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A Safety and Feasibility Trial Protocol of Metformin in Infants after Perinatal Brain Injury 围产期脑损伤后婴儿服用二甲双胍的安全性和可行性试验方案
medRxiv - Pediatrics Pub Date : 2024-05-27 DOI: 10.1101/2024.05.26.24307924
A Hutchinson, R Pais, AN Edginton, B Pilon, JM MacDonald, ME MacDonald, T Lewis, M Offringa, BT Kalish
{"title":"A Safety and Feasibility Trial Protocol of Metformin in Infants after Perinatal Brain Injury","authors":"A Hutchinson, R Pais, AN Edginton, B Pilon, JM MacDonald, ME MacDonald, T Lewis, M Offringa, BT Kalish","doi":"10.1101/2024.05.26.24307924","DOIUrl":"https://doi.org/10.1101/2024.05.26.24307924","url":null,"abstract":"<strong>Introduction</strong> Infants with hypoxic-ischemic encephalopathy (HIE) are at high risk for neurodevelopmental impairment, despite current standards of care. Adjunctive treatments to promote brain repair are needed. The antidiabetic drug metformin has recently been recognized as a neurorestorative agent, but, to date, has not been used in infants. Herein, we describe a clinical trial with the aim of demonstrating the safety and feasibility of metformin use to improve neurodevelopmental outcomes in infants with HIE.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141167204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics and valve lesions in rheumatic heart disease among children admitted to a selected tertiary teaching hospital in eastern Ethiopia. 埃塞俄比亚东部一家选定的三级教学医院收治的风湿性心脏病患儿的临床特征和瓣膜病变。
medRxiv - Pediatrics Pub Date : 2024-05-11 DOI: 10.1101/2024.05.08.24307081
Temesgen Teferi Libe, Yunus Edris Kelil, Samrawit Abebaw Tegene, Faisel Abdi, Kibrom Hailemariam Mesfin
{"title":"Clinical characteristics and valve lesions in rheumatic heart disease among children admitted to a selected tertiary teaching hospital in eastern Ethiopia.","authors":"Temesgen Teferi Libe, Yunus Edris Kelil, Samrawit Abebaw Tegene, Faisel Abdi, Kibrom Hailemariam Mesfin","doi":"10.1101/2024.05.08.24307081","DOIUrl":"https://doi.org/10.1101/2024.05.08.24307081","url":null,"abstract":"Background: Rheumatic heart disease remains a significant public health concern, especially among children in resource-limited settings like Ethiopia. Despite effective prevention strategies, RHD persists due to factors such as poverty and limited healthcare access. Understanding the clinical characteristics and valve lesions of rheumatic heart disease is crucial for improving diagnosis and management.\u0000Objective: This study aimed to characterize the clinical features and valve lesions in children with rheumatic heart disease admitted to a tertiary teaching hospital in Eastern Ethiopia.\u0000Methods: A hospital-based cross-sectional study was conducted from September 1, 2020, to August 31, 2021, at Hiwot Fana Comprehensive Specialized Hospital. Data were collected from medical records, clinical assessments, echocardiography reports, and laboratory tests. Descriptive statistics were used for analysis.\u0000Results: A total of 39 children with rheumatic heart disease were included, predominantly females (71.8%). Shortness of breath (53.9%) and cough (38.5%) were common presenting symptoms. Acute decompensated heart failure (ADHF) was prevalent (89.7%). Mitral regurgitation (94.9%) and aortic regurgitation (66.7%) were frequent valve lesions. Other findings included mitral stenosis (56.4%) and left atrial enlargement (86.1%). Laboratory results showed mean hemoglobin of 10.29 g/dL and mean ESR of 45 mm/hr.\u0000Conclusions: This study highlights the burden of RHD in Eastern Ethiopia, with advanced disease at presentation. Mitral and aortic valve lesions were predominant, emphasizing the need for early detection and comprehensive management strategies. Collaboration among healthcare providers and policymakers is essential to address the challenges of RHD in resource-limited settings.\u0000Keywords: Rheumatic heart disease, clinical characteristics, valve lesions, Eastern Ethiopia","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Nasal High-Frequency Oscillation in Preventing Intubation in Very-Low-Birth-Weight Infants with Respiratory Distress Syndrome 鼻腔高频振荡对预防呼吸窘迫综合征极低出生体重儿插管的有效性和安全性
medRxiv - Pediatrics Pub Date : 2024-05-10 DOI: 10.1101/2024.05.10.24307155
Buu Quoc Dang, Tam Thi Thanh Pham, Duc Ninh Nguyen, Nguyen Phuoc Long, Tinh Thu Nguyen
{"title":"Efficacy and Safety of Nasal High-Frequency Oscillation in Preventing Intubation in Very-Low-Birth-Weight Infants with Respiratory Distress Syndrome","authors":"Buu Quoc Dang, Tam Thi Thanh Pham, Duc Ninh Nguyen, Nguyen Phuoc Long, Tinh Thu Nguyen","doi":"10.1101/2024.05.10.24307155","DOIUrl":"https://doi.org/10.1101/2024.05.10.24307155","url":null,"abstract":"<strong>Background</strong> Invasive mechanical ventilation in very-low-birth-weight infants (VLBWI) was associated with immediate and long-term complications. Nasal high-frequency oscillation (nHFO) has recently become a new non-invasive ventilation (NIV) mode for treating respiratory failure in VLBWI. This study aimed to investigate the safety and efficacy of nHFO as an alternative respiratory support to prevent intubation in VLBWI who have failed other NIV modes.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"138 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated Neuroprognostication via Machine Learning in Neonates with Hypoxic-Ischemic Encephalopathy 通过机器学习对缺氧缺血性脑病新生儿进行自动神经诊断
medRxiv - Pediatrics Pub Date : 2024-05-08 DOI: 10.1101/2024.05.07.24306996
John D. Lewis, Atiyeh A. Miran, Michelle Stoopler, Helen M. Branson, Ashley Danguecan, Krishna Raghu, Linh G. Ly, Mehmet N. Cizmeci, Brian T. Kalish
{"title":"Automated Neuroprognostication via Machine Learning in Neonates with Hypoxic-Ischemic Encephalopathy","authors":"John D. Lewis, Atiyeh A. Miran, Michelle Stoopler, Helen M. Branson, Ashley Danguecan, Krishna Raghu, Linh G. Ly, Mehmet N. Cizmeci, Brian T. Kalish","doi":"10.1101/2024.05.07.24306996","DOIUrl":"https://doi.org/10.1101/2024.05.07.24306996","url":null,"abstract":"<strong>Objectives</strong> Neonatal hypoxic-ischemic encephalopathy is a serious neurologic condition associated with death or neurodevelopmental impairments. Magnetic resonance imaging (MRI) is routinely used for neuroprognostication, but there is substantial subjectivity and uncertainty about neurodevelopmental outcome prediction. We sought to develop an objective and automated approach for the analysis of newborn brain MRI to improve the accuracy of prognostication.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive detection of bilirubin concentrations during the first week of life in a low-resource setting along the Thailand-Myanmar border 在泰缅边境资源匮乏的地区，对婴儿出生第一周的胆红素浓度进行无创检测
medRxiv - Pediatrics Pub Date : 2024-05-08 DOI: 10.1101/2024.05.06.24306917
Germana Bancone, Mary Ellen Gilder, Elsie Win, Gornpan Gornsawun, Paw Khu Moo, Laypaw Archasuksan, Nan San Wai, Sylverine Win, Borimas Hanboonkunupakarn, Francois Nosten, Verena I Carrara, Rose McGready
{"title":"Non-invasive detection of bilirubin concentrations during the first week of life in a low-resource setting along the Thailand-Myanmar border","authors":"Germana Bancone, Mary Ellen Gilder, Elsie Win, Gornpan Gornsawun, Paw Khu Moo, Laypaw Archasuksan, Nan San Wai, Sylverine Win, Borimas Hanboonkunupakarn, Francois Nosten, Verena I Carrara, Rose McGready","doi":"10.1101/2024.05.06.24306917","DOIUrl":"https://doi.org/10.1101/2024.05.06.24306917","url":null,"abstract":"<strong>Background</strong> Neonatal hyperbilirubinaemia (NH) is a common problem worldwide and causes morbidity and mortality especially in low-resource settings.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota development in very preterm infants following fortification of human milk 母乳强化后早产儿肠道微生物群的发育情况
medRxiv - Pediatrics Pub Date : 2024-05-07 DOI: 10.1101/2024.05.07.24306981
Lin Yang, Yan Hui, Per Torp Sangild, Witold Piotr Kot, Lise Aunsholt, Gitte Zachariassen, Ping-Ping Jiang, Dennis Sandris Nielsen
{"title":"Gut microbiota development in very preterm infants following fortification of human milk","authors":"Lin Yang, Yan Hui, Per Torp Sangild, Witold Piotr Kot, Lise Aunsholt, Gitte Zachariassen, Ping-Ping Jiang, Dennis Sandris Nielsen","doi":"10.1101/2024.05.07.24306981","DOIUrl":"https://doi.org/10.1101/2024.05.07.24306981","url":null,"abstract":"<strong>Background</strong> Very preterm infants (VPIs) are born with an immature gut, being sensitive to gut microbiota dysbiosis-related disease like necrotizing enterocolitis. While human milk is the best source of nutrition for VPIs, it requires fortification to meet their nutrient requirements for optimal growth. However, the optimal type of fortifier remains uncertain. Bovine colostrum (BC), rich in protein and bioactive components, may be an alternative to conventional fortifiers (CF). We aimed to investigate the distinct impacts of different bovine fortifiers, BC and CF, on the gut microbiota of VPIs. The gut microbiota of 225 VPIs who were fed human milk fortified with either BC or CF, were profiled by 16S rRNA gene amplicon sequencing of fecal samples collected before, one and two weeks of fortification.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140938595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vietnam National Survey on Parenteral Nutrition Practice in Preterm Neonates: Status, Barriers, and Implications 越南早产新生儿肠外营养实践全国调查：现状、障碍和影响
medRxiv - Pediatrics Pub Date : 2024-05-02 DOI: 10.1101/2024.04.30.24306616
Thu Tinh Nguyen, Phan Minh Nhat Nguyen, Thanh Thien Nguyen, Thi Hieu Vu, Pham Minh Tri Nguyen, Duc Ninh Nguyen
{"title":"Vietnam National Survey on Parenteral Nutrition Practice in Preterm Neonates: Status, Barriers, and Implications","authors":"Thu Tinh Nguyen, Phan Minh Nhat Nguyen, Thanh Thien Nguyen, Thi Hieu Vu, Pham Minh Tri Nguyen, Duc Ninh Nguyen","doi":"10.1101/2024.04.30.24306616","DOIUrl":"https://doi.org/10.1101/2024.04.30.24306616","url":null,"abstract":"<strong>Background</strong> Due to high risks of feeding intolerance, preterm infants often receive parenteral nutrition (PN) to ensure sufficient nutrition and energy intake. However, there is a lack of data on the status of clinical PN practice and barriers among neonatal care units in low to middle-income countries like Vietnam. This extensive survey explores the status and barriers of PN practice for preterm infants in neonatal units across Vietnam and identifies the practical implications of enhancing nutritional outcomes in preterm infants.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140883095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection 脐带血降钙素原在诊断新生儿早期感染中的有效性
medRxiv - Pediatrics Pub Date : 2024-05-01 DOI: 10.1101/2024.04.30.24306628
Uyen Le Tran, Linh Tran Phuong Giang, Tinh Thu Nguyen
{"title":"Validity of Umbilical Cord Blood Procalcitonin in the Diagnosis of Early-Onset Neonatal Infection","authors":"Uyen Le Tran, Linh Tran Phuong Giang, Tinh Thu Nguyen","doi":"10.1101/2024.04.30.24306628","DOIUrl":"https://doi.org/10.1101/2024.04.30.24306628","url":null,"abstract":"<strong>Introduction</strong> Early-onset neonatal infection (EONI) poses significant risks to neonatal health, necessitating reliable diagnostic markers for early detection. This study aims to evaluate the diagnostic validity of procalcitonin (PCT) concentration in umbilical cord blood as a biomarker for EONI.","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140883155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocol on an Integrative review on nomenclature and outcomes in paediatric complex critical illness - The basis for consensus definition 儿科复杂危重症术语和结果综合审查议定书--共识定义的基础
medRxiv - Pediatrics Pub Date : 2024-05-01 DOI: 10.1101/2024.04.29.24306579
Sofia Cuevas-Asturias, Will Tremlett, Hannah Mitchell, Padmanabhan Ramnarayan, Natalie Pattison
{"title":"Protocol on an Integrative review on nomenclature and outcomes in paediatric complex critical illness - The basis for consensus definition","authors":"Sofia Cuevas-Asturias, Will Tremlett, Hannah Mitchell, Padmanabhan Ramnarayan, Natalie Pattison","doi":"10.1101/2024.04.29.24306579","DOIUrl":"https://doi.org/10.1101/2024.04.29.24306579","url":null,"abstract":"Paediatric Critical Care (PCC) supports the recovery of children with severe illness. Nationally, there are 30 PCC units with a total of approximately 400 beds. There is constant demand for these beds with an average five-day length of stay and admissions increasing at a greater rate than age-specific population growth[1, 2]. Prolonged stay patients account for approximately half of all PCC patient bed days[3].","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"151 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140883159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children COVID-19 mRNA 疫苗可在幼儿口咽部诱导大量 IgG，但诱导的 IgA 数量有限
medRxiv - Pediatrics Pub Date : 2024-04-16 DOI: 10.1101/2024.04.15.24305767
Ying Tang, Brittany P. Boribong, Zoe N. Swank, Melina Demokritou, Maria A.F. Luban, Alessio Fasano, Michelle Du, Rebecca L. Wolf, Joseph Griffiths, John Shultz, Ella Borberg, Sujata Chalise, Wanda I. Gonzalez, David R. Walt, Lael M. Yonker, Bruce H. Horwitz
{"title":"COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children","authors":"Ying Tang, Brittany P. Boribong, Zoe N. Swank, Melina Demokritou, Maria A.F. Luban, Alessio Fasano, Michelle Du, Rebecca L. Wolf, Joseph Griffiths, John Shultz, Ella Borberg, Sujata Chalise, Wanda I. Gonzalez, David R. Walt, Lael M. Yonker, Bruce H. Horwitz","doi":"10.1101/2024.04.15.24305767","DOIUrl":"https://doi.org/10.1101/2024.04.15.24305767","url":null,"abstract":"<strong>Key points</strong>","PeriodicalId":501549,"journal":{"name":"medRxiv - Pediatrics","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140617841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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