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The Journal of Antibiotics最新文献

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Correction: New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602. 更正：当与共同生产的化合物 L-156,602 结合使用时，来自一种白花蛇舌草菌株的新蛇床子素 B 和 C 对耐甲氧西林金黄色葡萄球菌具有协同活性。
The Journal of Antibiotics Pub Date : 2024-05-17 DOI: 10.1038/s41429-024-00722-6
H. Hashizume, Shigeko Harada, R. Sawa, K. Iijima, Y. Kubota, Y. Shibuya, Ryoko Nagasaka, Masaki Hatano, Masayuki Igarashi
{"title":"Correction: New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602.","authors":"H. Hashizume, Shigeko Harada, R. Sawa, K. Iijima, Y. Kubota, Y. Shibuya, Ryoko Nagasaka, Masaki Hatano, Masayuki Igarashi","doi":"10.1038/s41429-024-00722-6","DOIUrl":"https://doi.org/10.1038/s41429-024-00722-6","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":"36 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140965254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cephalosporin resistance, tolerance, and approaches to improve their activities 头孢菌素的耐药性、耐受性和改善其活性的方法
The Journal of Antibiotics Pub Date : 2023-12-19 DOI: 10.1038/s41429-023-00687-y
Alison H. Araten, Rachel S. Brooks, Sarah D. W. Choi, Laura L. Esguerra, Diana Savchyn, Emily J. Wu, Gabrielle Leon, Katherine J. Sniezek, Mark P. Brynildsen
{"title":"Cephalosporin resistance, tolerance, and approaches to improve their activities","authors":"Alison H. Araten, Rachel S. Brooks, Sarah D. W. Choi, Laura L. Esguerra, Diana Savchyn, Emily J. Wu, Gabrielle Leon, Katherine J. Sniezek, Mark P. Brynildsen","doi":"10.1038/s41429-023-00687-y","DOIUrl":"https://doi.org/10.1038/s41429-023-00687-y","url":null,"abstract":"<p>Cephalosporins comprise a β-lactam antibiotic class whose first members were discovered in 1945 from the fungus <i>Cephalosporium acremonium</i>. Their clinical use for Gram-negative bacterial infections is widespread due to their ability to traverse outer membranes through porins to gain access to the periplasm and disrupt peptidoglycan synthesis. More recent members of the cephalosporin class are administered as last resort treatments for complicated urinary tract infections, MRSA, and other multi-drug resistant pathogens, such as <i>Neisseria gonorrhoeae</i>. Unfortunately, there has been a global increase in cephalosporin-resistant strains, heteroresistance to this drug class has been a topic of increasing concern, and tolerance and persistence are recognized as potential causes of cephalosporin treatment failure. In this review, we summarize the cephalosporin antibiotic class from discovery to their mechanisms of action, and discuss the causes of cephalosporin treatment failure, which include resistance, tolerance, and phenomena when those qualities are exhibited by only small subpopulations of bacterial cultures (heteroresistance and persistence). Further, we discuss how recent efforts with cephalosporin conjugates and combination treatments aim to reinvigorate this antibiotic class.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138818829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic activity of pure penicillin N and isopenicillin N. 纯青霉素N和异霉素N的抗生素活性。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.637
J L Ott, N Neuss
{"title":"Antibiotic activity of pure penicillin N and isopenicillin N.","authors":"J L Ott,&nbsp;N Neuss","doi":"10.7164/antibiotics.35.637","DOIUrl":"https://doi.org/10.7164/antibiotics.35.637","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"637-8"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.637","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Isolation and characterization of a new antibiotic U-62162. 新型抗生素U-62162的分离与鉴定。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.556
L Slechta, J I Cialdella, S A Mizsak, H Hoeksema
{"title":"Isolation and characterization of a new antibiotic U-62162.","authors":"L Slechta,&nbsp;J I Cialdella,&nbsp;S A Mizsak,&nbsp;H Hoeksema","doi":"10.7164/antibiotics.35.556","DOIUrl":"https://doi.org/10.7164/antibiotics.35.556","url":null,"abstract":"<p><p>A new antibiotic U-62162 has been isolated from the fermentations of Streptomyces verdensis Dietz, sp. n. (UC-8157). The compound has been characterized and its gross structure has been elucidated. The antibiotic inhibited the growth of Gram-positive bacteria (particularly Staphylococcus aureus) but was inactive in experimentally infected animals.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"556-60"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.556","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Chemical modification of everninomicins. 抗菌药物的化学修饰。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.561
A K Ganguly, V M Girijavallabhan, G H Miller, O Z Sarre
{"title":"Chemical modification of everninomicins.","authors":"A K Ganguly,&nbsp;V M Girijavallabhan,&nbsp;G H Miller,&nbsp;O Z Sarre","doi":"10.7164/antibiotics.35.561","DOIUrl":"https://doi.org/10.7164/antibiotics.35.561","url":null,"abstract":"<p><p>Novel antibiotic everninomicin D is chemically transformed into new biologically active derivatives. Reactions of a nitro group attached to a tertiary carbon center have been investigated. Synthesis and reactions of hydroxylaminoeverninomicin D, aminoeverninomicin D and their derivatives have been discussed.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"561-70"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
16,17-dihdrorifamycin S and 16,17-dihydro-17-hydroxyrifamycin S. Two novel rifamycins from a recombinant strain C 5/42 of Nocardia mediterranei. 16,17-二氢-17-羟基利福霉素S和16,17-二氢-17-羟基利福霉素S。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.594
P Traxler, T Schupp, W Wehrli
{"title":"16,17-dihdrorifamycin S and 16,17-dihydro-17-hydroxyrifamycin S. Two novel rifamycins from a recombinant strain C 5/42 of Nocardia mediterranei.","authors":"P Traxler,&nbsp;T Schupp,&nbsp;W Wehrli","doi":"10.7164/antibiotics.35.594","DOIUrl":"https://doi.org/10.7164/antibiotics.35.594","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"594-601"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.594","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Biosynthesis of vineomycins A1 and B2. 葡萄菌素A1和B2的生物合成。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.602
N Imamura, K Kakinuma, N Ikekawa, H Tanaka, S Omura
{"title":"Biosynthesis of vineomycins A1 and B2.","authors":"N Imamura,&nbsp;K Kakinuma,&nbsp;N Ikekawa,&nbsp;H Tanaka,&nbsp;S Omura","doi":"10.7164/antibiotics.35.602","DOIUrl":"https://doi.org/10.7164/antibiotics.35.602","url":null,"abstract":"<p><p>Biosynthetic studies of the antibacterial and antitumor antibiotics vineomycins A1 (1) and B2 (2), produced by Streptomyces matensis subsp. vineus, were carried out by labeling experiments with [1-13C]- and [1,2-18C2]sodium acetate followed by 18C NMR spectroscopy. The results show that the benz[a]anthraquinone chromophore of 1 is derived from a decacetate metabolite with decarboxylation at the carboxyl end and that 2 is formed via C-C bond cleavage of 1. Isolation of rabelomycin from the fermentation broth of the same strain suggests a close biosynthetic relationship among the simple benz[a]anthraquinone antibiotics such as rabelomycin, tetrangomycin, aquayamycin, a C-glycosylated benz[a]anthraquinone, and vineomycins. These biosynthetic data prompted us to reconsider the previously published structure of the antibiotic SS-228Y, which has not been revised.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"602-8"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 55
2-Ethyl-5-(3-indolyl)oxazole from Streptomyces cinnamomeus discovered by chemical screening. Characterization and structure elucidation by X-ray analysis. 化学筛选从肉桂链霉菌中发现2-乙基-5-(3-吲哚基)恶唑。用x射线分析表征和结构。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.549
M Noltemeyer, G M Sheldrick, H U Hoppe, A Zeeck
{"title":"2-Ethyl-5-(3-indolyl)oxazole from Streptomyces cinnamomeus discovered by chemical screening. Characterization and structure elucidation by X-ray analysis.","authors":"M Noltemeyer,&nbsp;G M Sheldrick,&nbsp;H U Hoppe,&nbsp;A Zeeck","doi":"10.7164/antibiotics.35.549","DOIUrl":"https://doi.org/10.7164/antibiotics.35.549","url":null,"abstract":"<p><p>In the lipophilic extracts from Streptomyces cinnamomeus 2-ethyl-5-(3-indolyl)oxazole (1a) was detected by chemical screening methods. The structure of the crystalline 1a was determined by spectroscopic and X-ray analysis. The new mono- and dibromo derivatives 1b and 1c are described. 1a is identical with pimprinethine and belongs to a group of microbial indole alkaloids, which can be regarded as masked tryptamine derivatives.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"549-55"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Effects of N-alkylation and n-acylation on tobramycin activity. n-烷基化和n-酰化对妥布霉素活性的影响。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.574
S Sicsic, J F Le Bigot, C Vincent, C Cerceau, F Le Goffic
{"title":"Effects of N-alkylation and n-acylation on tobramycin activity.","authors":"S Sicsic,&nbsp;J F Le Bigot,&nbsp;C Vincent,&nbsp;C Cerceau,&nbsp;F Le Goffic","doi":"10.7164/antibiotics.35.574","DOIUrl":"https://doi.org/10.7164/antibiotics.35.574","url":null,"abstract":"<p><p>The activities of tobramycin derivatives acetylated and ethylated on the 6'-N,2'-N and 3-N positions were examined. The MICs of these derivatives against tobramycin sensitive strains indicated that 2'-N-ethylated and 6'-N-ethylated derivatives have a fairly good activity, and confirmed that the 3-N position is the most important one for antibiotic activity since 3-N derivatives were less active. The MICs of these derivatives against tobramycin resistant strains, and their inactivation by tobramycin modifying enzymes were examined. These results showed that 2'-N or 6'-N ethylation protects the drug against inactivation by AAC(2') or AAC(6'), respectively, and 2'-N-ethyltobramycin and 6'-N-ethyltobramycin were active against strains containing these modifying enzymes. On the other hand, 3-N ethylation protects the drug against inactivation by AAC(3) but 3-N-ethyl tobramycin does not inhibit strains containing this enzyme.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"574-9"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.574","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
New semisynthetic antitumor antibiotics, SF-1739 HP and naphthocyanidine. 新型半合成抗肿瘤抗生素sf - 1739hp和萘花青素。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-05-01 DOI: 10.7164/antibiotics.35.642
J Itoh, S Omoto, S Inouye, Y Kodama, T Hisamatsu, T Niida, Y Ogawa
{"title":"New semisynthetic antitumor antibiotics, SF-1739 HP and naphthocyanidine.","authors":"J Itoh,&nbsp;S Omoto,&nbsp;S Inouye,&nbsp;Y Kodama,&nbsp;T Hisamatsu,&nbsp;T Niida,&nbsp;Y Ogawa","doi":"10.7164/antibiotics.35.642","DOIUrl":"https://doi.org/10.7164/antibiotics.35.642","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"642-4"},"PeriodicalIF":3.3,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40719764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
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