosynthesis were proposed in each mutant. Mutant KY 11564 was found to produce gentamicin C2a (C-6'-epimer of gentamicin C2) together with gentamicin C1a and sagamicin. KY 11525 transformed gentamicin C2a into C2 and C1, whereas KY 11564 lacked the activity. KY 11565 produced gentamicin X2 and antibiotic G-418, and lacked 6'-amino substitution activities. KY 11566 appeared to be partially blocked in 6'-N-methylation activities, and the major products were gentamicin C2a and C1a. From these results, sagamicin biosynthesis in M. sagamiensis is discussed.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"1-9"},"PeriodicalIF":3.3,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35257897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"STREPTOMYCES TROPICALENSIS, A NEW WHORL-FORMING SPECIES OF STREPTOMYCES.","authors":"K C GUPTA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"53-5"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40782085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H KAWAGUCHI, H TSUKIURA, M OKANISHI, T MIYAKI, T OHMORI, K FUJISAWA, H KOSHIYAMA
{"title":"STUDIES ON COUMERMYCIN, A NEW ANTIBIOTIC. I. PRODUCTION, ISOLATION AND CHARACTERIZATION OF COUMERMYCIN A1.","authors":"H KAWAGUCHI, H TSUKIURA, M OKANISHI, T MIYAKI, T OHMORI, K FUJISAWA, H KOSHIYAMA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"1-10"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40881421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"STUDIES ON QUINOXALINE ANTIBIOTICS. IV. SELECTIVE ANTITUMOR ACTIVITY OF EACH QUINOXALINE ANTIBIOTIC.","authors":"S MATSUURA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"43-6"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40782083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"POLYCHLOROSUBTILIN, AN ANTIBIOTIC NEWLY ISOLATED FROM METABOLITES OF BACILLUS SUBTILIS.","authors":"I R SHIMI, M W KELADA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"58-9"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40782086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"STUDIES ON COUMERMYCIN. A NEW ANTIBIOTIC. II. STRUCTURE OF COUMERMYCIN A1.","authors":"H KAWAGUCHI, T NAITO, H TSUKIURA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"11-25"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40881420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"STRUCTURES OF BOTTROMYCINS A AND B.","authors":"S NAKAMURA, T CHIKAIKE, H YONEHARA, H UMEZAWA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"60-1"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40782087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S I KONDO, M SEZAKI, M KOIKE, M SHIMURA, E AKITA, K SATOH, T HARA
{"title":"DESTOMYCINS A AND B, TWO NEW ANTIBIOTICS PRODUCED BY A STREPTOMYCES.","authors":"S I KONDO, M SEZAKI, M KOIKE, M SHIMURA, E AKITA, K SATOH, T HARA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"38-42"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40881422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S NAKAMURA, T CHIKAIKE, K KARASAWA, N TANAKA, H YONEHARA, H UMEZAWA
{"title":"ISOLATION AND CHARACTERIZATION OF BOTTROMYCINS A AND B.","authors":"S NAKAMURA, T CHIKAIKE, K KARASAWA, N TANAKA, H YONEHARA, H UMEZAWA","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"47-52"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40782084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E HIGASHIDE, T HASEGAWA, M SHIBATA, K MIZUNO, M IMANISHI, A MIYAKE
{"title":"STUDIES ON STREPTOMYCETES. SIMULTANEOUS PRODUCTION OF OLEANDOMYCIN AND CHROMOMYCINS BY STREPTOMYCES OLIVOCHROMOGENES NO. 69895.","authors":"E HIGASHIDE, T HASEGAWA, M SHIBATA, K MIZUNO, M IMANISHI, A MIYAKE","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"26-37"},"PeriodicalIF":3.3,"publicationDate":"1965-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40782082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}