Smart Molecules最新文献_第4页

Smart DNA sensors-based molecular identification for cancer subtyping 基于智能 DNA 传感器的癌症亚型分子识别技术

Smart Molecules Pub Date : 2023-12-12 DOI: 10.1002/smo.20230020

Yingying Gao, Mengyi Xiong, Chaonan Gong, Bo Wang, Longwei Bai, Xiao-Bing Zhang

{"title":"Smart DNA sensors-based molecular identification for cancer subtyping","authors":"Yingying Gao, Mengyi Xiong, Chaonan Gong, Bo Wang, Longwei Bai, Xiao-Bing Zhang","doi":"10.1002/smo.20230020","DOIUrl":"https://doi.org/10.1002/smo.20230020","url":null,"abstract":"Molecular subtyping of cancer can greatly help to understand the development of disease and predict tumor behavior. Exploring detection methods for precise subtyping is appealing to prognosis and personalized therapy. During the past decades, DNA-based biosensors have exhibited great potential in cancer diagnosis due to their structural programmability and functional diversity. Despite the encouraging progress that has been made, there remains an issue in improving the accuracy and sensitivity of cancer subtyping due to the complex process of disease, especially in preclinical or clinical applications. To accelerate the development of DNA sensors in the identification of cancer subtypes, in this review, we summarized their advances in molecular subtyping by analyzing the heterogeneity in categories and levels of biomarkers between cancer subtypes. The strategies toward genomic and proteomic heterogeneity in cells or on the cell surface, as well as the cancer excretions including extracellular vesicles (EVs) and microRNA (miRNAs) in serum, are summarized. Current challenges and the opportunities of DNA-based sensors in this field are also discussed.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138574385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in low-swellable polymer-based smart photonic crystal sensors 低膨胀聚合物智能光子晶体传感器的最新进展

Smart Molecules Pub Date : 2023-12-07 DOI: 10.1002/smo.20230018

Yong Qi, Shufen Zhang

{"title":"Recent progress in low-swellable polymer-based smart photonic crystal sensors","authors":"Yong Qi, Shufen Zhang","doi":"10.1002/smo.20230018","DOIUrl":"https://doi.org/10.1002/smo.20230018","url":null,"abstract":"Low-swelling polymers (LSPs) generally refer to materials with a low solvent absorption ratio or volume expansion rate at swelling equilibrium. LSPs with exceptional responsiveness could be upgraded to smart sensors with structural color self-reporting by bridging photonic crystals (PCs). Based on the regulation of swelling to effective refractive index, lattice spacing, the order-disorder arrangement of nanostructures, and incident/detection angle, the structural color feedback of smart photonic crystal sensors (SPCSs) can quantitatively and visually reveal the stimulus, which greatly promotes the interdisciplinary development of nanophotonic technology in the fields of chemical engineering, materials science, engineering mechanics, biomedicine, environmental engineering, etc. Herein, to clarify the role of the photonic structures and polymer molecules in high-performance SPCSs, LSP-based SPCSs are summarized and discussed, including general swelling mechanisms, color change strategies, structural design, and typical functional applications. It aims to figure out the combination rule between PC structures and LSPs, optimize the design of PC structures, and expound the corresponding structural color sensing mechanisms, inspiring the fabrication of next-generation SPCSs. Finally, perspectives on future structural design and sensing applications are also presented. It is believed that SPCSs are multifunctional nanophotonic tools for the interdisciplinary development of numerous engineering fields in the future.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138548636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-acceptor engineering of donor-acceptor type molecules for all-round boosting anti-tumor phototherapy 供体-受体型分子的双受体工程，全面提升抗肿瘤光疗效果

Smart Molecules Pub Date : 2023-11-23 DOI: 10.1002/smo.20230014

Hua Gu, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng

引用次数: 0

[2]Biphenyl-extended pillar[6]arene functionalized silver nanoparticles for catalysis and label-free detection 用于催化和无标记检测的[2]联苯延伸柱[6]炔功能化银纳米粒子

Smart Molecules Pub Date : 2023-11-14 DOI: 10.1002/smo.20230016

Dongxia Li, Gengxin Wu, Xin Wang, Jia-Rui Wu, Ying-Wei Yang

引用次数: 0