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The Journal of Antibiotics最新文献

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Novel fermentation products from Streptomyces fradiae: X-ray crystal structure of 5-O-mycarosyltylactone and proof of the absolute configuration of tylosin. 传统链霉菌的新型发酵产物:5- o - mycarcarylylactone的x射线晶体结构和tylosin绝对构型的证明。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.420
N D Jones, M O Chaney, H A Kirst, G M Wild, R H Baltz, R L Hamill, J W Paschal
{"title":"Novel fermentation products from Streptomyces fradiae: X-ray crystal structure of 5-O-mycarosyltylactone and proof of the absolute configuration of tylosin.","authors":"N D Jones,&nbsp;M O Chaney,&nbsp;H A Kirst,&nbsp;G M Wild,&nbsp;R H Baltz,&nbsp;R L Hamill,&nbsp;J W Paschal","doi":"10.7164/antibiotics.35.420","DOIUrl":"https://doi.org/10.7164/antibiotics.35.420","url":null,"abstract":"<p><p>5-O-Mycarosyltylactone has been isolated as a predominant factor from fermentation broths of a Streptomyces fradiae mutant. The relative configurations of mycarose and tylactone (protylonolide) have been determined by X-ray crystal structure analysis. Hydrolysis of 5-O-mycarosyltylactone yielded (-)-tylactone and L-(-)-mycarose. Taken together, these two experiments establish the absolute configuration of (-)-tylactone. Bioconversion of (-)-tylactone to tylosin by tyl G mutants of S. fradiae proves the absolute configuration of tylosin. Physicochemical data for tylactone and a unique component piece of tylactone are also reported.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"420-5"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35272378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Structure of gliocladic acid. 胶质酸的结构。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.541
Y Itoh, S Takahashi, M Arai
{"title":"Structure of gliocladic acid.","authors":"Y Itoh,&nbsp;S Takahashi,&nbsp;M Arai","doi":"10.7164/antibiotics.35.541","DOIUrl":"https://doi.org/10.7164/antibiotics.35.541","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"541-2"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35359186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Studies on the mechanism of actin of gilvocarcin V and chrysomycin A. gilvocarcin V和chrysyycin A肌动蛋白作用机理的研究。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.545
T T Wei, K M Byrne, D Warnick-Pickle, M Greenstein
{"title":"Studies on the mechanism of actin of gilvocarcin V and chrysomycin A.","authors":"T T Wei,&nbsp;K M Byrne,&nbsp;D Warnick-Pickle,&nbsp;M Greenstein","doi":"10.7164/antibiotics.35.545","DOIUrl":"https://doi.org/10.7164/antibiotics.35.545","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"545-8"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35359187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
A new naturally occurring erythromycin: erythromycin F. 一种新的天然红霉素:红霉素F。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.426
J R Martin, R L DeVault, A C Sinclair, R S Stanaszek, P Johnson
{"title":"A new naturally occurring erythromycin: erythromycin F.","authors":"J R Martin,&nbsp;R L DeVault,&nbsp;A C Sinclair,&nbsp;R S Stanaszek,&nbsp;P Johnson","doi":"10.7164/antibiotics.35.426","DOIUrl":"https://doi.org/10.7164/antibiotics.35.426","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"426-30"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.426","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35272379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
An enrichment isolation procedure for minor Bacillus populations. 小型芽孢杆菌群体的富集分离方法。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.450
Y Wakisaka, K Koizumi
{"title":"An enrichment isolation procedure for minor Bacillus populations.","authors":"Y Wakisaka,&nbsp;K Koizumi","doi":"10.7164/antibiotics.35.450","DOIUrl":"https://doi.org/10.7164/antibiotics.35.450","url":null,"abstract":"In general, spores of B. cereus, B. megaterium, B. Sphaericus and B. subtilis strains germinated uniformly within a short time of incubation in a germination medium. In contrast, spores of B, circulans, B. brevis, B. laterosporus, B. pulvifaciens, B. polymyxa, B. pumilus, B. licheniformis and B. coagulans strains were usually slow and/or uneven germinators under the same conditions of incubation. The former group of Bacillus strains occur frequently in soils as the predominant population and the latter group of Bacillus species are found in many cases as minor populations. The minor populations of Bacillus were isolated with difficulty by the standard dilution-plate technique, but could easily be enriched by treating the soil sample in a germination medium for 2 to 3 hours at 30 to 35 degrees C, followed by heating it at 65 degrees C for 10 minutes (\"minor-shifted isolation\"). Using this technique, the minor Bacillus strains could be isolated from samples containing 100- to 1,000-fold more of the rapid germinators of Bacillus.","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"450-7"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35272381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Thiolactomycin, a new antibiotic. I. Taxonomy of the producing organism, fermentation and biological properties. 硫霉素，一种新的抗生素。1 .产菌分类、发酵及生物学特性。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.391
H Oishi, T Noto, H Sasaki, K Suzuki, T Hayashi, H Okazaki, K Ando, M Sawada
{"title":"Thiolactomycin, a new antibiotic. I. Taxonomy of the producing organism, fermentation and biological properties.","authors":"H Oishi,&nbsp;T Noto,&nbsp;H Sasaki,&nbsp;K Suzuki,&nbsp;T Hayashi,&nbsp;H Okazaki,&nbsp;K Ando,&nbsp;M Sawada","doi":"10.7164/antibiotics.35.391","DOIUrl":"https://doi.org/10.7164/antibiotics.35.391","url":null,"abstract":"<p><p>A strain of actinomycetes, isolated from a soil sample, has produced a novel antibiotic (C11H14O2S) containing a unique thiolactone moiety in its molecule. On the basis of taxonomic studies the producing organism was identified as belonging to the genus Nocardia. The antibiotic, named thiolactomycin, exhibits a broad antibacterial spectrum and particularly potent activity against Salmonella, Serratia and Bacteroides. Furthermore, the acute toxicity is weak in experimental animals. These results indicate that thiolactomycin is distinct from other known antibiotics and represents a new type of antibiotic.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"391-5"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35272375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 169
Cyanonaphthyridinomycin: a derivative of naphthyridinomycin. 氰萘环霉素:萘环霉素的衍生物。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.524
M J Zmijewski, M Goebel
{"title":"Cyanonaphthyridinomycin: a derivative of naphthyridinomycin.","authors":"M J Zmijewski,&nbsp;M Goebel","doi":"10.7164/antibiotics.35.524","DOIUrl":"https://doi.org/10.7164/antibiotics.35.524","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"524-6"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.524","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35359182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Thiolactomycin, a new antibiotic. II. Structure elucidation. 硫霉素，一种新的抗生素。2结构说明。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.396
H Sasaki, H Oishi, T Hayashi, I Matsuura, K Ando, M Sawada
{"title":"Thiolactomycin, a new antibiotic. II. Structure elucidation.","authors":"H Sasaki,&nbsp;H Oishi,&nbsp;T Hayashi,&nbsp;I Matsuura,&nbsp;K Ando,&nbsp;M Sawada","doi":"10.7164/antibiotics.35.396","DOIUrl":"https://doi.org/10.7164/antibiotics.35.396","url":null,"abstract":"","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"396-400"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.396","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35272376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 74
Cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to penicillins by cell-free extracts of Streptomyces clavuligerus. 棒状链霉菌无细胞提取物环化δ -(l- α -氨基二酰)- l-半胱氨酸- d -缬氨酸合成青霉素。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.483
S E Jensen, D W Westlake, S Wolfe
{"title":"Cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to penicillins by cell-free extracts of Streptomyces clavuligerus.","authors":"S E Jensen,&nbsp;D W Westlake,&nbsp;S Wolfe","doi":"10.7164/antibiotics.35.483","DOIUrl":"https://doi.org/10.7164/antibiotics.35.483","url":null,"abstract":"<p><p>Cell-free extracts prepared by sonication of Streptomyces clavuligerus cyclized delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) into a penicillin-type antibiotic. The antibacterial spectrum of this antibiotic suggested it was a mixture of isopenicillin N and penicillin N indicating that both cyclization and racemase activities were present. Cyclization activity was optimal in extracts prepared from 48 hours cultures. Extracts incubated at 20 degrees C produced antibiotic for 2 hours before activity ceased. Cyclization activity showed an absolute requirement for dithiothreitol (DTT) and O2 and was stimulated by ascorbic acid and FeSO4. No requirement for ATP was observed.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"483-90"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35358708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
Genetic and biochemical features of spiramycin biosynthesis in Streptomyces ambofaciens--curing, protoplast regeneration and plasmid transfer. 双歧杆菌链霉菌螺旋霉素生物合成的遗传和生化特征——固化、原生质体再生和质粒转移。
IF 3.3
The Journal of Antibiotics Pub Date : 1982-04-01 DOI: 10.7164/antibiotics.35.507
H Ikeda, H Tanaka, S Omura
{"title":"Genetic and biochemical features of spiramycin biosynthesis in Streptomyces ambofaciens--curing, protoplast regeneration and plasmid transfer.","authors":"H Ikeda,&nbsp;H Tanaka,&nbsp;S Omura","doi":"10.7164/antibiotics.35.507","DOIUrl":"https://doi.org/10.7164/antibiotics.35.507","url":null,"abstract":"<p><p>Spiramycin-producing Streptomyces ambofaciens KA-1028 harboring the pSA1 plasmid gave rise to spiramycin non-producing variants at high frequencies by various curing treatments. However, a number of the spiramycin non-producing progeny obtained by treatment with acridine dyes, still harbored plasmid DNAs which could not be differentiated from plasmid pSA1 by contour length, cleavage patterns and heteroduplex analysis. By treatment with mitomycin C, plasmid pSA1 was cured at high efficiency and spiramycin non-producing strains were obtained. Strain U-1717R obtained by regeneration of protoplasts of plasmid-cured strain U-1717 regained spiramycin production on growth on solid medium only. Furthermore, transconjugants obtained by mating between strain KA-1028 and U-1717R-24 (streptomycin-resistant) regained spiramycin production in both liquid and solid media. We conclude that the genes for the biosynthesis of spiramycin are encoded in a replicon other than plasmid pSA1 but that this plasmid plays a role in the regulation of spiramycin production.</p>","PeriodicalId":501839,"journal":{"name":"The Journal of Antibiotics","volume":" ","pages":"507-16"},"PeriodicalIF":3.3,"publicationDate":"1982-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.7164/antibiotics.35.507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35359179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
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