Scandinavian Journal of Clinical and Laboratory Investigation最新文献

Clinical performance of a particle enhanced turbidimetric immunoassay (PETIA) for detecting fecal calprotectin. 用于检测粪便钙粘蛋白的颗粒增强比浊免疫分析法（PETIA）的临床性能。

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-09-18 DOI: 10.1080/00365513.2024.2403006

Tieshan Wang,Wei Wang,Siying Zhu,Minsi Zhou,Peng Li,Jing Wu,Shutian Zhang,Haiyun Shi

{"title":"Clinical performance of a particle enhanced turbidimetric immunoassay (PETIA) for detecting fecal calprotectin.","authors":"Tieshan Wang,Wei Wang,Siying Zhu,Minsi Zhou,Peng Li,Jing Wu,Shutian Zhang,Haiyun Shi","doi":"10.1080/00365513.2024.2403006","DOIUrl":"https://doi.org/10.1080/00365513.2024.2403006","url":null,"abstract":"Particle-enhanced turbidimetric immunoassay (PETIA) is a new measurement procedure for detecting fecal calprotectin (FC). We aimed to investigate the accuracy and clinical performance of PETIA for FC. We assessed the accuracy of PETIA for FC measurements through concordance analysis, Passing-Bablok regression and Bland-Altman analysis, using enzyme-linked immunosorbent assay (ELISA) as the reference. To evaluate the clinical performance of PETIA, the FC levels of individuals with significant and non-significant bowel diseases were compared. The receiver operating characteristic (ROC) analysis was performed to determine the appropriate cut-off value of FC detected by PETIA for discriminating subjects with significant and non-significant colorectal lesions. Of the 413 cases analyzed, 340 (82.3%) were concordant between PETIA and ELISA. No significant discordance was observed. There was a good agreement (y = -7.710+0.957x) between PETIA and ELISA for detecting FC. The FC level detected by PETIA in patients with significant bowel diseases (159.1 [31.3, 821.0] µg/g) was significantly higher than that of subjects with non-significant bowel diseases (10.3 [4.2, 38.5] µg/g) (p < 0.001). The AUC of FC for identifying significant bowel diseases detected by PETIA was 0.82 (p < 0.001). With a cut-off value of 77.6µg/g, the specificity and positive predictive value were 92.2% and 97.1%, respectively. The PETIA for FC measurement showed good clinical performance for detecting bowel diseases.","PeriodicalId":501634,"journal":{"name":"Scandinavian Journal of Clinical and Laboratory Investigation","volume":"7 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human papilloma virus vaccine induced thrombocytopenia accompanied by a wide spectrum of reversible inflammatory responses - a case report. 人乳头状瘤病毒疫苗诱发血小板减少并伴有广泛的可逆炎症反应--病例报告。

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-09-12 DOI: 10.1080/00365513.2024.2400663

S Holm,A E Michelsen,N H Schultz,T Ueland,H Reikvam,P A Holme,P Aukrust,B Halvorsen

引用次数: 0

Salivary cortisol and cortisone are stable after long-term storage. 唾液皮质醇和可的松在长期储存后是稳定的。

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-09-12 DOI: 10.1080/00365513.2024.2403005

Marcus Imamovic,Nils Bäcklund,Staffan Lundstedt,Göran Brattsand,Elisabeth Aardal,Per Dahlqvist

引用次数: 0

Stability of serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) 血清胎盘生长因子（PlGF）和可溶性 fms 样酪氨酸激酶 1（sFlt-1）的稳定性

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-04-26 DOI: 10.1080/00365513.2024.2340037

Ingrid Alsos Lian, Tone Dypdalsbakk, Arne Åsberg

引用次数: 0

Linkage of cell division cycle 42 with clinical features, treatment response and survival in adult Philadelphia chromosome negative acute lymphoblastic leukemia. 细胞分裂周期 42 与成人费城染色体阴性急性淋巴细胞白血病的临床特征、治疗反应和存活率的关系。

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-04-25 DOI: 10.1080/00365513.2024.2333027

Qi Chen, Xiaoling Zhu, Di He, Wanbao Ding

{"title":"Linkage of cell division cycle 42 with clinical features, treatment response and survival in adult Philadelphia chromosome negative acute lymphoblastic leukemia.","authors":"Qi Chen, Xiaoling Zhu, Di He, Wanbao Ding","doi":"10.1080/00365513.2024.2333027","DOIUrl":"https://doi.org/10.1080/00365513.2024.2333027","url":null,"abstract":"Cell division cycle 42 (CDC42) regulates the progression of leukemia via mediating proliferation and immune evasion of malignant cells. The study aimed to investigate the correlation of CDC42 with clinical features, treatment response, event-free survival (EFS) and overall survival (OS) in adult Philadelphia chromosome negative acute lymphoblastic leukemia (Ph- ALL) patients. CDC42 expression in bone marrow mononuclear cells was detected in 78 adult Ph- ALL patients and 10 donors using real-time reverse transcriptase-polymerase chain reaction. CDC42 was increased in adult Ph- ALL patients compared with donors (p < .001). Besides, elevated CDC42 was linked with pro-B ALL or early-T ALL (p = .038) and white blood cell (WBC) elevation at diagnosis (p = .025). Fifty (64.1%) and 23 (29.5%) patients had complete remission (CR) at 1 month and minimal residual disease (MRD) after CR, respectively. CDC42 was inversely associated with CR at 1 month (p = .034), but not MRD after CR (p = .066). Concerning survival, patients with CDC42 ≥ 3.310 (cut by median value in patients) showed a shortened EFS (p = .006) and OS (p = .036) compared to those with CDC42 < 3.310. In detail, patients with CDC42 ≥ 3.310 and CDC42 < 3.310 had 5-year EFS rate of 29.9% and 45.4%, and 5-year OS rate of 39.4% and 63.6%, correspondingly. Further multivariate Cox's regression analyses revealed that CDC42 ≥ 3.310 was independently related to shorter EFS (hazard ratio = 2.933, p = .005). Elevated CDC42 is related with pro-B ALL or early-T ALL, WBC elevation at diagnosis, unfavorable treatment response and worse survival in adult Ph- ALL patients.","PeriodicalId":501634,"journal":{"name":"Scandinavian Journal of Clinical and Laboratory Investigation","volume":"35 39","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140657684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical test result management at Danish hospital laboratories: a national survey. 丹麦医院实验室的关键检验结果管理：一项全国性调查。

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-04-22 DOI: 10.1080/00365513.2024.2343906

Kaja Kastberg Faurø, Steen Antonsen, M. Nybo

{"title":"Critical test result management at Danish hospital laboratories: a national survey.","authors":"Kaja Kastberg Faurø, Steen Antonsen, M. Nybo","doi":"10.1080/00365513.2024.2343906","DOIUrl":"https://doi.org/10.1080/00365513.2024.2343906","url":null,"abstract":"Critical test results in clinical laboratories are crucial for timely patient care, serving as indicators of potentially life-threatening conditions. Despite their importance, a notable heterogeneity in management practices exists globally. This study investigates the current practices of managing critical results at Danish clinical biochemistry laboratories and identifies areas prone for improvement. A comprehensive online survey was distributed to all 21 Danish clinical biochemistry laboratories regarding their critical result management, including documentation practices, critical limit selection, and quality assurance measures. A total of 17 laboratories (81%) responded. The answers revealed a generally uniform approach to managing critical results, with all laboratories having 24-h reporting, local instructions and using the telephone as communication channel. However, variations were noted in documentation practices and critical limit selection. Notably, 23.5% of the laboratories reported that one out of every ten critical results was not reported, indicating a significant risk of delayed critical results. This is further complicated by the limited use of predefined timeframes for reporting and also, only few laboratories actively monitored response times. The findings emphasize the need for more standardized documentation and evaluation practices to align with international standards and to enhance patient safety. While the laboratories showed a commitment to standardized procedures, the study emphasizes the necessity of a National or Nordic guideline to supplement the ISO 15189:2022. This study is a step towards optimizing critical result management, not only in Danish clinical biochemistry laboratories but also across various laboratory specialties, thereby improving overall laboratory quality, efficiency, and patient safety.","PeriodicalId":501634,"journal":{"name":"Scandinavian Journal of Clinical and Laboratory Investigation","volume":"5 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140673728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolvin D1 level during different trimesters of pregnancy for predicting the risk of fetal growth retardation in elderly pregnancy 预测高龄孕妇胎儿发育迟缓风险的不同孕期 Resolvin D1 水平

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-04-19 DOI: 10.1080/00365513.2024.2338739

Ying Han, Dandan Wang, Shufang Cai, Lina Zhang, Jingxian Xue

引用次数: 0

Baseline glycated albumin level and risk of type 2 diabetes mellitus in Healthy individuals: a retrospective longitudinal observation in Korea 基线糖化白蛋白水平与健康人罹患 2 型糖尿病的风险：韩国的一项回顾性纵向观察结果

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-04-18 DOI: 10.1080/00365513.2024.2341412

Kang-Su Shin, Min-Seung Park, Mi Yeon Lee, Eun Hye Cho, Hee-Yeon Woo, Hyosoon Park, Min-Jung Kwon

引用次数: 0

Appearance of hexahydrocannabinols as recreational drugs and implications for cannabis drug testing – focus on HHC, HHC-P, HHC-O and HHC-H 六氢大麻酚作为娱乐药物的出现及其对大麻药物检测的影响--重点关注 HHC、HHC-P、HHC-O 和 HHC-H

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-04-15 DOI: 10.1080/00365513.2024.2340039

Anders Helander, Malin Johansson, Tomas Villén, Annika Andersson

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Establishing a pediatric reference interval for plasma calprotectin 建立儿科血浆钙蛋白参考区间

Scandinavian Journal of Clinical and Laboratory Investigation Pub Date : 2024-04-13 DOI: 10.1080/00365513.2024.2338744

Anne-Birgitte Garm Blavnsfeldt, Tina Parkner, Cindy Soendersoe Knudsen

引用次数: 0