arXiv - QuanBio - Tissues and Organs最新文献_第2页

Mechanics promotes coherence in heterogeneous active media 力学促进异质活性介质中的相干性

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-20 DOI: arxiv-2408.10603

Soling Zimik, Sitabhra Sinha

引用次数: 0

Acto-myosin clusters as active units shaping living matter 肌动蛋白集群是塑造生命物质的活性单元

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-09 DOI: arxiv-2408.05119

Karsten Kruse, Rémi Berthoz, Luca Barberi, Anne-Cécile Reymann, Daniel Riveline

引用次数: 0

Computational modelling of bone growth and mineralization surrounding biodegradable Mg-based and permanent Ti implants 生物可降解镁基和永久性钛植入物周围骨生长和矿化的计算建模

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-07 DOI: arxiv-2408.03820

Domenik Priebe, Nik Pohl, Tamadur AlBaraghtheh, Sven Schimek, Florian Wieland, Diana Krüger, Sascha Trostorff, Regine Willumeit-Römer, Ralf Köhl, Berit Zeller-Plumhoff

{"title":"Computational modelling of bone growth and mineralization surrounding biodegradable Mg-based and permanent Ti implants","authors":"Domenik Priebe, Nik Pohl, Tamadur AlBaraghtheh, Sven Schimek, Florian Wieland, Diana Krüger, Sascha Trostorff, Regine Willumeit-Römer, Ralf Köhl, Berit Zeller-Plumhoff","doi":"arxiv-2408.03820","DOIUrl":"https://doi.org/arxiv-2408.03820","url":null,"abstract":"In silico testing of implant materials is a research area of high interest,\u0000as cost- and labour-intensive experiments may be omitted. However, assessing\u0000the tissue-material interaction mathematically and computationally can be very\u0000complex, in particular when functional, such as biodegradable, implant\u0000materials are investigated. In this work, we expand and refine suitable\u0000existing mathematical models of bone growth and magnesium-based implant\u0000degradation based on ordinary differential equations. We show that we can\u0000simulate the implant degradation, as well as the osseointegration in terms of\u0000relative bone volume fraction and changes in bone ultrastructure when applying\u0000the model to experimental data from titanium and magnesium-gadolinium implants\u0000for healing times up to 32 weeks. By conducting a parameter study we further\u0000show that a lack of data at early time points has little influence on the\u0000simulation outcome. Moreover, we show that the model is predictive in terms of\u0000relative bone volume fraction with mean absolute errors below 6%","PeriodicalId":501572,"journal":{"name":"arXiv - QuanBio - Tissues and Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolving the kinetics of an ensemble of muscle myosin motors via a temperature-dependent fitting procedure 通过与温度相关的拟合程序解析肌肉肌球蛋白马达集合的动力学特性

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-07 DOI: arxiv-2408.03676

Valentina Buonfiglio, Niccolò Zagli, Irene Pertici, Vincenzo Lombardi, Pasquale Bianco, Duccio Fanelli

引用次数: 0

Mechanics of poking a cyst 戳破囊肿的原理

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-07 DOI: arxiv-2408.03716

Shiheng Zhao, Pierre A. Haas

引用次数: 0

The Role of Biomarkers on Haemodynamics in Atherosclerotic Artery 生物标记物对动脉粥样硬化血流动力学的作用

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-06 DOI: arxiv-2408.03117

Ruchira Ray, Bibaswan Dey

{"title":"The Role of Biomarkers on Haemodynamics in Atherosclerotic Artery","authors":"Ruchira Ray, Bibaswan Dey","doi":"arxiv-2408.03117","DOIUrl":"https://doi.org/arxiv-2408.03117","url":null,"abstract":"Atherosclerosis, a chronic inflammatory cardiovascular disease, leads to\u0000arterial constriction caused by the accumulation of lipids, cholesterol, and\u0000various substances within artery walls. Such plaque can rupture, resulting in a\u0000blood clot that obstructs major arteries and may initiate myocardial\u0000infarction, ischemic stroke, etc. Atherosclerotic plaque formation begins with\u0000the accumulation of foam cells and macrophages within the intima layer of the\u0000arterial wall. At the latter stage, the smooth muscle cells migrated from\u0000deeper artery wall layers, contributing to the fibrous cap formation and plaque\u0000stabilizing. A developed plaque gradually enters the lumen and narrows down the\u0000lumen to impede blood flow. We introduce a two-phase and macroscopic model to\u0000investigate the progression of plaque growth in its advanced stage and analyze\u0000the minimum gap (Lumen Clearance) within an atherosclerotic artery so that\u0000blood cells can pass through. Cardiac troponin, a high specificity and\u0000sensitivity biomarker, facilitates early detection of elevated myocardial\u0000infarction, Ischemic stroke, etc. risks. This study aims to establish a\u0000relationship between the troponin concentration in atherosclerotic arteries and\u0000their internal clearance, which could significantly improve our understanding\u0000of disease progression. Our observations show that the plaque undergoes rapid\u0000evolution in its initial stages, gradually slowing down over time to reach a\u0000steady state. At the same time, the lumen clearance exhibits an opposite\u0000behavior, decreasing slowly over time. Our study finds a positive correlation\u0000between plaque depth and troponin concentration in the blood and a negative\u0000relationship between troponin concentrations and lumen clearance in\u0000atherosclerotic arteries.","PeriodicalId":501572,"journal":{"name":"arXiv - QuanBio - Tissues and Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfluidic 3D Cell Culture: Potential Application of Collagen Hydrogels with an Optimal Dose of Bioactive Glasses 微流控三维细胞培养：具有最佳生物活性玻璃剂量的胶原水凝胶的潜在应用

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-06 DOI: arxiv-2408.03196

Faezeh Ghobadi, Maryam Saadatmand, Sara Simorgh, Peiman Brouki Milan

{"title":"Microfluidic 3D Cell Culture: Potential Application of Collagen Hydrogels with an Optimal Dose of Bioactive Glasses","authors":"Faezeh Ghobadi, Maryam Saadatmand, Sara Simorgh, Peiman Brouki Milan","doi":"arxiv-2408.03196","DOIUrl":"https://doi.org/arxiv-2408.03196","url":null,"abstract":"We engineered a microfluidic platform to study the effects of bioactive glass\u0000nanoparticles (BGNs) on cell viability under static culture. We incorporated\u0000different concentrations of BGNs (1%, 2%, and 3% w/v) in collagen hydrogel\u0000(with a concentration of 3.0 mg/mL). The microfluidic chip's dimensions were\u0000optimized through fluid flow and mass transfer simulations. Collagen type I\u0000extracted from rat tail tendons was used as the main material, and BGNs\u0000synthesized by the sol-gel method were used to enhance the mechanical\u0000properties of the hydrogel. The extracted collagen was characterized using FTIR\u0000and SDS-PAGE, and BGNs were analyzed using XRD, FTIR, DLS, and FE-SEM/EDX. The\u0000structure of the collagen-BGNs hydrogels was examined using SEM, and their\u0000mechanical properties were determined using rheological analysis. The\u0000cytotoxicity of BGNs was assessed using the MTT assay, and the viability of\u0000fibroblast (L929) cells encapsulated in the collagen-BGNs hydrogel inside the\u0000microfluidic device was assessed using a live/dead assay. Based on all these\u0000test results, the L929 cells showed high cell viability in vitro and promising\u0000microenvironment mimicry in a microfluidic device. Collagen3-BGNs3 (Collagen 3\u0000mg/mL + BGNs 3% (w/v)) was chosen as the most suitable sample for further\u0000research on a microfluidic platform.","PeriodicalId":501572,"journal":{"name":"arXiv - QuanBio - Tissues and Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlling moving interfaces in solid state batteries 控制固态电池中的移动界面

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-06 DOI: arxiv-2408.03175

Salem Mosleh, Emil Annevelink, Venkatasubramanian Viswanathan, L. Mahadevan

{"title":"Controlling moving interfaces in solid state batteries","authors":"Salem Mosleh, Emil Annevelink, Venkatasubramanian Viswanathan, L. Mahadevan","doi":"arxiv-2408.03175","DOIUrl":"https://doi.org/arxiv-2408.03175","url":null,"abstract":"Safe, all-solid-state lithium metal batteries enable high energy density\u0000applications, but suffer from instabilities during operation that lead to rough\u0000interfaces between the metal and electrolyte and subsequently cause void\u0000formation and dendrite growth that degrades performance and safety. Inspired by\u0000the morphogenetic control of thin lamina such as tree leaves that robustly grow\u0000into flat shapes -- we propose a range of approaches to control lithium metal\u0000stripping and plating. To guide discovery of materials that will implement\u0000these feedback mechanisms, we develop a reduced order model that captures\u0000couplings between mechanics, interface growth, temperature, and electrochemical\u0000variables. We find that long-range feedback is required to achieve true\u0000interface stability, while approaches based on local feedback always eventually\u0000grow into rough interfaces. All together, our study provides the beginning of a\u0000practical framework for analyzing and designing stable electrochemical\u0000interfaces in terms of the mechanical properties and the physical chemistry\u0000that underlie their dynamics.","PeriodicalId":501572,"journal":{"name":"arXiv - QuanBio - Tissues and Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Force and kinetics of fast and slow muscle myosin determined with a synthetic sarcomere-like nanomachine 用合成的类肉瘤纳米机械测定快慢肌肌球蛋白的力量和动力学特性

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-08-01 DOI: arxiv-2408.00373

Valentina Buonfiglio, Irene Pertici, Matteo Marcello, Ilaria Morotti, Marco Caremani, Massimo Reconditi, Marco Linari, Duccio Fanelli, Vincenzo Lombardi, Pasquale Bianco

{"title":"Force and kinetics of fast and slow muscle myosin determined with a synthetic sarcomere-like nanomachine","authors":"Valentina Buonfiglio, Irene Pertici, Matteo Marcello, Ilaria Morotti, Marco Caremani, Massimo Reconditi, Marco Linari, Duccio Fanelli, Vincenzo Lombardi, Pasquale Bianco","doi":"arxiv-2408.00373","DOIUrl":"https://doi.org/arxiv-2408.00373","url":null,"abstract":"Myosin II is the muscle molecular motor that works in two bipolar arrays in\u0000each thick filament of the striated (skeletal and cardiac) muscle, converting\u0000the chemical energy into steady force and shortening by cyclic ATP--driven\u0000interactions with the nearby actin filaments. Different isoforms of the myosin\u0000motor in the skeletal muscles account for the different functional requirements\u0000of the slow muscles (primarily responsible for the posture) and fast muscles\u0000(responsible for voluntary movements). To clarify the molecular basis of the\u0000differences, here the isoform--dependent mechanokinetic parameters underpinning\u0000the force of slow and fast muscles are defined with a unidimensional synthetic\u0000nanomachine powered by pure myosin isoforms from either slow or fast rabbit\u0000skeletal muscle. Data fitting with a stochastic model provides a\u0000self--consistent estimate of all the mechanokinetic properties of the motor\u0000ensemble including the motor force, the fraction of actin--attached motors and\u0000the rate of transition through the attachment--detachment cycle. The\u0000achievements in this paper set the stage for any future study on the emergent\u0000mechanokinetic properties of an ensemble of myosin molecules either engineered\u0000or purified from mutant animal models or human biopsies.","PeriodicalId":501572,"journal":{"name":"arXiv - QuanBio - Tissues and Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141883938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SepAl: Sepsis Alerts On Low Power Wearables With Digital Biomarkers and On-Device Tiny Machine Learning SepAl：利用数字生物标志物和设备上的微型机器学习在低功耗可穿戴设备上发出败血症警报

arXiv - QuanBio - Tissues and Organs Pub Date : 2024-07-31 DOI: arxiv-2408.08316

Marco Giordano, Kanika Dheman, Michele Magno

{"title":"SepAl: Sepsis Alerts On Low Power Wearables With Digital Biomarkers and On-Device Tiny Machine Learning","authors":"Marco Giordano, Kanika Dheman, Michele Magno","doi":"arxiv-2408.08316","DOIUrl":"https://doi.org/arxiv-2408.08316","url":null,"abstract":"Sepsis is a lethal syndrome of organ dysfunction that is triggered by an\u0000infection and claims 11 million lives per year globally. Prognostic algorithms\u0000based on deep learning have shown promise in detecting the onset of sepsis\u0000hours before the actual event but use a large number of bio-markers, including\u0000vital signs and laboratory tests. The latter makes the deployment of such\u0000systems outside hospitals or in resource-limited environments extremely\u0000challenging. This paper introduces SepAl, an energy-efficient and lightweight\u0000neural network, using only data from low-power wearable sensors, such as\u0000photoplethysmography (PPG), inertial measurement units (IMU), and body\u0000temperature sensors, designed to deliver alerts in real-time. SepAl leverages\u0000only six digitally acquirable vital signs and tiny machine learning algorithms,\u0000enabling on-device real-time sepsis prediction. SepAl uses a lightweight temporal convolution neural network capable of\u0000providing sepsis alerts with a median predicted time to sepsis of 9.8 hours.\u0000The model has been fully quantized, being able to be deployed on any low-power\u0000processors, and evaluated on an ARM Cortex-M33 core. Experimental evaluations\u0000show an inference efficiency of 0.11MAC/Cycle and a latency of 143ms, with an\u0000energy per inference of 2.68mJ. This work aims at paving the way toward\u0000accurate disease prediction, deployable in a long-lasting multi-vital sign\u0000wearable device, suitable for providing sepsis onset alerts at the point of\u0000care. The code used in this work has been open-sourced and is available at\u0000https://github.com/mgiordy/sepsis-prediction","PeriodicalId":501572,"journal":{"name":"arXiv - QuanBio - Tissues and Organs","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142183355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0