Smart Molecules最新文献

Light-controlled smart materials: Supramolecular regulation and applications 光控智能材料：超分子调控与应用

Smart Molecules Pub Date : 2024-09-15 DOI: 10.1002/smo.20240036

Zi-Hao Liao, Feng Wang

{"title":"Light-controlled smart materials: Supramolecular regulation and applications","authors":"Zi-Hao Liao, Feng Wang","doi":"10.1002/smo.20240036","DOIUrl":"https://doi.org/10.1002/smo.20240036","url":null,"abstract":"Smart materials serve as the fundamental cornerstone supporting humanity's transition into the intelligent era. Smart materials possess the capability to perceive external stimuli and respond accordingly. Light-controlled smart materials (LCSMs) are a significant category that can sense and respond to light stimuli. Light, being a non-invasive, precisely regulated, and remotely controllable source of physical stimulation, makes LCSMs indispensable in certain application scenarios. Recently, the construction of LCSMs using supramolecular strategies has emerged as a significant research focus. Supramolecular assembly, based on non-covalent bonding, offers dynamic, reversible, and biomimetic properties. By integrating supramolecular systems with photoresponsive molecular building blocks, these materials can achieve synergistic and rich intelligent stimulus responses. This review delves into the latest research advancements in LCSMs based on supramolecular strategies. There are four sections in this review. The first section defines LCSMs and outlines their advantages. The second section discusses the design approaches of supramolecular LCSMs. The third section highlights the latest advancements on supramolecular LCSMs over the past 3 years. The fourth section summarizes the current research and provides insights into the future development of this field.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances of organic long persistent luminescence: Design strategy and internal mechanism 有机长持续发光的最新进展：设计策略和内部机制

Smart Molecules Pub Date : 2024-09-11 DOI: 10.1002/smo.20240034

Jie Yang, Zhijian Chen, Manman Fang, Zhen Li

引用次数: 0

Ru@NiMoS aggregate with boosted electrochemical catalysis for enhanced electrochemiluminescence and lidocaine detection 具有增强型电化学催化作用的 Ru@NiMoS 聚合物，用于增强电化学发光和利多卡因检测

Smart Molecules Pub Date : 2024-09-11 DOI: 10.1002/smo.20240011

Yongzhuang Lu, Haoran Wang, Qiyao Li, Qian Liu, Xiaoxu Zhang, Yuying Jia, Xiangyu Cai, Zheng Zhao, Yanfu Huan, Ben Zhong Tang

{"title":"Ru@NiMoS aggregate with boosted electrochemical catalysis for enhanced electrochemiluminescence and lidocaine detection","authors":"Yongzhuang Lu, Haoran Wang, Qiyao Li, Qian Liu, Xiaoxu Zhang, Yuying Jia, Xiangyu Cai, Zheng Zhao, Yanfu Huan, Ben Zhong Tang","doi":"10.1002/smo.20240011","DOIUrl":"https://doi.org/10.1002/smo.20240011","url":null,"abstract":"A binder-free Ru@NiMoS electrode was engineered by in situ growth of two-dimensional NiMoS nanosheets on nickel foam. This process effectively promoted the electrostatic-driven aggregation of Ru(bpy)32+, harnessing the synergistic effect to enhance electrochemiluminescence (ECL) performance. The integration (Ru@NiMoS) achieved an impressive ECL efficiency of 70.1%, marking an impressive 36.9-fold enhancement over conventional Ru. Additionally, its ECL intensity was found to be remarkably 172.2 times greater than that of Ru. Within the Ru(bpy)32+/TPA system, NiMoS emerged as a pivotal electrochemical catalyst, markedly boosting both the oxygen evolution reaction and the generation of reactive intermediates. Leveraging these distinctive properties, a highly efficient ECL sensor for lidocaine detection was developed. This sensor exhibited a linear response within the concentration range of 1 nM to 1 μM and achieved a remarkably low detection limit of 0.22 nM, underlining its substantial potential for practical application.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart molecular probes with controllable photophysical property for smart medicine 具有可控光物理特性的智能分子探针用于智能医疗

Smart Molecules Pub Date : 2024-09-04 DOI: 10.1002/smo.20240033

Xiaoying Kang, Zekun Du, Shuxuan Yang, Mengyun Liang, Qian Liu, Ji Qi

{"title":"Smart molecular probes with controllable photophysical property for smart medicine","authors":"Xiaoying Kang, Zekun Du, Shuxuan Yang, Mengyun Liang, Qian Liu, Ji Qi","doi":"10.1002/smo.20240033","DOIUrl":"https://doi.org/10.1002/smo.20240033","url":null,"abstract":"Precision medicine calls for advanced theranostics that integrate controllable diagnostic and therapeutic capabilities into one platform for disease treatment in the early stage. Phototheranostics such as fluorescence imaging (FLI), photoacoustic imaging (PAI), photodynamic therapy (PDT), and photothermal therapy (PTT) have attracted considerable attention in recent years, which mainly employ different excited-state energy dissipation pathways of a chromophore. According to the Jablonski diagram, FLI is related to the radiative process, PAI and PTT are derived from the nonradiative thermal deactivation, and PDT originates from the triplet state energy, in which these processes are usually competitive. Therefore, it is critically important to precisely tune the photophysical energy transformation processes to realize certain diagnosis and treatment properties in optimal state for boosting biomedical applications. Currently, there are mainly two strategies including chemical structure and aggregate behavior changes that relate to the regulation of excited state energy dissipation. In this review, we will discuss the recent advances of smart molecular probes that the photophysical properties can be regulated by external triggers and their applications in biomedical fields. We will summarize the development of activatable phototheranostic molecular probes in response to stimuli such as reactive oxygen species, pH, light, hypoxia, enzyme and gas. The assembly and disassembly of molecular aggregates that greatly affect the photophysical energy transformation processes will also be highlighted. This review aims to provide valuable insights into the development of more accurate diagnostic and therapeutic systems, thereby advancing the emerging field of smart medicine.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An azo substituted quinoline-malononitrile enzyme-activable aggregation-induced emission nanoprobe for hypoxia imaging 用于缺氧成像的偶氮取代喹啉-丙二腈酶促聚集诱导发射纳米探针

Smart Molecules Pub Date : 2024-09-04 DOI: 10.1002/smo.20240028

Zhirong Zhu, Shichang Liu, Xupeng Wu, Qianqian Yu, Yi Duan, Shanshan Hu, Wei-Hong Zhu, Qi Wang

{"title":"An azo substituted quinoline-malononitrile enzyme-activable aggregation-induced emission nanoprobe for hypoxia imaging","authors":"Zhirong Zhu, Shichang Liu, Xupeng Wu, Qianqian Yu, Yi Duan, Shanshan Hu, Wei-Hong Zhu, Qi Wang","doi":"10.1002/smo.20240028","DOIUrl":"https://doi.org/10.1002/smo.20240028","url":null,"abstract":"The development of efficient aggregation-induced emission (AIE) active probes is crucial for disease diagnosis, particularly for tumors and cardiovascular diseases. Current AIE-active probes primarily focus on improving their water solubility to resist aggregation, thereby achieving an initial fluorescence-off state. However, the complex biological environment can cause undesirable aggregation, resulting in false signals. To address this issue, we have ingeniously introduced an azo group into the AIE luminogen (AIEgen), developing a reductase-activated AIE probe, Azo-quinoline-malononitrile (QM)-PN, for imaging hypoxic environments. In this probe, the azo group promotes intramolecular motion through rapid E/Z isomerization, causing the excited state energy to dissipate via non-radiative decay, thus turning off the initial fluorescence. In the presence of reductase, Azo-QM-PN is reduced and cleaved to produce the hydrophobic AIEgen NH2-QM-PN, which subsequently aggregates and generates an in situ AIE signal, thereby imaging the hypoxic environment with reductase. Encapsulation of Azo-QM-PN with DSPE-PEG2000 results in the formation of the nanoprobe Azo-QM-PN NPs, which can effectively penetrate cell membranes, specifically illuminate tumor cells, monitor fluctuations in azo reductase levels, and deeply penetrate and image multicellular tumor spheroids, demonstrating potential for hypoxic tumor imaging. Additionally, the nanoprobe Azo-QM-PN NPs can selectively image hypoxic atherosclerotic plaque tissues, showing potential for detecting atherosclerosis. Therefore, in this study, we successfully developed an enzyme-activated AIE probe for imaging hypoxic environments, laying the foundation for further clinical applications.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in stimuli-activable metallo-prodrugs for cancer therapy 用于癌症治疗的可刺激激活金属前体药物的最新进展

Smart Molecules Pub Date : 2024-08-29 DOI: 10.1002/smo.20240030

Jinzhe Liang, Fangmian Wei, Hui Chao

引用次数: 0

Visual detection of anti-icing fluids freezing by a low-temperature viscosity-sensitive aggregation-induced emission probe 用低温粘度敏感聚集诱导发射探针目测防冰液冻结情况

Smart Molecules Pub Date : 2024-08-27 DOI: 10.1002/smo.20240014

Honghong Zhang, Fanghui Li, Jiahong Yu, Weijun Zhao

{"title":"Visual detection of anti-icing fluids freezing by a low-temperature viscosity-sensitive aggregation-induced emission probe","authors":"Honghong Zhang, Fanghui Li, Jiahong Yu, Weijun Zhao","doi":"10.1002/smo.20240014","DOIUrl":"https://doi.org/10.1002/smo.20240014","url":null,"abstract":"Icing detection is critically important for preventing safety accidents and economic losses, especially concerning ice formation from invalidated anti-icing fluids (water and ethylene glycol) under extreme conditions. Traditional technologies like ultrasonics and capacitor-antenna face challenges with limited detection areas, lower accuracy, and susceptibility to electromagnetic interference. Here, we introduce a novel viscosity-ultrasensitive fluorescent probe 4′,4‴-(2,2-diphenylethene-1,1-diyl) bis-(3,5-dicarboxylate) (TPE-2B4C) based on AIEgens for monitoring ice formation of anti-icing fluids in low-temperature environments. TPE-2B4C, consisting of four sodium carboxylate groups and multiple freely rotating benzene rings, demonstrates outstanding solubility in anti-icing fluids and exhibits no fluorescent background signal even at low temperatures (<−20°C). Upon freezing, TPE-2B4C relocates from the water phase to higher viscosity ethylene glycol, causing restriction of benzene rings and a significantly increased green fluorescence signal. TPE-2B4C can successfully determine whether the anti-icing fluids are icing from −5 to −20°C with a high contrast ratio. Due to its simple setup, fast operation, and broad applicability, our new method is anticipated to be employed for rapid, real-time, and large-scale icing detection.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in self-immobilizing fluorescent probes for in vivo imaging 用于体内成像的自固定荧光探针的最新进展

Smart Molecules Pub Date : 2024-08-23 DOI: 10.1002/smo.20240031

Yong Zhang, Xuemei Lv, Yafu Wang, Xueqian Chen, Jinchao Zhang, Dongdong Su

引用次数: 0

Highly tough, crack-resistant and self-healable piezo-ionic skin enabled by dynamic hard domains with mechanosensitive ionic channel 具有机械敏感离子通道的动态硬域可实现高韧性、抗裂性和自愈性的压电离子皮肤

Smart Molecules Pub Date : 2024-08-19 DOI: 10.1002/smo.20240008

XueBin Wang, Tong Liu, FuYao Sun, Jingyi Zhang, BoWen Yao, JianHua Xu, JiaJun Fu

{"title":"Highly tough, crack-resistant and self-healable piezo-ionic skin enabled by dynamic hard domains with mechanosensitive ionic channel","authors":"XueBin Wang, Tong Liu, FuYao Sun, Jingyi Zhang, BoWen Yao, JianHua Xu, JiaJun Fu","doi":"10.1002/smo.20240008","DOIUrl":"https://doi.org/10.1002/smo.20240008","url":null,"abstract":"Robust and reliable piezo-ionic materials that are both crack resistant and self-healable like biological skin hold great promise for applications inflexible electronics and intelligent systems with prolonged service lives. However, such a combination of high toughness, superior crack resistance, autonomous self-healing and effective control of ion dynamics is rarely seen in artificial iontronic skin because these features are seemingly incompatible in materials design. Here, we resolve this perennial mismatch through a molecularly engineered strategy of implanting carboxyl-functionalized groups into the dynamic hard domain structure of synthesized poly(urethane-urea). This design provides an ultra-high fracture energy of 211.27 kJ m−2 that is over 123.54 times that of tough human skin, while maintaining skin-like stretchability, elasticity, and autonomous self-healing with a 96.40% healing efficiency. Moreover, the carboxyl anion group allows the dynamic confinement of ionic fluids though electrostatic interaction, thereby ensuring a remarkable pressure sensitivity of 7.03 kPa−1 for the tactile sensors. As such, we successfully demonstrated the enormous potential ability of this skin-like piezo-ionic sensor for biomedical monitoring and robotic item identification, which indicates promising future uses in flexible electronics and human–machine interactions.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the unexpected sinking and embedding dynamics of surface supported Mo/S clusters on 2D MoS2 with active machine learning 用主动式机器学习揭示二维 MoS2 上表面支持的 Mo/S 簇意外下沉和嵌入动力学

Smart Molecules Pub Date : 2024-08-08 DOI: 10.1002/smo.20240018

Luneng Zhao, Yanhan Ren, Xiaoran Shi, Hongsheng Liu, Zhigen Yu, Junfeng Gao, Jijun Zhao

{"title":"Unveiling the unexpected sinking and embedding dynamics of surface supported Mo/S clusters on 2D MoS2 with active machine learning","authors":"Luneng Zhao, Yanhan Ren, Xiaoran Shi, Hongsheng Liu, Zhigen Yu, Junfeng Gao, Jijun Zhao","doi":"10.1002/smo.20240018","DOIUrl":"https://doi.org/10.1002/smo.20240018","url":null,"abstract":"Surface-supported clusters forming by aggregation of excessive adatoms could be the main defects of 2D materials after chemical vapor deposition. They will significantly impact the electronic/magnetic properties. Moreover, surface supported atoms are also widely explored for high active and selecting catalysts. Severe deformation, even dipping into the surface, of these clusters can be expected because of the very active edge of clusters and strong interaction between supported clusters and surfaces. However, most models of these clusters are supposed to simply float on the top of the surface because ab initio simulations cannot afford the complex reconstructions. Here, we develop an accurate graph neural network machine learning potential (MLP) from ab initio data by active learning architecture through fine-tuning pre-trained models, and then employ the MLP into Monte Carlo to explore the structural evolutions of Mo and S clusters (1–8 atoms) on perfect and various defective MoS2 monolayers. Interestingly, Mo clusters can always sink and embed themselves into MoS2 layers. In contrast, S clusters float on perfect surfaces. On the defective surface, a few S atoms will fill the vacancy and rest S clusters float on the top. Such significant structural reconstructions should be carefully taken into account.","PeriodicalId":501601,"journal":{"name":"Smart Molecules","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0