Chondrodysplasia in the Norwegian Elkhound.

The American Journal of Pathology Pub Date : 1982-05-01
S A Bingel, R D Sande
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Abstract

Dwarfism in the Norwegian Elkhound occurred as a result of a generalized disturbance in endochondral ossification. Radiographic changes included flaring and increased width of the distal metaphyses of the radius and ulna, delayed ossification of the cuboid bones of the carpus, and reduction in length of the vertebral bodies. The zone of chondrocyte proliferation was decreased in width and contained areas of abnormal cell column formation alternated with wide areas of matrix. Chondrocytes in all zones contained one or more inclusions bounded by a smooth discontinuous membrane. The material within the inclusions appeared homogeneous and stained blue-green with Movat's pentachrome and deep blue with alcian blue-periodic acid-Schiff at pH 1.0 and 2.6. The distribution of ruthenium red granules in the matrix frequently revealed poor differentiation into territorial and interterritorial zones. Twenty-four-hour urine samples were negative for glucose, and the glycosaminoglycan excretion pattern was normal.

挪威麋鹿的软骨发育不良。
挪威麋鹿的侏儒症是软骨内成骨普遍紊乱的结果。x线改变包括桡骨和尺骨远端外骺变宽,宽度增加,腕骨长方体骨化延迟,椎体长度减少。软骨细胞增殖区宽度减小,细胞柱形成异常区与基质宽区交替出现。所有区的软骨细胞都含有一个或多个包涵体,包涵体由光滑的不连续膜包围。包裹体内的物质呈均匀状,在pH为1.0和2.6时呈莫伐特五色蓝绿色,阿利新蓝-希夫周期酸呈深蓝色。钌红颗粒在基质中的分布往往表现为疆域和疆域间的弱分异。24小时尿样葡萄糖呈阴性,糖胺聚糖排泄模式正常。
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