npj Biological Physics and Mechanics最新文献

Physical principles and mechanisms of cell migration. 细胞迁移的物理原理和机制。

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-01-16 DOI: 10.1038/s44341-024-00008-w

Roberto Alonso-Matilla, Paolo P Provenzano, David J Odde

引用次数: 0

Mechanical signatures in cancer metastasis.

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1038/s44341-024-00007-x

Ayushi Agrawal, Yousef Javanmardi, Sara A Watson, Bianca Serwinski, Boris Djordjevic, Wenbin Li, Amir R Aref, Russell W Jenkins, Emad Moeendarbary

引用次数: 0

Relaxation of mucosal fibronectin fibers in late gut inflammation following neutrophil infiltration in mice.

npj Biological Physics and Mechanics Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1038/s44341-024-00006-y

Ronja Rappold, Konstantinos Kalogeropoulos, Gianna La Regina, Ulrich Auf dem Keller, Emma Slack, Viola Vogel

{"title":"Relaxation of mucosal fibronectin fibers in late gut inflammation following neutrophil infiltration in mice.","authors":"Ronja Rappold, Konstantinos Kalogeropoulos, Gianna La Regina, Ulrich Auf dem Keller, Emma Slack, Viola Vogel","doi":"10.1038/s44341-024-00006-y","DOIUrl":"10.1038/s44341-024-00006-y","url":null,"abstract":"The continuously remodeled extracellular matrix (ECM) plays a pivotal role in gastrointestinal health and disease, yet its precise functions remain elusive. In this study, we employed laser capture microdissection combined with low-input proteomics to investigate ECM remodeling during Salmonella-driven inflammation. To complement this, we probed how fibronectin fiber tension is altered using a mechanosensitive peptide probe. While fibronectin fibers in healthy intestinal tissue are typically stretched, many lose their tension in intestinal smooth muscles only hours after infection, despite the absence of bacteria in that area. In contrast, within the mucosa, where Salmonella is present starting 12 h post infection, fibronectin fiber relaxation occurred exclusively during late-stage infection at 72 h and was localized to already existing clusters of infiltrated neutrophils. Using N-terminomics, we identified three new cleavage sites in fibronectin in the inflamed cecum. The unique, tissue layer-specific changes in the molecular compositions and ECM fiber tension revealed herein might trigger new therapeutic strategies to fight acute intestinal inflammation.","PeriodicalId":501703,"journal":{"name":"npj Biological Physics and Mechanics","volume":"2 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11794144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy. 肿瘤生长、血管生成和免疫反应的混合模型为改善抗血管生成治疗提供了策略。

npj Biological Physics and Mechanics Pub Date : 2024-01-01 Epub Date: 2024-12-02 DOI: 10.1038/s44341-024-00002-2

Andreas G Hadjigeorgiou, Triantafyllos Stylianopoulos

{"title":"Hybrid model of tumor growth, angiogenesis and immune response yields strategies to improve antiangiogenic therapy.","authors":"Andreas G Hadjigeorgiou, Triantafyllos Stylianopoulos","doi":"10.1038/s44341-024-00002-2","DOIUrl":"https://doi.org/10.1038/s44341-024-00002-2","url":null,"abstract":"Solid tumors harbor a complex and dynamic microenvironment that hinders the delivery and efficacy of therapeutic interventions. In this study, we developed and utilized a hybrid, discrete-continuous mathematical model to explore the interplay between solid tumor growth, immune response, tumor-induced angiogenesis, and antiangiogenic drugs. By integrating published data with anti-angiogenic drugs, we elucidate three primary mechanisms by which anti-angiogenesis influences tumor progression and treatment outcomes: reduction in tumor growth rate by mitigating and temporally delaying angiogenesis, normalization of blood vessel structure and function, and improving immune cell extravasation and activation. Our results indicate a significant increase in functional blood vessels and perfusion following anti-angiogenic treatment, which in turn improves the intratumoral distribution of immune cells. The normalization window, or optimal time frame for anti-angiogenic drug administration, and the dose of the drug arise naturally in the model and are highlighted as crucial factors in maximizing treatment benefits. Prolonged anti-angiogenic treatment triggers cancer cell migration into healthy tissue and induces immunosuppression due to hypoxia, potentially leading to negative effects because these cancer cells will rapidly proliferate upon treatment termination. In conclusion, the positive contribution of anti-angiogenic treatment must balance the possible negative effects by choosing a proper treatment protocol as well as combining it with proper anti-cancer treatment. Our findings provide valuable insights and a framework for the design of protocols with anti-angiogenic treatment, targeted immunotherapy, and non-targeted anti-cancer therapies.","PeriodicalId":501703,"journal":{"name":"npj Biological Physics and Mechanics","volume":"1 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0