The Journal of Spinal Cord Medicine最新文献

{"title":"Long-term radial extracorporeal shock wave therapy for neurogenic heterotopic ossification after spinal cord injury: A case report.","authors":"Yun Li,&nbsp;Yulan Zhu,&nbsp;Zhen Xie,&nbsp;Congyu Jiang,&nbsp;Fang Li","doi":"10.1080/10790268.2020.1760507","DOIUrl":"https://doi.org/10.1080/10790268.2020.1760507","url":null,"abstract":"<p><p><b>Context:</b> Heterotopic ossification is characterized by abnormal growth of bone in soft tissues. Neurogenic heterotopic ossification is also closely related to central nervous system injuries and has been reported to respond to radial extracorporeal shock wave therapy.<b>Findings:</b> In this case, a radial extracorporeal shock wave therapy (five times per week, lasted for almost one year) was applied to a patient with neurogenic heterotopic ossification on the left hip as a result of spinal cord injury. Throughout the treatment session, the heterotopic ossification lesion was gradually diminished, associated with the increase in joint range of motion, pain mitigation and decrease in serum alkaline phosphatase level.<b>Conclusion/clinical relevance:</b> Long-term radial extracorporeal shock wave therapy offers a promising therapeutic alternative for neurogenic heterotopic ossification.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"476-480"},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1760507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37927945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum levels of brain-derived neurotrophic factor following wheelchair half marathon race in individuals with spinal cord injury.","authors":"Yukihide Nishimura,&nbsp;Takeshi Nakamura,&nbsp;Yoshi-Ichiro Kamijo,&nbsp;Hideki Arakawa,&nbsp;Yasunori Umemoto,&nbsp;Tokio Kinoshita,&nbsp;Yuta Sakurai,&nbsp;Fumihiro Tajima","doi":"10.1080/10790268.2020.1816402","DOIUrl":"https://doi.org/10.1080/10790268.2020.1816402","url":null,"abstract":"<p><p><b>Objective:</b> Brain-derived neurotrophic factor (BDNF) has beneficial effects on metabolism as well as the peripheral and central nervous systems. The aim of this study was to assess the response of serum BDNF concentration ([BDNF]s) to wheelchair half marathon race in individuals with spinal cord injury (SCI).<b>Design:</b> Prospective observational study.<b>Setting:</b> The 34th Oita International Wheelchair Marathon Race in Japan.<b>Participants:</b> Nine cervical SCIs (CSCI) and 8 thoracic and lumber SCIs (LSCI) male athletes. <i>Interventions:</i> Wheelchair half-Marathon Race.<b>Outcome measures:</b> [BDNF]s, plasma concentrations of adrenaline ([Ad]p), noradrenaline ([Nor]p), and cortisol ([Cor]p), hematocrit, and platelet count were measured the day before, immediately after, and an hour after the race.<b>Results:</b> [BDNF]s increased significantly immediately after the race in both groups (CSCI; P = 0.0055, LSCI; P = 0.0312) but returned to the baseline levels at one hour after the race. However, [BDNF]s immediately and one hour after the race were significantly higher in LSCI than in CSCI (immediately after the race; P = 0.0037, 1 h after the race; P = 0.0206). Hematocrit and platelet count remained unchanged throughout the study. In LSCI, [Ad]p, [Nor]p and [Cor]p increased significantly immediately after and one hour after the race, compared with the baseline values (P < 0.05). On the other hand, these variables remained unchanged throughout the study in the CSCI.<b>Conclusions:</b> [BDNF]_s increased significantly from the baseline in both LCSI and CSCI but was higher in LSCI than in CSCI immediately after and one hour after the race.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"455-460"},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1816402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38486364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does lack of brain injury mean lack of cognitive impairment in traumatic spinal cord injury?","authors":"Eyal Heled,&nbsp;Keren Tal,&nbsp;Gabi Zeilig","doi":"10.1080/10790268.2020.1847564","DOIUrl":"https://doi.org/10.1080/10790268.2020.1847564","url":null,"abstract":"<p><strong>Objective: </strong>Traumatic spinal cord injury (tSCI) has implications in many areas, including cognitive functioning. Findings regarding cognitive problems in people with SCI are inconsistent, presumably due to multiple variables than can affect performance, among them emotional variables. The purpose of the current study was to elucidate cognitive sequalae in some individuals with tSCI with no medical record of brain injury, while taking emotional variables into consideration.</p><p><strong>Design: </strong>Cross-sectional, with two groups.</p><p><strong>Setting: </strong>A public rehabilitation center.</p><p><strong>Participants: </strong>Twenty participants with tSCI at least ten months post injury and twenty non-SCI controls, matched for sex, age, and education.</p><p><strong>Intervention: </strong>None.</p><p><strong>Outcome measures: </strong>A battery of neuropsychological tests tapping executive functions, memory, attention, and naming abilities, in addition to questionnaires assessing depression and distress.</p><p><strong>Results: </strong>When emotional variables were statistically controlled, participants with tSCI showed higher levels of depression and distress and scored lower than non-SCI control participants on all cognitive tests except naming. Executive functions were found to have the highest effect size, though no specific ability was sensitive enough to differentiate between the groups in a binary logistic regression analysis.</p><p><strong>Conclusion: </strong>In some individuals with chronic tSCI, lower cognitive ability that is unrelated to emotional distress might result from spinal cord damage and its implications in a population who's medical records show no indication of brain injury. This highlights the importance of conducting cognitive evaluation following SCI, so that deficits can be effectively addressed during rehabilitation.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"373-380"},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1847564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38713536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing accessible educational resources for people living with spinal cord injury.","authors":"Michael Todorovic,&nbsp;Matthew Barton,&nbsp;Steven Bentley,&nbsp;James A St John,&nbsp;Jenny Ekberg","doi":"10.1080/10790268.2020.1808772","DOIUrl":"https://doi.org/10.1080/10790268.2020.1808772","url":null,"abstract":"<p><p><b>Context/objective:</b> To identify themes of interest for the production of educational resources for people with spinal cord injury (SCI).<b>Design:</b> A mixed-method study.<b>Setting:</b> Outpatient SCI community in Australia.<b>Participants:</b> Individuals with a SCI, or carers, family & friends of people who live with a SCI (<i>n</i> = 116).<b>Interventions:</b> Not applicable.<b>Outcome measures:</b> Quantify themes of interest perceived within the Australian SCI community as necessary for the development of SCI educational resources.<b>Results:</b> All seven individuals from the focus-group interviews suggested that educational resources on body physiology, secondary complications, injury pathophysiology, and health and wellbeing maintenance would be most pertinent for development. These themes (among others) were further explored and quantitatively evaluated via an online survey which demonstrated that interviewees ranked 'Your injury' as being of highest importance for the production of educational resources. Within each theme, the sub-categories; 'Bowel/bladder' and 'What equipment is covered in the National Disability Insurance Scheme (NDIS)' were ranked as being of highest importance for the production of educational resources.<b>Conclusion:</b> We have identified multiple areas of interest in the design and production of educational resources for individuals with SCI.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"442-454"},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1808772","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38417816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The measurement properties of the Lean-and-Release test in people with incomplete spinal cord injury or disease.","authors":"Janelle Unger,&nbsp;Alison R Oates,&nbsp;Joel Lanovaz,&nbsp;Katherine Chan,&nbsp;Jae W Lee,&nbsp;Pirashanth Theventhiran,&nbsp;Kei Masani,&nbsp;Kristin E Musselman","doi":"10.1080/10790268.2020.1847562","DOIUrl":"https://doi.org/10.1080/10790268.2020.1847562","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate test-retest reliability, agreement, and convergent validity of the Lean-and-Release test for the assessment of reactive stepping among individuals with incomplete spinal cord injury or disease (iSCI/D).</p><p><strong>Design: </strong>Multi-center cross-sectional multiple test design.</p><p><strong>Setting: </strong>SCI/D rehabilitation hospital and biomechanics laboratory.</p><p><strong>Participants: </strong>Individuals with motor incomplete SCI/D (iSCI/D).</p><p><strong>Interventions: </strong>None.</p><p><strong>Outcome measures: </strong>Twenty-six participants attended two sessions to complete the Lean-and-Release test and a battery of clinical tests. Behavioral (<i>i.e.</i> one-step, multi-step, loss of balance) and temporal (<i>i.e.</i> timing of foot off, foot contact, swing of reactive step) parameters were measured. Test-retest reliability was determined with intraclass correlation coefficients, and agreement was evaluated with Bland-Altman plots. Convergent validity was assessed through correlations with clinical tests.</p><p><strong>Results: </strong>The behavioral responses were reliable for the Lean-and-Release test (ICC = 0.76), but foot contact was the only reliable temporal parameter using data from a single site (ICC = 0.79). All variables showed agreement according to the Bland-Altman plots. The behavioral responses correlated with scores of lower extremity strength (0.54, P<0.01) and balance confidence (0.55, P < 0.01). Swing time of reactive stepping correlated with step time (0.73, P < 0.01) and cadence (-0.73 P < 0.01) of over ground walking.</p><p><strong>Conclusions: </strong>The behavioral response of the Lean-and-Release test is a reliable and valid measure for people with iSCI/D. Our findings support the use of the behavioral responses to evaluate reactive stepping for research and clinical purposes.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT02960178.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"426-435"},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1847562","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38664848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulocytic sarcoma causing long spinal cord compression: Case report and literature review.","authors":"Shiyuan Han,&nbsp;Yongning Li,&nbsp;Tong Niu,&nbsp;Xin Wang,&nbsp;Zhimin Li,&nbsp;Xinyu Ren,&nbsp;Jun Gao","doi":"10.1080/10790268.2020.1771506","DOIUrl":"https://doi.org/10.1080/10790268.2020.1771506","url":null,"abstract":"<p><p><b>Context:</b> Granulocytic sarcoma (GS) is an extramedullary form of proliferating myeloblasts. It is frequently reported in patients with acute myeloid leukemia (AML) but rarely in patients with chronic myeloid leukemia (CML). Spinal cord compression caused by CML-associated GS is exceedingly rare, with only few cases reported in the literature. To our knowledge, this is the first reported case in which GS caused such extensive compression.<b>Findings:</b> A 37-year-old man with CML suffered from back pain for 2 months. Notably, he had already achieved molecular remission (MR) after receiving imatinib mesylate for CML; bone marrow aspiration results were consistent with CML in chronic phase. Image examination revealed that developed GS occupied nearly the entire thoracic spinal canal, thereby causing extensive spinal cord compression. The tumor completely diminished after his treatment regimen was upgraded. He showed no signs of recurrence after 1-year follow-up.<b>Conclusion:</b> Extramedullary infiltration of CML should be taken into consideration when a mass lesion develops and compresses the spinal cord in a CML patient who has been receiving routine and standard treatment modalities; thus, a sudden and unexpected progression mandates a refinement and upgrade of treatment modality.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"481-485"},"PeriodicalIF":1.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1771506","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38053343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of lower extremity deep sensory impairments on walking capability in patients with incomplete cervical spinal cord injury.","authors":"Tomoki Naka,&nbsp;Tetsuo Hayashi,&nbsp;Atsushi Sugyo,&nbsp;Ryouichi Watanabe,&nbsp;Fumihiro Towatari,&nbsp;Takeshi Maeda","doi":"10.1080/10790268.2020.1788879","DOIUrl":"https://doi.org/10.1080/10790268.2020.1788879","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the impact of lower extremity deep sensory impairment on the walking capability of patients with incomplete cervical spinal cord injury.<b>Design:</b> Retrospective cohort study.<b>Setting:</b> Spinal Injuries Center, Fukuoka, Japan.<b>Participants:</b> Patients with incomplete cervical spinal cord injury who were transferred to the Spinal Injuries Center within 2 weeks of injury and whose progress was monitored for 6 months postinjury were included. Sixty-three patients with a lower extremity motor score of 42 points or more were enrolled. They were divided into lower extremity deep sensory impairment (16 patients) and normal (47 patients) groups, and their walking capability was compared.<b>Interventions:</b> Not applicable.<b>Outcome Measures:</b> Upper and lower extremity motor scores, the presence or absence of deep sensation impairment, and walking capability indices at 6 months postinjury were evaluated.<b>Results:</b> The deep sensory impairment group performed significantly worse than the normal group across items in the Walking Index for Spinal Cord Injury II and in the indoor and outdoor mobility items of the Spinal Cord Independence Measure III. Indoor and outdoor mobility independence levels decreased further in the lower extremity deep sensory impairment group than in the normal group.<b>Conclusions:</b> The presence of lower extremity deep sensation impairments was an important factor affecting the achievement of independent walking capabilities in patients with incomplete cervical spinal cord injury. Hence, when patients with incomplete cervical spinal cord injury undergo walking training, not only their lower extremity muscle strength but also their level of deep sensation impairment must be evaluated.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"287-292"},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1788879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38182697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep vein thrombosis of the common iliac vein caused by neurogenic heterotopic ossification in the anterior lower lumbar spine of a patient with complete paraplegia due to radiation-induced myelopathy.","authors":"Du Hwan Kim,&nbsp;Mathieu Boudier-Revéret,&nbsp;Duk Hyun Sung,&nbsp;Min Cheol Chang","doi":"10.1080/10790268.2020.1807767","DOIUrl":"https://doi.org/10.1080/10790268.2020.1807767","url":null,"abstract":"<p><p><b>Context</b>: Deep vein thrombosis (DVT), a frequent complication of spinal cord injury, is occasionally caused by neurogenic heterotopic ossification (NHO). In most cases of NHO, the hip joint is affected. Herein, we present a case of paraplegia following radiation-induced myelopathy that presented with left leg swelling due to DVT in the common iliac vein (CIV) caused by venous compression by NHO on the anterior lower lumbar spine.<b>Findings</b>: A 28-year-old man with complete paraplegia due to radiation-induced myelopathy presented with left lower extremity swelling 6 years after the onset of paraplegia. DVT in the left CIV was observed on computed tomography venography. The left CIV was significantly compressed between the NHO at the anterior longitudinal ligament of the lumbar spine and the right common iliac artery, suggestive of May-Thurner syndrome. Slightly distal to that compressed area, the left CIV was significantly compressed by the large NHO at the anterior longitudinal ligament of the lumbar spine.<b>Conclusions</b>: We believe that such compression of the left CIV would have contributed to the development of DVT. This case shows that DVT might be caused by NHO at the anterior aspect of the lumbar vertebral body, and this may help clinicians identify the main cause of DVT in the leg.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"316-319"},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1807767","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38284878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of lateral epicondylosis in veteran manual wheelchair users participating in adaptive sports.","authors":"Andrea K Cyr,&nbsp;Berdale S Colorado,&nbsp;Michael J Uihlein,&nbsp;Kristin L Garlanger,&nbsp;Sergey S Tarima,&nbsp;Kenneth Lee","doi":"10.1080/10790268.2020.1771243","DOIUrl":"https://doi.org/10.1080/10790268.2020.1771243","url":null,"abstract":"<p><p><b>Objective:</b> Determine the prevalence of lateral epicondylosis (LE) of the dominant elbow in manual wheelchair users based on ultrasound assessment and physical exam.<b>Design:</b> Prospective, cross-sectional.<b>Setting:</b> National Veteran Wheelchair Games 2018 and 2019 (event medical services).<b>Participants:</b> Manual wheelchair users who attended the National Veteran Wheelchair Games (<i>n </i>= 87).<b>Interventions:</b> Participants completed a questionnaire then underwent an ultrasound assessment and a physical exam of their dominant arm evaluating for common extensor tendinopathy (CET) or clinically LE.<b>Main Outcome Measure:</b> Prevalence of CET diagnosed by ultrasound criteria was compared with other diagnostic criteria with MaNemar test for paired binary data.<b>Results:</b> Forty-six percent (<i>N</i> = 40) of participants met diagnostic criteria for CET by ultrasound assessment and 17% (<i>N </i>= 15) of participants met criteria for LE based on physical exam. These values are dramatically higher than what has been reported in the able-bodied population where the prevalence is estimated to be <2%. Age and number of years of wheelchair use were significant predictors of ultrasound diagnosis of LE (P = 0.02, 95% confidence interval [CI] 1.01-1.11) and (P = 0.05, 95% CI 1.00-1.09), respectively. Association analysis based on odds ratio and CI found no association between ultrasound findings suggestive of LE with regular adaptive sport participation greater than 1.5 h per week.<b>Conclusion:</b> Compared to able-bodied population, there is an increased prevalence of both CET and LE in manual wheelchair users based on either ultrasound assessment or physical exam. CET is associated with increased age and increased years using a manual wheelchair. There is no association between the diagnosis of LE and participation in adaptive sport.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"238-244"},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1771243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38038643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alteration of cortical but not spinal inhibitory circuits in idiopathic scoliosis.","authors":"Václav Boček,&nbsp;Martin Krbec,&nbsp;Peter Vaško,&nbsp;Karel Brabec,&nbsp;Markéta Pavlíková,&nbsp;Ivana Štětkářová","doi":"10.1080/10790268.2020.1739893","DOIUrl":"https://doi.org/10.1080/10790268.2020.1739893","url":null,"abstract":"<p><p><b>Background:</b> The pathogenesis of adolescent idiopathic scoliosis (AIS), including the role of brain and spinal inhibitory circuits, is still poorly elucidated. The aim of this study was to identify which central inhibitory mechanisms are involved in the pathogenesis of AIS.<b>Design:</b> A prospective neurophysiological study, using a battery of neurophysiological tests, such as cutaneous (CuSP) and cortical (CoSP) silent periods, motor evoked potentials (MEP) and paired-pulse transcranial magnetic stimulation (ppTMS).<b>Settings:</b> Neurophysiological laboratory.<b>Participants:</b> Sixteen patients with AIS (14 females, median age 14.4) and healthy controls.<b>Outcome measures:</b> MEPs were obtained after transcranial magnetic stimulation (TMS) and recorded from the abductor pollicis muscle (APB). ppTMS was obtained at interval ratios (ISI) of 1, 2, 3, 6, 10, 15 and 20 ms. The cortical silent period (CoSP) was recorded from the APB. The cutaneous silent period (CuSP) was measured after painful stimuli delivered to the thumb while the subjects maintained voluntary contraction of the intrinsic hand muscles. The data were analyzed and compared with those from healthy subjects.<b>Results:</b> The CoSP duration was significantly prolonged in AIS patients. A significantly higher amplitude of ppTMS for ISI was found in all AIS patients, without remarkable left-right side differences. No significant difference in MEP latency or amplitude nor in the CuSP duration was obtained.<b>Conclusion:</b> Our observation demonstrates evidence of central nervous system involvement in adolescent idiopathic scoliosis (AIS). Lower intracortical inhibition, higher motor cortex excitability, and preserved spinal inhibitory circuits are the main findings of this study. A possible explanation of these changes could be attributed to impaired sensorimotor integration predominantly at the cortical level.</p>","PeriodicalId":501560,"journal":{"name":"The Journal of Spinal Cord Medicine","volume":" ","pages":"186-193"},"PeriodicalIF":1.7,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10790268.2020.1739893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37762935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}