The American Journal of Pathology最新文献_第4页

The genesis of paired cisternae during the mitotic cycle. 有丝分裂周期中成对池的发生。

IF 6

The American Journal of Pathology Pub Date : 1982-05-01

S Sato, G F Murphy, T J Harrist

{"title":"The genesis of paired cisternae during the mitotic cycle.","authors":"S Sato, G F Murphy, T J Harrist","doi":"","DOIUrl":"","url":null,"abstract":"Paired cisternae, which are conspicuous in mitotically active cells, are two or more flattened, membrane-bound saccules stacked in parallel arrays. The origin, development, and fate of paired cisternae during the cell cycle were studied in a poorly differentiated carcinoma of the eyelid. Early in the mitotic cycle, multiple membrane-bound, ovoid vesicles separated by interconnecting septa formed at the nuclear-cytoplasmic interface coincident with the disappearance of the nuclear envelope. These vesicles became progressively flattened and elongated to form paired cisternae, and by late prophase, had migrated to the cell periphery. During early anaphase, intimate association of paired cisternae with condensing chromosomes was observed. During late anaphase and telophase, distension of the cisternae resulted in vesicles similar to those observed in prophase cells. An apparent coalescence of these distended vesicles around the aggregated chromatin of daughter cells resulted in newly formed nuclear envelopes. Paired cisternae appear to be specialized nuclear membrane-derived structures that are fundamental in the generation of nuclear membranes of daughter cells. An infrequently observed variant of paired cisternae, subsurface confronting cisternae, is briefly described.","PeriodicalId":501602,"journal":{"name":"The American Journal of Pathology","volume":" ","pages":"150-60"},"PeriodicalIF":6.0,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916009/pdf/amjpathol00206-0030.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35257291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental silicosis. I. Acute effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs. 实验性矽肺。1 .气管内灌注石英对大鼠肺胶原代谢及形态学特征的急性影响。

IF 6

The American Journal of Pathology Pub Date : 1982-05-01

K M Reiser, T W Hesterberg, W M Haschek, J A Last

{"title":"Experimental silicosis. I. Acute effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs.","authors":"K M Reiser, T W Hesterberg, W M Haschek, J A Last","doi":"","DOIUrl":"","url":null,"abstract":"Rats were intratracheally instilled with 50 mg of silica as quartz (0.5-mu particles) at day 0. One and 2 weeks later, lungs were evaluated histologically and by a variety of biochemical measurements. Protein, proline, and hydroxyproline content (as an index of total lung collagen) were quantitated, as were the lung collagen synthesis rate and the total lung protein biosynthesis rate (evaluated with lung minces in vitro). The ratio of newly synthesized Type I/Type III collagen was determined, as was the same ratio for total lung collagen. These experiments were performed in parallel on chronic respiratory disease-free rats and in a strain of conventional animals. The authors conclude that 1) changes in lung structure and composition can be appreciated as early as 1 week, the earliest time point studied, after intratracheal instillation of 50 mg of quartz; 2) observed morphologic changes during the first 2 weeks are consistent with biochemical changes; 3) there are essentially no differences in the response of chronic respiratory disease-free Sprague-Dawley and conventional Wistar rats to intratracheally instilled silica. Both strains of rats developed silica-containing granulomas, which ultimately developed into silicotic nodules, as well as areas of alveolar lipoproteinosis associated with interstitial pneumonitis.","PeriodicalId":501602,"journal":{"name":"The American Journal of Pathology","volume":" ","pages":"176-85"},"PeriodicalIF":6.0,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916000/pdf/amjpathol00206-0056.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35257292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Animal model of human disease: atrial thrombosis in aged Syrian hamsters. 人类疾病动物模型:老年叙利亚仓鼠心房血栓形成。

IF 6

The American Journal of Pathology Pub Date : 1982-05-01

D N McMartin, W J Dodds

引用次数: 0

Chondrodysplasia in the Norwegian Elkhound. 挪威麋鹿的软骨发育不良。

IF 6

The American Journal of Pathology Pub Date : 1982-05-01

S A Bingel, R D Sande

引用次数: 0

Presentation of the rous-whipple award to morris j. Karnovsky-1981. 劳斯-惠普尔奖颁发给莫里斯·j·卡诺夫斯基，1981。