npj Biological Physics and Mechanics最新文献

Physical principles and mechanisms of cell migration. 细胞迁移的物理原理和机制。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1038/s44341-024-00008-w

Roberto Alonso-Matilla, Paolo P Provenzano, David J Odde

引用次数: 0

Mechanical signatures in cancer metastasis. 癌症转移的机械特征。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1038/s44341-024-00007-x

Ayushi Agrawal, Yousef Javanmardi, Sara A Watson, Bianca Serwinski, Boris Djordjevic, Wenbin Li, Amir R Aref, Russell W Jenkins, Emad Moeendarbary

引用次数: 0

Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction. 探讨血小板收缩对纤维蛋白凝块收缩的动力学、热力学和机制的影响。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-02-24 DOI: 10.1038/s44341-025-00011-9

Evgenii Kliuchnikov, Alina D Peshkova, Minh Quan Vo, Kenneth A Marx, Rustem I Litvinov, John W Weisel, Prashant K Purohit, Valeri Barsegov

{"title":"Exploring effects of platelet contractility on the kinetics, thermodynamics, and mechanisms of fibrin clot contraction.","authors":"Evgenii Kliuchnikov, Alina D Peshkova, Minh Quan Vo, Kenneth A Marx, Rustem I Litvinov, John W Weisel, Prashant K Purohit, Valeri Barsegov","doi":"10.1038/s44341-025-00011-9","DOIUrl":"10.1038/s44341-025-00011-9","url":null,"abstract":"Mechanisms of blood clot contraction - platelet-driven fibrin network remodeling, are not fully understood. We developed a detailed computational ClotDynaMo model of fibrin network with activated platelets, whose clot contraction rate for normal 450,000/µl human platelets depends on serum viscosity η, platelet filopodia length l, and weakly depends on filopodia traction force f and filopodia extension-retraction speed v. Final clot volume is independent of η, but depends on v, f and l. Analysis of ClotDynaMo output revealed a 2.24 TJ/mol clot contraction free energy change, with ~67% entropy and ~33% internal energy changes. The results illuminate the \"optimal contraction principle\" that maximizes volume change while minimizing energy cost. An 8-chain continuum model of polymer elasticity containing platelet forces, captures clot contractility as a function of platelet count, η and l. The ClotDynaMo and continuum models can be extended to include red blood cells, variable platelet properties, and mechanics of fibrin network.","PeriodicalId":501703,"journal":{"name":"npj Biological Physics and Mechanics","volume":"2 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relaxation of mucosal fibronectin fibers in late gut inflammation following neutrophil infiltration in mice. 小鼠中性粒细胞浸润后的晚期肠道炎症中粘膜纤维连接蛋白的松弛。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1038/s44341-024-00006-y

Ronja Rappold, Konstantinos Kalogeropoulos, Gianna La Regina, Ulrich Auf dem Keller, Emma Slack, Viola Vogel

{"title":"Relaxation of mucosal fibronectin fibers in late gut inflammation following neutrophil infiltration in mice.","authors":"Ronja Rappold, Konstantinos Kalogeropoulos, Gianna La Regina, Ulrich Auf dem Keller, Emma Slack, Viola Vogel","doi":"10.1038/s44341-024-00006-y","DOIUrl":"10.1038/s44341-024-00006-y","url":null,"abstract":"The continuously remodeled extracellular matrix (ECM) plays a pivotal role in gastrointestinal health and disease, yet its precise functions remain elusive. In this study, we employed laser capture microdissection combined with low-input proteomics to investigate ECM remodeling during Salmonella-driven inflammation. To complement this, we probed how fibronectin fiber tension is altered using a mechanosensitive peptide probe. While fibronectin fibers in healthy intestinal tissue are typically stretched, many lose their tension in intestinal smooth muscles only hours after infection, despite the absence of bacteria in that area. In contrast, within the mucosa, where Salmonella is present starting 12 h post infection, fibronectin fiber relaxation occurred exclusively during late-stage infection at 72 h and was localized to already existing clusters of infiltrated neutrophils. Using N-terminomics, we identified three new cleavage sites in fibronectin in the inflamed cecum. The unique, tissue layer-specific changes in the molecular compositions and ECM fiber tension revealed herein might trigger new therapeutic strategies to fight acute intestinal inflammation.","PeriodicalId":501703,"journal":{"name":"npj Biological Physics and Mechanics","volume":"2 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of extracellular matrix viscoelasticity in development and disease. 细胞外基质粘弹性在发育和疾病中的作用。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-04-03 DOI: 10.1038/s44341-025-00014-6

Olivia Courbot, Alberto Elosegui-Artola

引用次数: 0

Unifying fragmented perspectives with additive deep learning for high-dimensional models from partial faceted datasets. 将碎片化视角与来自部分面数据集的高维模型的加性深度学习统一起来。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-02-24 DOI: 10.1038/s44341-025-00009-3

Yufei Wu, Pei-Hsun Wu, Allison Chambliss, Denis Wirtz, Sean X Sun

引用次数: 0

The synergistic potential of mechanotherapy and sonopermeation to enhance cancer treatment effectiveness. 机械治疗和超声手术的协同潜力，以提高癌症的治疗效果。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-05-05 DOI: 10.1038/s44341-025-00017-3

Constantina Neophytou, Triantafyllos Stylianopoulos, Fotios Mpekris

引用次数: 0

Premetastatic niche mechanics and organotropism in breast cancer. 乳腺癌转移前生态位机制和器官亲和性。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-04-03 DOI: 10.1038/s44341-025-00015-5

Sarah Libring, Cynthia A Reinhart-King

引用次数: 0

Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression. 核膜蛋白、机械转导及其对乳腺癌进展的影响。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-05-05 DOI: 10.1038/s44341-025-00018-2

Sarah Henretta, Jan Lammerding

引用次数: 0

Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy. 肿瘤生长、血管生成和免疫反应的混合模型为改善抗血管生成治疗提供了策略。

npj Biological Physics and Mechanics Pub Date : 2024-01-01 Epub Date: 2024-12-02 DOI: 10.1038/s44341-024-00002-2

Andreas G Hadjigeorgiou, Triantafyllos Stylianopoulos

{"title":"Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy.","authors":"Andreas G Hadjigeorgiou, Triantafyllos Stylianopoulos","doi":"10.1038/s44341-024-00002-2","DOIUrl":"https://doi.org/10.1038/s44341-024-00002-2","url":null,"abstract":"Solid tumors harbor a complex and dynamic microenvironment that hinders the delivery and efficacy of therapeutic interventions. In this study, we developed and utilized a hybrid, discrete-continuous mathematical model to explore the interplay between solid tumor growth, immune response, tumor-induced angiogenesis, and antiangiogenic drugs. By integrating published data with anti-angiogenic drugs, we elucidate three primary mechanisms by which anti-angiogenesis influences tumor progression and treatment outcomes: reduction in tumor growth rate by mitigating and temporally delaying angiogenesis, normalization of blood vessel structure and function, and improving immune cell extravasation and activation. Our results indicate a significant increase in functional blood vessels and perfusion following anti-angiogenic treatment, which in turn improves the intratumoral distribution of immune cells. The normalization window, or optimal time frame for anti-angiogenic drug administration, and the dose of the drug arise naturally in the model and are highlighted as crucial factors in maximizing treatment benefits. Prolonged anti-angiogenic treatment triggers cancer cell migration into healthy tissue and induces immunosuppression due to hypoxia, potentially leading to negative effects because these cancer cells will rapidly proliferate upon treatment termination. In conclusion, the positive contribution of anti-angiogenic treatment must balance the possible negative effects by choosing a proper treatment protocol as well as combining it with proper anti-cancer treatment. Our findings provide valuable insights and a framework for the design of protocols with anti-angiogenic treatment, targeted immunotherapy, and non-targeted anti-cancer therapies.","PeriodicalId":501703,"journal":{"name":"npj Biological Physics and Mechanics","volume":"1 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0